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UniProtKB - Q9HBX8 (LGR6_HUMAN)

Entry version 171 (02 Dec 2020)
Sequence version 3 (11 Sep 2007)
Previous versions | rss
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Protein

Leucine-rich repeat-containing G-protein coupled receptor 6

Gene

LGR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HBX8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4641263, Regulation of FZD by ubiquitination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing G-protein coupled receptor 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGR6
ORF Names:UNQ6427/PRO21331, VTS20631
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000133067.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:19719, LGR6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606653, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HBX8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 567ExtracellularSequence analysisAdd BLAST543
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei568 – 588Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini589 – 598CytoplasmicSequence analysis10
Transmembranei599 – 619Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini620 – 644ExtracellularSequence analysisAdd BLAST25
Transmembranei645 – 665Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini666 – 687CytoplasmicSequence analysisAdd BLAST22
Transmembranei688 – 708Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini709 – 727ExtracellularSequence analysisAdd BLAST19
Transmembranei728 – 748Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini749 – 774CytoplasmicSequence analysisAdd BLAST26
Transmembranei775 – 795Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini796 – 809ExtracellularSequence analysisAdd BLAST14
Transmembranei810 – 830Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini831 – 967CytoplasmicSequence analysisAdd BLAST137

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		59352

Open Targets

More...OpenTargetsi		ENSG00000133067

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134927114

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HBX8, Tbio

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		149

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LGR6

Domain mapping of disease mutations (DMDM)

More...DMDMi		158519993

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000006969925 – 967Leucine-rich repeat-containing G-protein coupled receptor 6Add BLAST943

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi642 ↔ 717By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HBX8

PeptideAtlas

More...PeptideAtlasi		Q9HBX8

PRoteomics IDEntifications database

More...PRIDEi		Q9HBX8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81604 [Q9HBX8-3]
81605 [Q9HBX8-1]
81606 [Q9HBX8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HBX8, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HBX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HBX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133067, Expressed in descending thoracic aorta and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HBX8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HBX8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000133067, Tissue enhanced (gallbladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121893, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356247

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HBX8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 66LRRNTAdd BLAST41
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati91 – 112LRR 1Add BLAST22
Repeati115 – 136LRR 2Add BLAST22
Repeati139 – 160LRR 3Add BLAST22
Repeati163 – 186LRR 4Add BLAST24
Repeati187 – 208LRR 5Add BLAST22
Repeati211 – 232LRR 6Add BLAST22
Repeati235 – 256LRR 7Add BLAST22
Repeati258 – 279LRR 8Add BLAST22
Repeati282 – 303LRR 9Add BLAST22
Repeati306 – 328LRR 10Add BLAST23
Repeati329 – 350LRR 11Add BLAST22
Repeati353 – 374LRR 12Add BLAST22
Repeati375 – 396LRR 13Add BLAST22
Repeati399 – 420LRR 14Add BLAST22
Repeati423 – 443LRR 15Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi952 – 955Poly-Gly4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota
KOG2087, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159939

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006843_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HBX8

Database of Orthologous Groups

More...OrthoDBi		340670at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HBX8

TreeFam database of animal gene trees

More...TreeFami		TF316814

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR002131, Gphrmn_rcpt_fam
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00373, GLYCHORMONER
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 14 hits
SM00013, LRRNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9HBX8-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSPPGLRAL WLCAALCASR RAGGAPQPGP GPTACPAPCH CQEDGIMLSA 
        60         70         80         90        100
DCSELGLSAV PGDLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN 
       110        120        130        140        150
HLSHIPGQAF SGLYSLKILM LQNNQLGGIP AEALWELPSL QSLRLDANLI 
       160        170        180        190        200
SLVPERSFEG LSSLRHLWLD DNALTEIPVR ALNNLPALQA MTLALNRISH 
       210        220        230        240        250
IPDYAFQNLT SLVVLHLHNN RIQHLGTHSF EGLHNLETLD LNYNKLQEFP 
       260        270        280        290        300
VAIRTLGRLQ ELGFHNNNIK AIPEKAFMGN PLLQTIHFYD NPIQFVGRSA 
       310        320        330        340        350
FQYLPKLHTL SLNGAMDIQE FPDLKGTTSL EILTLTRAGI RLLPSGMCQQ 
       360        370        380        390        400
LPRLRVLELS HNQIEELPSL HRCQKLEEIG LQHNRIWEIG ADTFSQLSSL 
       410        420        430        440        450
QALDLSWNAI RSIHPEAFST LHSLVKLDLT DNQLTTLPLA GLGGLMHLKL 
       460        470        480        490        500
KGNLALSQAF SKDSFPKLRI LEVPYAYQCC PYGMCASFFK ASGQWEAEDL 
       510        520        530        540        550
HLDDEESSKR PLGLLARQAE NHYDQDLDEL QLEMEDSKPH PSVQCSPTPG 
       560        570        580        590        600
PFKPCEYLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFAGG PVPLPPVKFV 
       610        620        630        640        650
VGAIAGANTL TGISCGLLAS VDALTFGQFS EYGARWETGL GCRATGFLAV 
       660        670        680        690        700
LGSEASVLLL TLAAVQCSVS VSCVRAYGKS PSLGSVRAGV LGCLALAGLA 
       710        720        730        740        750
AALPLASVGE YGASPLCLPY APPEGQPAAL GFTVALVMMN SFCFLVVAGA 
       760        770        780        790        800
YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF ADGLLYCPVA FLSFASMLGL 
       810        820        830        840        850
FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR LRPRAGDSGP 
       860        870        880        890        900
LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGRPPG LETYGFPSVT 
       910        920        930        940        950
LISCQQPGAP RLEGSHCVEP EGNHFGNPQP SMDGELLLRA EGSTPAGGGL 
       960 
SGGGGFQPSG LAFASHV
Length:967
Mass (Da):104,298
Last modified:September 11, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22E332E85DF8DCE0
GO
Isoform 1 (identifier: Q9HBX8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: MPSPPGLRAL...GDLDPLTAYL → MRLEGEGRSARAGQNLSRAGSARRGAPR
     144-239: Missing.

Show »
Length:828
Mass (Da):89,302
Checksum:i1B5971445AA2D8B4
GO
Isoform 2 (identifier: Q9HBX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: MPSPPGLRAL...GDLDPLTAYL → MGRPRLTLVCQVSIIISAR

Show »
Length:915
Mass (Da):99,295
Checksum:i2925C7AC50B8CEF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T508Q5T508_HUMAN
Leucine-rich repeat-containing G-pr...
LGR6
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9F0D6R9F0_HUMAN
Leucine-rich repeat-containing G-pr...
LGR6
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55071 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545 – 549CSPTP → MISPT in BAB89329 (PubMed:12044878).Curated5
Sequence conflicti767W → R in BAB55071 (PubMed:14702039).Curated1
Sequence conflicti963 – 967FASHV → LLHTY in AAG17168 (PubMed:10935549).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049413267N → K. Corresponds to variant dbSNP:rs7553800Ensembl.1
Natural variantiVAR_033479516A → S. Corresponds to variant dbSNP:rs6668765Ensembl.1
Natural variantiVAR_059324592V → A2 PublicationsCorresponds to variant dbSNP:rs788795Ensembl.1
Natural variantiVAR_035762725G → C in a colorectal cancer sample; somatic mutation; no effect Wnt signlaing upon RSPO1-binding. 2 Publications1
Natural variantiVAR_035763928P → H in a colorectal cancer sample; somatic mutation; no effect Wnt signlaing upon RSPO1-binding. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0280061 – 71MPSPP…LTAYL → MRLEGEGRSARAGQNLSRAG SARRGAPR in isoform 1. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0135961 – 71MPSPP…LTAYL → MGRPRLTLVCQVSIIISAR in isoform 2. 2 PublicationsAdd BLAST71
Alternative sequenceiVSP_028007144 – 239Missing in isoform 1. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF190501 mRNA Translation: AAG17168.1
AY358119 mRNA Translation: AAQ88486.1
AL356953 Genomic DNA No translation available.
BC047905 mRNA Translation: AAH47905.2
AB049405 mRNA Translation: BAB39854.1
AB083616 Genomic DNA Translation: BAB89329.1
AK027377 mRNA Translation: BAB55071.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1424.1 [Q9HBX8-2]
CCDS30971.1 [Q9HBX8-3]
CCDS30972.1 [Q9HBX8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001017403.1, NM_001017403.1 [Q9HBX8-3]
NP_001017404.1, NM_001017404.1 [Q9HBX8-1]
NP_067649.2, NM_021636.2 [Q9HBX8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000255432; ENSP00000255432; ENSG00000133067 [Q9HBX8-2]
ENST00000367278; ENSP00000356247; ENSG00000133067 [Q9HBX8-3]
ENST00000439764; ENSP00000387869; ENSG00000133067 [Q9HBX8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		59352

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:59352

UCSC genome browser

More...UCSCi		uc001gxu.4, human [Q9HBX8-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190501 mRNA Translation: AAG17168.1
AY358119 mRNA Translation: AAQ88486.1
AL356953 Genomic DNA No translation available.
BC047905 mRNA Translation: AAH47905.2
AB049405 mRNA Translation: BAB39854.1
AB083616 Genomic DNA Translation: BAB89329.1
AK027377 mRNA Translation: BAB55071.1 Different initiation.
CCDSiCCDS1424.1 [Q9HBX8-2]
CCDS30971.1 [Q9HBX8-3]
CCDS30972.1 [Q9HBX8-1]
RefSeqiNP_001017403.1, NM_001017403.1 [Q9HBX8-3]
NP_001017404.1, NM_001017404.1 [Q9HBX8-1]
NP_067649.2, NM_021636.2 [Q9HBX8-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121893, 1 interactor
STRINGi9606.ENSP00000356247

Chemistry databases

GuidetoPHARMACOLOGYi149

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ9HBX8, 2 sites
iPTMnetiQ9HBX8
PhosphoSitePlusiQ9HBX8

Polymorphism and mutation databases

BioMutaiLGR6
DMDMi158519993

Proteomic databases

PaxDbiQ9HBX8
PeptideAtlasiQ9HBX8
PRIDEiQ9HBX8
ProteomicsDBi81604 [Q9HBX8-3]
81605 [Q9HBX8-1]
81606 [Q9HBX8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34525, 335 antibodies

Genome annotation databases

EnsembliENST00000255432; ENSP00000255432; ENSG00000133067 [Q9HBX8-2]
ENST00000367278; ENSP00000356247; ENSG00000133067 [Q9HBX8-3]
ENST00000439764; ENSP00000387869; ENSG00000133067 [Q9HBX8-1]
GeneIDi59352
KEGGihsa:59352
UCSCiuc001gxu.4, human [Q9HBX8-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		59352
DisGeNETi59352
EuPathDBiHostDB:ENSG00000133067.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		LGR6
HGNCiHGNC:19719, LGR6
HPAiENSG00000133067, Tissue enhanced (gallbladder)
MIMi606653, gene
neXtProtiNX_Q9HBX8
OpenTargetsiENSG00000133067
PharmGKBiPA134927114

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
KOG2087, Eukaryota
GeneTreeiENSGT00940000159939
HOGENOMiCLU_006843_0_0_1
InParanoidiQ9HBX8
OrthoDBi340670at2759
PhylomeDBiQ9HBX8
TreeFamiTF316814

Enzyme and pathway databases

PathwayCommonsiQ9HBX8
ReactomeiR-HSA-4641263, Regulation of FZD by ubiquitination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		59352, 1 hit in 834 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LGR6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		59352
PharosiQ9HBX8, Tbio

Protein Ontology

More...PROi		PR:Q9HBX8
RNActiQ9HBX8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133067, Expressed in descending thoracic aorta and 173 other tissues
ExpressionAtlasiQ9HBX8, baseline and differential
GenevisibleiQ9HBX8, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR002131, Gphrmn_rcpt_fam
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
PfamiView protein in Pfam
PF13855, LRR_8, 4 hits
PRINTSiPR00373, GLYCHORMONER
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM00369, LRR_TYP, 14 hits
SM00013, LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLGR6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBX8
Secondary accession number(s): Q5T509
, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: September 11, 2007
Last modified: December 2, 2020
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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