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Protein

Lysophosphatidic acid receptor 2

Gene

LPAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.2 Publications

Miscellaneous

PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: ProtInc
  • lysophosphatidic acid receptor activity Source: InterPro

GO - Biological processi

  • activation of phospholipase C activity Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiQ9HBW0

Protein family/group databases

TCDBi9.A.14.2.5 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsiSLP:000001569

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 2
Short name:
LPA receptor 2
Short name:
LPA-2
Alternative name(s):
Lysophosphatidic acid receptor Edg-4
Gene namesi
Name:LPAR2
Synonyms:EDG4, LPA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000064547.13
HGNCiHGNC:3168 LPAR2
MIMi605110 gene
neXtProtiNX_Q9HBW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 69CytoplasmicSequence analysisAdd BLAST15
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 103ExtracellularSequence analysisAdd BLAST13
Transmembranei104 – 126Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini127 – 146CytoplasmicSequence analysisAdd BLAST20
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 188ExtracellularSequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 242CytoplasmicSequence analysisAdd BLAST33
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 279ExtracellularSequence analysisAdd BLAST16
Transmembranei280 – 297Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini298 – 351CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi348D → A: Abolishes interaction with MAGI3. 1 Publication1
Mutagenesisi349S → A: Abolishes interaction with MAGI3. 1 Publication1
Mutagenesisi350T → A: Does not affect interaction with MAGI3. 1 Publication1
Mutagenesisi351L → A: Abolishes interaction with MAGI3. 1 Publication1

Organism-specific databases

DisGeNETi9170
OpenTargetsiENSG00000064547
PharmGKBiPA162394202

Chemistry databases

ChEMBLiCHEMBL3724
GuidetoPHARMACOLOGYi273

Polymorphism and mutation databases

BioMutaiLPAR2
DMDMi26393399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694241 – 351Lysophosphatidic acid receptor 2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi311S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiQ9HBW0
MaxQBiQ9HBW0
PaxDbiQ9HBW0
PeptideAtlasiQ9HBW0
PRIDEiQ9HBW0
ProteomicsDBi81600

PTM databases

iPTMnetiQ9HBW0
PhosphoSitePlusiQ9HBW0

Expressioni

Tissue specificityi

Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.

Gene expression databases

BgeeiENSG00000064547
CleanExiHS_LPAR2
ExpressionAtlasiQ9HBW0 baseline and differential
GenevisibleiQ9HBW0 HS

Organism-specific databases

HPAiHPA019616

Interactioni

Subunit structurei

Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114611, 9 interactors
CORUMiQ9HBW0
IntActiQ9HBW0, 4 interactors
STRINGi9606.ENSP00000384665

Chemistry databases

BindingDBiQ9HBW0

Structurei

3D structure databases

ProteinModelPortaliQ9HBW0
SMRiQ9HBW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi348 – 351PDZ-binding4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ9HBW0
KOiK04291
OMAiVVYSCRD
OrthoDBiEOG091G0DD4
PhylomeDBiQ9HBW0

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR004066 LPA_rcpt_EDG4
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01528 EDG4RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIMGQCYYN ETIGFFYNNS GKELSSHWRP KDVVVVALGL TVSVLVLLTN
60 70 80 90 100
LLVIAAIASN RRFHQPIYYL LGNLAAADLF AGVAYLFLMF HTGPRTARLS
110 120 130 140 150
LEGWFLRQGL LDTSLTASVA TLLAIAVERH RSVMAVQLHS RLPRGRVVML
160 170 180 190 200
IVGVWVAALG LGLLPAHSWH CLCALDRCSR MAPLLSRSYL AVWALSSLLV
210 220 230 240 250
FLLMVAVYTR IFFYVRRRVQ RMAEHVSCHP RYRETTLSLV KTVVIILGAF
260 270 280 290 300
VVCWTPGQVV LLLDGLGCES CNVLAVEKYF LLLAEANSLV NAAVYSCRDA
310 320 330 340 350
EMRRTFRRLL CCACLRQSTR ESVHYTSSAQ GGASTRIMLP ENGHPLMDST

L
Length:351
Mass (Da):39,084
Last modified:December 6, 2002 - v2
Checksum:iDE225B0B3E9351B8
GO

Sequence cautioni

The sequence AAC27728 differs from that shown. Reason: Frameshift at position 348.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221R → S in AAG28521 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011466 mRNA Translation: AAC27728.1 Frameshift.
AF233092 mRNA Translation: AAF43409.1
AF197929 mRNA Translation: AAG28521.1
AY322548 mRNA Translation: AAP84361.1
AC002306 Genomic DNA Translation: AAB61528.1
BC025695 mRNA Translation: AAH25695.1
CCDSiCCDS12407.1
RefSeqiNP_004711.2, NM_004720.5
XP_011526723.1, XM_011528421.2
XP_016882957.1, XM_017027468.1
XP_016882958.1, XM_017027469.1
UniGeneiHs.122575

Genome annotation databases

EnsembliENST00000407877; ENSP00000384665; ENSG00000064547
ENST00000542587; ENSP00000443256; ENSG00000064547
ENST00000586703; ENSP00000465280; ENSG00000064547
GeneIDi9170
KEGGihsa:9170
UCSCiuc002nna.6 human

Similar proteinsi

Entry informationi

Entry nameiLPAR2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBW0
Secondary accession number(s): O00543, O43431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: July 18, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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