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Protein

Sperm acrosome membrane-associated protein 1

Gene

SPACA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility (PubMed:11870081).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome membrane-associated protein 1
Alternative name(s):
Sperm acrosomal membrane-associated protein 32
Gene namesi
Name:SPACA1
Synonyms:SAMP32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118434.8
HGNCiHGNC:14967 SPACA1
MIMi612739 gene
neXtProtiNX_Q9HBV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 221ExtracellularSequence analysisAdd BLAST192
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 294CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81833
OpenTargetsiENSG00000118434
PharmGKBiPA37943

Polymorphism and mutation databases

BioMutaiSPACA1
DMDMi74752784

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024815230 – 294Sperm acrosome membrane-associated protein 1Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei256Phosphoserine1 Publication1
Modified residuei269PhosphotyrosineBy similarity1
Modified residuei290PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HBV2
PeptideAtlasiQ9HBV2
PRIDEiQ9HBV2
ProteomicsDBi81599

PTM databases

iPTMnetiQ9HBV2
PhosphoSitePlusiQ9HBV2

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000118434
CleanExiHS_SPACA1
GenevisibleiQ9HBV2 HS

Organism-specific databases

HPAiHPA026744
HPA043297

Interactioni

Protein-protein interaction databases

BioGridi123591, 71 interactors
IntActiQ9HBV2, 16 interactors
STRINGi9606.ENSP00000237201

Structurei

3D structure databases

ProteinModelPortaliQ9HBV2
SMRiQ9HBV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFV6 Eukaryota
ENOG410YPX9 LUCA
GeneTreeiENSGT00390000004211
HOGENOMiHOG000049221
HOVERGENiHBG080320
InParanoidiQ9HBV2
OMAiWGAKAST
OrthoDBiEOG091G0M9J
PhylomeDBiQ9HBV2
TreeFamiTF336918

Family and domain databases

CDDicd13783 SPACA1, 1 hit
InterProiView protein in InterPro
IPR037878 SPACA1

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRGTGCSA GLLMTVGWLL LAGLQSARGT NVTAAVQDAG LAHEGEGEEE
60 70 80 90 100
TENNDSETAE NYAPPETEDV SNRNVVKEVE FGMCTVTCGI GVREVILTNG
110 120 130 140 150
CPGGESKCVV RVEECRGPTD CGWGKPISES LESVRLACIH TSPLNRFKYM
160 170 180 190 200
WKLLRQDQQS IILVNDSAIL EVRKESHPLA FECDTLDNNE IVATIKFTVY
210 220 230 240 250
TSSELQMRRS SLPATDAALI FVLTIGVIIC VFIIFLLIFI IINWAAVKAF
260 270 280 290
WGAKASTPEV QSEQSSVRYK DSTSLDQLPT EMPGEDDALS EWNE
Length:294
Mass (Da):32,143
Last modified:March 1, 2001 - v1
Checksum:i60DB3107E1B03D12
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027258237L → S. Corresponds to variant dbSNP:rs2276089Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203447 mRNA Translation: AAG31422.1
AL136096 Genomic DNA No translation available.
BC029488 mRNA Translation: AAH29488.1
CCDSiCCDS5014.1
RefSeqiNP_112222.1, NM_030960.2
UniGeneiHs.161241

Genome annotation databases

EnsembliENST00000237201; ENSP00000237201; ENSG00000118434
GeneIDi81833
KEGGihsa:81833
UCSCiuc003pmn.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSACA1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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