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Entry version 141 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

NADPH oxidase 3

Gene

NOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HBY0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5668599, RHO GTPases Activate NADPH Oxidases
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HBY0

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
5960, HsNOx03

Transport Classification Database

More...
TCDBi
5.B.1.1.4, the phagocyte (gp91(phox)) nadph oxidase family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADPH oxidase 3 (EC:1.6.3.-)
Alternative name(s):
Mitogenic oxidase 2
Short name:
MOX-2
gp91phox homolog 3
Short name:
GP91-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOX3
Synonyms:MOX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7890, NOX3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607105, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HBY0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000074771

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 51ExtracellularSequence analysisAdd BLAST17
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 103CytoplasmicSequence analysisAdd BLAST31
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 167ExtracellularSequence analysisAdd BLAST43
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 395ExtracellularSequence analysisAdd BLAST173
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 568CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi413P → H: Loss of catalytic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
50508

Open Targets

More...
OpenTargetsi
ENSG00000074771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31691

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HBY0, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1741216

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOX3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752785

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002275961 – 568NADPH oxidase 3Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HBY0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HBY0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HBY0

PeptideAtlas

More...
PeptideAtlasi
Q9HBY0

PRoteomics IDEntifications database

More...
PRIDEi
Q9HBY0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81611

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9HBY0, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HBY0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HBY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal kidney and to a lower extent in liver, lung and spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074771, Expressed in kidney and 7 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HBY0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000074771, Tissue enhanced (adrenal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with and stabilizes CYBA/p22phox.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119079, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9HBY0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000159060

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HBY0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 284Ferric oxidoreductaseAdd BLAST230
Domaini285 – 395FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0039, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160501

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005646_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HBY0

Identification of Orthologs from Complete Genome Data

More...
OMAi
YWICRDA

Database of Orthologous Groups

More...
OrthoDBi
936110at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HBY0

TreeFam database of animal gene trees

More...
TreeFami
TF105354

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000778, Cyt_b245_heavy_chain
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR029653, NOX3
IPR017938, Riboflavin_synthase-like_b-brl

The PANTHER Classification System

More...
PANTHERi
PTHR11972:SF12, PTHR11972:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00466, GP91PHOX

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51384, FAD_FR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HBY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGCWILNEG LSTILVLSWL GINFYLFIDT FYWYEEEESF HYTRVILGST
60 70 80 90 100
LAWARASALC LNFNCMLILI PVSRNLISFI RGTSICCRGP WRRQLDKNLR
110 120 130 140 150
FHKLVAYGIA VNATIHIVAH FFNLERYHWS QSEEAQGLLA ALSKLGNTPN
160 170 180 190 200
ESYLNPVRTF PTNTTTELLR TIAGVTGLVI SLALVLIMTS STEFIRQASY
210 220 230 240 250
ELFWYTHHVF IVFFLSLAIH GTGRIVRGQT QDSLSLHNIT FCRDRYAEWQ
260 270 280 290 300
TVAQCPVPQF SGKEPSAWKW ILGPVVLYAC ERIIRFWRFQ QEVVITKVVS
310 320 330 340 350
HPSGVLELHM KKRGFKMAPG QYILVQCPAI SSLEWHPFTL TSAPQEDFFS
360 370 380 390 400
VHIRAAGDWT AALLEAFGAE GQALQEPWSL PRLAVDGPFG TALTDVFHYP
410 420 430 440 450
VCVCVAAGIG VTPFAALLKS IWYKCSEAQT PLKLSKVYFY WICRDARAFE
460 470 480 490 500
WFADLLLSLE TRMSEQGKTH FLSYHIFLTG WDENQALHIA LHWDENTDVI
510 520 530 540 550
TGLKQKTFYG RPNWNNEFKQ IAYNHPSSSI GVFFCGPKAL SRTLQKMCHL
560
YSSADPRGVH FYYNKESF
Length:568
Mass (Da):64,935
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10BCD6BEB18D0583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti328P → S in AAG15435 (PubMed:10974555).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049103171T → K. Corresponds to variant dbSNP:rs3749930Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF190122 mRNA Translation: AAG17121.1
AL031773 Genomic DNA No translation available.
AF229177 mRNA Translation: AAG15435.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5250.1

NCBI Reference Sequences

More...
RefSeqi
NP_056533.1, NM_015718.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000159060; ENSP00000159060; ENSG00000074771

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50508

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50508

UCSC genome browser

More...
UCSCi
uc003qqm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190122 mRNA Translation: AAG17121.1
AL031773 Genomic DNA No translation available.
AF229177 mRNA Translation: AAG15435.1
CCDSiCCDS5250.1
RefSeqiNP_056533.1, NM_015718.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119079, 1 interactor
IntActiQ9HBY0, 1 interactor
STRINGi9606.ENSP00000159060

Chemistry databases

ChEMBLiCHEMBL1741216

Protein family/group databases

PeroxiBasei5960, HsNOx03
TCDBi5.B.1.1.4, the phagocyte (gp91(phox)) nadph oxidase family

PTM databases

GlyGeniQ9HBY0, 2 sites
iPTMnetiQ9HBY0
PhosphoSitePlusiQ9HBY0

Genetic variation databases

BioMutaiNOX3
DMDMi74752785

Proteomic databases

jPOSTiQ9HBY0
MassIVEiQ9HBY0
PaxDbiQ9HBY0
PeptideAtlasiQ9HBY0
PRIDEiQ9HBY0
ProteomicsDBi81611

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46722, 214 antibodies

The DNASU plasmid repository

More...
DNASUi
50508

Genome annotation databases

EnsembliENST00000159060; ENSP00000159060; ENSG00000074771
GeneIDi50508
KEGGihsa:50508
UCSCiuc003qqm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50508
DisGeNETi50508

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOX3
HGNCiHGNC:7890, NOX3
HPAiENSG00000074771, Tissue enhanced (adrenal)
MIMi607105, gene
neXtProtiNX_Q9HBY0
OpenTargetsiENSG00000074771
PharmGKBiPA31691
VEuPathDBiHostDB:ENSG00000074771

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
GeneTreeiENSGT00940000160501
HOGENOMiCLU_005646_3_1_1
InParanoidiQ9HBY0
OMAiYWICRDA
OrthoDBi936110at2759
PhylomeDBiQ9HBY0
TreeFamiTF105354

Enzyme and pathway databases

PathwayCommonsiQ9HBY0
ReactomeiR-HSA-5668599, RHO GTPases Activate NADPH Oxidases
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
SIGNORiQ9HBY0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
50508, 7 hits in 998 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NOX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50508
PharosiQ9HBY0, Tbio

Protein Ontology

More...
PROi
PR:Q9HBY0
RNActiQ9HBY0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074771, Expressed in kidney and 7 other tissues
GenevisibleiQ9HBY0, HS

Family and domain databases

Gene3Di3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR000778, Cyt_b245_heavy_chain
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR029653, NOX3
IPR017938, Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF12, PTHR11972:SF12, 1 hit
PfamiView protein in Pfam
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00466, GP91PHOX
SUPFAMiSSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384, FAD_FR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBY0
Secondary accession number(s): Q9HBJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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