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Entry version 150 (12 Aug 2020)
Sequence version 3 (03 Mar 2009)
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Protein

Vezatin

Gene

VEZT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.By similarity
(Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HBM0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vezatin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VEZT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000028203.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18258, VEZT

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HBM0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55591

Open Targets

More...
OpenTargetsi
ENSG00000028203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485667

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HBM0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VEZT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
224471870

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000657831 – 779VezatinAdd BLAST779

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HBM0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HBM0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HBM0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HBM0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HBM0

PeptideAtlas

More...
PeptideAtlasi
Q9HBM0

PRoteomics IDEntifications database

More...
PRIDEi
Q9HBM0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81573 [Q9HBM0-1]
81574 [Q9HBM0-2]
81575 [Q9HBM0-5]
81576 [Q9HBM0-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HBM0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HBM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000028203, Expressed in adrenal tissue and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HBM0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HBM0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000028203, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with USH2A (via the cytoplasmic region); the interaction associates VEZT with the USH2 complex at the stereocilia base (By similarity).

Interacts with myosin MYO7A and the cadherin-catenins complex (PubMed:11080149).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120736, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HBM0, 21 interactors

Molecular INTeraction database

More...
MINTi
Q9HBM0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000410083

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HBM0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili430 – 462Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi763 – 766Poly-Glu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vezatin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTQW, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003290

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HBM0

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMDSDFR

Database of Orthologous Groups

More...
OrthoDBi
1379096at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HBM0

TreeFam database of animal gene trees

More...
TreeFami
TF332269

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026859, Myosin-bd
IPR026858, Vezatin

The PANTHER Classification System

More...
PANTHERi
PTHR15989, PTHR15989, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12632, Vezatin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HBM0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPEFDEEVV FENSPLYQYL QDLGHTDFEI CSSLSPKTEK CTTEGQQKPP
60 70 80 90 100
TRVLPKQGIL LKVAETIKSW IFFSQCNKKD DLLHKLDIGF RLDSLHTILQ
110 120 130 140 150
QEVLLQEDVE LIELLDPSIL SAGQSQQQEN GHLPTLCSLA TPNIWDLSML
160 170 180 190 200
FAFISLLVML PTWWIVSSWL VWGVILFVYL VIRALRLWRT AKLQVTLKKY
210 220 230 240 250
SVHLEDMATN SRAFTNLVRK ALRLIQETEV ISRGFTLVSA ACPFNKAGQH
260 270 280 290 300
PSQHLIGLRK AVYRTLRANF QAARLATLYM LKNYPLNSES DNVTNYICVV
310 320 330 340 350
PFKELGLGLS EEQISEEEAH NFTDGFSLPA LKVLFQLWVA QSSEFFRRLA
360 370 380 390 400
LLLSTANSPP GPLLTPALLP HRILSDVTQG LPHAHSACLE ELKRSYEFYR
410 420 430 440 450
YFETQHQSVP QCLSKTQQKS RELNNVHTAV RSLQLHLKAL LNEVIILEDE
460 470 480 490 500
LEKLVCTKET QELVSEAYPI LEQKLKLIQP HVQASNNCWE EAISQVDKLL
510 520 530 540 550
RRNTDKKGKP EIACENPHCT VVPLKQPTLH IADKDPIPEE QELEAYVDDI
560 570 580 590 600
DIDSDFRKDD FYYLSQEDKE RQKREHEESK RVLQELKSVL GFKASEAERQ
610 620 630 640 650
KWKQLLFSDH AVLKSLSPVD PVEPISNSEP SMNSDMGKVS KNDTEEESNK
660 670 680 690 700
SATTDNEISR TEYLCENSLE GKNKDNSSNE VFPQGAEERM CYQCESEDEP
710 720 730 740 750
QADGSGLTTA PPTPRDSLQP SIKQRLARLQ LSPDFTFTAG LAAEVAARSL
760 770
SFTTMQEQTF GGEEEEQIIE ENKNEIEEK
Length:779
Mass (Da):88,665
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B59BBAA491A71A5
GO
Isoform 2 (identifier: Q9HBM0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-55: PPTRVLP → MLKEWAI
     611-617: AVLKSLS → GVKSAWN
     618-779: Missing.

Note: Due to intron retention.Curated
Show »
Length:569
Mass (Da):65,424
Checksum:i22A06379729FAB16
GO
Isoform 5 (identifier: Q9HBM0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-65: QGILLKVAE → GSLSAICLH
     66-779: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:65
Mass (Da):7,315
Checksum:i94071F7D3D93001A
GO
Isoform 6 (identifier: Q9HBM0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-79: QGILLKVAETIKSWIFFSQCNKK → YLGYSNHSMNINCTYWHAQGMGY
     80-779: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:79
Mass (Da):9,126
Checksum:i23C6D52B54707F19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W8C2F8W8C2_HUMAN
Vezatin
VEZT
723Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3A6F2Z3A6_HUMAN
Vezatin
VEZT
460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVS3F8VVS3_HUMAN
Vezatin
VEZT
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXA0F8VXA0_HUMAN
Vezatin
VEZT
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0S0F8W0S0_HUMAN
Vezatin
VEZT
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS43F8VS43_HUMAN
Vezatin
VEZT
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPN9F8VPN9_HUMAN
Vezatin
VEZT
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUB7F8VUB7_HUMAN
Vezatin
VEZT
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W048F8W048_HUMAN
Vezatin
VEZT
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W088F8W088_HUMAN
Vezatin
VEZT
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG38514 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH64939 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA91634 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAB70772 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46Q → R in BAA91634 (PubMed:14702039).Curated1
Sequence conflicti169W → R in AAG38485 (PubMed:11080149).Curated1
Sequence conflicti334L → W in AAG09719 (Ref. 1) Curated1
Sequence conflicti396Y → I in AAG09719 (Ref. 1) Curated1
Sequence conflicti432S → T in AAG09719 (Ref. 1) Curated1
Sequence conflicti617S → F in AAG09719 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046303162T → A. Corresponds to variant dbSNP:rs17855933Ensembl.1
Natural variantiVAR_046304496V → I1 PublicationCorresponds to variant dbSNP:rs10507051Ensembl.1
Natural variantiVAR_046305612V → M1 PublicationCorresponds to variant dbSNP:rs17344738Ensembl.1
Natural variantiVAR_046306668S → A. Corresponds to variant dbSNP:rs17855934Ensembl.1
Natural variantiVAR_014945762G → D2 PublicationsCorresponds to variant dbSNP:rs14121Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0040101 – 48Missing in isoform 2. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_00401149 – 55PPTRVLP → MLKEWAI in isoform 2. 2 Publications7
Alternative sequenceiVSP_04085357 – 79QGILL…QCNKK → YLGYSNHSMNINCTYWHAQG MGY in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_04085457 – 65QGILLKVAE → GSLSAICLH in isoform 5. 1 Publication9
Alternative sequenceiVSP_04085566 – 779Missing in isoform 5. 1 PublicationAdd BLAST714
Alternative sequenceiVSP_04085680 – 779Missing in isoform 6. 1 PublicationAdd BLAST700
Alternative sequenceiVSP_004014611 – 617AVLKSLS → GVKSAWN in isoform 2. 2 Publications7
Alternative sequenceiVSP_004017618 – 779Missing in isoform 2. 2 PublicationsAdd BLAST162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF225417 mRNA Translation: AAG09719.1
AF216644 mRNA Translation: AAG38485.1
AF277625 mRNA Translation: AAG38514.1 Sequence problems.
AK001338 mRNA Translation: BAA91634.1 Sequence problems.
AC084879 Genomic DNA No translation available.
AC127165 Genomic DNA No translation available.
BC064939 mRNA Translation: AAH64939.1 Sequence problems.
AL133113 mRNA Translation: CAB61416.1
AL137497 mRNA Translation: CAB70772.2 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS44954.1 [Q9HBM0-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46251

NCBI Reference Sequences

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RefSeqi
NP_060069.3, NM_017599.3 [Q9HBM0-1]
XP_006719553.1, XM_006719490.3
XP_016875091.1, XM_017019602.1 [Q9HBM0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000436874; ENSP00000410083; ENSG00000028203 [Q9HBM0-1]
ENST00000546557; ENSP00000447080; ENSG00000028203 [Q9HBM0-6]
ENST00000547484; ENSP00000447010; ENSG00000028203 [Q9HBM0-6]
ENST00000547997; ENSP00000449346; ENSG00000028203 [Q9HBM0-6]
ENST00000548455; ENSP00000447044; ENSG00000028203 [Q9HBM0-6]
ENST00000549624; ENSP00000448555; ENSG00000028203 [Q9HBM0-6]
ENST00000550803; ENSP00000449056; ENSG00000028203 [Q9HBM0-6]
ENST00000552660; ENSP00000447786; ENSG00000028203 [Q9HBM0-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55591

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55591

UCSC genome browser

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UCSCi
uc001tdz.2, human [Q9HBM0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225417 mRNA Translation: AAG09719.1
AF216644 mRNA Translation: AAG38485.1
AF277625 mRNA Translation: AAG38514.1 Sequence problems.
AK001338 mRNA Translation: BAA91634.1 Sequence problems.
AC084879 Genomic DNA No translation available.
AC127165 Genomic DNA No translation available.
BC064939 mRNA Translation: AAH64939.1 Sequence problems.
AL133113 mRNA Translation: CAB61416.1
AL137497 mRNA Translation: CAB70772.2 Sequence problems.
CCDSiCCDS44954.1 [Q9HBM0-1]
PIRiT46251
RefSeqiNP_060069.3, NM_017599.3 [Q9HBM0-1]
XP_006719553.1, XM_006719490.3
XP_016875091.1, XM_017019602.1 [Q9HBM0-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120736, 38 interactors
IntActiQ9HBM0, 21 interactors
MINTiQ9HBM0
STRINGi9606.ENSP00000410083

PTM databases

iPTMnetiQ9HBM0
PhosphoSitePlusiQ9HBM0

Polymorphism and mutation databases

BioMutaiVEZT
DMDMi224471870

Proteomic databases

EPDiQ9HBM0
jPOSTiQ9HBM0
MassIVEiQ9HBM0
MaxQBiQ9HBM0
PaxDbiQ9HBM0
PeptideAtlasiQ9HBM0
PRIDEiQ9HBM0
ProteomicsDBi81573 [Q9HBM0-1]
81574 [Q9HBM0-2]
81575 [Q9HBM0-5]
81576 [Q9HBM0-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1345, 59 antibodies

Genome annotation databases

EnsembliENST00000436874; ENSP00000410083; ENSG00000028203 [Q9HBM0-1]
ENST00000546557; ENSP00000447080; ENSG00000028203 [Q9HBM0-6]
ENST00000547484; ENSP00000447010; ENSG00000028203 [Q9HBM0-6]
ENST00000547997; ENSP00000449346; ENSG00000028203 [Q9HBM0-6]
ENST00000548455; ENSP00000447044; ENSG00000028203 [Q9HBM0-6]
ENST00000549624; ENSP00000448555; ENSG00000028203 [Q9HBM0-6]
ENST00000550803; ENSP00000449056; ENSG00000028203 [Q9HBM0-6]
ENST00000552660; ENSP00000447786; ENSG00000028203 [Q9HBM0-6]
GeneIDi55591
KEGGihsa:55591
UCSCiuc001tdz.2, human [Q9HBM0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55591
DisGeNETi55591
EuPathDBiHostDB:ENSG00000028203.17

GeneCards: human genes, protein and diseases

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GeneCardsi
VEZT
HGNCiHGNC:18258, VEZT
HPAiENSG00000028203, Low tissue specificity
neXtProtiNX_Q9HBM0
OpenTargetsiENSG00000028203
PharmGKBiPA143485667

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTQW, Eukaryota
GeneTreeiENSGT00390000003290
InParanoidiQ9HBM0
OMAiDMDSDFR
OrthoDBi1379096at2759
PhylomeDBiQ9HBM0
TreeFamiTF332269

Enzyme and pathway databases

PathwayCommonsiQ9HBM0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55591, 321 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VEZT, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VEZT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55591
PharosiQ9HBM0, Tbio

Protein Ontology

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PROi
PR:Q9HBM0
RNActiQ9HBM0, protein

Gene expression databases

BgeeiENSG00000028203, Expressed in adrenal tissue and 226 other tissues
ExpressionAtlasiQ9HBM0, baseline and differential
GenevisibleiQ9HBM0, HS

Family and domain databases

InterProiView protein in InterPro
IPR026859, Myosin-bd
IPR026858, Vezatin
PANTHERiPTHR15989, PTHR15989, 1 hit
PfamiView protein in Pfam
PF12632, Vezatin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVEZA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBM0
Secondary accession number(s): Q6P1Q3
, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 3, 2009
Last modified: August 12, 2020
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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