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Protein

Glyoxalase domain-containing protein 4

Gene

GLOD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxalase domain-containing protein 4
Gene namesi
Name:GLOD4
Synonyms:C17orf25
ORF Names:CGI-150, My027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167699.13
HGNCiHGNC:14111 GLOD4
neXtProtiNX_Q9HC38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi51031
OpenTargetsiENSG00000167699
PharmGKBiPA162389795

Polymorphism and mutation databases

BioMutaiGLOD4
DMDMi74718831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803911 – 313Glyoxalase domain-containing protein 4Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineBy similarity1
Modified residuei288N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HC38
MaxQBiQ9HC38
PeptideAtlasiQ9HC38
PRIDEiQ9HC38
ProteomicsDBi81633
81634 [Q9HC38-2]
81635 [Q9HC38-3]
TopDownProteomicsiQ9HC38-2 [Q9HC38-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00792035

PTM databases

iPTMnetiQ9HC38
PhosphoSitePlusiQ9HC38
SwissPalmiQ9HC38

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung.1 Publication

Gene expression databases

BgeeiENSG00000167699 Expressed in 231 organ(s), highest expression level in frontal cortex
CleanExiHS_GLOD4
ExpressionAtlasiQ9HC38 baseline and differential
GenevisibleiQ9HC38 HS

Organism-specific databases

HPAiHPA021623
HPA023246
HPA023248

Interactioni

Subunit structurei

Interacts with NUDT9.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119237, 34 interactors
IntActiQ9HC38, 4 interactors
MINTiQ9HC38

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HC38
SMRiQ9HC38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 145VOC 1PROSITE-ProRule annotationAdd BLAST141
Domaini152 – 273VOC 2PROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000012340
HOGENOMiHOG000006776
HOVERGENiHBG056038
InParanoidiQ9HC38
OMAiCEAACNG
PhylomeDBiQ9HC38
TreeFamiTF105801

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR037523 VOC
SUPFAMiSSF54593 SSF54593, 2 hits
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HC38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS
60 70 80 90 100
DYTRITEDSF SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND
110 120 130 140 150
FMGITLASSQ AVSNARKLEW PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS
160 170 180 190 200
DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE KDEEKQRALL GYADNQCKLE
210 220 230 240 250
LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI LTPLVSLDTP
260 270 280 290 300
GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
310
EWFAKHNKPK ASG
Length:313
Mass (Da):34,793
Last modified:March 1, 2001 - v1
Checksum:i43DB04159153F07C
GO
Isoform 2 (identifier: Q9HC38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG

Show »
Length:298
Mass (Da):33,233
Checksum:i92A5D51488DC8C02
GO
Isoform 3 (identifier: Q9HC38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
     197-203: CKLELQG → VSNLGEE
     204-313: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,258
Checksum:iD60B2D0ABEF774CE
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TLX2F6TLX2_HUMAN
Glyoxalase domain-containing protei...
GLOD4
502Annotation score:
I3L3Q4I3L3Q4_HUMAN
Glyoxalase domain-containing protei...
GLOD4
227Annotation score:
I3L1F4I3L1F4_HUMAN
Glyoxalase domain-containing protei...
GLOD4
59Annotation score:
I3NI27I3NI27_HUMAN
Glyoxalase domain-containing protei...
GLOD4
36Annotation score:
I3L277I3L277_HUMAN
Glyoxalase domain-containing protei...
GLOD4
76Annotation score:
I3NI24I3NI24_HUMAN
Glyoxalase domain-containing protei...
GLOD4
36Annotation score:
I3L2C2I3L2C2_HUMAN
Glyoxalase domain-containing protei...
GLOD4
52Annotation score:
I3L1I0I3L1I0_HUMAN
Glyoxalase domain-containing protei...
GLOD4
115Annotation score:
K7ENF2K7ENF2_HUMAN
Glyoxalase domain-containing protei...
GLOD4
68Annotation score:
I3L3G0I3L3G0_HUMAN
Glyoxalase domain-containing protei...
GLOD4
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295A → S in AAG17987 (PubMed:11642406).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031128282M → I1 PublicationCorresponds to variant dbSNP:rs17851349Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02364632 – 62ESCSV…DSFSK → LRHEEFEEGCKAACNG in isoform 2 and isoform 3. 4 PublicationsAdd BLAST31
Alternative sequenceiVSP_023647197 – 203CKLELQG → VSNLGEE in isoform 3. 1 Publication7
Alternative sequenceiVSP_023648204 – 313Missing in isoform 3. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA Translation: AAG17986.1
AF177343 mRNA Translation: AAG17987.1
AF061730 mRNA Translation: AAG43141.1
AK001488 mRNA No translation available.
CH471108 Genomic DNA Translation: EAW90645.1
CH471108 Genomic DNA Translation: EAW90646.1
CH471108 Genomic DNA Translation: EAW90647.1
CH471108 Genomic DNA Translation: EAW90649.1
CH471108 Genomic DNA Translation: EAW90650.1
BC008605 mRNA Translation: AAH08605.1
BC015848 mRNA Translation: AAH15848.1
CCDSiCCDS32520.1 [Q9HC38-2]
RefSeqiNP_057164.3, NM_016080.3 [Q9HC38-2]
UniGeneiHs.279061
Hs.595572

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699 [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699 [Q9HC38-2]
GeneIDi51031
KEGGihsa:51031
UCSCiuc002fru.4 human [Q9HC38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA Translation: AAG17986.1
AF177343 mRNA Translation: AAG17987.1
AF061730 mRNA Translation: AAG43141.1
AK001488 mRNA No translation available.
CH471108 Genomic DNA Translation: EAW90645.1
CH471108 Genomic DNA Translation: EAW90646.1
CH471108 Genomic DNA Translation: EAW90647.1
CH471108 Genomic DNA Translation: EAW90649.1
CH471108 Genomic DNA Translation: EAW90650.1
BC008605 mRNA Translation: AAH08605.1
BC015848 mRNA Translation: AAH15848.1
CCDSiCCDS32520.1 [Q9HC38-2]
RefSeqiNP_057164.3, NM_016080.3 [Q9HC38-2]
UniGeneiHs.279061
Hs.595572

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
ProteinModelPortaliQ9HC38
SMRiQ9HC38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119237, 34 interactors
IntActiQ9HC38, 4 interactors
MINTiQ9HC38

PTM databases

iPTMnetiQ9HC38
PhosphoSitePlusiQ9HC38
SwissPalmiQ9HC38

Polymorphism and mutation databases

BioMutaiGLOD4
DMDMi74718831

2D gel databases

REPRODUCTION-2DPAGEiIPI00792035

Proteomic databases

EPDiQ9HC38
MaxQBiQ9HC38
PeptideAtlasiQ9HC38
PRIDEiQ9HC38
ProteomicsDBi81633
81634 [Q9HC38-2]
81635 [Q9HC38-3]
TopDownProteomicsiQ9HC38-2 [Q9HC38-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699 [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699 [Q9HC38-2]
GeneIDi51031
KEGGihsa:51031
UCSCiuc002fru.4 human [Q9HC38-1]

Organism-specific databases

CTDi51031
DisGeNETi51031
EuPathDBiHostDB:ENSG00000167699.13
GeneCardsiGLOD4
HGNCiHGNC:14111 GLOD4
HPAiHPA021623
HPA023246
HPA023248
neXtProtiNX_Q9HC38
OpenTargetsiENSG00000167699
PharmGKBiPA162389795
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000012340
HOGENOMiHOG000006776
HOVERGENiHBG056038
InParanoidiQ9HC38
OMAiCEAACNG
PhylomeDBiQ9HC38
TreeFamiTF105801

Miscellaneous databases

ChiTaRSiGLOD4 human
GeneWikiiGLOD4
GenomeRNAii51031
PROiPR:Q9HC38

Gene expression databases

BgeeiENSG00000167699 Expressed in 231 organ(s), highest expression level in frontal cortex
CleanExiHS_GLOD4
ExpressionAtlasiQ9HC38 baseline and differential
GenevisibleiQ9HC38 HS

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR037523 VOC
SUPFAMiSSF54593 SSF54593, 2 hits
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGLOD4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC38
Secondary accession number(s): D3DTG9
, D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9NVN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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