Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase 29

Gene

USP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei294NucleophilePROSITE-ProRule annotation1
Active sitei840Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.040

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 29 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29
Gene namesi
Name:USP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000131864.10
HGNCiHGNC:18563 USP29
MIMi609546 gene
neXtProtiNX_Q9HBJ7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131864
PharmGKBiPA38349

Polymorphism and mutation databases

BioMutaiUSP29
DMDMi23396891

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806601 – 922Ubiquitin carboxyl-terminal hydrolase 29Add BLAST922

Proteomic databases

EPDiQ9HBJ7
PaxDbiQ9HBJ7
PeptideAtlasiQ9HBJ7
PRIDEiQ9HBJ7
ProteomicsDBi81564

PTM databases

iPTMnetiQ9HBJ7
PhosphoSitePlusiQ9HBJ7

Expressioni

Gene expression databases

BgeeiENSG00000131864
CleanExiHS_USP29
ExpressionAtlasiQ9HBJ7 baseline and differential
GenevisibleiQ9HBJ7 HS

Organism-specific databases

HPAiHPA021064

Interactioni

Protein-protein interaction databases

BioGridi121696, 4 interactors
IntActiQ9HBJ7, 2 interactors
MINTiQ9HBJ7
STRINGi9606.ENSP00000254181

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ7
SMRiQ9HBJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 885USPAdd BLAST601

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1868 Eukaryota
ENOG410XP8T LUCA
GeneTreeiENSGT00440000033542
HOGENOMiHOG000060197
HOVERGENiHBG055893
InParanoidiQ9HBJ7
KOiK11850
OMAiVFVCPVV
OrthoDBiEOG091G01DZ
PhylomeDBiQ9HBJ7
TreeFamiTF323032

Family and domain databases

CDDicd13312 PH_USP37_like, 1 hit
Gene3Di2.30.29.180, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR032069 USP37-like_PH
IPR038093 USP37-like_PH_sf
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF16674 UCH_N, 1 hit
SUPFAMiSSF54001 SSF54001, 4 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI
60 70 80 90 100
FQLSNNIRSV VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD
110 120 130 140 150
IIHQNKSQQP MKSDDDWSVF ESRNMLKEID KTSFYSICNK PSYQKMPLFM
160 170 180 190 200
SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN EDILKEDNPV PNKKYKTDSL
210 220 230 240 250
KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE TVLATQTLNA
260 270 280 290 300
KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL
310 320 330 340 350
QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL
360 370 380 390 400
LGNVKKVISA VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE
410 420 430 440 450
CGDENSSPQM HVGSAATKVF VCPVVANFEF ELQLSLICKA CGHAVLKVEP
460 470 480 490 500
NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE ELEYNCQMCK QKSCVARHTF
510 520 530 540 550
SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY CNESTKPPLP
560 570 580 590 600
LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN
610 620 630 640 650
ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS
660 670 680 690 700
LMDQGDISLP VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF
710 720 730 740 750
VEFNFDSVTE STNGFYDCKE NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA
760 770 780 790 800
PPPGVRKLDA QEHTEETLNQ STELRLQKAD LNHLGALGSD NPGNKNILDA
810 820 830 840 850
ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH YISDVYDFQK
860 870 880 890 900
QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL
910 920
PSTQAGVIPQ GEYEGDSLYR PA
Length:922
Mass (Da):104,156
Last modified:March 1, 2001 - v1
Checksum:i122B56AE6FFFF364
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024590368N → S. Corresponds to variant dbSNP:rs1027392Ensembl.1
Natural variantiVAR_022055586E → K. Corresponds to variant dbSNP:rs3795003Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229438 mRNA Translation: AAG10401.1
CCDSiCCDS33124.1
RefSeqiNP_065954.1, NM_020903.2
UniGeneiHs.515632

Genome annotation databases

EnsembliENST00000254181; ENSP00000254181; ENSG00000131864
ENST00000598197; ENSP00000470747; ENSG00000131864
GeneIDi57663
KEGGihsa:57663
UCSCiuc002qny.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBP29_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health