Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G protein-coupled receptor L4

Gene

ADGRL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endothelial orphan receptor that acts as a key regulator of angiogenesis.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein coupled receptor activity Source: GDB
  • protein dimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandCalcium

Protein family/group databases

MEROPSiP02.013
TCDBi9.A.14.6.3 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L41 Publication
Alternative name(s):
EGF, latrophilin and seven transmembrane domain-containing protein 1
EGF-TM7-latrophilin-related protein
Short name:
ETL protein
Gene namesi
Name:ADGRL41 Publication
Synonyms:ELTD1, ETL
ORF Names:UNQ202/PRO228
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162618.12
HGNCiHGNC:20822 ADGRL4
MIMi616419 gene
neXtProtiNX_Q9HBW9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 432ExtracellularCuratedAdd BLAST413
Transmembranei433 – 453Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini454 – 460CytoplasmicCurated7
Transmembranei461 – 481Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini482 – 499ExtracellularCuratedAdd BLAST18
Transmembranei500 – 520Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini521 – 532CytoplasmicCuratedAdd BLAST12
Transmembranei533 – 553Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini554 – 573ExtracellularCuratedAdd BLAST20
Transmembranei574 – 594Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini595 – 618CytoplasmicCuratedAdd BLAST24
Transmembranei619 – 639Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini640 – 646ExtracellularCurated7
Transmembranei647 – 667Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini668 – 690CytoplasmicCuratedAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64123
OpenTargetsiENSG00000162618
PharmGKBiPA134946418

Polymorphism and mutation databases

BioMutaiELTD1
DMDMi212276505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001287020 – 690Adhesion G protein-coupled receptor L4Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi22 ↔ 33PROSITE-ProRule annotation
Disulfide bondi27 ↔ 42PROSITE-ProRule annotation
Disulfide bondi44 ↔ 56PROSITE-ProRule annotation
Disulfide bondi62 ↔ 75PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi69 ↔ 84PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 107PROSITE-ProRule annotation
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei406 – 407CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9HBW9
PaxDbiQ9HBW9
PeptideAtlasiQ9HBW9
PRIDEiQ9HBW9
ProteomicsDBi81602

PTM databases

iPTMnetiQ9HBW9
PhosphoSitePlusiQ9HBW9

Expressioni

Tissue specificityi

Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.1 Publication

Developmental stagei

Up-regulated in the adult heart.1 Publication

Inductioni

Up-regulated in tumor endothelial cells. Up-regulated by DLL4.1 Publication

Gene expression databases

BgeeiENSG00000162618 Expressed in 205 organ(s), highest expression level in visceral pleura
CleanExiHS_ELTD1
ExpressionAtlasiQ9HBW9 baseline and differential
GenevisibleiQ9HBW9 HS

Organism-specific databases

HPAiHPA025229

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122076, 1 interactor
IntActiQ9HBW9, 1 interactor
STRINGi9606.ENSP00000359778

Structurei

3D structure databases

ProteinModelPortaliQ9HBW9
SMRiQ9HBW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 57EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini58 – 108EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST51
Domaini367 – 418GPSPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 329Poly-Glu4

Domaini

The transmembrane domain is not required for cleavage, but it is required for dimer formation.By similarity

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00900000140800
HOGENOMiHOG000112361
HOVERGENiHBG101117
InParanoidiQ9HBW9
KOiK04595
OMAiYKVFRHT
OrthoDBiEOG091G00GJ
PhylomeDBiQ9HBW9
TreeFamiTF316380

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00018 EF_HAND_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9HBW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG
60 70 80 90 100
NGVTICEDDN ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI
110 120 130 140 150
TNDGTVCIEN VNANCHLDNV CIAANINKTL TKIRSIKEPV ALLQEVYRNS
160 170 180 190 200
VTDLSPTDII TYIEILAESS SLLGYKNNTI SAKDTLSNST LTEFVKTVNN
210 220 230 240 250
FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF QKTTEFDTNS
260 270 280 290 300
TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV
310 320 330 340 350
YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL
360 370 380 390 400
EKITFTLSHR KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS
410 420 430 440 450
CRCNHLTHFA ILMSSGPSIG IKDYNILTRI TQLGIIISLI CLAICIFTFW
460 470 480 490 500
FFSEIQSTRT TIHKNLCCSL FLAELVFLVG INTNTNKLFC SIIAGLLHYF
510 520 530 540 550
FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS PAVVVGFSAA
560 570 580 590 600
LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT
610 620 630 640 650
AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT
660 670 680 690
VSNAFQGMFI FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR
Length:690
Mass (Da):77,811
Last modified:November 4, 2008 - v3
Checksum:i38BFEEBCEADDEFC8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AR72B1AR72_HUMAN
Adhesion G protein-coupled receptor...
ADGRL4
149Annotation score:
A0A1W2PP07A0A1W2PP07_HUMAN
Adhesion G protein-coupled receptor...
ADGRL4
158Annotation score:

Sequence cautioni

The sequence AAG33021 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH25721 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047072300V → L3 PublicationsCorresponds to variant dbSNP:rs12754818Ensembl.1
Natural variantiVAR_047073599H → Q. Corresponds to variant dbSNP:rs1968956Ensembl.1
Natural variantiVAR_047074620A → G1 PublicationCorresponds to variant dbSNP:rs2275902Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032017 mRNA Translation: BAD83584.1
AY358360 mRNA Translation: AAQ88726.1
AC098651 Genomic DNA No translation available.
AC099674 Genomic DNA No translation available.
AL596269 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06345.1
BC025721 mRNA Translation: AAH25721.1 Different initiation.
AF192403 mRNA Translation: AAG33021.1 Different initiation.
CCDSiCCDS41352.1
RefSeqiNP_071442.2, NM_022159.3
UniGeneiHs.132314

Genome annotation databases

EnsembliENST00000370742; ENSP00000359778; ENSG00000162618
GeneIDi64123
KEGGihsa:64123
UCSCiuc001diq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032017 mRNA Translation: BAD83584.1
AY358360 mRNA Translation: AAQ88726.1
AC098651 Genomic DNA No translation available.
AC099674 Genomic DNA No translation available.
AL596269 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06345.1
BC025721 mRNA Translation: AAH25721.1 Different initiation.
AF192403 mRNA Translation: AAG33021.1 Different initiation.
CCDSiCCDS41352.1
RefSeqiNP_071442.2, NM_022159.3
UniGeneiHs.132314

3D structure databases

ProteinModelPortaliQ9HBW9
SMRiQ9HBW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122076, 1 interactor
IntActiQ9HBW9, 1 interactor
STRINGi9606.ENSP00000359778

Protein family/group databases

MEROPSiP02.013
TCDBi9.A.14.6.3 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ9HBW9
PhosphoSitePlusiQ9HBW9

Polymorphism and mutation databases

BioMutaiELTD1
DMDMi212276505

Proteomic databases

EPDiQ9HBW9
PaxDbiQ9HBW9
PeptideAtlasiQ9HBW9
PRIDEiQ9HBW9
ProteomicsDBi81602

Protocols and materials databases

DNASUi64123
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370742; ENSP00000359778; ENSG00000162618
GeneIDi64123
KEGGihsa:64123
UCSCiuc001diq.5 human

Organism-specific databases

CTDi64123
DisGeNETi64123
EuPathDBiHostDB:ENSG00000162618.12
GeneCardsiADGRL4
H-InvDBiHIX0000724
HGNCiHGNC:20822 ADGRL4
HPAiHPA025229
MIMi616419 gene
neXtProtiNX_Q9HBW9
OpenTargetsiENSG00000162618
PharmGKBiPA134946418
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00900000140800
HOGENOMiHOG000112361
HOVERGENiHBG101117
InParanoidiQ9HBW9
KOiK04595
OMAiYKVFRHT
OrthoDBiEOG091G00GJ
PhylomeDBiQ9HBW9
TreeFamiTF316380

Miscellaneous databases

ChiTaRSiADGRL4 human
GeneWikiiELTD1
GenomeRNAii64123
PROiPR:Q9HBW9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162618 Expressed in 205 organ(s), highest expression level in visceral pleura
CleanExiHS_ELTD1
ExpressionAtlasiQ9HBW9 baseline and differential
GenevisibleiQ9HBW9 HS

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF07645 EGF_CA, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00018 EF_HAND_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGRL4_HUMAN
AccessioniPrimary (citable) accession number: Q9HBW9
Secondary accession number(s): B1AR71, Q5KU34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again