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Protein

Chromobox protein homolog 8

Gene

CBX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.1 Publication

Miscellaneous

The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 8
Alternative name(s):
Polycomb 3 homolog
Short name:
Pc3
Short name:
hPc3
Rectachrome 1
Gene namesi
Name:CBX8
Synonyms:PC3, RC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141570.10
HGNCiHGNC:15962 CBX8
MIMi617354 gene
neXtProtiNX_Q9HC52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57332
OpenTargetsiENSG00000141570
PharmGKBiPA26133

Chemistry databases

ChEMBLiCHEMBL3232684

Polymorphism and mutation databases

BioMutaiCBX8
DMDMi78099843

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802151 – 389Chromobox protein homolog 8Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HC52
MaxQBiQ9HC52
PaxDbiQ9HC52
PeptideAtlasiQ9HC52
PRIDEiQ9HC52
ProteomicsDBi81638

PTM databases

iPTMnetiQ9HC52
PhosphoSitePlusiQ9HC52

Expressioni

Gene expression databases

BgeeiENSG00000141570 Expressed in 123 organ(s), highest expression level in right uterine tube
CleanExiHS_CBX8
ExpressionAtlasiQ9HC52 baseline and differential
GenevisibleiQ9HC52 HS

Organism-specific databases

HPAiHPA031462

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121487, 136 interactors
CORUMiQ9HC52
DIPiDIP-44566N
IntActiQ9HC52, 194 interactors
MINTiQ9HC52
STRINGi9606.ENSP00000269385

Chemistry databases

BindingDBiQ9HC52

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HC52
SMRiQ9HC52
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HC52

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 69ChromoPROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiENOG410IPQ7 Eukaryota
ENOG410XRRX LUCA
GeneTreeiENSGT00530000063056
HOGENOMiHOG000233642
HOVERGENiHBG003608
InParanoidiQ9HC52
KOiK11455
OMAiQCGVASP
OrthoDBiEOG091G0MFV
PhylomeDBiQ9HC52
TreeFamiTF106456

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9HC52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD
60 70 80 90 100
ARLLAAFEER EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSAR
110 120 130 140 150
GIRIPYPGRS PQDLASTSRA REGLRNMGLS PPASSTSTSS TCRAEAPRDR
160 170 180 190 200
DRDRDRDRER DRERERERER ERERERERER GTSRVDDKPS SPGDSSKKRG
210 220 230 240 250
PKPRKELPDP SQRPLGEPSA GLGEYLKGRK LDDTPSGAGK FPAGHSVIQL
260 270 280 290 300
ARRQDSDLVQ CGVTSPSSAE ATGKLAVDTF PARVIKHRAA FLEAKGQGAL
310 320 330 340 350
DPNGTRVRHG SGPPSSGGGL YRDMGAQGGR PSLIARIPVA RILGDPEEES
360 370 380
WSPSLTNLEK VVVTDVTSNF LTVTIKESNT DQGFFKEKR
Length:389
Mass (Da):43,396
Last modified:May 10, 2005 - v3
Checksum:i651263C85B0ECD93
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6K3C9J6K3_HUMAN
Chromobox protein homolog 8
CBX8
242Annotation score:
C9JM54C9JM54_HUMAN
Chromobox protein homolog 8
CBX8
175Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014954317G → V2 PublicationsCorresponds to variant dbSNP:rs4889891Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174482 mRNA Translation: AAG09180.1
AF266479 mRNA Translation: AAF76328.2
AK074560 mRNA Translation: BAC11061.1
BC008937 mRNA Translation: AAH08937.1
BC009376 mRNA Translation: AAH09376.1
BC019289 mRNA Translation: AAH19289.1
CCDSiCCDS11765.1
RefSeqiNP_065700.1, NM_020649.2
UniGeneiHs.387258

Genome annotation databases

EnsembliENST00000269385; ENSP00000269385; ENSG00000141570
GeneIDi57332
KEGGihsa:57332
UCSCiuc002jxd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174482 mRNA Translation: AAG09180.1
AF266479 mRNA Translation: AAF76328.2
AK074560 mRNA Translation: BAC11061.1
BC008937 mRNA Translation: AAH08937.1
BC009376 mRNA Translation: AAH09376.1
BC019289 mRNA Translation: AAH19289.1
CCDSiCCDS11765.1
RefSeqiNP_065700.1, NM_020649.2
UniGeneiHs.387258

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N4QNMR-A327-349[»]
3I91X-ray1.55A/B8-61[»]
5EQ0X-ray1.18A7-61[»]
ProteinModelPortaliQ9HC52
SMRiQ9HC52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121487, 136 interactors
CORUMiQ9HC52
DIPiDIP-44566N
IntActiQ9HC52, 194 interactors
MINTiQ9HC52
STRINGi9606.ENSP00000269385

Chemistry databases

BindingDBiQ9HC52
ChEMBLiCHEMBL3232684

PTM databases

iPTMnetiQ9HC52
PhosphoSitePlusiQ9HC52

Polymorphism and mutation databases

BioMutaiCBX8
DMDMi78099843

Proteomic databases

EPDiQ9HC52
MaxQBiQ9HC52
PaxDbiQ9HC52
PeptideAtlasiQ9HC52
PRIDEiQ9HC52
ProteomicsDBi81638

Protocols and materials databases

DNASUi57332
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269385; ENSP00000269385; ENSG00000141570
GeneIDi57332
KEGGihsa:57332
UCSCiuc002jxd.3 human

Organism-specific databases

CTDi57332
DisGeNETi57332
EuPathDBiHostDB:ENSG00000141570.10
GeneCardsiCBX8
HGNCiHGNC:15962 CBX8
HPAiHPA031462
MIMi617354 gene
neXtProtiNX_Q9HC52
OpenTargetsiENSG00000141570
PharmGKBiPA26133
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPQ7 Eukaryota
ENOG410XRRX LUCA
GeneTreeiENSGT00530000063056
HOGENOMiHOG000233642
HOVERGENiHBG003608
InParanoidiQ9HC52
KOiK11455
OMAiQCGVASP
OrthoDBiEOG091G0MFV
PhylomeDBiQ9HC52
TreeFamiTF106456

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

EvolutionaryTraceiQ9HC52
GeneWikiiCBX8
GenomeRNAii57332
PROiPR:Q9HC52
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141570 Expressed in 123 organ(s), highest expression level in right uterine tube
CleanExiHS_CBX8
ExpressionAtlasiQ9HC52 baseline and differential
GenevisibleiQ9HC52 HS

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBX8_HUMAN
AccessioniPrimary (citable) accession number: Q9HC52
Secondary accession number(s): Q96H39, Q9NR07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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