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Protein

WAP four-disulfide core domain protein 1

Gene

WFDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has growth inhibitory activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 1
Alternative name(s):
Prostate stromal protein ps20
ps20 growth inhibitor
Gene namesi
Name:WFDC1
Synonyms:PS20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103175.10
HGNCiHGNC:15466 WFDC1
MIMi605322 gene
neXtProtiNX_Q9HC57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi58189
OpenTargetsiENSG00000103175
PharmGKBiPA37963

Polymorphism and mutation databases

BioMutaiWFDC1
DMDMi22096244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000004136532 – 220WAP four-disulfide core domain protein 1Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 96PROSITE-ProRule annotation
Disulfide bondi78 ↔ 100PROSITE-ProRule annotation
Disulfide bondi83 ↔ 95PROSITE-ProRule annotation
Disulfide bondi89 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9HC57
PeptideAtlasiQ9HC57
PRIDEiQ9HC57
ProteomicsDBi81641

PTM databases

iPTMnetiQ9HC57
PhosphoSitePlusiQ9HC57

Expressioni

Gene expression databases

BgeeiENSG00000103175 Expressed in 191 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_WFDC1
ExpressionAtlasiQ9HC57 baseline and differential
GenevisibleiQ9HC57 HS

Organism-specific databases

HPAiHPA031411

Interactioni

Protein-protein interaction databases

BioGridi121803, 7 interactors
IntActiQ9HC57, 5 interactors
STRINGi9606.ENSP00000219454

Structurei

3D structure databases

ProteinModelPortaliQ9HC57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 108WAPPROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 70Poly-Pro4
Compositional biasi109 – 112Poly-Pro4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH18 Eukaryota
ENOG41106Q5 LUCA
GeneTreeiENSGT00390000014299
HOGENOMiHOG000290176
HOVERGENiHBG075889
InParanoidiQ9HC57
OMAiQPRADRC
OrthoDBiEOG091G0I2U
PhylomeDBiQ9HC57
TreeFamiTF328768

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 1 hit
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390 WAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HC57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE
60 70 80 90 100
EAGAPGGPRQ PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC
110 120 130 140 150
AYACLEAVPP PPVLDWLVQP KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG
160 170 180 190 200
AEPLLCPSGY ECHILSPGDV AEGIPNRGQC VKQRRQADGR ILRHKLYKEY
210 220
PEGDSKNVAE PGRGQQKHFQ
Length:220
Mass (Da):23,977
Last modified:August 2, 2002 - v2
Checksum:i8098EB9379F88CBD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY77A0A087WY77_HUMAN
WAP four-disulfide core domain prot...
WFDC1
66Annotation score:

Sequence cautioni

The sequence AAG15263 differs from that shown. Reason: Frameshift at positions 166 and 173.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33N → D in BAC11377 (PubMed:14702039).Curated1
Sequence conflicti79Q → R in BAC11377 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036489138V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs11643870Ensembl.1
Natural variantiVAR_052948196L → V. Corresponds to variant dbSNP:rs35504166Ensembl.1
Natural variantiVAR_052949217K → R2 PublicationsCorresponds to variant dbSNP:rs12933084Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169631 mRNA Translation: AAG16647.1
AF302109 mRNA Translation: AAG15263.1 Frameshift.
AK075061 mRNA Translation: BAC11377.1
CH471114 Genomic DNA Translation: EAW95486.1
CH471114 Genomic DNA Translation: EAW95487.1
BC029159 mRNA Translation: AAH29159.1
CCDSiCCDS10946.1
RefSeqiNP_001269395.1, NM_001282466.1
NP_001269396.1, NM_001282467.1
NP_067020.2, NM_021197.3
UniGeneiHs.36688

Genome annotation databases

EnsembliENST00000219454; ENSP00000219454; ENSG00000103175
ENST00000568638; ENSP00000456920; ENSG00000103175
GeneIDi58189
KEGGihsa:58189
UCSCiuc002fhv.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169631 mRNA Translation: AAG16647.1
AF302109 mRNA Translation: AAG15263.1 Frameshift.
AK075061 mRNA Translation: BAC11377.1
CH471114 Genomic DNA Translation: EAW95486.1
CH471114 Genomic DNA Translation: EAW95487.1
BC029159 mRNA Translation: AAH29159.1
CCDSiCCDS10946.1
RefSeqiNP_001269395.1, NM_001282466.1
NP_001269396.1, NM_001282467.1
NP_067020.2, NM_021197.3
UniGeneiHs.36688

3D structure databases

ProteinModelPortaliQ9HC57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121803, 7 interactors
IntActiQ9HC57, 5 interactors
STRINGi9606.ENSP00000219454

PTM databases

iPTMnetiQ9HC57
PhosphoSitePlusiQ9HC57

Polymorphism and mutation databases

BioMutaiWFDC1
DMDMi22096244

Proteomic databases

PaxDbiQ9HC57
PeptideAtlasiQ9HC57
PRIDEiQ9HC57
ProteomicsDBi81641

Protocols and materials databases

DNASUi58189
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219454; ENSP00000219454; ENSG00000103175
ENST00000568638; ENSP00000456920; ENSG00000103175
GeneIDi58189
KEGGihsa:58189
UCSCiuc002fhv.5 human

Organism-specific databases

CTDi58189
DisGeNETi58189
EuPathDBiHostDB:ENSG00000103175.10
GeneCardsiWFDC1
HGNCiHGNC:15466 WFDC1
HPAiHPA031411
MIMi605322 gene
neXtProtiNX_Q9HC57
OpenTargetsiENSG00000103175
PharmGKBiPA37963
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH18 Eukaryota
ENOG41106Q5 LUCA
GeneTreeiENSGT00390000014299
HOGENOMiHOG000290176
HOVERGENiHBG075889
InParanoidiQ9HC57
OMAiQPRADRC
OrthoDBiEOG091G0I2U
PhylomeDBiQ9HC57
TreeFamiTF328768

Miscellaneous databases

GeneWikiiWFDC1
GenomeRNAii58189
PROiPR:Q9HC57
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103175 Expressed in 191 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_WFDC1
ExpressionAtlasiQ9HC57 baseline and differential
GenevisibleiQ9HC57 HS

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 1 hit
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390 WAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWFDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9HC57
Secondary accession number(s): D3DUL7, Q8NC27, Q9HAU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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