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Protein

Popeye domain-containing protein 2

Gene

POPDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.By similarity

GO - Molecular functioni

  • cAMP binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 2
Short name:
Popeye protein 2
Gene namesi
Name:POPDC2
Synonyms:POP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000121577.13
HGNCiHGNC:17648 POPDC2
MIMi605823 gene
neXtProtiNX_Q9HBU9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64091
OpenTargetsiENSG00000121577
PharmGKBiPA134982197

Polymorphism and mutation databases

BioMutaiPOPDC2
DMDMi38258244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467931 – 364Popeye domain-containing protein 2Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei361PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HBU9
PeptideAtlasiQ9HBU9
PRIDEiQ9HBU9
ProteomicsDBi81596
81597 [Q9HBU9-2]

PTM databases

iPTMnetiQ9HBU9
PhosphoSitePlusiQ9HBU9

Expressioni

Tissue specificityi

Expressed predominantly in the heart and in the skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000121577 Expressed in 127 organ(s), highest expression level in heart left ventricle
CleanExiHS_POPDC2
ExpressionAtlasiQ9HBU9 baseline and differential
GenevisibleiQ9HBU9 HS

Organism-specific databases

HPAiHPA024255

Interactioni

Protein-protein interaction databases

BioGridi122053, 24 interactors
IntActiQ9HBU9, 1 interactor
MINTiQ9HBU9
STRINGi9606.ENSP00000264231

Structurei

3D structure databases

ProteinModelPortaliQ9HBU9
SMRiQ9HBU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9HBU9
PhylomeDBiQ9HBU9
TreeFamiTF326644

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HBU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC
60 70 80 90 100
FYLFGFLSAG YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR
110 120 130 140 150
EDTLPEEFDL LYKTLCLPLQ VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG
160 170 180 190 200
ETPINRLSLL LSGRVRVSQD GQFLHYIFPY QFMDSPEWES LQPSEEGVFQ
210 220 230 240 250
VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD ISEKLYTLND
260 270 280 290 300
KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT
310 320 330 340 350
PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS
360
RGQAPLAPTH TPEL
Length:364
Mass (Da):40,448
Last modified:October 31, 2003 - v2
Checksum:iF29AA48CD611BE51
GO
Isoform 2 (identifier: Q9HBU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-364: ASRIPLQSYSQVISRGQAPLAPTHTPEL → EIDDFPSYFHQFGFSGKVAAGRIP

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):40,115
Checksum:i497BDAC0D50C6EE9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J3P7C9J3P7_HUMAN
Popeye domain-containing protein 2
POPDC2
368Annotation score:
H7C5T7H7C5T7_HUMAN
Popeye domain-containing protein 2
POPDC2
25Annotation score:

Sequence cautioni

The sequence AAH26911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311S → F in AAG23406 (PubMed:10882522).Curated1
Sequence conflicti315 – 328ATTNF…TRARL → RFPPTFPALSYRGQVC in AAG23406 (PubMed:10882522).CuratedAdd BLAST14
Sequence conflicti331 – 333PDS → ASN in AAG23406 (PubMed:10882522).Curated3
Sequence conflicti339R → K in AAG23406 (PubMed:10882522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05360129V → I. Corresponds to variant dbSNP:rs4688023Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008743337 – 364ASRIP…HTPEL → EIDDFPSYFHQFGFSGKVAA GRIP in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204173 mRNA Translation: AAG23406.1
BC026911 mRNA Translation: AAH26911.1 Different initiation.
BC044929 mRNA Translation: AAH44929.1
CCDSiCCDS2992.1 [Q9HBU9-1]
CCDS77797.1 [Q9HBU9-2]
RefSeqiNP_001295262.1, NM_001308333.1 [Q9HBU9-2]
NP_071418.2, NM_022135.3 [Q9HBU9-1]
UniGeneiHs.534383
Hs.656031

Genome annotation databases

EnsembliENST00000264231; ENSP00000264231; ENSG00000121577 [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577 [Q9HBU9-2]
GeneIDi64091
KEGGihsa:64091
UCSCiuc003ecx.2 human [Q9HBU9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204173 mRNA Translation: AAG23406.1
BC026911 mRNA Translation: AAH26911.1 Different initiation.
BC044929 mRNA Translation: AAH44929.1
CCDSiCCDS2992.1 [Q9HBU9-1]
CCDS77797.1 [Q9HBU9-2]
RefSeqiNP_001295262.1, NM_001308333.1 [Q9HBU9-2]
NP_071418.2, NM_022135.3 [Q9HBU9-1]
UniGeneiHs.534383
Hs.656031

3D structure databases

ProteinModelPortaliQ9HBU9
SMRiQ9HBU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122053, 24 interactors
IntActiQ9HBU9, 1 interactor
MINTiQ9HBU9
STRINGi9606.ENSP00000264231

PTM databases

iPTMnetiQ9HBU9
PhosphoSitePlusiQ9HBU9

Polymorphism and mutation databases

BioMutaiPOPDC2
DMDMi38258244

Proteomic databases

PaxDbiQ9HBU9
PeptideAtlasiQ9HBU9
PRIDEiQ9HBU9
ProteomicsDBi81596
81597 [Q9HBU9-2]

Protocols and materials databases

DNASUi64091
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264231; ENSP00000264231; ENSG00000121577 [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577 [Q9HBU9-2]
GeneIDi64091
KEGGihsa:64091
UCSCiuc003ecx.2 human [Q9HBU9-1]

Organism-specific databases

CTDi64091
DisGeNETi64091
EuPathDBiHostDB:ENSG00000121577.13
GeneCardsiPOPDC2
HGNCiHGNC:17648 POPDC2
HPAiHPA024255
MIMi605823 gene
neXtProtiNX_Q9HBU9
OpenTargetsiENSG00000121577
PharmGKBiPA134982197
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9HBU9
PhylomeDBiQ9HBU9
TreeFamiTF326644

Miscellaneous databases

GeneWikiiPOPDC2
GenomeRNAii64091
PROiPR:Q9HBU9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121577 Expressed in 127 organ(s), highest expression level in heart left ventricle
CleanExiHS_POPDC2
ExpressionAtlasiQ9HBU9 baseline and differential
GenevisibleiQ9HBU9 HS

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBU9
Secondary accession number(s): Q86UE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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