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Protein

Zinc finger protein 287

Gene

ZNF287

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri361 – 383C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 663C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 287
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 13
Gene namesi
Name:ZNF287
Synonyms:ZKSCAN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141040.14
HGNCiHGNC:13502 ZNF287
neXtProtiNX_Q9HBT7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37788

Polymorphism and mutation databases

BioMutaiZNF287
DMDMi20141038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475111 – 754Zinc finger protein 287Add BLAST754

Proteomic databases

MaxQBiQ9HBT7
PaxDbiQ9HBT7
PeptideAtlasiQ9HBT7
PRIDEiQ9HBT7
ProteomicsDBi81591

PTM databases

iPTMnetiQ9HBT7
PhosphoSitePlusiQ9HBT7

Expressioni

Gene expression databases

BgeeiENSG00000141040
CleanExiHS_ZNF287
ExpressionAtlasiQ9HBT7 baseline and differential
GenevisibleiQ9HBT7 HS

Organism-specific databases

HPAiHPA029290

Interactioni

Protein-protein interaction databases

BioGridi121490, 10 interactors
IntActiQ9HBT7, 1 interactor
STRINGi9606.ENSP00000379168

Structurei

3D structure databases

ProteinModelPortaliQ9HBT7
SMRiQ9HBT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini163 – 231KRABPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri361 – 383C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 663C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9HBT7
OrthoDBiEOG091G02KC
PhylomeDBiQ9HBT7
TreeFamiTF350843

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

Q9HBT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSSRSQIL LRWKSDKAQS GPYNVEKEIL TSRFLRDTET CRQNFRNFPY
60 70 80 90 100
PDLAGPRKAL SQLRELCLKW LRPEIHSKEQ ILELLVLEQF LTILPGEVRT
110 120 130 140 150
WVKSQYPESS EEAVTLVEDL TQILEEEAPQ NSTLSQDTPE EDPRGKHAFQ
160 170 180 190 200
TGWLNDLVTK ESMTFKDVAV DITQEDWELM RPVQKELYKT VTLQNYWNMV
210 220 230 240 250
SLGLTVYRPT VIPILEEPWM VIKEILEGPS PEWETKAQAC TPVEDMSKLT
260 270 280 290 300
KEETHTIKLE DSYDYDDRLE RRGKGGFWKI HTDERGFSLK SVLSQEYDPT
310 320 330 340 350
EECLSKYDIY RNNFEKHSNL IVQFDTQLDN KTSVYNEGRA TFNHVSYGIV
360 370 380 390 400
HRKILPGEKP YKCNVCGKKF RKYPSLLKHQ STHAKEKSYE CEECGKEFRH
410 420 430 440 450
ISSLIAHQRM HTGEKPYECH QCGKAFSQRA HLTIHQRIHT GEKPYKCDDC
460 470 480 490 500
GKDFSQRAHL TIHQRTHTGE KPYKCLECGK TFSHSSSLIN HQRVHTGEKP
510 520 530 540 550
YICNECGKTF SQSTHLLQHQ KIHTGKKPYK CNECWKVFSQ STYLIRHQRI
560 570 580 590 600
HSGEKCYKCN ECGKAFAHSS TLIQHQTTHT GEKSYICNIC GKAFSQSANL
610 620 630 640 650
TQHHRTHTGE KPYKCSVCGK AFSQSVHLTQ HQRIHNGEKP FKCNICGKAY
660 670 680 690 700
RQGANLTQHQ RIHTGEKPYK CNECGKAFIY SSSLNQHQRT HTGERPYKCN
710 720 730 740 750
ECDKDFSQRT CLIQHQRIHT GEKPYACRIC GKTFTQSTNL IQHQRVHTGA

KHRN
Length:754
Mass (Da):87,565
Last modified:March 1, 2001 - v1
Checksum:iA1CCF1F5180601C5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024207274K → T. Corresponds to variant dbSNP:rs7224723Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217227 mRNA Translation: AAG09702.1
CR457194 mRNA Translation: CAG33475.1
AC127540 Genomic DNA No translation available.
BC101487 mRNA Translation: AAI01488.1
BC113363 mRNA Translation: AAI13364.1
UniGeneiHs.99724

Genome annotation databases

EnsembliENST00000395824; ENSP00000379168; ENSG00000141040
ENST00000395825; ENSP00000379169; ENSG00000141040
UCSCiuc002gqi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN287_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT7
Secondary accession number(s): Q6IAG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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