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Protein

Cadherin-20

Gene

CDH20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-20
Gene namesi
Name:CDH20
Synonyms:CDH7L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101542.9
HGNCiHGNC:1760 CDH20
MIMi605807 gene
neXtProtiNX_Q9HBT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini60 – 619ExtracellularSequence analysisAdd BLAST560
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 801CytoplasmicSequence analysisAdd BLAST161

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28316
OpenTargetsiENSG00000101542
PharmGKBiPA26294

Polymorphism and mutation databases

BioMutaiCDH20
DMDMi190359622

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
PropeptideiPRO_000000381935 – 59Sequence analysisAdd BLAST25
ChainiPRO_000000382060 – 801Cadherin-20Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi542N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

EPDiQ9HBT6
PaxDbiQ9HBT6
PeptideAtlasiQ9HBT6
PRIDEiQ9HBT6
ProteomicsDBi81590

PTM databases

iPTMnetiQ9HBT6
PhosphoSitePlusiQ9HBT6

Expressioni

Tissue specificityi

Expressed in placenta, adult brain, and fetal brain.

Gene expression databases

BgeeiENSG00000101542
CleanExiHS_CDH20
GenevisibleiQ9HBT6 HS

Organism-specific databases

HPAiHPA015490

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262717

Structurei

3D structure databases

ProteinModelPortaliQ9HBT6
SMRiQ9HBT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 165Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini166 – 274Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini275 – 389Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini390 – 494Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini494 – 610Cadherin 5PROSITE-ProRule annotationAdd BLAST117

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ9HBT6
KOiK06807
OMAiEERSQYT
OrthoDBiEOG091G01U9
PhylomeDBiQ9HBT6
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK
60 70 80 90 100
PQSHQRTKRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG
110 120 130 140 150
EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE
160 170 180 190 200
FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS
210 220 230 240 250
ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV IIQAKDMGGQ
260 270 280 290 300
LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
310 320 330 340 350
LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT
360 370 380 390 400
LKVEGANPHL EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE
410 420 430 440 450
DVAIGTTIQI ISAKDPDVTN NSIRYSIDRS SDPGRFFYVD ITTGALMTAR
460 470 480 490 500
PLDREEFSWH NITVLAMEMN NPSQVGSVPV TIKVLDVNDN APEFPRFYEA
510 520 530 540 550
FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN PNFTIRDNQD
560 570 580 590 600
NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD
610 620 630 640 650
GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY
660 670 680 690 700
IIDDEENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD
710 720 730 740 750
MLPEIESLSR YVPQTCAVNS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF
760 770 780 790 800
EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPAPL

W
Length:801
Mass (Da):88,993
Last modified:February 26, 2008 - v2
Checksum:i6B8B226519F49C5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti621A → P in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti694A → G in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti709S → F in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti739A → T in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti755S → P in AAG23739 (PubMed:10995570).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036103228M → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_039119328P → H. Corresponds to variant dbSNP:rs1943330Ensembl.1
Natural variantiVAR_039120371Q → R. Corresponds to variant dbSNP:rs35923922Ensembl.1
Natural variantiVAR_039121391P → L. Corresponds to variant dbSNP:rs17068463Ensembl.1
Natural variantiVAR_036104416P → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036105746Q → H in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217289 mRNA Translation: AAG23739.1
CH471096 Genomic DNA Translation: EAW63108.1
BC101047 mRNA Translation: AAI01048.1
BC101048 mRNA Translation: AAI01049.1
BC101049 mRNA Translation: AAI01050.1
CCDSiCCDS11977.1
RefSeqiNP_114097.2, NM_031891.3
UniGeneiHs.671510

Genome annotation databases

EnsembliENST00000262717; ENSP00000262717; ENSG00000101542
ENST00000536675; ENSP00000444767; ENSG00000101542
ENST00000538374; ENSP00000442226; ENSG00000101542
GeneIDi28316
KEGGihsa:28316
UCSCiuc002lif.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAD20_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT6
Secondary accession number(s): Q495S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: February 26, 2008
Last modified: July 18, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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