UniProtKB - Q9HBT6 (CAD20_HUMAN)
Protein
Cadherin-20
Gene
CDH20
Organism
Homo sapiens (Human)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- adherens junction organization Source: GO_Central
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell-cell junction assembly Source: GO_Central
- cell morphogenesis Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- multicellular organism development Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9HBT6 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-20 |
Gene namesi | Name:CDH20 Synonyms:CDH7L3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101542.9 |
HGNCi | HGNC:1760, CDH20 |
MIMi | 605807, gene |
neXtProti | NX_Q9HBT6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- catenin complex Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 60 – 619 | ExtracellularSequence analysisAdd BLAST | 560 | |
Transmembranei | 620 – 640 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 641 – 801 | CytoplasmicSequence analysisAdd BLAST | 161 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 28316 |
OpenTargetsi | ENSG00000101542 |
PharmGKBi | PA26294 |
Miscellaneous databases
Pharosi | Q9HBT6, Tbio |
Polymorphism and mutation databases
BioMutai | CDH20 |
DMDMi | 190359622 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
PropeptideiPRO_0000003819 | 35 – 59 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000003820 | 60 – 801 | Cadherin-20Add BLAST | 742 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 261 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 420 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 461 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 542 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, GlycoproteinProteomic databases
EPDi | Q9HBT6 |
MassIVEi | Q9HBT6 |
PaxDbi | Q9HBT6 |
PeptideAtlasi | Q9HBT6 |
PRIDEi | Q9HBT6 |
ProteomicsDBi | 81590 |
PTM databases
GlyGeni | Q9HBT6, 4 sites |
iPTMneti | Q9HBT6 |
PhosphoSitePlusi | Q9HBT6 |
Expressioni
Tissue specificityi
Expressed in placenta, adult brain, and fetal brain.
Gene expression databases
Bgeei | ENSG00000101542, Expressed in cerebellum and 104 other tissues |
Genevisiblei | Q9HBT6, HS |
Organism-specific databases
HPAi | ENSG00000101542, Group enriched (adipose tissue, brain) |
Interactioni
GO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 118200, 1 interactor |
IntActi | Q9HBT6, 1 interactor |
STRINGi | 9606.ENSP00000262717 |
Miscellaneous databases
RNActi | Q9HBT6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 165 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 166 – 274 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 275 – 389 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 390 – 494 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 494 – 610 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 117 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000158167 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | Q9HBT6 |
OMAi | DGHVLSC |
OrthoDBi | 217088at2759 |
PhylomeDBi | Q9HBT6 |
TreeFami | TF329887 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin_binding_dom_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9HBT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK
60 70 80 90 100
PQSHQRTKRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG
110 120 130 140 150
EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE
160 170 180 190 200
FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS
210 220 230 240 250
ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV IIQAKDMGGQ
260 270 280 290 300
LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
310 320 330 340 350
LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT
360 370 380 390 400
LKVEGANPHL EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE
410 420 430 440 450
DVAIGTTIQI ISAKDPDVTN NSIRYSIDRS SDPGRFFYVD ITTGALMTAR
460 470 480 490 500
PLDREEFSWH NITVLAMEMN NPSQVGSVPV TIKVLDVNDN APEFPRFYEA
510 520 530 540 550
FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN PNFTIRDNQD
560 570 580 590 600
NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD
610 620 630 640 650
GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY
660 670 680 690 700
IIDDEENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD
710 720 730 740 750
MLPEIESLSR YVPQTCAVNS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF
760 770 780 790 800
EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPAPL
W
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 621 | A → P in AAG23739 (PubMed:10995570).Curated | 1 | |
Sequence conflicti | 694 | A → G in AAG23739 (PubMed:10995570).Curated | 1 | |
Sequence conflicti | 709 | S → F in AAG23739 (PubMed:10995570).Curated | 1 | |
Sequence conflicti | 739 | A → T in AAG23739 (PubMed:10995570).Curated | 1 | |
Sequence conflicti | 755 | S → P in AAG23739 (PubMed:10995570).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036103 | 228 | M → I in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_039119 | 328 | P → H. Corresponds to variant dbSNP:rs1943330Ensembl. | 1 | |
Natural variantiVAR_039120 | 371 | Q → R. Corresponds to variant dbSNP:rs35923922Ensembl. | 1 | |
Natural variantiVAR_039121 | 391 | P → L. Corresponds to variant dbSNP:rs17068463Ensembl. | 1 | |
Natural variantiVAR_036104 | 416 | P → T in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_036105 | 746 | Q → H in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF217289 mRNA Translation: AAG23739.1 CH471096 Genomic DNA Translation: EAW63108.1 BC101047 mRNA Translation: AAI01048.1 BC101048 mRNA Translation: AAI01049.1 BC101049 mRNA Translation: AAI01050.1 |
CCDSi | CCDS11977.1 |
RefSeqi | NP_114097.2, NM_031891.3 |
Genome annotation databases
Ensembli | ENST00000262717; ENSP00000262717; ENSG00000101542 ENST00000536675; ENSP00000444767; ENSG00000101542 ENST00000538374; ENSP00000442226; ENSG00000101542 |
GeneIDi | 28316 |
KEGGi | hsa:28316 |
UCSCi | uc002lif.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF217289 mRNA Translation: AAG23739.1 CH471096 Genomic DNA Translation: EAW63108.1 BC101047 mRNA Translation: AAI01048.1 BC101048 mRNA Translation: AAI01049.1 BC101049 mRNA Translation: AAI01050.1 |
CCDSi | CCDS11977.1 |
RefSeqi | NP_114097.2, NM_031891.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118200, 1 interactor |
IntActi | Q9HBT6, 1 interactor |
STRINGi | 9606.ENSP00000262717 |
PTM databases
GlyGeni | Q9HBT6, 4 sites |
iPTMneti | Q9HBT6 |
PhosphoSitePlusi | Q9HBT6 |
Polymorphism and mutation databases
BioMutai | CDH20 |
DMDMi | 190359622 |
Proteomic databases
EPDi | Q9HBT6 |
MassIVEi | Q9HBT6 |
PaxDbi | Q9HBT6 |
PeptideAtlasi | Q9HBT6 |
PRIDEi | Q9HBT6 |
ProteomicsDBi | 81590 |
Protocols and materials databases
Antibodypediai | 2286, 109 antibodies |
Genome annotation databases
Ensembli | ENST00000262717; ENSP00000262717; ENSG00000101542 ENST00000536675; ENSP00000444767; ENSG00000101542 ENST00000538374; ENSP00000442226; ENSG00000101542 |
GeneIDi | 28316 |
KEGGi | hsa:28316 |
UCSCi | uc002lif.3, human |
Organism-specific databases
CTDi | 28316 |
DisGeNETi | 28316 |
EuPathDBi | HostDB:ENSG00000101542.9 |
GeneCardsi | CDH20 |
HGNCi | HGNC:1760, CDH20 |
HPAi | ENSG00000101542, Group enriched (adipose tissue, brain) |
MIMi | 605807, gene |
neXtProti | NX_Q9HBT6 |
OpenTargetsi | ENSG00000101542 |
PharmGKBi | PA26294 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000158167 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | Q9HBT6 |
OMAi | DGHVLSC |
OrthoDBi | 217088at2759 |
PhylomeDBi | Q9HBT6 |
TreeFami | TF329887 |
Enzyme and pathway databases
PathwayCommonsi | Q9HBT6 |
Miscellaneous databases
BioGRID-ORCSi | 28316, 1 hit in 838 CRISPR screens |
ChiTaRSi | CDH20, human |
GenomeRNAii | 28316 |
Pharosi | Q9HBT6, Tbio |
PROi | PR:Q9HBT6 |
RNActi | Q9HBT6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101542, Expressed in cerebellum and 104 other tissues |
Genevisiblei | Q9HBT6, HS |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin_binding_dom_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAD20_HUMAN | |
Accessioni | Q9HBT6Primary (citable) accession number: Q9HBT6 Secondary accession number(s): Q495S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2001 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations