Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription initiation factor TFIID subunit 9B

Gene

TAF9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: InterPro
  • thiol-dependent ubiquitinyl hydrolase activity Source: Reactome
  • transcription corepressor activity Source: BHF-UCL
  • transcription factor binding Source: GO_Central
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-5689880 Ub-specific processing proteases
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 9B
Alternative name(s):
Neuronal cell death-related protein 7
Short name:
DN-7
Transcription initiation factor TFIID subunit 9-like
Transcription-associated factor TAFII31L
Gene namesi
Name:TAF9B
Synonyms:TAF9L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000187325.4
HGNCiHGNC:17306 TAF9B
MIMi300754 gene
neXtProtiNX_Q9HBM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187325
PharmGKBiPA38225

Polymorphism and mutation databases

BioMutaiTAF9B
DMDMi74752778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188911 – 251Transcription initiation factor TFIID subunit 9BAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei159PhosphothreonineCombined sources1
Modified residuei174PhosphothreonineCombined sources1
Modified residuei177PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HBM6
MaxQBiQ9HBM6
PaxDbiQ9HBM6
PeptideAtlasiQ9HBM6
PRIDEiQ9HBM6
ProteomicsDBi81578

PTM databases

iPTMnetiQ9HBM6
PhosphoSitePlusiQ9HBM6

Expressioni

Gene expression databases

BgeeiENSG00000187325 Expressed in 215 organ(s), highest expression level in female gonad
CleanExiHS_TAF9B
GenevisibleiQ9HBM6 HS

Organism-specific databases

HPAiHPA045275

Interactioni

Subunit structurei

Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119639, 42 interactors
CORUMiQ9HBM6
IntActiQ9HBM6, 7 interactors
STRINGi9606.ENSP00000339917

Structurei

3D structure databases

ProteinModelPortaliQ9HBM6
SMRiQ9HBM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 249Poly-AspSequence analysis6

Sequence similaritiesi

Belongs to the TAF9 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3334 Eukaryota
COG5094 LUCA
GeneTreeiENSGT00390000001626
HOGENOMiHOG000231730
HOVERGENiHBG002304
InParanoidiQ9HBM6
KOiK03133
OMAiNMANESN
OrthoDBiEOG091G0RPE
PhylomeDBiQ9HBM6
TreeFamiTF351417

Family and domain databases

CDDicd07979 TAF9, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR003162 TFIID-31
PfamiView protein in Pfam
PF02291 TFIID-31kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGKMAPPK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI
60 70 80 90 100
LDDAKIYSSH AKKPNVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN
110 120 130 140 150
QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLIKKGPNQG RLVPRLSVGA
160 170 180 190 200
VSSKPTTPTI ATPQTVSVPN KVATPMSVTS QRFTVQIPPS QSTPVKPVPA
210 220 230 240 250
TTAVQNVLIN PSMIGPKNIL ITTNMVSSQN TANEANPLKR KHEDDDDNDI

M
Length:251
Mass (Da):27,622
Last modified:March 1, 2001 - v1
Checksum:iEB3A1116F7E8BCA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → L in AAD27786 (Ref. 1) Curated1
Sequence conflicti209I → D in AAD27786 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077053 mRNA Translation: AAD27786.1
AF220509 mRNA Translation: AAG09711.1
AL049589 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98601.1
BC009566 mRNA Translation: AAH09566.1
BC010350 mRNA Translation: AAH10350.1
BC071649 mRNA Translation: AAH71649.1
BC146952 mRNA Translation: AAI46953.1
BC146960 mRNA Translation: AAI46961.1
CCDSiCCDS35340.1
RefSeqiNP_057059.2, NM_015975.4
UniGeneiHs.592248

Genome annotation databases

EnsembliENST00000341864; ENSP00000339917; ENSG00000187325
GeneIDi51616
KEGGihsa:51616
UCSCiuc004eda.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077053 mRNA Translation: AAD27786.1
AF220509 mRNA Translation: AAG09711.1
AL049589 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98601.1
BC009566 mRNA Translation: AAH09566.1
BC010350 mRNA Translation: AAH10350.1
BC071649 mRNA Translation: AAH71649.1
BC146952 mRNA Translation: AAI46953.1
BC146960 mRNA Translation: AAI46961.1
CCDSiCCDS35340.1
RefSeqiNP_057059.2, NM_015975.4
UniGeneiHs.592248

3D structure databases

ProteinModelPortaliQ9HBM6
SMRiQ9HBM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119639, 42 interactors
CORUMiQ9HBM6
IntActiQ9HBM6, 7 interactors
STRINGi9606.ENSP00000339917

PTM databases

iPTMnetiQ9HBM6
PhosphoSitePlusiQ9HBM6

Polymorphism and mutation databases

BioMutaiTAF9B
DMDMi74752778

Proteomic databases

EPDiQ9HBM6
MaxQBiQ9HBM6
PaxDbiQ9HBM6
PeptideAtlasiQ9HBM6
PRIDEiQ9HBM6
ProteomicsDBi81578

Protocols and materials databases

DNASUi51616
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341864; ENSP00000339917; ENSG00000187325
GeneIDi51616
KEGGihsa:51616
UCSCiuc004eda.4 human

Organism-specific databases

CTDi51616
EuPathDBiHostDB:ENSG00000187325.4
GeneCardsiTAF9B
H-InvDBiHIX0176727
HGNCiHGNC:17306 TAF9B
HPAiHPA045275
MIMi300754 gene
neXtProtiNX_Q9HBM6
OpenTargetsiENSG00000187325
PharmGKBiPA38225
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3334 Eukaryota
COG5094 LUCA
GeneTreeiENSGT00390000001626
HOGENOMiHOG000231730
HOVERGENiHBG002304
InParanoidiQ9HBM6
KOiK03133
OMAiNMANESN
OrthoDBiEOG091G0RPE
PhylomeDBiQ9HBM6
TreeFamiTF351417

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-5689880 Ub-specific processing proteases
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

GeneWikiiTAF9B
GenomeRNAii51616
PROiPR:Q9HBM6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187325 Expressed in 215 organ(s), highest expression level in female gonad
CleanExiHS_TAF9B
GenevisibleiQ9HBM6 HS

Family and domain databases

CDDicd07979 TAF9, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR003162 TFIID-31
PfamiView protein in Pfam
PF02291 TFIID-31kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF9B_HUMAN
AccessioniPrimary (citable) accession number: Q9HBM6
Secondary accession number(s): B2RUZ9, Q9Y2S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again