UniProtKB - Q9HBW1 (LRRC4_HUMAN)

BLAST

>sp|Q9HBW1|LRRC4_HUMAN Leucine-rich repeat-containing protein 4 OS=Homo sapiens OX=9606 GN=LRRC4 PE=1 SV=2
MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVV
CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN
GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGE
LKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHG
LSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN
PWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR
DLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTG
VYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTS
TGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLA
AAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPT
IHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

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History
Entry version 158 (07 Nov 2018)
Sequence version 2 (01 Oct 2001)
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Protein

Leucine-rich repeat-containing protein 4

Gene

LRRC4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).By similarity

GO - Biological processⁱ

modulation of chemical synaptic transmission Source: Ensembl
postsynaptic density protein 95 clustering Source: Ensembl
regulation of synapse organization Source: Ensembl
synaptic membrane adhesion Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich repeat-containing protein 4 Alternative name(s): Brain tumor-associated protein BAG Nasopharyngeal carcinoma-associated gene 14 protein Netrin-G2 ligand Short name: NGL-2
Gene namesⁱ	Name:LRRC4 Synonyms:BAG ORF Names:NAG14, UNQ554/PRO1111
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128594.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15586 LRRC4
MIMⁱ	610486 gene
neXtProtⁱ	NX_Q9HBW1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	39 – 527	ExtracellularSequence analysisAdd BLAST	489
Transmembraneⁱ	528 – 548	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	549 – 653	CytoplasmicSequence analysisAdd BLAST	105

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64101
Open Targets More...OpenTargetsⁱ	ENSG00000128594
PharmGKBⁱ	PA30463

Polymorphism and mutation databases

BioMutaⁱ	LRRC4
DMDMⁱ	51701696

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 38	Sequence analysisAdd BLAST		38
ChainⁱPRO_0000014833	39 – 653	Leucine-rich repeat-containing protein 4Add BLAST		615

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	46 ↔ 52	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	50 ↔ 61	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	277	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	304 ↔ 329	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	306 ↔ 350	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	322	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	363	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	374 ↔ 424	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	388	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	410	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	434	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	440	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	447	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	450	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q9HBW1
PaxDbⁱ	Q9HBW1
PeptideAtlas More...PeptideAtlasⁱ	Q9HBW1
PRIDEⁱ	Q9HBW1
ProteomicsDBⁱ	81601

PTM databases

GlyConnectⁱ	1453
iPTMnetⁱ	Q9HBW1
PhosphoSitePlusⁱ	Q9HBW1

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000128594 Expressed in 140 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_LRRC4
ExpressionAtlasⁱ	Q9HBW1 baseline and differential
Genevisibleⁱ	Q9HBW1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051100

HPAⁱ

HPA051100

Interactionⁱ

Subunit structureⁱ

Interacts with DLG4 (By similarity). Interacts (via LRR repeats) with NTNG2. Forms a complex with DLG4 and with NMDA receptors.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NTNG1	Q9Y2I2	2	EBI-7444327,EBI-7444396
NTNG2	Q96CW9	4	EBI-7444327,EBI-750795

Protein-protein interaction databases

BioGridⁱ	122061, 13 interactors
IntActⁱ	Q9HBW1, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9HBW1
STRINGⁱ	9606.ENSP00000249363

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	54 – 56	Combined sources	3
Beta strandⁱ	58 – 60	Combined sources	3
Beta strandⁱ	78 – 81	Combined sources	4
Turnⁱ	92 – 97	Combined sources	6
Beta strandⁱ	103 – 105	Combined sources	3
Turnⁱ	116 – 121	Combined sources	6
Beta strandⁱ	127 – 129	Combined sources	3
Turnⁱ	140 – 142	Combined sources	3
Beta strandⁱ	143 – 145	Combined sources	3
Beta strandⁱ	151 – 153	Combined sources	3
Turnⁱ	164 – 169	Combined sources	6
Beta strandⁱ	175 – 177	Combined sources	3
Turnⁱ	189 – 194	Combined sources	6
Beta strandⁱ	200 – 202	Combined sources	3
Beta strandⁱ	222 – 224	Combined sources	3
Beta strandⁱ	231 – 233	Combined sources	3
Helixⁱ	235 – 238	Combined sources	4
Beta strandⁱ	246 – 248	Combined sources	3
Turnⁱ	259 – 264	Combined sources	6
Beta strandⁱ	270 – 272	Combined sources	3
Beta strandⁱ	294 – 296	Combined sources	3
Turnⁱ	306 – 308	Combined sources	3
Helixⁱ	309 – 318	Combined sources	10
Beta strandⁱ	328 – 332	Combined sources	5
Turnⁱ	333 – 337	Combined sources	5
Helixⁱ	345 – 347	Combined sources	3
Beta strandⁱ	362 – 365	Combined sources	4
Beta strandⁱ	370 – 372	Combined sources	3
Beta strandⁱ	380 – 385	Combined sources	6
Turnⁱ	387 – 389	Combined sources	3
Beta strandⁱ	390 – 393	Combined sources	4
Beta strandⁱ	399 – 403	Combined sources	5
Beta strandⁱ	405 – 407	Combined sources	3
Beta strandⁱ	409 – 413	Combined sources	5
Turnⁱ	416 – 418	Combined sources	3
Beta strandⁱ	420 – 427	Combined sources	8
Beta strandⁱ	432 – 440	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9HBW1
SMRⁱ	Q9HBW1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9HBW1

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	39 – 75	LRRNTAdd BLAST	37
Repeatⁱ	76 – 97	LRR 1Add BLAST	22
Repeatⁱ	100 – 121	LRR 2Add BLAST	22
Repeatⁱ	124 – 145	LRR 3Add BLAST	22
Repeatⁱ	148 – 169	LRR 4Add BLAST	22
Repeatⁱ	172 – 194	LRR 5Add BLAST	23
Repeatⁱ	197 – 218	LRR 6Add BLAST	22
Repeatⁱ	219 – 240	LRR 7Add BLAST	22
Repeatⁱ	243 – 264	LRR 8Add BLAST	22
Repeatⁱ	267 – 288	LRR 9Add BLAST	22
Domainⁱ	300 – 352	LRRCTAdd BLAST	53
Domainⁱ	353 – 442	Ig-likeAdd BLAST	90

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	455 – 526	Thr-richAdd BLAST		72

Domainⁱ

The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.By similarity

Keywords - Domainⁱ

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118831
HOGENOMⁱ	HOG000252924
HOVERGENⁱ	HBG052359
InParanoidⁱ	Q9HBW1
KEGG Orthology (KO) More...KOⁱ	K16351
OMAⁱ	SWWLREY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G037N
PhylomeDBⁱ	Q9HBW1
TreeFamⁱ	TF324303

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR026882 Lrrc4 IPR000372 LRRNT
PANTHERⁱ	PTHR24369:SF9 PTHR24369:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679 I-set, 1 hit PF13855 LRR_8, 3 hits
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00408 IGc2, 1 hit SM00369 LRR_TYP, 7 hits SM00082 LRRCT, 1 hit SM00013 LRRNT, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51450 LRR, 7 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9HBW1-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKLLWQVTVH HHTWNAILLP FVYLTAQVWI LCAAIAAAAS AGPQNCPSVC 
        60         70         80         90        100
SCSNQFSKVV CTRRGLSEVP QGIPSNTRYL NLMENNIQMI QADTFRHLHH 
       110        120        130        140        150
LEVLQLGRNS IRQIEVGAFN GLASLNTLEL FDNWLTVIPS GAFEYLSKLR 
       160        170        180        190        200
ELWLRNNPIE SIPSYAFNRV PSLMRLDLGE LKKLEYISEG AFEGLFNLKY 
       210        220        230        240        250
LNLGMCNIKD MPNLTPLVGL EELEMSGNHF PEIRPGSFHG LSSLKKLWVM 
       260        270        280        290        300
NSQVSLIERN AFDGLASLVE LNLAHNNLSS LPHDLFTPLR YLVELHLHHN 
       310        320        330        340        350
PWNCDCDILW LAWWLREYIP TNSTCCGRCH APMHMRGRYL VEVDQASFQC 
       360        370        380        390        400
SAPFIMDAPR DLNISEGRMA ELKCRTPPMS SVKWLLPNGT VLSHASRHPR 
       410        420        430        440        450
ISVLNDGTLN FSHVLLSDTG VYTCMVTNVA GNSNASAYLN VSTAELNTSN 
       460        470        480        490        500
YSFFTTVTVE TTEISPEDTT RKYKPVPTTS TGYQPAYTTS TTVLIQTTRV 
       510        520        530        540        550
PKQVAVPATD TTDKMQTSLD EVMKTTKIII GCFVAVTLLA AAMLIVFYKL 
       560        570        580        590        600
RKRHQQRSTV TAARTVEIIQ VDEDIPAATS AAATAAPSGV SGEGAVVLPT 
       610        620        630        640        650
IHDHINYNTY KPAHGAHWTE NSLGNSLHPT VTTISEPYII QTHTKDKVQE 

TQI

Length:653

Mass (Da):72,717

Last modified:October 1, 2001 - v2

Checksum:ⁱ38159C81F6850E37

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JA92	C9JA92_HUMAN	Leucine-rich repeat-containing prot... Leucine-rich repeat-containing protein 4	LRRC4	94	Annotation score:
C9J7K7	C9J7K7_HUMAN	Leucine-rich repeat-containing prot... Leucine-rich repeat-containing protein 4	LRRC4	50	Annotation score:
C9J7V8	C9J7V8_HUMAN	Leucine-rich repeat-containing prot... Leucine-rich repeat-containing protein 4	LRRC4	78	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4	L → S in BAD18737 (PubMed:14702039).Curated	1
Sequence conflictⁱ	253 – 257	QVSLI → H in CAC82651 (Ref. 2) Curated	5
Sequence conflictⁱ	300	N → D in BAD18737 (PubMed:14702039).Curated	1
Sequence conflictⁱ	315	L → F in BAD18737 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035519	579	T → A in a colorectal cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF196976 mRNA Translation: AAG28019.2 AJ297858 mRNA Translation: CAC82651.1 AY358307 mRNA Translation: AAQ88674.1 AK172751 mRNA Translation: BAD18737.1 AK314047 mRNA Translation: BAG36756.1 CH236947 Genomic DNA Translation: EAL24316.1 BC111561 mRNA Translation: AAI11562.1 BC111745 mRNA Translation: AAI11746.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5799.1
NCBI Reference Sequences More...RefSeqⁱ	NP_071426.1, NM_022143.4 XP_011514763.1, XM_011516461.2 XP_016867994.1, XM_017012505.1
UniGeneⁱ	Hs.655003

Genome annotation databases

Ensemblⁱ	ENST00000249363; ENSP00000249363; ENSG00000128594
GeneIDⁱ	64101
KEGGⁱ	hsa:64101
UCSC genome browser More...UCSCⁱ	uc003vmk.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HBW1	LRRC4 isoform 3		PANTR		653	UniRef100_Q9HBW1
Leucine-rich repeat-containing protein 4 (Fragment)		HUMAN		94
LRRC4 isoform 2 (Fragment)		PANTR		51
LRRC4 isoform 1 (Fragment)		PANTR		94
Leucine-rich repeat-containing protein 4 (Fragment)		HUMAN		50

Protein	Similar proteins		Species	Score	Length	Source
Q9HBW1	Leucine-rich repeat-containing protein 4		MOUSE		652	UniRef90_Q99PH1
Leucine-rich repeat-containing protein 4		RAT		652
Uncharacterized protein		SHEEP		682
Leucine-rich repeat-containing protein 4 (Fragment)		HUMAN		78
LRRC4 isoform 4 (Fragment)		PONAB		78
+105

Protein	Similar proteins		Species	Score	Length	Source
Q9HBW1	Leucine-rich repeat-containing protein 4		MOUSE		652	UniRef50_Q99PH1
Leucine-rich repeat-containing protein 4		RAT		652
Uncharacterized protein		SHEEP		682
Leucine-rich repeat-containing protein 4 (Fragment)		HUMAN		78
LRRC4 isoform 4 (Fragment)		PONAB		78
+236

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF196976 mRNA Translation: AAG28019.2 AJ297858 mRNA Translation: CAC82651.1 AY358307 mRNA Translation: AAQ88674.1 AK172751 mRNA Translation: BAD18737.1 AK314047 mRNA Translation: BAG36756.1 CH236947 Genomic DNA Translation: EAL24316.1 BC111561 mRNA Translation: AAI11562.1 BC111745 mRNA Translation: AAI11746.1
CCDSⁱ	CCDS5799.1
RefSeqⁱ	NP_071426.1, NM_022143.4 XP_011514763.1, XM_011516461.2 XP_016867994.1, XM_017012505.1
UniGeneⁱ	Hs.655003

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DL9	NMR	-	A	353-442	[»]
	3ZYI	X-ray	2.60	A	1-444	[»]
ProteinModelPortalⁱ	Q9HBW1
SMRⁱ	Q9HBW1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122061, 13 interactors
IntActⁱ	Q9HBW1, 3 interactors
MINTⁱ	Q9HBW1
STRINGⁱ	9606.ENSP00000249363

PTM databases

GlyConnectⁱ	1453
iPTMnetⁱ	Q9HBW1
PhosphoSitePlusⁱ	Q9HBW1

Polymorphism and mutation databases

BioMutaⁱ	LRRC4
DMDMⁱ	51701696

Proteomic databases

EPDⁱ	Q9HBW1
PaxDbⁱ	Q9HBW1
PeptideAtlasⁱ	Q9HBW1
PRIDEⁱ	Q9HBW1
ProteomicsDBⁱ	81601

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000249363; ENSP00000249363; ENSG00000128594
GeneIDⁱ	64101
KEGGⁱ	hsa:64101
UCSCⁱ	uc003vmk.4 human

Organism-specific databases

CTDⁱ	64101
DisGeNETⁱ	64101
EuPathDBⁱ	HostDB:ENSG00000128594.7
GeneCardsⁱ	LRRC4
HGNCⁱ	HGNC:15586 LRRC4
HPAⁱ	HPA051100
MIMⁱ	610486 gene
neXtProtⁱ	NX_Q9HBW1
OpenTargetsⁱ	ENSG00000128594
PharmGKBⁱ	PA30463
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00760000118831
HOGENOMⁱ	HOG000252924
HOVERGENⁱ	HBG052359
InParanoidⁱ	Q9HBW1
KOⁱ	K16351
OMAⁱ	SWWLREY
OrthoDBⁱ	EOG091G037N
PhylomeDBⁱ	Q9HBW1
TreeFamⁱ	TF324303

Miscellaneous databases

EvolutionaryTraceⁱ	Q9HBW1
GeneWikiⁱ	LRRC4
GenomeRNAiⁱ	64101
Protein Ontology More...PROⁱ	PR:Q9HBW1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128594 Expressed in 140 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_LRRC4
ExpressionAtlasⁱ	Q9HBW1 baseline and differential
Genevisibleⁱ	Q9HBW1 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR026882 Lrrc4 IPR000372 LRRNT
PANTHERⁱ	PTHR24369:SF9 PTHR24369:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF07679 I-set, 1 hit PF13855 LRR_8, 3 hits
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00408 IGc2, 1 hit SM00369 LRR_TYP, 7 hits SM00082 LRRCT, 1 hit SM00013 LRRNT, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS51450 LRR, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRRC4_HUMAN
Accessionⁱ	Q9HBW1Primary (citable) accession number: Q9HBW1 Secondary accession number(s): A4D0Y9 , Q14DU9, Q6ZMI8, Q96A85
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	October 1, 2001
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q9HBW1 (LRRC4_HUMAN)

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Leucine-rich repeat-containing protein 4

LRRC4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ