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Protein

rRNA methyltransferase 3, mitochondrial

Gene

MRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.3 Publications

Catalytic activityi

S-adenosyl-L-methionine + guanosine(1370) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1370) in 16S rRNA.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei356S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei380S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei389S-adenosyl-L-methionine; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6793080 rRNA modification in the mitochondrion

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 3, mitochondrial1 Publication (EC:2.1.1.-2 Publications)
Alternative name(s):
16S rRNA (guanosine(1370)-2'-O)-methyltransferase1 Publication
16S rRNA [Gm1370] 2'-O-methyltransferase1 Publication
RNA methyltransferase-like protein 11 Publication
Gene namesi
Name:MRM31 PublicationImported
Synonyms:RNMTL11 Publication
ORF Names:HC90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171861.10
HGNCiHGNC:18485 MRM3
MIMi612600 gene
neXtProtiNX_Q9HC36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171861
PharmGKBiPA38341

Polymorphism and mutation databases

BioMutaiRNMTL1
DMDMi74734265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionSequence analysisAdd BLAST40
ChainiPRO_000031130141 – 420rRNA methyltransferase 3, mitochondrialAdd BLAST380

Proteomic databases

EPDiQ9HC36
MaxQBiQ9HC36
PaxDbiQ9HC36
PeptideAtlasiQ9HC36
PRIDEiQ9HC36
ProteomicsDBi81632

PTM databases

iPTMnetiQ9HC36
PhosphoSitePlusiQ9HC36

Expressioni

Tissue specificityi

Expressed at same level in normal liver and hepatocarcinoma.1 Publication

Gene expression databases

BgeeiENSG00000171861 Expressed in 206 organ(s), highest expression level in endothelial cell
CleanExiHS_RNMTL1
ExpressionAtlasiQ9HC36 baseline and differential
GenevisibleiQ9HC36 HS

Organism-specific databases

HPAiHPA022534
HPA023031
HPA023292

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136435EBI-1045440,EBI-741101

Protein-protein interaction databases

BioGridi120477, 58 interactors
IntActiQ9HC36, 24 interactors
MINTiQ9HC36
STRINGi9606.ENSP00000306080

Structurei

3D structure databases

ProteinModelPortaliQ9HC36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2506 Eukaryota
COG0566 LUCA
GeneTreeiENSGT00390000017317
HOGENOMiHOG000154151
HOVERGENiHBG108411
InParanoidiQ9HC36
KOiK20095
OMAiINNLDWE
OrthoDBiEOG091G0OPI
PhylomeDBiQ9HC36
TreeFamiTF323420

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029064 L30e-like
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
SMARTiView protein in SMART
SM00967 SpoU_sub_bind, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF75217 SSF75217, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9HC36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ
60 70 80 90 100
KRAPGKQPRK APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG
110 120 130 140 150
DRRLSSVMTI VKSRPFREKQ GKILLEGRRL ISDALKAGAV PKMFFFSRLE
160 170 180 190 200
YLKELPVDKL KGVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDHVKMTYP
210 220 230 240 250
KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP
260 270 280 290 300
KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN
310 320 330 340 350
KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP
360 370 380 390 400
AAVVIGGETY GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF
410 420
EGKRQLRGRA EDLSRDRSYH
Length:420
Mass (Da):47,020
Last modified:June 1, 2002 - v2
Checksum:iCC06C27489A89FC3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L443I3L443_HUMAN
rRNA methyltransferase 3, mitochond...
MRM3
177Annotation score:
I3L0T6I3L0T6_HUMAN
rRNA methyltransferase 3, mitochond...
MRM3
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247A → V in BAD96620 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0372178A → S1 PublicationCorresponds to variant dbSNP:rs2273454Ensembl.1
Natural variantiVAR_03721845G → E. Corresponds to variant dbSNP:rs2249542Ensembl.1
Natural variantiVAR_037219185I → V1 PublicationCorresponds to variant dbSNP:rs17854653Ensembl.1
Natural variantiVAR_037220326E → Q. Corresponds to variant dbSNP:rs35780267Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001443 mRNA Translation: BAA91694.1
AK222900 mRNA Translation: BAD96620.1
AF177344 mRNA Translation: AAG17988.2
CH471108 Genomic DNA Translation: EAW90642.1
BC011550 mRNA Translation: AAH11550.1
BC050614 mRNA Translation: AAH50614.1
CCDSiCCDS10997.1
RefSeqiNP_001304876.1, NM_001317947.1
NP_060616.1, NM_018146.3
UniGeneiHs.182729

Genome annotation databases

EnsembliENST00000304478; ENSP00000306080; ENSG00000171861
GeneIDi55178
KEGGihsa:55178
UCSCiuc002frw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRM3_HUMAN
AccessioniPrimary (citable) accession number: Q9HC36
Secondary accession number(s): Q53GN1
, Q86VC3, Q96F76, Q9NVQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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