UniProtKB - Q9HBM6 (TAF9B_HUMAN)
Transcription initiation factor TFIID subunit 9B
TAF9B
Functioni
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
- RNA polymerase II general transcription initiation factor activity Source: ARUK-UCL
- transcription corepressor activity Source: BHF-UCL
GO - Biological processi
- DNA-templated transcription, initiation Source: InterPro
- negative regulation of apoptotic process Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of cell growth Source: UniProtKB
- protein stabilization Source: BHF-UCL
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9HBM6 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-5689880, Ub-specific processing proteases R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SignaLinki | Q9HBM6 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 9BAlternative name(s): Neuronal cell death-related protein 7 Short name: DN-7 Transcription initiation factor TFIID subunit 9-like Transcription-associated factor TAFII31L |
Gene namesi | Name:TAF9B Synonyms:TAF9L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17306, TAF9B |
MIMi | 300754, gene |
neXtProti | NX_Q9HBM6 |
VEuPathDBi | HostDB:ENSG00000187325 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: Reactome
- transcription factor TFIID complex Source: UniProtKB
- transcription factor TFTC complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000187325 |
PharmGKBi | PA38225 |
Miscellaneous databases
Pharosi | Q9HBM6, Tbio |
Genetic variation databases
BioMutai | TAF9B |
DMDMi | 74752778 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118891 | 1 – 251 | Transcription initiation factor TFIID subunit 9BAdd BLAST | 251 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 174 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 177 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9HBM6 |
jPOSTi | Q9HBM6 |
MassIVEi | Q9HBM6 |
MaxQBi | Q9HBM6 |
PaxDbi | Q9HBM6 |
PeptideAtlasi | Q9HBM6 |
PRIDEi | Q9HBM6 |
ProteomicsDBi | 81578 |
PTM databases
GlyGeni | Q9HBM6, 7 sites, 2 O-linked glycans (7 sites) |
iPTMneti | Q9HBM6 |
PhosphoSitePlusi | Q9HBM6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187325, Expressed in female gonad and 226 other tissues |
Genevisiblei | Q9HBM6, HS |
Organism-specific databases
HPAi | ENSG00000187325, Low tissue specificity |
Interactioni
Subunit structurei
Binds TAF5 and TAF6.
Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription.
1 PublicationBinary interactionsi
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 119639, 87 interactors |
CORUMi | Q9HBM6 |
IntActi | Q9HBM6, 25 interactors |
MINTi | Q9HBM6 |
STRINGi | 9606.ENSP00000339917 |
Miscellaneous databases
RNActi | Q9HBM6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 251 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 236 – 251 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3334, Eukaryota |
GeneTreei | ENSGT00940000161697 |
HOGENOMi | CLU_068315_2_0_1 |
InParanoidi | Q9HBM6 |
OMAi | DDNDTMI |
OrthoDBi | 1429345at2759 |
PhylomeDBi | Q9HBM6 |
TreeFami | TF351417 |
Family and domain databases
CDDi | cd07979, TAF9, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR003162, TFIID-31 |
Pfami | View protein in Pfam PF02291, TFIID-31kDa, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MESGKMAPPK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI
60 70 80 90 100
LDDAKIYSSH AKKPNVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN
110 120 130 140 150
QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLIKKGPNQG RLVPRLSVGA
160 170 180 190 200
VSSKPTTPTI ATPQTVSVPN KVATPMSVTS QRFTVQIPPS QSTPVKPVPA
210 220 230 240 250
TTAVQNVLIN PSMIGPKNIL ITTNMVSSQN TANEANPLKR KHEDDDDNDI
M
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | S → L in AAD27786 (Ref. 1) Curated | 1 | |
Sequence conflicti | 209 | I → D in AAD27786 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF077053 mRNA Translation: AAD27786.1 AF220509 mRNA Translation: AAG09711.1 AL049589 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98601.1 BC009566 mRNA Translation: AAH09566.1 BC010350 mRNA Translation: AAH10350.1 BC071649 mRNA Translation: AAH71649.1 BC146952 mRNA Translation: AAI46953.1 BC146960 mRNA Translation: AAI46961.1 |
CCDSi | CCDS35340.1 |
RefSeqi | NP_057059.2, NM_015975.4 |
Genome annotation databases
Ensembli | ENST00000341864; ENSP00000339917; ENSG00000187325 |
GeneIDi | 51616 |
KEGGi | hsa:51616 |
MANE-Selecti | ENST00000341864.6; ENSP00000339917.5; NM_015975.5; NP_057059.2 |
UCSCi | uc004eda.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF077053 mRNA Translation: AAD27786.1 AF220509 mRNA Translation: AAG09711.1 AL049589 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98601.1 BC009566 mRNA Translation: AAH09566.1 BC010350 mRNA Translation: AAH10350.1 BC071649 mRNA Translation: AAH71649.1 BC146952 mRNA Translation: AAI46953.1 BC146960 mRNA Translation: AAI46961.1 |
CCDSi | CCDS35340.1 |
RefSeqi | NP_057059.2, NM_015975.4 |
3D structure databases
SMRi | Q9HBM6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119639, 87 interactors |
CORUMi | Q9HBM6 |
IntActi | Q9HBM6, 25 interactors |
MINTi | Q9HBM6 |
STRINGi | 9606.ENSP00000339917 |
PTM databases
GlyGeni | Q9HBM6, 7 sites, 2 O-linked glycans (7 sites) |
iPTMneti | Q9HBM6 |
PhosphoSitePlusi | Q9HBM6 |
Genetic variation databases
BioMutai | TAF9B |
DMDMi | 74752778 |
Proteomic databases
EPDi | Q9HBM6 |
jPOSTi | Q9HBM6 |
MassIVEi | Q9HBM6 |
MaxQBi | Q9HBM6 |
PaxDbi | Q9HBM6 |
PeptideAtlasi | Q9HBM6 |
PRIDEi | Q9HBM6 |
ProteomicsDBi | 81578 |
Protocols and materials databases
Antibodypediai | 28250, 133 antibodies from 23 providers |
DNASUi | 51616 |
Genome annotation databases
Ensembli | ENST00000341864; ENSP00000339917; ENSG00000187325 |
GeneIDi | 51616 |
KEGGi | hsa:51616 |
MANE-Selecti | ENST00000341864.6; ENSP00000339917.5; NM_015975.5; NP_057059.2 |
UCSCi | uc004eda.4, human |
Organism-specific databases
CTDi | 51616 |
GeneCardsi | TAF9B |
HGNCi | HGNC:17306, TAF9B |
HPAi | ENSG00000187325, Low tissue specificity |
MIMi | 300754, gene |
neXtProti | NX_Q9HBM6 |
OpenTargetsi | ENSG00000187325 |
PharmGKBi | PA38225 |
VEuPathDBi | HostDB:ENSG00000187325 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3334, Eukaryota |
GeneTreei | ENSGT00940000161697 |
HOGENOMi | CLU_068315_2_0_1 |
InParanoidi | Q9HBM6 |
OMAi | DDNDTMI |
OrthoDBi | 1429345at2759 |
PhylomeDBi | Q9HBM6 |
TreeFami | TF351417 |
Enzyme and pathway databases
PathwayCommonsi | Q9HBM6 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-5689880, Ub-specific processing proteases R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
SignaLinki | Q9HBM6 |
Miscellaneous databases
BioGRID-ORCSi | 51616, 5 hits in 674 CRISPR screens |
ChiTaRSi | TAF9B, human |
GeneWikii | TAF9B |
GenomeRNAii | 51616 |
Pharosi | Q9HBM6, Tbio |
PROi | PR:Q9HBM6 |
RNActi | Q9HBM6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187325, Expressed in female gonad and 226 other tissues |
Genevisiblei | Q9HBM6, HS |
Family and domain databases
CDDi | cd07979, TAF9, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR003162, TFIID-31 |
Pfami | View protein in Pfam PF02291, TFIID-31kDa, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF9B_HUMAN | |
Accessioni | Q9HBM6Primary (citable) accession number: Q9HBM6 Secondary accession number(s): B2RUZ9, Q9Y2S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families