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Protein

Popeye domain-containing protein 3

Gene

POPDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • heart development Source: GO_Central
  • regulation of membrane potential Source: UniProtKB
  • skeletal muscle tissue development Source: GO_Central

Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 3
Short name:
Popeye protein 3
Gene namesi
Name:POPDC3
Synonyms:POP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000132429.9
HGNCiHGNC:17649 POPDC3
MIMi605824 gene
neXtProtiNX_Q9HBV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 44HelicalSequence analysisAdd BLAST18
Transmembranei48 – 70HelicalSequence analysisAdd BLAST23
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64208
OpenTargetsiENSG00000132429
PharmGKBiPA134935151

Polymorphism and mutation databases

BioMutaiPOPDC3
DMDMi38258245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467951 – 291Popeye domain-containing protein 3Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HBV1
PeptideAtlasiQ9HBV1
PRIDEiQ9HBV1
ProteomicsDBi81598

PTM databases

PhosphoSitePlusiQ9HBV1

Expressioni

Tissue specificityi

Expressed predominantly in skeletal muscle and detected in heart.1 Publication

Gene expression databases

BgeeiENSG00000132429 Expressed in 148 organ(s), highest expression level in biceps brachii
CleanExiHS_POPDC3
ExpressionAtlasiQ9HBV1 baseline and differential
GenevisibleiQ9HBV1 HS

Organism-specific databases

HPAiHPA012514

Interactioni

Protein-protein interaction databases

BioGridi122102, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9HBV1
SMRiQ9HBV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9HBV1
OMAiDIRLPNY
OrthoDBiEOG091G0CVO
PhylomeDBiQ9HBV1
TreeFamiTF326644

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HBV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERNSSLWKN LIDEHPVCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL
60 70 80 90 100
LYVFSLLGLG FLCSAVWAWV DVCAADIFSW NFVLFVICFM QFVHIAYQVR
110 120 130 140 150
SITFAREFQV LYSSLFQPLG ISLPVFRTIA LSSEVVTLEK EHCYAMQGKT
160 170 180 190 200
SIDKLSLLVS GRIRVTVDGE FLHYIFPLQF LDSPEWDSLR PTEEGIFQVT
210 220 230 240 250
LTAETDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA DKLYALNDRV
260 270 280 290
YIGKRYHYDI RLPNFYQMST PEIRRSPLTQ HFQNSRRYCD K
Length:291
Mass (Da):33,870
Last modified:October 31, 2003 - v2
Checksum:i49A3EF5216B2DDC2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T554Q5T554_HUMAN
Popeye domain-containing protein 3
POPDC3
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176F → S in AAG23404 (PubMed:10882522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053602106R → Q. Corresponds to variant dbSNP:rs11961225Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204171 mRNA Translation: AAG23404.1
AK314101 mRNA Translation: BAG36795.1
AL359709 Genomic DNA No translation available.
AL356775 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48427.1
BC022323 mRNA Translation: AAH22323.1
CCDSiCCDS5052.1
RefSeqiNP_071756.2, NM_022361.4
XP_011534369.1, XM_011536067.2
XP_016866683.1, XM_017011194.1
XP_016866684.1, XM_017011195.1
UniGeneiHs.458336

Genome annotation databases

EnsembliENST00000254765; ENSP00000254765; ENSG00000132429
GeneIDi64208
KEGGihsa:64208
UCSCiuc003prb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204171 mRNA Translation: AAG23404.1
AK314101 mRNA Translation: BAG36795.1
AL359709 Genomic DNA No translation available.
AL356775 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48427.1
BC022323 mRNA Translation: AAH22323.1
CCDSiCCDS5052.1
RefSeqiNP_071756.2, NM_022361.4
XP_011534369.1, XM_011536067.2
XP_016866683.1, XM_017011194.1
XP_016866684.1, XM_017011195.1
UniGeneiHs.458336

3D structure databases

ProteinModelPortaliQ9HBV1
SMRiQ9HBV1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122102, 1 interactor

PTM databases

PhosphoSitePlusiQ9HBV1

Polymorphism and mutation databases

BioMutaiPOPDC3
DMDMi38258245

Proteomic databases

PaxDbiQ9HBV1
PeptideAtlasiQ9HBV1
PRIDEiQ9HBV1
ProteomicsDBi81598

Protocols and materials databases

DNASUi64208
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254765; ENSP00000254765; ENSG00000132429
GeneIDi64208
KEGGihsa:64208
UCSCiuc003prb.4 human

Organism-specific databases

CTDi64208
DisGeNETi64208
EuPathDBiHostDB:ENSG00000132429.9
GeneCardsiPOPDC3
HGNCiHGNC:17649 POPDC3
HPAiHPA012514
MIMi605824 gene
neXtProtiNX_Q9HBV1
OpenTargetsiENSG00000132429
PharmGKBiPA134935151
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9HBV1
OMAiDIRLPNY
OrthoDBiEOG091G0CVO
PhylomeDBiQ9HBV1
TreeFamiTF326644

Miscellaneous databases

GeneWikiiPOPDC3
GenomeRNAii64208
PROiPR:Q9HBV1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132429 Expressed in 148 organ(s), highest expression level in biceps brachii
CleanExiHS_POPDC3
ExpressionAtlasiQ9HBV1 baseline and differential
GenevisibleiQ9HBV1 HS

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD3_HUMAN
AccessioniPrimary (citable) accession number: Q9HBV1
Secondary accession number(s): B2RA98, Q5T3Y8, Q8TBW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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