UniProtKB - Q9HBX8 (LGR6_HUMAN)
Protein
Leucine-rich repeat-containing G-protein coupled receptor 6
Gene
LGR6
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.2 Publications
GO - Molecular functioni
- heparin binding Source: GO_Central
- protein-hormone receptor activity Source: InterPro
- Roundabout binding Source: GO_Central
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- axon guidance Source: GO_Central
- bone regeneration Source: Ensembl
- G protein-coupled receptor signaling pathway Source: UniProtKB-KW
- negative chemotaxis Source: GO_Central
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of Wnt signaling pathway Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9HBX8 |
Reactomei | R-HSA-4641263, Regulation of FZD by ubiquitination |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing G-protein coupled receptor 6 |
Gene namesi | Name:LGR6 ORF Names:UNQ6427/PRO21331, VTS20631 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000133067.17 |
HGNCi | HGNC:19719, LGR6 |
MIMi | 606653, gene |
neXtProti | NX_Q9HBX8 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- trans-Golgi network membrane Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 567 | ExtracellularSequence analysisAdd BLAST | 543 | |
Transmembranei | 568 – 588 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 589 – 598 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 599 – 619 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 620 – 644 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 645 – 665 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 666 – 687 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 688 – 708 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 709 – 727 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 728 – 748 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 749 – 774 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 775 – 795 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 796 – 809 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 810 – 830 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 831 – 967 | CytoplasmicSequence analysisAdd BLAST | 137 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 59352 |
OpenTargetsi | ENSG00000133067 |
PharmGKBi | PA134927114 |
Miscellaneous databases
Pharosi | Q9HBX8, Tbio |
Chemistry databases
GuidetoPHARMACOLOGYi | 149 |
Polymorphism and mutation databases
BioMutai | LGR6 |
DMDMi | 158519993 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000069699 | 25 – 967 | Leucine-rich repeat-containing G-protein coupled receptor 6Add BLAST | 943 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 208 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 642 ↔ 717 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9HBX8 |
PeptideAtlasi | Q9HBX8 |
PRIDEi | Q9HBX8 |
ProteomicsDBi | 81604 [Q9HBX8-3] 81605 [Q9HBX8-1] 81606 [Q9HBX8-2] |
PTM databases
GlyGeni | Q9HBX8, 2 sites |
iPTMneti | Q9HBX8 |
PhosphoSitePlusi | Q9HBX8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133067, Expressed in descending thoracic aorta and 173 other tissues |
ExpressionAtlasi | Q9HBX8, baseline and differential |
Genevisiblei | Q9HBX8, HS |
Organism-specific databases
HPAi | ENSG00000133067, Tissue enhanced (gallbladder) |
Interactioni
GO - Molecular functioni
- Roundabout binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121893, 1 interactor |
STRINGi | 9606.ENSP00000356247 |
Miscellaneous databases
RNActi | Q9HBX8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 66 | LRRNTAdd BLAST | 41 | |
Repeati | 91 – 112 | LRR 1Add BLAST | 22 | |
Repeati | 115 – 136 | LRR 2Add BLAST | 22 | |
Repeati | 139 – 160 | LRR 3Add BLAST | 22 | |
Repeati | 163 – 186 | LRR 4Add BLAST | 24 | |
Repeati | 187 – 208 | LRR 5Add BLAST | 22 | |
Repeati | 211 – 232 | LRR 6Add BLAST | 22 | |
Repeati | 235 – 256 | LRR 7Add BLAST | 22 | |
Repeati | 258 – 279 | LRR 8Add BLAST | 22 | |
Repeati | 282 – 303 | LRR 9Add BLAST | 22 | |
Repeati | 306 – 328 | LRR 10Add BLAST | 23 | |
Repeati | 329 – 350 | LRR 11Add BLAST | 22 | |
Repeati | 353 – 374 | LRR 12Add BLAST | 22 | |
Repeati | 375 – 396 | LRR 13Add BLAST | 22 | |
Repeati | 399 – 420 | LRR 14Add BLAST | 22 | |
Repeati | 423 – 443 | LRR 15Add BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 952 – 955 | Poly-Gly | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota KOG2087, Eukaryota |
GeneTreei | ENSGT00940000159939 |
HOGENOMi | CLU_006843_0_0_1 |
InParanoidi | Q9HBX8 |
OrthoDBi | 340670at2759 |
PhylomeDBi | Q9HBX8 |
TreeFami | TF316814 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR002131, Gphrmn_rcpt_fam IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13855, LRR_8, 4 hits |
PRINTSi | PR00373, GLYCHORMONER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM00369, LRR_TYP, 14 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 13 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: Q9HBX8-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSPPGLRAL WLCAALCASR RAGGAPQPGP GPTACPAPCH CQEDGIMLSA
60 70 80 90 100
DCSELGLSAV PGDLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN
110 120 130 140 150
HLSHIPGQAF SGLYSLKILM LQNNQLGGIP AEALWELPSL QSLRLDANLI
160 170 180 190 200
SLVPERSFEG LSSLRHLWLD DNALTEIPVR ALNNLPALQA MTLALNRISH
210 220 230 240 250
IPDYAFQNLT SLVVLHLHNN RIQHLGTHSF EGLHNLETLD LNYNKLQEFP
260 270 280 290 300
VAIRTLGRLQ ELGFHNNNIK AIPEKAFMGN PLLQTIHFYD NPIQFVGRSA
310 320 330 340 350
FQYLPKLHTL SLNGAMDIQE FPDLKGTTSL EILTLTRAGI RLLPSGMCQQ
360 370 380 390 400
LPRLRVLELS HNQIEELPSL HRCQKLEEIG LQHNRIWEIG ADTFSQLSSL
410 420 430 440 450
QALDLSWNAI RSIHPEAFST LHSLVKLDLT DNQLTTLPLA GLGGLMHLKL
460 470 480 490 500
KGNLALSQAF SKDSFPKLRI LEVPYAYQCC PYGMCASFFK ASGQWEAEDL
510 520 530 540 550
HLDDEESSKR PLGLLARQAE NHYDQDLDEL QLEMEDSKPH PSVQCSPTPG
560 570 580 590 600
PFKPCEYLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFAGG PVPLPPVKFV
610 620 630 640 650
VGAIAGANTL TGISCGLLAS VDALTFGQFS EYGARWETGL GCRATGFLAV
660 670 680 690 700
LGSEASVLLL TLAAVQCSVS VSCVRAYGKS PSLGSVRAGV LGCLALAGLA
710 720 730 740 750
AALPLASVGE YGASPLCLPY APPEGQPAAL GFTVALVMMN SFCFLVVAGA
760 770 780 790 800
YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF ADGLLYCPVA FLSFASMLGL
810 820 830 840 850
FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR LRPRAGDSGP
860 870 880 890 900
LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGRPPG LETYGFPSVT
910 920 930 940 950
LISCQQPGAP RLEGSHCVEP EGNHFGNPQP SMDGELLLRA EGSTPAGGGL
960
SGGGGFQPSG LAFASHV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T508 | Q5T508_HUMAN | Leucine-rich repeat-containing G-pr... | LGR6 | 232 | Annotation score: | ||
D6R9F0 | D6R9F0_HUMAN | Leucine-rich repeat-containing G-pr... | LGR6 | 348 | Annotation score: |
Sequence cautioni
The sequence BAB55071 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 545 – 549 | CSPTP → MISPT in BAB89329 (PubMed:12044878).Curated | 5 | |
Sequence conflicti | 767 | W → R in BAB55071 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 963 – 967 | FASHV → LLHTY in AAG17168 (PubMed:10935549).Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049413 | 267 | N → K. Corresponds to variant dbSNP:rs7553800Ensembl. | 1 | |
Natural variantiVAR_033479 | 516 | A → S. Corresponds to variant dbSNP:rs6668765Ensembl. | 1 | |
Natural variantiVAR_059324 | 592 | V → A2 PublicationsCorresponds to variant dbSNP:rs788795Ensembl. | 1 | |
Natural variantiVAR_035762 | 725 | G → C in a colorectal cancer sample; somatic mutation; no effect Wnt signlaing upon RSPO1-binding. 2 Publications | 1 | |
Natural variantiVAR_035763 | 928 | P → H in a colorectal cancer sample; somatic mutation; no effect Wnt signlaing upon RSPO1-binding. 2 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028006 | 1 – 71 | MPSPP…LTAYL → MRLEGEGRSARAGQNLSRAG SARRGAPR in isoform 1. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_013596 | 1 – 71 | MPSPP…LTAYL → MGRPRLTLVCQVSIIISAR in isoform 2. 2 PublicationsAdd BLAST | 71 | |
Alternative sequenceiVSP_028007 | 144 – 239 | Missing in isoform 1. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF190501 mRNA Translation: AAG17168.1 AY358119 mRNA Translation: AAQ88486.1 AL356953 Genomic DNA No translation available. BC047905 mRNA Translation: AAH47905.2 AB049405 mRNA Translation: BAB39854.1 AB083616 Genomic DNA Translation: BAB89329.1 AK027377 mRNA Translation: BAB55071.1 Different initiation. |
CCDSi | CCDS1424.1 [Q9HBX8-2] CCDS30971.1 [Q9HBX8-3] CCDS30972.1 [Q9HBX8-1] |
RefSeqi | NP_001017403.1, NM_001017403.1 [Q9HBX8-3] NP_001017404.1, NM_001017404.1 [Q9HBX8-1] NP_067649.2, NM_021636.2 [Q9HBX8-2] |
Genome annotation databases
Ensembli | ENST00000255432; ENSP00000255432; ENSG00000133067 [Q9HBX8-2] ENST00000367278; ENSP00000356247; ENSG00000133067 [Q9HBX8-3] ENST00000439764; ENSP00000387869; ENSG00000133067 [Q9HBX8-1] |
GeneIDi | 59352 |
KEGGi | hsa:59352 |
UCSCi | uc001gxu.4, human [Q9HBX8-3] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF190501 mRNA Translation: AAG17168.1 AY358119 mRNA Translation: AAQ88486.1 AL356953 Genomic DNA No translation available. BC047905 mRNA Translation: AAH47905.2 AB049405 mRNA Translation: BAB39854.1 AB083616 Genomic DNA Translation: BAB89329.1 AK027377 mRNA Translation: BAB55071.1 Different initiation. |
CCDSi | CCDS1424.1 [Q9HBX8-2] CCDS30971.1 [Q9HBX8-3] CCDS30972.1 [Q9HBX8-1] |
RefSeqi | NP_001017403.1, NM_001017403.1 [Q9HBX8-3] NP_001017404.1, NM_001017404.1 [Q9HBX8-1] NP_067649.2, NM_021636.2 [Q9HBX8-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121893, 1 interactor |
STRINGi | 9606.ENSP00000356247 |
Chemistry databases
GuidetoPHARMACOLOGYi | 149 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9HBX8, 2 sites |
iPTMneti | Q9HBX8 |
PhosphoSitePlusi | Q9HBX8 |
Polymorphism and mutation databases
BioMutai | LGR6 |
DMDMi | 158519993 |
Proteomic databases
PaxDbi | Q9HBX8 |
PeptideAtlasi | Q9HBX8 |
PRIDEi | Q9HBX8 |
ProteomicsDBi | 81604 [Q9HBX8-3] 81605 [Q9HBX8-1] 81606 [Q9HBX8-2] |
Protocols and materials databases
Antibodypediai | 34525, 335 antibodies |
Genome annotation databases
Ensembli | ENST00000255432; ENSP00000255432; ENSG00000133067 [Q9HBX8-2] ENST00000367278; ENSP00000356247; ENSG00000133067 [Q9HBX8-3] ENST00000439764; ENSP00000387869; ENSG00000133067 [Q9HBX8-1] |
GeneIDi | 59352 |
KEGGi | hsa:59352 |
UCSCi | uc001gxu.4, human [Q9HBX8-3] |
Organism-specific databases
CTDi | 59352 |
DisGeNETi | 59352 |
EuPathDBi | HostDB:ENSG00000133067.17 |
GeneCardsi | LGR6 |
HGNCi | HGNC:19719, LGR6 |
HPAi | ENSG00000133067, Tissue enhanced (gallbladder) |
MIMi | 606653, gene |
neXtProti | NX_Q9HBX8 |
OpenTargetsi | ENSG00000133067 |
PharmGKBi | PA134927114 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota KOG2087, Eukaryota |
GeneTreei | ENSGT00940000159939 |
HOGENOMi | CLU_006843_0_0_1 |
InParanoidi | Q9HBX8 |
OrthoDBi | 340670at2759 |
PhylomeDBi | Q9HBX8 |
TreeFami | TF316814 |
Enzyme and pathway databases
PathwayCommonsi | Q9HBX8 |
Reactomei | R-HSA-4641263, Regulation of FZD by ubiquitination |
Miscellaneous databases
BioGRID-ORCSi | 59352, 1 hit in 834 CRISPR screens |
GeneWikii | LGR6 |
GenomeRNAii | 59352 |
Pharosi | Q9HBX8, Tbio |
PROi | PR:Q9HBX8 |
RNActi | Q9HBX8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133067, Expressed in descending thoracic aorta and 173 other tissues |
ExpressionAtlasi | Q9HBX8, baseline and differential |
Genevisiblei | Q9HBX8, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR002131, Gphrmn_rcpt_fam IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13855, LRR_8, 4 hits |
PRINTSi | PR00373, GLYCHORMONER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM00369, LRR_TYP, 14 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LGR6_HUMAN | |
Accessioni | Q9HBX8Primary (citable) accession number: Q9HBX8 Secondary accession number(s): Q5T509 Q9BYD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | September 11, 2007 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries