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Protein

Echinoderm microtubule-associated protein-like 4

Gene

EML4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

GO - Molecular functioni

GO - Biological processi

  • microtubule-based process Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB

Enzyme and pathway databases

SignaLinkiQ9HC35

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 4
Short name:
EMAP-4
Alternative name(s):
Restrictedly overexpressed proliferation-associated protein
Ropp 120
Gene namesi
Name:EML4
Synonyms:C2orf2, EMAPL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143924.18
HGNCiHGNC:1316 EML4
MIMi607442 gene
neXtProtiNX_Q9HC35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi27436
OpenTargetsiENSG00000143924
Orphaneti357191 Selection of therapeutic option in non-small cell lung carcinoma
PharmGKBiPA27769

Polymorphism and mutation databases

BioMutaiEML4
DMDMi296439364

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509631 – 981Echinoderm microtubule-associated protein-like 4Add BLAST981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei96PhosphothreonineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei226PhosphotyrosineCombined sources1
Modified residuei237PhosphothreonineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei897PhosphothreonineCombined sources1
Modified residuei899PhosphothreonineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HC35
MaxQBiQ9HC35
PaxDbiQ9HC35
PeptideAtlasiQ9HC35
PRIDEiQ9HC35
ProteomicsDBi81631

PTM databases

iPTMnetiQ9HC35
PhosphoSitePlusiQ9HC35

Expressioni

Developmental stagei

Strongly overexpressed during mitosis.

Gene expression databases

BgeeiENSG00000143924
CleanExiHS_EML4
ExpressionAtlasiQ9HC35 baseline and differential
GenevisibleiQ9HC35 HS

Organism-specific databases

HPAiHPA036687
HPA036688
HPA065337

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118169, 25 interactors
IntActiQ9HC35, 11 interactors
STRINGi9606.ENSP00000320663

Structurei

Secondary structure

1981
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi18 – 43Combined sources26

3D structure databases

ProteinModelPortaliQ9HC35
SMRiQ9HC35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati259 – 297WD 1Add BLAST39
Repeati301 – 348WD 2Add BLAST48
Repeati356 – 396WD 3Add BLAST41
Repeati403 – 438WD 4Add BLAST36
Repeati445 – 484WD 5Add BLAST40
Repeati500 – 538WD 6Add BLAST39
Repeati543 – 579WD 7Add BLAST37
Repeati582 – 621WD 8Add BLAST40
Repeati625 – 662WD 9Add BLAST38
Repeati668 – 704WD 10Add BLAST37
Repeati711 – 750WD 11Add BLAST40
Repeati760 – 818WD 12Add BLAST59
Repeati825 – 864WD 13Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410ISA0 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00550000074369
HOGENOMiHOG000294061
HOVERGENiHBG051470
InParanoidiQ9HC35
KOiK15420
PhylomeDBiQ9HC35
TreeFamiTF317832

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03451 HELP, 1 hit
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 9 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HC35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR
60 70 80 90 100
RLAISEDHVA SVKKSVSSKG QPSPRAVIPM SCITNGSGAN RKPSHTSAVS
110 120 130 140 150
IAGKETLSSA AKSGTEKKKE KPQGQREKKE ESHSNDQSPQ IRASPSPQPS
160 170 180 190 200
SQPLQIHRQT PESKNATPTK SIKRPSPAEK SHNSWENSDD SRNKLSKIPS
210 220 230 240 250
TPKLIPKVTK TADKHKDVII NQEGEYIKMF MRGRPITMFI PSDVDNYDDI
260 270 280 290 300
RTELPPEKLK LEWAYGYRGK DCRANVYLLP TGKIVYFIAS VVVLFNYEER
310 320 330 340 350
TQRHYLGHTD CVKCLAIHPD KIRIATGQIA GVDKDGRPLQ PHVRVWDSVT
360 370 380 390 400
LSTLQIIGLG TFERGVGCLD FSKADSGVHL CIIDDSNEHM LTVWDWQKKA
410 420 430 440 450
KGAEIKTTNE VVLAVEFHPT DANTIITCGK SHIFFWTWSG NSLTRKQGIF
460 470 480 490 500
GKYEKPKFVQ CLAFLGNGDV LTGDSGGVML IWSKTTVEPT PGKGPKGVYQ
510 520 530 540 550
ISKQIKAHDG SVFTLCQMRN GMLLTGGGKD RKIILWDHDL NPEREIEVPD
560 570 580 590 600
QYGTIRAVAE GKADQFLVGT SRNFILRGTF NDGFQIEVQG HTDELWGLAT
610 620 630 640 650
HPFKDLLLTC AQDRQVCLWN SMEHRLEWTR LVDEPGHCAD FHPSGTVVAI
660 670 680 690 700
GTHSGRWFVL DAETRDLVSI HTDGNEQLSV MRYSIDGTFL AVGSHDNFIY
710 720 730 740 750
LYVVSENGRK YSRYGRCTGH SSYITHLDWS PDNKYIMSNS GDYEILYWDI
760 770 780 790 800
PNGCKLIRNR SDCKDIDWTT YTCVLGFQVF GVWPEGSDGT DINALVRSHN
810 820 830 840 850
RKVIAVADDF CKVHLFQYPC SKAKAPSHKY SAHSSHVTNV SFTHNDSHLI
860 870 880 890 900
STGGKDMSII QWKLVEKLSL PQNETVADTT LTKAPVSSTE SVIQSNTPTP
910 920 930 940 950
PPSQPLNETA EEESRISSSP TLLENSLEQT VEPSEDHSEE ESEEGSGDLG
960 970 980
EPLYEEPCNE ISKEQAKATL LEDQQDPSPS S
Length:981
Mass (Da):108,916
Last modified:May 18, 2010 - v3
Checksum:i7E8F2585747736B9
GO
Isoform 2 (identifier: Q9HC35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-169: Missing.

Note: No experimental confirmation available.
Show »
Length:923
Mass (Da):102,444
Checksum:i82F2C3F43C4C8836
GO

Sequence cautioni

The sequence AAI04648 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti768 – 773WTTYTC → SSRPCW in AAY15086 (PubMed:15815621).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031726283K → E3 PublicationsCorresponds to variant dbSNP:rs6736913Ensembl.1
Natural variantiVAR_031727382I → V3 PublicationsCorresponds to variant dbSNP:rs10202624Ensembl.1
Natural variantiVAR_031728398K → R2 PublicationsCorresponds to variant dbSNP:rs28651764Ensembl.1
Natural variantiVAR_031729978S → L. Corresponds to variant dbSNP:rs28364731Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047192112 – 169Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177377 mRNA Translation: AAG09279.2
AK001804 mRNA Translation: BAA91919.1 Different initiation.
AK314702 mRNA Translation: BAG37250.1
AC006038 Genomic DNA Translation: AAY15086.1
AC083949 Genomic DNA No translation available.
AC096668 Genomic DNA Translation: AAY14895.1
BC023522 mRNA Translation: AAH23522.1
BC104647 mRNA Translation: AAI04648.1 Sequence problems.
BC140845 mRNA Translation: AAI40846.1
BC146799 mRNA Translation: AAI46800.1
CCDSiCCDS1807.1 [Q9HC35-1]
CCDS46266.1 [Q9HC35-2]
RefSeqiNP_001138548.1, NM_001145076.2
NP_061936.2, NM_019063.4
UniGeneiHs.713173

Genome annotation databases

EnsembliENST00000318522; ENSP00000320663; ENSG00000143924 [Q9HC35-1]
ENST00000402711; ENSP00000385059; ENSG00000143924 [Q9HC35-2]
GeneIDi27436
KEGGihsa:27436
UCSCiuc002rsi.3 human [Q9HC35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEMAL4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC35
Secondary accession number(s): A6H8Y6
, B2RBK3, B2RTW7, B5MCW9, Q3SWW0, Q53R29, Q53TW8, Q6PJ45, Q9NV40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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