CDH20

Functionⁱ

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cadherin-20
Gene namesⁱ	Name:CDH20 Synonyms:CDH7L3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101542.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1760 CDH20
MIMⁱ	605807 gene
neXtProtⁱ	NX_Q9HBT6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	60 – 619	ExtracellularSequence analysisAdd BLAST	560
Transmembraneⁱ	620 – 640	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	641 – 801	CytoplasmicSequence analysisAdd BLAST	161

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28316
Open Targets More...OpenTargetsⁱ	ENSG00000101542
PharmGKBⁱ	PA26294

Polymorphism and mutation databases

BioMutaⁱ	CDH20
DMDMⁱ	190359622

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 34	Sequence analysisAdd BLAST	34
PropeptideⁱPRO_0000003819	35 – 59	Sequence analysisAdd BLAST	25
ChainⁱPRO_0000003820	60 – 801	Cadherin-20Add BLAST	742

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	261	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	420	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	461	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	542	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

EPDⁱ	Q9HBT6
PaxDbⁱ	Q9HBT6
PeptideAtlas More...PeptideAtlasⁱ	Q9HBT6
PRIDEⁱ	Q9HBT6
ProteomicsDBⁱ	81590

PTM databases

iPTMnetⁱ	Q9HBT6
PhosphoSitePlusⁱ	Q9HBT6

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta, adult brain, and fetal brain.

Gene expression databases

Bgeeⁱ	ENSG00000101542
CleanExⁱ	HS_CDH20
Genevisibleⁱ	Q9HBT6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015490

HPAⁱ

HPA015490

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000262717

STRINGⁱ

9606.ENSP00000262717

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9HBT6
SMRⁱ	Q9HBT6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	61 – 165	Cadherin 1PROSITE-ProRule annotationAdd BLAST	105
Domainⁱ	166 – 274	Cadherin 2PROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	275 – 389	Cadherin 3PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	390 – 494	Cadherin 4PROSITE-ProRule annotationAdd BLAST	105
Domainⁱ	494 – 610	Cadherin 5PROSITE-ProRule annotationAdd BLAST	117

Domainⁱ

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118954
HOGENOMⁱ	HOG000231252
HOVERGENⁱ	HBG005217
InParanoidⁱ	Q9HBT6
KEGG Orthology (KO) More...KOⁱ	K06807
OMAⁱ	EERSQYT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01U9
PhylomeDBⁱ	Q9HBT6
TreeFamⁱ	TF329887

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 3 hits PS50268 CADHERIN_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9HBT6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK 
        60         70         80         90        100
PQSHQRTKRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG 
       110        120        130        140        150
EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE 
       160        170        180        190        200
FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS 
       210        220        230        240        250
ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV IIQAKDMGGQ 
       260        270        280        290        300
LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD 
       310        320        330        340        350
LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT 
       360        370        380        390        400
LKVEGANPHL EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE 
       410        420        430        440        450
DVAIGTTIQI ISAKDPDVTN NSIRYSIDRS SDPGRFFYVD ITTGALMTAR 
       460        470        480        490        500
PLDREEFSWH NITVLAMEMN NPSQVGSVPV TIKVLDVNDN APEFPRFYEA 
       510        520        530        540        550
FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN PNFTIRDNQD 
       560        570        580        590        600
NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD 
       610        620        630        640        650
GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY 
       660        670        680        690        700
IIDDEENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD 
       710        720        730        740        750
MLPEIESLSR YVPQTCAVNS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF 
       760        770        780        790        800
EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPAPL 

W

Length:801

Mass (Da):88,993

Last modified:February 26, 2008 - v2

Checksum:ⁱ6B8B226519F49C5E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	621	A → P in AAG23739 (PubMed:10995570).Curated	1
Sequence conflictⁱ	694	A → G in AAG23739 (PubMed:10995570).Curated	1
Sequence conflictⁱ	709	S → F in AAG23739 (PubMed:10995570).Curated	1
Sequence conflictⁱ	739	A → T in AAG23739 (PubMed:10995570).Curated	1
Sequence conflictⁱ	755	S → P in AAG23739 (PubMed:10995570).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036103	228	M → I in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_039119	328	P → H. Corresponds to variant dbSNP:rs1943330Ensembl.	1
Natural variantⁱVAR_039120	371	Q → R. Corresponds to variant dbSNP:rs35923922Ensembl.	1
Natural variantⁱVAR_039121	391	P → L. Corresponds to variant dbSNP:rs17068463Ensembl.	1
Natural variantⁱVAR_036104	416	P → T in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_036105	746	Q → H in a breast cancer sample; somatic mutation. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF217289 mRNA Translation: AAG23739.1 CH471096 Genomic DNA Translation: EAW63108.1 BC101047 mRNA Translation: AAI01048.1 BC101048 mRNA Translation: AAI01049.1 BC101049 mRNA Translation: AAI01050.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11977.1
NCBI Reference Sequences More...RefSeqⁱ	NP_114097.2, NM_031891.3
UniGeneⁱ	Hs.671510

Genome annotation databases

Ensemblⁱ	ENST00000262717; ENSP00000262717; ENSG00000101542 ENST00000536675; ENSP00000444767; ENSG00000101542 ENST00000538374; ENSP00000442226; ENSG00000101542
GeneIDⁱ	28316
KEGGⁱ	hsa:28316
UCSC genome browser More...UCSCⁱ	uc002lif.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9HBT6	Cadherin 20		GORGO		801
cDNA FLJ37047 fis, clone BRACE2012232, highly similar to Homo sapiens cadherin 20 (CDH20) mRNA		HUMAN		335

Protein	Similar proteins		Species	Score	Length
Q9HBT6	Cadherin 20		GORGO		801
cDNA FLJ37047 fis, clone BRACE2012232, highly similar to Homo sapiens cadherin 20 (CDH20) mRNA		HUMAN		335
UPI00057A2979		CAMBA		845
UPI00083C4E96		RHIBE		825
UPI00057BB550		CAMDR		819
+125

Protein	Similar proteins		Species	Score	Length
Q9HBT6	Cadherin-8	)	MOUSE		799
UPI000A308CDC		MUSPA		799
UPI0003C870EA		CAMFR		799
UPI0004ED2522		NANGA		799
Cadherin-8		RAT		799
+2306

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF217289 mRNA Translation: AAG23739.1 CH471096 Genomic DNA Translation: EAW63108.1 BC101047 mRNA Translation: AAI01048.1 BC101048 mRNA Translation: AAI01049.1 BC101049 mRNA Translation: AAI01050.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11977.1
NCBI Reference Sequences More...RefSeqⁱ	NP_114097.2, NM_031891.3
UniGeneⁱ	Hs.671510

3D structure databases

ProteinModelPortalⁱ	Q9HBT6
SMRⁱ	Q9HBT6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000262717

STRINGⁱ

9606.ENSP00000262717

PTM databases

iPTMnetⁱ	Q9HBT6
PhosphoSitePlusⁱ	Q9HBT6

Polymorphism and mutation databases

BioMutaⁱ	CDH20
DMDMⁱ	190359622

Proteomic databases

EPDⁱ	Q9HBT6
PaxDbⁱ	Q9HBT6
PeptideAtlas More...PeptideAtlasⁱ	Q9HBT6
PRIDEⁱ	Q9HBT6
ProteomicsDBⁱ	81590

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262717; ENSP00000262717; ENSG00000101542 ENST00000536675; ENSP00000444767; ENSG00000101542 ENST00000538374; ENSP00000442226; ENSG00000101542
GeneIDⁱ	28316
KEGGⁱ	hsa:28316
UCSC genome browser More...UCSCⁱ	uc002lif.3 human

Organism-specific databases

CTDⁱ	28316
DisGeNET More...DisGeNETⁱ	28316
EuPathDBⁱ	HostDB:ENSG00000101542.9
GeneCardsⁱ	CDH20
H-InvDBⁱ	HIX0014487
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1760 CDH20
Human Protein Atlas More...HPAⁱ	HPA015490
MIMⁱ	605807 gene
neXtProtⁱ	NX_Q9HBT6
Open Targets More...OpenTargetsⁱ	ENSG00000101542
PharmGKBⁱ	PA26294
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118954
HOGENOMⁱ	HOG000231252
HOVERGENⁱ	HBG005217
InParanoidⁱ	Q9HBT6
KEGG Orthology (KO) More...KOⁱ	K06807
OMAⁱ	EERSQYT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01U9
PhylomeDBⁱ	Q9HBT6
TreeFamⁱ	TF329887

Miscellaneous databases

ChiTaRSⁱ	CDH20 human
GenomeRNAiⁱ	28316
Protein Ontology More...PROⁱ	PR:Q9HBT6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101542
CleanExⁱ	HS_CDH20
Genevisibleⁱ	Q9HBT6 HS

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 3 hits PS50268 CADHERIN_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAD20_HUMAN
Accessionⁱ	Q9HBT6Primary (citable) accession number: Q9HBT6 Secondary accession number(s): Q495S3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
	Last sequence update:	February 26, 2008
	Last modified:	July 18, 2018
	This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q9HBT6 (CAD20_HUMAN)

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Cadherin-20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ