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Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene

SLC38A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.By similarity

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Ion transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

TCDBi2.A.18.6.16 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene namesi
ORF Names:PP1744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000157637.12
HGNCiHGNC:28237 SLC38A10
MIMi616525 gene
neXtProtiNX_Q9HBR0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei36 – 58HelicalSequence analysisAdd BLAST23
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157637
PharmGKBiPA162403738

Polymorphism and mutation databases

BioMutaiSLC38A10
DMDMi172045932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189751 – 1119Putative sodium-coupled neutral amino acid transporter 10Add BLAST1119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei612PhosphoserineBy similarity1
Modified residuei772PhosphothreonineCombined sources1
Modified residuei802PhosphoserineCombined sources1
Modified residuei889PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1
Modified residuei997PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HBR0
MaxQBiQ9HBR0
PaxDbiQ9HBR0
PeptideAtlasiQ9HBR0
PRIDEiQ9HBR0
ProteomicsDBi81585
81586 [Q9HBR0-2]
81587 [Q9HBR0-3]

PTM databases

iPTMnetiQ9HBR0
PhosphoSitePlusiQ9HBR0

Expressioni

Gene expression databases

BgeeiENSG00000157637 Expressed in 207 organ(s), highest expression level in right lobe of liver
CleanExiHS_SLC38A10
ExpressionAtlasiQ9HBR0 baseline and differential
GenevisibleiQ9HBR0 HS

Organism-specific databases

HPAiHPA021374
HPA023161
HPA024631

Interactioni

Protein-protein interaction databases

BioGridi125874, 20 interactors
IntActiQ9HBR0, 10 interactors
MINTiQ9HBR0
STRINGi9606.ENSP00000363891

Structurei

3D structure databases

ProteinModelPortaliQ9HBR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOGENOMiHOG000154237
HOVERGENiHBG097690
InParanoidiQ9HBR0
KOiK14996
OMAiILKEANW
OrthoDBiEOG091G0IDE
PhylomeDBiQ9HBR0
TreeFamiTF320116

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HBR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT
60 70 80 90 100
HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF
110 120 130 140 150
YVVIGDLGSN FFARLFGFQV GGTFRMFLLF AVSLCIVLPL SLQRNMMASI
160 170 180 190 200
QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRRVSYVR WEGVFRCIPI
210 220 230 240 250
FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF YVMVGFFGYV
260 270 280 290 300
SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL
310 320 330 340 350
CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG
360 370 380 390 400
ATMGSLICFI CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE
410 420 430 440 450
VPEDLAEEAP GGRLGEAEGL MKVEAARLSA QDPVVAVAED GREKPKLPKE
460 470 480 490 500
REELEQAQIK GPVDVPGRED GKEAPEEAQL DRPGQGIAVP VGEAHRHEPP
510 520 530 540 550
VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP PLPDSEREKQ
560 570 580 590 600
EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD
610 620 630 640 650
RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG
660 670 680 690 700
KPPLPAEKPA PGPGLPPEPR EQRDVERAGG NQAASQLEEA GRAEMLDHAV
710 720 730 740 750
LLQVIKEQQV QQKRLLDQQE KLLAVIEEQH KEIHQQRQED EEDKPRQVEV
760 770 780 790 800
HQEPGAAVPR GQEAPEGKAR ETVENLPPLP LDPVLRAPGG RPAPSQDLNQ
810 820 830 840 850
RSLEHSEGPV GRDPAGPPDG GPDTEPRAAQ AKLRDGQKDA APRAAGTVKE
860 870 880 890 900
LPKGPEQVPV PDPAREAGGP EERLAEEFPG QSQDVTGGSQ DRKKPGKEVA
910 920 930 940 950
ATGTSILKEA NWLVAGPGAE TGDPRMKPKQ VSRDLGLAAD LPGGAEGAAA
960 970 980 990 1000
QPQAVLRQPE LRVISDGEQG GQQGHRLDHG GHLEMRKARG GDHVPVSHEQ
1010 1020 1030 1040 1050
PRGGEDAAVQ EPRQRPEPEL GLKRAVPGGQ RPDNAKPNRD LKLQAGSDLR
1060 1070 1080 1090 1100
RRRRDLGPHA EGQLAPRDGV IIGLNPLPDV QVNDLRGALD AQLRQAAGGA
1110
LQVVHSRQLR QAPGPPEES
Length:1,119
Mass (Da):119,762
Last modified:February 26, 2008 - v2
Checksum:iF328CFEB6A5336D9
GO
Isoform 2 (identifier: Q9HBR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     689-780: EAGRAEMLDH...ETVENLPPLP → GKASALQPPA...DYRFISLAPL
     781-1119: Missing.

Show »
Length:780
Mass (Da):83,324
Checksum:iE529A228C8842312
GO
Isoform 3 (identifier: Q9HBR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     768-768: K → S
     769-1119: Missing.

Note: No experimental confirmation available.
Show »
Length:686
Mass (Da):73,978
Checksum:iF260EB0E42807634
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3T4F5H3T4_HUMAN
Putative sodium-coupled neutral ami...
SLC38A10
119Annotation score:
H0YGS1H0YGS1_HUMAN
Putative sodium-coupled neutral ami...
SLC38A10
70Annotation score:
H0YF92H0YF92_HUMAN
Putative sodium-coupled neutral ami...
SLC38A10
298Annotation score:
I3L0Q8I3L0Q8_HUMAN
Putative sodium-coupled neutral ami...
SLC38A10
258Annotation score:

Sequence cautioni

The sequence AAG17235 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04027 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1071Missing in AAG17235 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048126559K → R. Corresponds to variant dbSNP:rs35546507Ensembl.1
Natural variantiVAR_038927831A → G1 PublicationCorresponds to variant dbSNP:rs2725405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0313231 – 82Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_031324689 – 780EAGRA…LPPLP → GKASALQPPASGPGSGSPLP QPWGDAQVILGSPARPPFSF QPPAEQTPRRAFCSLPISSL LSGNLLSALLPFKHLRHRHM ACDYRFISLAPL in isoform 2. 2 PublicationsAdd BLAST92
Alternative sequenceiVSP_031325768K → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_031326769 – 1119Missing in isoform 3. 1 PublicationAdd BLAST351
Alternative sequenceiVSP_031327781 – 1119Missing in isoform 2. 2 PublicationsAdd BLAST339

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093037 mRNA Translation: BAC04027.1 Different initiation.
AK128330 mRNA Translation: BAC87387.1
AC027601 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89643.1
BC014642 mRNA Translation: AAH14642.1
AF217993 mRNA Translation: AAG17235.1 Different initiation.
CCDSiCCDS11780.1 [Q9HBR0-2]
CCDS42397.1 [Q9HBR0-1]
RefSeqiNP_001033073.1, NM_001037984.2 [Q9HBR0-1]
NP_612637.1, NM_138570.3 [Q9HBR0-2]
UniGeneiHs.352240

Genome annotation databases

EnsembliENST00000288439; ENSP00000288439; ENSG00000157637 [Q9HBR0-2]
ENST00000374759; ENSP00000363891; ENSG00000157637 [Q9HBR0-1]
GeneIDi124565
KEGGihsa:124565
UCSCiuc002jzz.3 human [Q9HBR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093037 mRNA Translation: BAC04027.1 Different initiation.
AK128330 mRNA Translation: BAC87387.1
AC027601 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89643.1
BC014642 mRNA Translation: AAH14642.1
AF217993 mRNA Translation: AAG17235.1 Different initiation.
CCDSiCCDS11780.1 [Q9HBR0-2]
CCDS42397.1 [Q9HBR0-1]
RefSeqiNP_001033073.1, NM_001037984.2 [Q9HBR0-1]
NP_612637.1, NM_138570.3 [Q9HBR0-2]
UniGeneiHs.352240

3D structure databases

ProteinModelPortaliQ9HBR0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125874, 20 interactors
IntActiQ9HBR0, 10 interactors
MINTiQ9HBR0
STRINGi9606.ENSP00000363891

Protein family/group databases

TCDBi2.A.18.6.16 the amino acid/auxin permease (aaap) family

PTM databases

iPTMnetiQ9HBR0
PhosphoSitePlusiQ9HBR0

Polymorphism and mutation databases

BioMutaiSLC38A10
DMDMi172045932

Proteomic databases

EPDiQ9HBR0
MaxQBiQ9HBR0
PaxDbiQ9HBR0
PeptideAtlasiQ9HBR0
PRIDEiQ9HBR0
ProteomicsDBi81585
81586 [Q9HBR0-2]
81587 [Q9HBR0-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288439; ENSP00000288439; ENSG00000157637 [Q9HBR0-2]
ENST00000374759; ENSP00000363891; ENSG00000157637 [Q9HBR0-1]
GeneIDi124565
KEGGihsa:124565
UCSCiuc002jzz.3 human [Q9HBR0-1]

Organism-specific databases

CTDi124565
EuPathDBiHostDB:ENSG00000157637.12
GeneCardsiSLC38A10
HGNCiHGNC:28237 SLC38A10
HPAiHPA021374
HPA023161
HPA024631
MIMi616525 gene
neXtProtiNX_Q9HBR0
OpenTargetsiENSG00000157637
PharmGKBiPA162403738
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOGENOMiHOG000154237
HOVERGENiHBG097690
InParanoidiQ9HBR0
KOiK14996
OMAiILKEANW
OrthoDBiEOG091G0IDE
PhylomeDBiQ9HBR0
TreeFamiTF320116

Miscellaneous databases

ChiTaRSiSLC38A10 human
GeneWikiiSLC38A10
GenomeRNAii124565
PROiPR:Q9HBR0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157637 Expressed in 207 organ(s), highest expression level in right lobe of liver
CleanExiHS_SLC38A10
ExpressionAtlasiQ9HBR0 baseline and differential
GenevisibleiQ9HBR0 HS

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS38AA_HUMAN
AccessioniPrimary (citable) accession number: Q9HBR0
Secondary accession number(s): Q6ZRC5, Q8NA99, Q96C66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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