Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase Sgk2

Gene

SGK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na+ channels: SCNN1A/ENAC, K+ channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase.7 Publications

Caution

Not regulated by serum or glucocorticoids.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124ATPPROSITE-ProRule annotation1
Active sitei219Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 109ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
SignaLinkiQ9HBY8
SIGNORiQ9HBY8

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Sgk2 (EC:2.7.11.1)
Alternative name(s):
Serum/glucocorticoid-regulated kinase 2
Gene namesi
Name:SGK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101049.14
HGNCiHGNC:13900 SGK2
MIMi607589 gene
neXtProtiNX_Q9HBY8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi416S → D: Increased activation. 1 Publication1

Organism-specific databases

DisGeNETi10110
OpenTargetsiENSG00000101049
PharmGKBiPA37824

Chemistry databases

ChEMBLiCHEMBL5794
GuidetoPHARMACOLOGYi1535

Polymorphism and mutation databases

BioMutaiSGK2
DMDMi28558166

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866461 – 427Serine/threonine-protein kinase Sgk2Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineBy similarity1
Modified residuei253Phosphothreonine; by PDPK11 Publication1
Modified residuei416PhosphoserineSequence analysis1

Post-translational modificationi

Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HBY8
PaxDbiQ9HBY8
PeptideAtlasiQ9HBY8
PRIDEiQ9HBY8
ProteomicsDBi81612
81613 [Q9HBY8-2]
81614 [Q9HBY8-3]

PTM databases

iPTMnetiQ9HBY8
PhosphoSitePlusiQ9HBY8

Expressioni

Tissue specificityi

Highly expressed in liver, kidney and pancreas, and at lower levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000101049 Expressed in 152 organ(s), highest expression level in cortex of kidney
CleanExiHS_SGK2
ExpressionAtlasiQ9HBY8 baseline and differential
GenevisibleiQ9HBY8 HS

Organism-specific databases

HPAiHPA008859
HPA011387

Interactioni

Protein-protein interaction databases

BioGridi115416, 23 interactors
IntActiQ9HBY8, 15 interactors
STRINGi9606.ENSP00000340608

Chemistry databases

BindingDBiQ9HBY8

Structurei

3D structure databases

ProteinModelPortaliQ9HBY8
SMRiQ9HBY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 352Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini353 – 427AGC-kinase C-terminalAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi128 – 138Nuclear localization signalBy similarityAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148938
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiQ9HBY8
KOiK13303
OrthoDBiEOG091G06FF
PhylomeDBiQ9HBY8
TreeFamiTF320906

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9HBY8-1) [UniParc]FASTAAdd to basket
Also known as: beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQGLLTSGRK PSGGGRCTGR GGWRGQWCLK PWMGGADPPT PTLSCLLLPV
60 70 80 90 100
PPELPDHCYR MNSSPAGTPS PQPSRANGNI NLGPSANPNA QPTDFDFLKV
110 120 130 140 150
IGKGNYGKVL LAKRKSDGAF YAVKVLQKKS ILKKKEQSHI MAERSVLLKN
160 170 180 190 200
VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE LFFHLQRERR FLEPRARFYA
210 220 230 240 250
AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL CKEGVEPEDT
260 270 280 290 300
TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFYSQDVS
310 320 330 340 350
QMYENILHQP LQIPGGRTVA ACDLLQSLLH KDQRQRLGSK ADFLEIKNHV
360 370 380 390 400
FFSPINWDDL YHKRLTPPFN PNVTGPADLK HFDPEFTQEA VSKSIGCTPD
410 420
TVASSSGASS AFLGFSYAPE DDDILDC
Length:427
Mass (Da):47,604
Last modified:March 1, 2001 - v1
Checksum:iD8F0FA6DF54B1370
GO
Isoform 1 (identifier: Q9HBY8-2) [UniParc]FASTAAdd to basket
Also known as: alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Show »
Length:367
Mass (Da):41,175
Checksum:iE53F1ABE253F648B
GO
Isoform 3 (identifier: Q9HBY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-52: Missing.

Note: No experimental confirmation available.
Show »
Length:393
Mass (Da):43,977
Checksum:iDB7303AF95D844CE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8H3X6R8H3_HUMAN
Serine/threonine-protein kinase Sgk...
SGK2
358Annotation score:
Q5H8Y5Q5H8Y5_HUMAN
Serine/threonine-protein kinase Sgk...
SGK2
198Annotation score:
F2Z3C8F2Z3C8_HUMAN
Serine/threonine-protein kinase Sgk...
SGK2
285Annotation score:
A0A0G2JNI2A0A0G2JNI2_HUMAN
Serine/threonine-protein kinase Sgk...
SGK2
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Missing in CAI42315 (PubMed:11780052).Curated1
Sequence conflicti168K → E in AAX88805 (Ref. 2) Curated1
Sequence conflicti208G → D in AAV38901 (Ref. 3) Curated1
Sequence conflicti337L → P in AAX88805 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04107312S → T1 PublicationCorresponds to variant dbSNP:rs33969356Ensembl.1
Natural variantiVAR_041074259E → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041075349H → Y1 PublicationCorresponds to variant dbSNP:rs35793869Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0049321 – 60Missing in isoform 1. 3 PublicationsAdd BLAST60
Alternative sequenceiVSP_02668219 – 52Missing in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169034 mRNA Translation: AAF12757.2
AF186470 mRNA Translation: AAG17012.1
AY987010 mRNA Translation: AAX88805.1
BT020098 mRNA Translation: AAV38901.1
Z98752 Genomic DNA Translation: CAC18509.1
Z98752 Genomic DNA Translation: CAI42312.1
Z98752 Genomic DNA Translation: CAI42315.1
BC014037 mRNA Translation: AAH14037.3
BC065511 mRNA Translation: AAH65511.1
CCDSiCCDS13320.1 [Q9HBY8-1]
CCDS13321.1 [Q9HBY8-2]
RefSeqiNP_001186193.1, NM_001199264.1 [Q9HBY8-2]
NP_057360.2, NM_016276.3 [Q9HBY8-1]
NP_733794.1, NM_170693.2 [Q9HBY8-2]
UniGeneiHs.300863
Hs.740147

Genome annotation databases

EnsembliENST00000341458; ENSP00000340608; ENSG00000101049 [Q9HBY8-1]
ENST00000373092; ENSP00000362184; ENSG00000101049 [Q9HBY8-2]
ENST00000373100; ENSP00000362192; ENSG00000101049 [Q9HBY8-2]
ENST00000423407; ENSP00000392795; ENSG00000101049 [Q9HBY8-2]
ENST00000426287; ENSP00000412214; ENSG00000101049 [Q9HBY8-3]
GeneIDi10110
KEGGihsa:10110
UCSCiuc002xkr.4 human [Q9HBY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169034 mRNA Translation: AAF12757.2
AF186470 mRNA Translation: AAG17012.1
AY987010 mRNA Translation: AAX88805.1
BT020098 mRNA Translation: AAV38901.1
Z98752 Genomic DNA Translation: CAC18509.1
Z98752 Genomic DNA Translation: CAI42312.1
Z98752 Genomic DNA Translation: CAI42315.1
BC014037 mRNA Translation: AAH14037.3
BC065511 mRNA Translation: AAH65511.1
CCDSiCCDS13320.1 [Q9HBY8-1]
CCDS13321.1 [Q9HBY8-2]
RefSeqiNP_001186193.1, NM_001199264.1 [Q9HBY8-2]
NP_057360.2, NM_016276.3 [Q9HBY8-1]
NP_733794.1, NM_170693.2 [Q9HBY8-2]
UniGeneiHs.300863
Hs.740147

3D structure databases

ProteinModelPortaliQ9HBY8
SMRiQ9HBY8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115416, 23 interactors
IntActiQ9HBY8, 15 interactors
STRINGi9606.ENSP00000340608

Chemistry databases

BindingDBiQ9HBY8
ChEMBLiCHEMBL5794
GuidetoPHARMACOLOGYi1535

PTM databases

iPTMnetiQ9HBY8
PhosphoSitePlusiQ9HBY8

Polymorphism and mutation databases

BioMutaiSGK2
DMDMi28558166

Proteomic databases

MaxQBiQ9HBY8
PaxDbiQ9HBY8
PeptideAtlasiQ9HBY8
PRIDEiQ9HBY8
ProteomicsDBi81612
81613 [Q9HBY8-2]
81614 [Q9HBY8-3]

Protocols and materials databases

DNASUi10110
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341458; ENSP00000340608; ENSG00000101049 [Q9HBY8-1]
ENST00000373092; ENSP00000362184; ENSG00000101049 [Q9HBY8-2]
ENST00000373100; ENSP00000362192; ENSG00000101049 [Q9HBY8-2]
ENST00000423407; ENSP00000392795; ENSG00000101049 [Q9HBY8-2]
ENST00000426287; ENSP00000412214; ENSG00000101049 [Q9HBY8-3]
GeneIDi10110
KEGGihsa:10110
UCSCiuc002xkr.4 human [Q9HBY8-1]

Organism-specific databases

CTDi10110
DisGeNETi10110
EuPathDBiHostDB:ENSG00000101049.14
GeneCardsiSGK2
H-InvDBiHIX0080189
HGNCiHGNC:13900 SGK2
HPAiHPA008859
HPA011387
MIMi607589 gene
neXtProtiNX_Q9HBY8
OpenTargetsiENSG00000101049
PharmGKBiPA37824
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148938
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiQ9HBY8
KOiK13303
OrthoDBiEOG091G06FF
PhylomeDBiQ9HBY8
TreeFamiTF320906

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
SignaLinkiQ9HBY8
SIGNORiQ9HBY8

Miscellaneous databases

ChiTaRSiSGK2 human
GeneWikiiSGK2
GenomeRNAii10110
PROiPR:Q9HBY8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101049 Expressed in 152 organ(s), highest expression level in cortex of kidney
CleanExiHS_SGK2
ExpressionAtlasiQ9HBY8 baseline and differential
GenevisibleiQ9HBY8 HS

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGK2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBY8
Secondary accession number(s): Q52PK5
, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9UKG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again