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Protein

Prokineticin-2

Gene

PROK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide
Biological processBiological rhythms

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HC23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prokineticin-2
Short name:
PK2
Alternative name(s):
Protein Bv8 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROK2
Synonyms:BV8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163421.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18455 PROK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607002 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HC23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 4 with or without anosmia (HH4)4 Publications
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROK2 as well as in other HH-associated genes including PROKR2 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
See also OMIM:610628
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06997024A → P in HH4; phenotype consistent with Kallmann syndrome. 2 PublicationsCorresponds to variant dbSNP:rs587777863EnsemblClinVar.1
Natural variantiVAR_03095532G → R in HH4; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs104893767EnsemblClinVar.1
Natural variantiVAR_07217734C → Y in HH4; totally abolished intracellular calcium mobilization. 1 PublicationCorresponds to variant dbSNP:rs587777864EnsemblClinVar.1
Natural variantiVAR_07299146C → Y in HH4. 1 Publication1
Natural variantiVAR_07217850I → M in HH4; no effect on intracellular calcium mobilization. 1 Publication1
Natural variantiVAR_03095673R → C in HH4; phenotype consistent with Kallmann syndrome; impaired calcium mobilization. 2 PublicationsCorresponds to variant dbSNP:rs121434272EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
60675

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PROK2

MalaCards human disease database

More...
MalaCardsi
PROK2
MIMi610628 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163421

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
478 Kallmann syndrome
432 Normosmic congenital hypogonadotropic hypogonadism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38540

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PROK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202953

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002580928 – 129Prokineticin-2Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 46By similarity
Disulfide bondi40 ↔ 58By similarity
Disulfide bondi45 ↔ 107By similarity
Disulfide bondi68 ↔ 115By similarity
Disulfide bondi109 ↔ 125By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HC23

PeptideAtlas

More...
PeptideAtlasi
Q9HC23

PRoteomics IDEntifications database

More...
PRIDEi
Q9HC23

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81626
81627 [Q9HC23-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the testis and, at low levels, in the small intestine.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activated by CLOCK and BMAL1 heterodimers and light; inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2).Curated

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163421 Expressed in 96 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_PROK2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HC23 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041408

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121950, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HC23, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000295619

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9HC23

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HC23

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HC23

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AVIT (prokineticin) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1F6 Eukaryota
ENOG4111YK9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162026

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004848

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG031845

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HC23

Identification of Orthologs from Complete Genome Data

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OMAi
FRCLPDF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0U3L

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HC23

TreeFam database of animal gene trees

More...
TreeFami
TF332732

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009523 Prokineticin
IPR023569 Prokineticin_domain

The PANTHER Classification System

More...
PANTHERi
PTHR18821 PTHR18821, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06607 Prokineticin, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD059788 Prokineticin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HC23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSLCCAPLL LLLLLPPLLL TPRAGDAAVI TGACDKDSQC GGGMCCAVSI
60 70 80 90 100
WVKSIRICTP MGKLGDSCHP LTRKNNFGNG RQERRKRKRS KRKKEVPFFG
110 120
RRMHHTCPCL PGLACLRTSF NRFICLAQK
Length:129
Mass (Da):14,314
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0487679E8700DA55
GO
Isoform 2 (identifier: Q9HC23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-95: Missing.

Show »
Length:108
Mass (Da):11,659
Checksum:iD7AF89D8551A97FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06997024A → P in HH4; phenotype consistent with Kallmann syndrome. 2 PublicationsCorresponds to variant dbSNP:rs587777863EnsemblClinVar.1
Natural variantiVAR_03095532G → R in HH4; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs104893767EnsemblClinVar.1
Natural variantiVAR_07217734C → Y in HH4; totally abolished intracellular calcium mobilization. 1 PublicationCorresponds to variant dbSNP:rs587777864EnsemblClinVar.1
Natural variantiVAR_07299146C → Y in HH4. 1 Publication1
Natural variantiVAR_07217850I → M in HH4; no effect on intracellular calcium mobilization. 1 Publication1
Natural variantiVAR_03095673R → C in HH4; phenotype consistent with Kallmann syndrome; impaired calcium mobilization. 2 PublicationsCorresponds to variant dbSNP:rs121434272EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00521975 – 95Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF333025 mRNA Translation: AAK49919.1
AY349131 mRNA Translation: AAR06657.1
CH471055 Genomic DNA Translation: EAW65506.1
BC069395 mRNA Translation: AAH69395.1
BC096695 mRNA Translation: AAH96695.1
BC098110 mRNA Translation: AAH98110.1
BC098162 mRNA Translation: AAH98162.1
AF182069 mRNA Translation: AAG16893.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2916.1 [Q9HC23-2]
CCDS46868.1 [Q9HC23-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001119600.1, NM_001126128.1 [Q9HC23-1]
NP_068754.1, NM_021935.3 [Q9HC23-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.528665

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295619; ENSP00000295619; ENSG00000163421 [Q9HC23-1]
ENST00000353065; ENSP00000295618; ENSG00000163421 [Q9HC23-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
60675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60675

UCSC genome browser

More...
UCSCi
uc003doz.5 human [Q9HC23-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333025 mRNA Translation: AAK49919.1
AY349131 mRNA Translation: AAR06657.1
CH471055 Genomic DNA Translation: EAW65506.1
BC069395 mRNA Translation: AAH69395.1
BC096695 mRNA Translation: AAH96695.1
BC098110 mRNA Translation: AAH98110.1
BC098162 mRNA Translation: AAH98162.1
AF182069 mRNA Translation: AAG16893.2
CCDSiCCDS2916.1 [Q9HC23-2]
CCDS46868.1 [Q9HC23-1]
RefSeqiNP_001119600.1, NM_001126128.1 [Q9HC23-1]
NP_068754.1, NM_021935.3 [Q9HC23-2]
UniGeneiHs.528665

3D structure databases

ProteinModelPortaliQ9HC23
SMRiQ9HC23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121950, 8 interactors
IntActiQ9HC23, 1 interactor
STRINGi9606.ENSP00000295619

Chemistry databases

BindingDBiQ9HC23

Polymorphism and mutation databases

BioMutaiPROK2
DMDMi18202953

Proteomic databases

PaxDbiQ9HC23
PeptideAtlasiQ9HC23
PRIDEiQ9HC23
ProteomicsDBi81626
81627 [Q9HC23-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295619; ENSP00000295619; ENSG00000163421 [Q9HC23-1]
ENST00000353065; ENSP00000295618; ENSG00000163421 [Q9HC23-2]
GeneIDi60675
KEGGihsa:60675
UCSCiuc003doz.5 human [Q9HC23-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60675
DisGeNETi60675
EuPathDBiHostDB:ENSG00000163421.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PROK2
GeneReviewsiPROK2
HGNCiHGNC:18455 PROK2
HPAiHPA041408
MalaCardsiPROK2
MIMi607002 gene
610628 phenotype
neXtProtiNX_Q9HC23
OpenTargetsiENSG00000163421
Orphaneti478 Kallmann syndrome
432 Normosmic congenital hypogonadotropic hypogonadism
PharmGKBiPA38540

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1F6 Eukaryota
ENOG4111YK9 LUCA
GeneTreeiENSGT00940000162026
HOGENOMiHOG000004848
HOVERGENiHBG031845
InParanoidiQ9HC23
OMAiFRCLPDF
OrthoDBiEOG091G0U3L
PhylomeDBiQ9HC23
TreeFamiTF332732

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiQ9HC23

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60675

Protein Ontology

More...
PROi
PR:Q9HC23

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163421 Expressed in 96 organ(s), highest expression level in blood
CleanExiHS_PROK2
GenevisibleiQ9HC23 HS

Family and domain databases

InterProiView protein in InterPro
IPR009523 Prokineticin
IPR023569 Prokineticin_domain
PANTHERiPTHR18821 PTHR18821, 1 hit
PfamiView protein in Pfam
PF06607 Prokineticin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD059788 Prokineticin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HC23
Secondary accession number(s): Q53Z79, Q6ISR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: December 5, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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