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UniProtKB - Q9HBI5 (CC014_HUMAN)

Entry version 110 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Uncharacterized protein C3orf14

Gene

C3orf14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HBI5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C3orf14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C3orf14
ORF Names:HT021
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000114405.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:25024, C3orf14

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HBI5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000114405

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134883066

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HBI5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C3orf14

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565304

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893881 – 128Uncharacterized protein C3orf14Add BLAST128

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HBI5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HBI5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HBI5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HBI5

PeptideAtlas

More...PeptideAtlasi		Q9HBI5

PRoteomics IDEntifications database

More...PRIDEi		Q9HBI5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81561

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HBI5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HBI5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114405, Expressed in cortical plate and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HBI5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HBI5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114405, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121516, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q9HBI5, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000418086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HBI5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HBI5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S7A9, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_133336_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HBI5

Identification of Orthologs from Complete Genome Data

More...OMAi		IGVENEN

Database of Orthologous Groups

More...OrthoDBi		1643090at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HBI5

TreeFam database of animal gene trees

More...TreeFami		TF335879

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028006, DUF4570

The PANTHER Classification System

More...PANTHERi		PTHR14286, PTHR14286, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15134, DUF4570, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9HBI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLFAQEIR LSKRHEEIVS QRLMLLQQME NKLGDQHTEK ASQLQTVETA 
        60         70         80         90        100
FKRNLSLLKD IEAAEKSLQT RIHPLPRPEV VSLETRYWAS VEEYIPKWEQ 
       110        120 
FLLGRAPYPF AVENQNEAEN TIQNEAQR
Length:128
Mass (Da):15,007
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9046B046B0ABD901
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JY17C9JY17_HUMAN
Uncharacterized protein C3orf14
C3orf14
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF236158 mRNA Translation: AAG09750.1
AK313915 mRNA Translation: BAG36637.1
CH471055 Genomic DNA Translation: EAW65400.1
BC017772 mRNA Translation: AAH17772.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2896.1

NCBI Reference Sequences

More...RefSeqi		NP_001278870.1, NM_001291941.1
NP_001278871.1, NM_001291942.1
NP_065736.1, NM_020685.4
XP_016862420.1, XM_017006931.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000232519; ENSP00000232519; ENSG00000114405
ENST00000462069; ENSP00000419977; ENSG00000114405
ENST00000494481; ENSP00000418086; ENSG00000114405
ENST00000542214; ENSP00000438275; ENSG00000114405

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57415

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57415

UCSC genome browser

More...UCSCi		uc003dlf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236158 mRNA Translation: AAG09750.1
AK313915 mRNA Translation: BAG36637.1
CH471055 Genomic DNA Translation: EAW65400.1
BC017772 mRNA Translation: AAH17772.1
CCDSiCCDS2896.1
RefSeqiNP_001278870.1, NM_001291941.1
NP_001278871.1, NM_001291942.1
NP_065736.1, NM_020685.4
XP_016862420.1, XM_017006931.1

3D structure databases

SMRiQ9HBI5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121516, 2 interactors
IntActiQ9HBI5, 2 interactors
STRINGi9606.ENSP00000418086

PTM databases

iPTMnetiQ9HBI5
PhosphoSitePlusiQ9HBI5

Polymorphism and mutation databases

BioMutaiC3orf14
DMDMi68565304

Proteomic databases

EPDiQ9HBI5
MassIVEiQ9HBI5
MaxQBiQ9HBI5
PaxDbiQ9HBI5
PeptideAtlasiQ9HBI5
PRIDEiQ9HBI5
ProteomicsDBi81561

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54678, 59 antibodies

The DNASU plasmid repository

More...DNASUi		57415

Genome annotation databases

EnsembliENST00000232519; ENSP00000232519; ENSG00000114405
ENST00000462069; ENSP00000419977; ENSG00000114405
ENST00000494481; ENSP00000418086; ENSG00000114405
ENST00000542214; ENSP00000438275; ENSG00000114405
GeneIDi57415
KEGGihsa:57415
UCSCiuc003dlf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57415
EuPathDBiHostDB:ENSG00000114405.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		C3orf14
HGNCiHGNC:25024, C3orf14
HPAiENSG00000114405, Low tissue specificity
neXtProtiNX_Q9HBI5
OpenTargetsiENSG00000114405
PharmGKBiPA134883066

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S7A9, Eukaryota
GeneTreeiENSGT00390000005214
HOGENOMiCLU_133336_0_0_1
InParanoidiQ9HBI5
OMAiIGVENEN
OrthoDBi1643090at2759
PhylomeDBiQ9HBI5
TreeFamiTF335879

Enzyme and pathway databases

PathwayCommonsiQ9HBI5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57415, 5 hits in 834 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C3orf14, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57415
PharosiQ9HBI5, Tdark

Protein Ontology

More...PROi		PR:Q9HBI5
RNActiQ9HBI5, protein

Gene expression databases

BgeeiENSG00000114405, Expressed in cortical plate and 225 other tissues
ExpressionAtlasiQ9HBI5, baseline and differential
GenevisibleiQ9HBI5, HS

Family and domain databases

InterProiView protein in InterPro
IPR028006, DUF4570
PANTHERiPTHR14286, PTHR14286, 1 hit
PfamiView protein in Pfam
PF15134, DUF4570, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC014_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBI5
Secondary accession number(s): B2R9U0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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