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Entry version 135 (22 Apr 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Glyoxalase domain-containing protein 4

Gene

GLOD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glyoxalase domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLOD4
Synonyms:C17orf25
ORF Names:CGI-150, My027
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14111 GLOD4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC38

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51031

Open Targets

More...
OpenTargetsi
ENSG00000167699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389795

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HC38 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLOD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74718831

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002803911 – 313Glyoxalase domain-containing protein 4Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineBy similarity1
Modified residuei288N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HC38

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HC38

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HC38

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HC38

PeptideAtlas

More...
PeptideAtlasi
Q9HC38

PRoteomics IDEntifications database

More...
PRIDEi
Q9HC38

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81633 [Q9HC38-1]
81634 [Q9HC38-2]
81635 [Q9HC38-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9HC38-2 [Q9HC38-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00792035

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HC38

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9HC38

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HC38

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9HC38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167699 Expressed in frontal cortex and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HC38 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HC38 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167699 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NUDT9.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119237, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HC38, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9HC38

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HC38 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HC38

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 145VOC 1PROSITE-ProRule annotationAdd BLAST141
Domaini152 – 273VOC 2PROSITE-ProRule annotationAdd BLAST122

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012340

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044479_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HC38

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEAACNG

Database of Orthologous Groups

More...
OrthoDBi
824414at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HC38

TreeFam database of animal gene trees

More...
TreeFami
TF105801

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.180.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR037523 VOC

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54593 SSF54593, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51819 VOC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HC38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS
60 70 80 90 100
DYTRITEDSF SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND
110 120 130 140 150
FMGITLASSQ AVSNARKLEW PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS
160 170 180 190 200
DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE KDEEKQRALL GYADNQCKLE
210 220 230 240 250
LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI LTPLVSLDTP
260 270 280 290 300
GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
310
EWFAKHNKPK ASG
Length:313
Mass (Da):34,793
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43DB04159153F07C
GO
Isoform 2 (identifier: Q9HC38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG

Show »
Length:298
Mass (Da):33,233
Checksum:i92A5D51488DC8C02
GO
Isoform 3 (identifier: Q9HC38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
     197-203: CKLELQG → VSNLGEE
     204-313: Missing.

Show »
Length:188
Mass (Da):21,258
Checksum:iD60B2D0ABEF774CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TLX2F6TLX2_HUMAN
Glyoxalase domain-containing protei...
GLOD4
502Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3Q4I3L3Q4_HUMAN
Glyoxalase domain-containing protei...
GLOD4
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1F4I3L1F4_HUMAN
Glyoxalase domain-containing protei...
GLOD4
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L277I3L277_HUMAN
Glyoxalase domain-containing protei...
GLOD4
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1I0I3L1I0_HUMAN
Glyoxalase domain-containing protei...
GLOD4
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2C2I3L2C2_HUMAN
Glyoxalase domain-containing protei...
GLOD4
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI27I3NI27_HUMAN
Glyoxalase domain-containing protei...
GLOD4
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI24I3NI24_HUMAN
Glyoxalase domain-containing protei...
GLOD4
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3G0I3L3G0_HUMAN
Glyoxalase domain-containing protei...
GLOD4
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENF2K7ENF2_HUMAN
Glyoxalase domain-containing protei...
GLOD4
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295A → S in AAG17987 (PubMed:11642406).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031128282M → I1 PublicationCorresponds to variant dbSNP:rs17851349Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02364632 – 62ESCSV…DSFSK → LRHEEFEEGCKAACNG in isoform 2 and isoform 3. 4 PublicationsAdd BLAST31
Alternative sequenceiVSP_023647197 – 203CKLELQG → VSNLGEE in isoform 3. 1 Publication7
Alternative sequenceiVSP_023648204 – 313Missing in isoform 3. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177342 mRNA Translation: AAG17986.1
AF177343 mRNA Translation: AAG17987.1
AF061730 mRNA Translation: AAG43141.1
AK001488 mRNA No translation available.
CH471108 Genomic DNA Translation: EAW90645.1
CH471108 Genomic DNA Translation: EAW90646.1
CH471108 Genomic DNA Translation: EAW90647.1
CH471108 Genomic DNA Translation: EAW90649.1
CH471108 Genomic DNA Translation: EAW90650.1
BC008605 mRNA Translation: AAH08605.1
BC015848 mRNA Translation: AAH15848.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32520.1 [Q9HC38-2]

NCBI Reference Sequences

More...
RefSeqi
NP_057164.3, NM_016080.3 [Q9HC38-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301328; ENSP00000301328; ENSG00000167699 [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699 [Q9HC38-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51031

UCSC genome browser

More...
UCSCi
uc002fru.4 human [Q9HC38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA Translation: AAG17986.1
AF177343 mRNA Translation: AAG17987.1
AF061730 mRNA Translation: AAG43141.1
AK001488 mRNA No translation available.
CH471108 Genomic DNA Translation: EAW90645.1
CH471108 Genomic DNA Translation: EAW90646.1
CH471108 Genomic DNA Translation: EAW90647.1
CH471108 Genomic DNA Translation: EAW90649.1
CH471108 Genomic DNA Translation: EAW90650.1
BC008605 mRNA Translation: AAH08605.1
BC015848 mRNA Translation: AAH15848.1
CCDSiCCDS32520.1 [Q9HC38-2]
RefSeqiNP_057164.3, NM_016080.3 [Q9HC38-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
SMRiQ9HC38
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119237, 54 interactors
IntActiQ9HC38, 7 interactors
MINTiQ9HC38

PTM databases

iPTMnetiQ9HC38
MetOSiteiQ9HC38
PhosphoSitePlusiQ9HC38
SwissPalmiQ9HC38

Polymorphism and mutation databases

BioMutaiGLOD4
DMDMi74718831

2D gel databases

REPRODUCTION-2DPAGEiIPI00792035

Proteomic databases

EPDiQ9HC38
jPOSTiQ9HC38
MassIVEiQ9HC38
MaxQBiQ9HC38
PeptideAtlasiQ9HC38
PRIDEiQ9HC38
ProteomicsDBi81633 [Q9HC38-1]
81634 [Q9HC38-2]
81635 [Q9HC38-3]
TopDownProteomicsiQ9HC38-2 [Q9HC38-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10285 104 antibodies

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699 [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699 [Q9HC38-2]
GeneIDi51031
KEGGihsa:51031
UCSCiuc002fru.4 human [Q9HC38-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51031
DisGeNETi51031

GeneCards: human genes, protein and diseases

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GeneCardsi
GLOD4
HGNCiHGNC:14111 GLOD4
HPAiENSG00000167699 Low tissue specificity
neXtProtiNX_Q9HC38
OpenTargetsiENSG00000167699
PharmGKBiPA162389795

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00390000012340
HOGENOMiCLU_044479_0_0_1
InParanoidiQ9HC38
OMAiCEAACNG
OrthoDBi824414at2759
PhylomeDBiQ9HC38
TreeFamiTF105801

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GLOD4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GLOD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51031
PharosiQ9HC38 Tdark

Protein Ontology

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PROi
PR:Q9HC38
RNActiQ9HC38 protein

Gene expression databases

BgeeiENSG00000167699 Expressed in frontal cortex and 230 other tissues
ExpressionAtlasiQ9HC38 baseline and differential
GenevisibleiQ9HC38 HS

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR037523 VOC
SUPFAMiSSF54593 SSF54593, 2 hits
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLOD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC38
Secondary accession number(s): D3DTG9
, D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9NVN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: April 22, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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