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Entry version 173 (10 Apr 2019)
Sequence version 3 (18 May 2010)
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Protein

Echinoderm microtubule-associated protein-like 4

Gene

EML4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9HC35

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 4
Short name:
EMAP-4
Alternative name(s):
Restrictedly overexpressed proliferation-associated protein
Ropp 120
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EML4
Synonyms:C2orf2, EMAPL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143924.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1316 EML4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607442 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27436

Open Targets

More...
OpenTargetsi
ENSG00000143924

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
357191 Selection of therapeutic option in non-small cell lung carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27769

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EML4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439364

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509631 – 981Echinoderm microtubule-associated protein-like 4Add BLAST981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei96PhosphothreonineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei226PhosphotyrosineCombined sources1
Modified residuei237PhosphothreonineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei897PhosphothreonineCombined sources1
Modified residuei899PhosphothreonineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HC35

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HC35

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HC35

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HC35

PeptideAtlas

More...
PeptideAtlasi
Q9HC35

PRoteomics IDEntifications database

More...
PRIDEi
Q9HC35

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81631

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HC35

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HC35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly overexpressed during mitosis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143924 Expressed in 204 organ(s), highest expression level in metanephros

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HC35 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HC35 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036687
HPA036688
HPA065337

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118169, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HC35, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320663

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1981
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CGCX-ray2.90A/B/C6-64[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HC35

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HC35

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati259 – 297WD 1Add BLAST39
Repeati301 – 348WD 2Add BLAST48
Repeati356 – 396WD 3Add BLAST41
Repeati403 – 438WD 4Add BLAST36
Repeati445 – 484WD 5Add BLAST40
Repeati500 – 538WD 6Add BLAST39
Repeati543 – 579WD 7Add BLAST37
Repeati582 – 621WD 8Add BLAST40
Repeati625 – 662WD 9Add BLAST38
Repeati668 – 704WD 10Add BLAST37
Repeati711 – 750WD 11Add BLAST40
Repeati760 – 818WD 12Add BLAST59
Repeati825 – 864WD 13Add BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISA0 Eukaryota
COG2319 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158434

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294061

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051470

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HC35

KEGG Orthology (KO)

More...
KOi
K15420

Database of Orthologous Groups

More...
OrthoDBi
271572at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HC35

TreeFam database of animal gene trees

More...
TreeFami
TF317832

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03451 HELP, 1 hit
PF00400 WD40, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HC35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR
60 70 80 90 100
RLAISEDHVA SVKKSVSSKG QPSPRAVIPM SCITNGSGAN RKPSHTSAVS
110 120 130 140 150
IAGKETLSSA AKSGTEKKKE KPQGQREKKE ESHSNDQSPQ IRASPSPQPS
160 170 180 190 200
SQPLQIHRQT PESKNATPTK SIKRPSPAEK SHNSWENSDD SRNKLSKIPS
210 220 230 240 250
TPKLIPKVTK TADKHKDVII NQEGEYIKMF MRGRPITMFI PSDVDNYDDI
260 270 280 290 300
RTELPPEKLK LEWAYGYRGK DCRANVYLLP TGKIVYFIAS VVVLFNYEER
310 320 330 340 350
TQRHYLGHTD CVKCLAIHPD KIRIATGQIA GVDKDGRPLQ PHVRVWDSVT
360 370 380 390 400
LSTLQIIGLG TFERGVGCLD FSKADSGVHL CIIDDSNEHM LTVWDWQKKA
410 420 430 440 450
KGAEIKTTNE VVLAVEFHPT DANTIITCGK SHIFFWTWSG NSLTRKQGIF
460 470 480 490 500
GKYEKPKFVQ CLAFLGNGDV LTGDSGGVML IWSKTTVEPT PGKGPKGVYQ
510 520 530 540 550
ISKQIKAHDG SVFTLCQMRN GMLLTGGGKD RKIILWDHDL NPEREIEVPD
560 570 580 590 600
QYGTIRAVAE GKADQFLVGT SRNFILRGTF NDGFQIEVQG HTDELWGLAT
610 620 630 640 650
HPFKDLLLTC AQDRQVCLWN SMEHRLEWTR LVDEPGHCAD FHPSGTVVAI
660 670 680 690 700
GTHSGRWFVL DAETRDLVSI HTDGNEQLSV MRYSIDGTFL AVGSHDNFIY
710 720 730 740 750
LYVVSENGRK YSRYGRCTGH SSYITHLDWS PDNKYIMSNS GDYEILYWDI
760 770 780 790 800
PNGCKLIRNR SDCKDIDWTT YTCVLGFQVF GVWPEGSDGT DINALVRSHN
810 820 830 840 850
RKVIAVADDF CKVHLFQYPC SKAKAPSHKY SAHSSHVTNV SFTHNDSHLI
860 870 880 890 900
STGGKDMSII QWKLVEKLSL PQNETVADTT LTKAPVSSTE SVIQSNTPTP
910 920 930 940 950
PPSQPLNETA EEESRISSSP TLLENSLEQT VEPSEDHSEE ESEEGSGDLG
960 970 980
EPLYEEPCNE ISKEQAKATL LEDQQDPSPS S
Length:981
Mass (Da):108,916
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E8F2585747736B9
GO
Isoform 2 (identifier: Q9HC35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-169: Missing.

Note: No experimental confirmation available.
Show »
Length:923
Mass (Da):102,444
Checksum:i82F2C3F43C4C8836
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MBZ0B5MBZ0_HUMAN
Echinoderm microtubule-associated p...
EML4
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI04648 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti768 – 773WTTYTC → SSRPCW in AAY15086 (PubMed:15815621).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031726283K → E3 PublicationsCorresponds to variant dbSNP:rs6736913Ensembl.1
Natural variantiVAR_031727382I → V3 PublicationsCorresponds to variant dbSNP:rs10202624Ensembl.1
Natural variantiVAR_031728398K → R2 PublicationsCorresponds to variant dbSNP:rs28651764Ensembl.1
Natural variantiVAR_031729978S → L. Corresponds to variant dbSNP:rs28364731Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047192112 – 169Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177377 mRNA Translation: AAG09279.2
AK001804 mRNA Translation: BAA91919.1 Different initiation.
AK314702 mRNA Translation: BAG37250.1
AC006038 Genomic DNA Translation: AAY15086.1
AC083949 Genomic DNA No translation available.
AC096668 Genomic DNA Translation: AAY14895.1
BC023522 mRNA Translation: AAH23522.1
BC104647 mRNA Translation: AAI04648.1 Sequence problems.
BC140845 mRNA Translation: AAI40846.1
BC146799 mRNA Translation: AAI46800.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1807.1 [Q9HC35-1]
CCDS46266.1 [Q9HC35-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001138548.1, NM_001145076.2
NP_061936.2, NM_019063.4 [Q9HC35-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.713173

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318522; ENSP00000320663; ENSG00000143924 [Q9HC35-1]
ENST00000402711; ENSP00000385059; ENSG00000143924 [Q9HC35-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27436

UCSC genome browser

More...
UCSCi
uc002rsi.3 human [Q9HC35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177377 mRNA Translation: AAG09279.2
AK001804 mRNA Translation: BAA91919.1 Different initiation.
AK314702 mRNA Translation: BAG37250.1
AC006038 Genomic DNA Translation: AAY15086.1
AC083949 Genomic DNA No translation available.
AC096668 Genomic DNA Translation: AAY14895.1
BC023522 mRNA Translation: AAH23522.1
BC104647 mRNA Translation: AAI04648.1 Sequence problems.
BC140845 mRNA Translation: AAI40846.1
BC146799 mRNA Translation: AAI46800.1
CCDSiCCDS1807.1 [Q9HC35-1]
CCDS46266.1 [Q9HC35-2]
RefSeqiNP_001138548.1, NM_001145076.2
NP_061936.2, NM_019063.4 [Q9HC35-1]
UniGeneiHs.713173

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CGCX-ray2.90A/B/C6-64[»]
ProteinModelPortaliQ9HC35
SMRiQ9HC35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118169, 26 interactors
IntActiQ9HC35, 10 interactors
STRINGi9606.ENSP00000320663

PTM databases

iPTMnetiQ9HC35
PhosphoSitePlusiQ9HC35

Polymorphism and mutation databases

BioMutaiEML4
DMDMi296439364

Proteomic databases

EPDiQ9HC35
jPOSTiQ9HC35
MaxQBiQ9HC35
PaxDbiQ9HC35
PeptideAtlasiQ9HC35
PRIDEiQ9HC35
ProteomicsDBi81631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318522; ENSP00000320663; ENSG00000143924 [Q9HC35-1]
ENST00000402711; ENSP00000385059; ENSG00000143924 [Q9HC35-2]
GeneIDi27436
KEGGihsa:27436
UCSCiuc002rsi.3 human [Q9HC35-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27436
DisGeNETi27436
EuPathDBiHostDB:ENSG00000143924.18

GeneCards: human genes, protein and diseases

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GeneCardsi
EML4
HGNCiHGNC:1316 EML4
HPAiHPA036687
HPA036688
HPA065337
MIMi607442 gene
neXtProtiNX_Q9HC35
OpenTargetsiENSG00000143924
Orphaneti357191 Selection of therapeutic option in non-small cell lung carcinoma
PharmGKBiPA27769

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410ISA0 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00940000158434
HOGENOMiHOG000294061
HOVERGENiHBG051470
InParanoidiQ9HC35
KOiK15420
OrthoDBi271572at2759
PhylomeDBiQ9HC35
TreeFamiTF317832

Enzyme and pathway databases

SignaLinkiQ9HC35

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EML4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EML4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27436

Protein Ontology

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PROi
PR:Q9HC35

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000143924 Expressed in 204 organ(s), highest expression level in metanephros
ExpressionAtlasiQ9HC35 baseline and differential
GenevisibleiQ9HC35 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03451 HELP, 1 hit
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 9 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMAL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC35
Secondary accession number(s): A6H8Y6
, B2RBK3, B2RTW7, B5MCW9, Q3SWW0, Q53R29, Q53TW8, Q6PJ45, Q9NV40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: April 10, 2019
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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