TAF9B

Functionⁱ

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.1 Publication

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro
thiol-dependent ubiquitinyl hydrolase activity Source: Reactome
transcription corepressor activity
Source: BHF-UCL
Inferred by curatorⁱ
- 12837753
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H3 acetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12837753
- 15899866
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Source: BHF-UCL
Inferred by curatorⁱ
- 15899866
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12837753
positive regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15899866
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein deubiquitination Source: Reactome
protein stabilization
Source: BHF-UCL
Inferred from direct assayⁱ
- 15899866
regulation of signal transduction by p53 class mediator Source: Reactome
RNA polymerase II preinitiation complex assembly Source: GOC
transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-5689880 Ub-specific processing proteases R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Reactomeⁱ

R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-5689880 Ub-specific processing proteases
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 9B Alternative name(s): Neuronal cell death-related protein 7 Short name: DN-7 Transcription initiation factor TFIID subunit 9-like Transcription-associated factor TAFII31L
Gene namesⁱ	Name:TAF9B Synonyms:TAF9L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187325.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17306 TAF9B
MIMⁱ	300754 gene
neXtProtⁱ	NX_Q9HBM6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000187325
PharmGKBⁱ	PA38225

Polymorphism and mutation databases

BioMutaⁱ	TAF9B
DMDMⁱ	74752778

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118891	1 – 251	Transcription initiation factor TFIID subunit 9BAdd BLAST		251

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	147	PhosphoserineCombined sources	1
Modified residueⁱ	159	PhosphothreonineCombined sources	1
Modified residueⁱ	174	PhosphothreonineCombined sources	1
Modified residueⁱ	177	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9HBM6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HBM6
PaxDbⁱ	Q9HBM6
PeptideAtlas More...PeptideAtlasⁱ	Q9HBM6
PRIDEⁱ	Q9HBM6
ProteomicsDBⁱ	81578

PTM databases

iPTMnetⁱ	Q9HBM6
PhosphoSitePlusⁱ	Q9HBM6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000187325 Expressed in 215 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TAF9B
Genevisibleⁱ	Q9HBM6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045275

HPAⁱ

HPA045275

Interactionⁱ

Subunit structureⁱ

Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DRAP1	Q14919	6	EBI-751601,EBI-712941
TAF6L	Q9Y6J9	7	EBI-751601,EBI-743984

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119639, 42 interactors
CORUMⁱ	Q9HBM6
IntActⁱ	Q9HBM6, 7 interactors
STRINGⁱ	9606.ENSP00000339917

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9HBM6
SMRⁱ	Q9HBM6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	244 – 249	Poly-AspSequence analysis		6

Sequence similaritiesⁱ

Belongs to the TAF9 family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3334 Eukaryota COG5094 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001626
HOGENOMⁱ	HOG000231730
HOVERGENⁱ	HBG002304
InParanoidⁱ	Q9HBM6
KEGG Orthology (KO) More...KOⁱ	K03133
OMAⁱ	NMANESN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RPE
PhylomeDBⁱ	Q9HBM6
TreeFamⁱ	TF351417

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07979 TAF9, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR003162 TFIID-31
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02291 TFIID-31kDa, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9HBM6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MESGKMAPPK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI 
        60         70         80         90        100
LDDAKIYSSH AKKPNVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN 
       110        120        130        140        150
QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLIKKGPNQG RLVPRLSVGA 
       160        170        180        190        200
VSSKPTTPTI ATPQTVSVPN KVATPMSVTS QRFTVQIPPS QSTPVKPVPA 
       210        220        230        240        250
TTAVQNVLIN PSMIGPKNIL ITTNMVSSQN TANEANPLKR KHEDDDDNDI 

M

Length:251

Mass (Da):27,622

Last modified:March 1, 2001 - v1

Checksum:ⁱEB3A1116F7E8BCA0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3	S → L in AAD27786 (Ref. 1) Curated		1
Sequence conflictⁱ	209	I → D in AAD27786 (Ref. 1) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF077053 mRNA Translation: AAD27786.1 AF220509 mRNA Translation: AAG09711.1 AL049589 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98601.1 BC009566 mRNA Translation: AAH09566.1 BC010350 mRNA Translation: AAH10350.1 BC071649 mRNA Translation: AAH71649.1 BC146952 mRNA Translation: AAI46953.1 BC146960 mRNA Translation: AAI46961.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35340.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057059.2, NM_015975.4
UniGeneⁱ	Hs.592248

Genome annotation databases

Ensemblⁱ	ENST00000341864; ENSP00000339917; ENSG00000187325
GeneIDⁱ	51616
KEGGⁱ	hsa:51616
UCSC genome browser More...UCSCⁱ	uc004eda.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HBM6	Transcription initiation factor TFIID subunit 9B		PONAB		251	UniRef100_Q9HBM6
Uncharacterized protein		PANPA		251
TATA-box binding protein associated factor 9b		GORGO		251
TAF9B isoform 1		PONAB		290
TAF9B isoform 2		PONAB		251

Protein	Similar proteins		Species	Score	Length	Source
Q9HBM6	Transcription initiation factor TFIID subunit 9B		PONAB		251	UniRef90_Q9HBM6
Uncharacterized protein		PANPA		251
TATA-box binding protein associated factor 9b		GORGO		251
TATA-box binding protein associated factor 9b		CALJA		312
Uncharacterized protein		AOTNA		293
+99

Protein	Similar proteins		Species	Score	Length	Source
Q9HBM6	Transcription initiation factor TFIID subunit 9B		PONAB		251	UniRef50_Q9HBM6
Uncharacterized protein		PANPA		251
TATA-box binding protein associated factor 9b		GORGO		251
TATA-box binding protein associated factor 9b		CALJA		312
Uncharacterized protein		AOTNA		293
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF077053 mRNA Translation: AAD27786.1 AF220509 mRNA Translation: AAG09711.1 AL049589 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98601.1 BC009566 mRNA Translation: AAH09566.1 BC010350 mRNA Translation: AAH10350.1 BC071649 mRNA Translation: AAH71649.1 BC146952 mRNA Translation: AAI46953.1 BC146960 mRNA Translation: AAI46961.1
CCDSⁱ	CCDS35340.1
RefSeqⁱ	NP_057059.2, NM_015975.4
UniGeneⁱ	Hs.592248

3D structure databases

ProteinModelPortalⁱ	Q9HBM6
SMRⁱ	Q9HBM6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119639, 42 interactors
CORUMⁱ	Q9HBM6
IntActⁱ	Q9HBM6, 7 interactors
STRINGⁱ	9606.ENSP00000339917

PTM databases

iPTMnetⁱ	Q9HBM6
PhosphoSitePlusⁱ	Q9HBM6

Polymorphism and mutation databases

BioMutaⁱ	TAF9B
DMDMⁱ	74752778

Proteomic databases

EPDⁱ	Q9HBM6
MaxQBⁱ	Q9HBM6
PaxDbⁱ	Q9HBM6
PeptideAtlasⁱ	Q9HBM6
PRIDEⁱ	Q9HBM6
ProteomicsDBⁱ	81578

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51616
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000341864; ENSP00000339917; ENSG00000187325
GeneIDⁱ	51616
KEGGⁱ	hsa:51616
UCSCⁱ	uc004eda.4 human

Organism-specific databases

CTDⁱ	51616
EuPathDBⁱ	HostDB:ENSG00000187325.4
GeneCardsⁱ	TAF9B
H-InvDBⁱ	HIX0176727
HGNCⁱ	HGNC:17306 TAF9B
HPAⁱ	HPA045275
MIMⁱ	300754 gene
neXtProtⁱ	NX_Q9HBM6
OpenTargetsⁱ	ENSG00000187325
PharmGKBⁱ	PA38225
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3334 Eukaryota COG5094 LUCA
GeneTreeⁱ	ENSGT00390000001626
HOGENOMⁱ	HOG000231730
HOVERGENⁱ	HBG002304
InParanoidⁱ	Q9HBM6
KOⁱ	K03133
OMAⁱ	NMANESN
OrthoDBⁱ	EOG091G0RPE
PhylomeDBⁱ	Q9HBM6
TreeFamⁱ	TF351417

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-5689880 Ub-specific processing proteases R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Reactomeⁱ

R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-5689880 Ub-specific processing proteases
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

GeneWikiⁱ	TAF9B
GenomeRNAiⁱ	51616
Protein Ontology More...PROⁱ	PR:Q9HBM6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187325 Expressed in 215 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TAF9B
Genevisibleⁱ	Q9HBM6 HS

Family and domain databases

CDDⁱ	cd07979 TAF9, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR003162 TFIID-31
Pfamⁱ	View protein in Pfam PF02291 TFIID-31kDa, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF9B_HUMAN
Accessionⁱ	Q9HBM6Primary (citable) accession number: Q9HBM6 Secondary accession number(s): B2RUZ9, Q9Y2S3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9HBM6 (TAF9B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription initiation factor TFIID subunit 9B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ