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Protein

Protein lifeguard 4

Gene

TMBIM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • regulation of calcium-mediated signaling Source: UniProtKB

Keywordsi

Biological processApoptosis

Protein family/group databases

TCDBi1.A.14.3.6 the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 4
Alternative name(s):
Golgi anti-apoptotic protein
Protein S1R
Transmembrane BAX inhibitor motif-containing protein 4
Z-protein
Gene namesi
Name:TMBIM4
Synonyms:GAAP, LFG4
ORF Names:CGI-119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000155957.17
HGNCiHGNC:24257 TMBIM4
neXtProtiNX_Q9HC24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 68LumenalSequence analysis9
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 97CytoplasmicSequence analysis8
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 120LumenalSequence analysis2
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 175LumenalSequence analysis3
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 208CytoplasmicSequence analysisAdd BLAST12
Intramembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 238CytoplasmicSequence analysis9

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51643
OpenTargetsiENSG00000155957
PharmGKBiPA142670805

Polymorphism and mutation databases

BioMutaiTMBIM4
DMDMi322510100

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790921 – 238Protein lifeguard 4Add BLAST238

Proteomic databases

EPDiQ9HC24
PaxDbiQ9HC24
PeptideAtlasiQ9HC24
PRIDEiQ9HC24
ProteomicsDBi81628

PTM databases

iPTMnetiQ9HC24
PhosphoSitePlusiQ9HC24

Expressioni

Gene expression databases

BgeeiENSG00000155957
CleanExiHS_TMBIM4
ExpressionAtlasiQ9HC24 baseline and differential
GenevisibleiQ9HC24 HS

Interactioni

Subunit structurei

Interacts with ITPR3.1 Publication

Protein-protein interaction databases

BioGridi119653, 10 interactors
IntActiQ9HC24, 36 interactors
STRINGi9606.ENSP00000350965

Structurei

3D structure databases

ProteinModelPortaliQ9HC24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ9HC24
KOiK06890
PhylomeDBiQ9HC24
TreeFamiTF321860

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HC24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT
60 70 80 90 100
VTSTVFLYFE SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL
110 120 130 140 150
LFGFTLLEAL TVAVVVTFYD VYIILQAFIL TTTVFFGLTV YTLQSKKDFS
160 170 180 190 200
KFGAGLFALL WILCLSGFLK FFFYSEIMEL VLAAAGALLF CGFIIYDTHS
210 220 230
LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK
Length:238
Mass (Da):26,971
Last modified:February 8, 2011 - v3
Checksum:i30CD39CF7F38564E
GO

Sequence cautioni

The sequence AAD34114 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0555472A → V. Corresponds to variant dbSNP:rs11176070Ensembl.1
Natural variantiVAR_01494688I → T3 PublicationsCorresponds to variant dbSNP:rs8793Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182041 mRNA Translation: AAG16898.1
AF151877 mRNA Translation: AAD34114.1 Different initiation.
AF113127 mRNA Translation: AAF14868.1
AK075069 mRNA Translation: BAC11384.1
AC078927 Genomic DNA No translation available.
BC020613 mRNA No translation available.
CCDSiCCDS41805.1
RefSeqiNP_001269535.1, NM_001282606.1
NP_001269538.1, NM_001282609.1
NP_001269539.1, NM_001282610.1
NP_057140.2, NM_016056.3
UniGeneiHs.505934

Genome annotation databases

EnsembliENST00000358230; ENSP00000350965; ENSG00000155957
GeneIDi51643
KEGGihsa:51643
UCSCiuc001stc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLFG4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC24
Secondary accession number(s): Q542Z6, Q9UHY5, Q9Y3C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 8, 2011
Last modified: July 18, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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