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Entry version 164 (07 Oct 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Gamma-parvin

Gene

PARVG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HBI0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-parvin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARVG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138964.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14654, PARVG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608122, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HBI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64098

Open Targets

More...
OpenTargetsi
ENSG00000138964

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32952

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HBI0, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5793

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARVG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20143882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001215851 – 331Gamma-parvinAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HBI0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HBI0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HBI0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HBI0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HBI0

PeptideAtlas

More...
PeptideAtlasi
Q9HBI0

PRoteomics IDEntifications database

More...
PRIDEi
Q9HBI0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18673
3899
81556 [Q9HBI0-1]
81557 [Q9HBI0-2]
81558 [Q9HBI0-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9HBI0-2 [Q9HBI0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HBI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HBI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138964, Expressed in granulocyte and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HBI0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HBI0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138964, Tissue enhanced (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with integrin-linked protein kinase and actin.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122059, 41 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HBI0, 41 interactors

Molecular INTeraction database

More...
MINTi
Q9HBI0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000391583

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HBI0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HBI0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 151Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini210 – 317Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST108

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3631, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047624_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HBI0

KEGG Orthology (KO)

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KOi
K06275

Identification of Orthologs from Complete Genome Data

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OMAi
HKVNTVK

Database of Orthologous Groups

More...
OrthoDBi
871306at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HBI0

TreeFam database of animal gene trees

More...
TreeFami
TF314025

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR028433, Parvin

The PANTHER Classification System

More...
PANTHERi
PTHR12114, PTHR12114, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307, CH, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF039131, Parvin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HBI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEFLYDLL QLPKGVEPPA EEELSKGGKK KYLPPTSRKD PKFEELQKVL
60 70 80 90 100
MEWINATLLP EHIVVRSLEE DMFDGLILHH LFQRLAALKL EAEDIALTAT
110 120 130 140 150
SQKHKLTVVL EAVNRSLQLE EWQAKWSVES IFNKDLLSTL HLLVALAKRF
160 170 180 190 200
QPDLSLPTNV QVEVITIEST KSGLKSEKLV EQLTEYSTDK DEPPKDVFDE
210 220 230 240 250
LFKLAPEKVN AVKEAIVNFV NQKLDRLGLS VQNLDTQFAD GVILLLLIGQ
260 270 280 290 300
LEGFFLHLKE FYLTPNSPAE MLHNVTLALE LLKDEGLLSC PVSPEDIVNK
310 320 330
DAKSTLRVLY GLFCKHTQKA HRDRTPHGAP N
Length:331
Mass (Da):37,485
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i392BFCDD0B7D86A4
GO
Isoform 2 (identifier: Q9HBI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-273: LH → IS
     274-331: Missing.

Show »
Length:273
Mass (Da):31,042
Checksum:iD9BCB325BE989A1A
GO
Isoform 3 (identifier: Q9HBI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: S → R
     188-331: Missing.

Show »
Length:187
Mass (Da):21,439
Checksum:i8B738B944A464753
GO
Isoform 4 (identifier: Q9HBI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAKEQVPGRCDSTQRCFPGPSNWTGAGGRAGSQPFVGDGTLGTPNFCWDHKEKRAAESQLQAWEAM
     49-70: VLMEWINATLLPEHIVVRSLEE → HTWPSPVTGTGDTICGLARKTW
     71-331: Missing.

Show »
Length:137
Mass (Da):15,114
Checksum:iA8F3E321CE899506
GO
Isoform 5 (identifier: Q9HBI0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-70: VLMEWINATLLPEHIVVRSLEE → HTWPSPVTGTGDTICGLARKTW
     71-331: Missing.

Show »
Length:70
Mass (Da):7,926
Checksum:i7D7626A275E126C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYM9B0QYM9_HUMAN
Gamma-parvin
PARVG
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYN0B0QYN0_HUMAN
Gamma-parvin
PARVG
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ67U3KQ67_HUMAN
Gamma-parvin
PARVG
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 5 (identifier: Q9HBI0-5)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63C → R in AK307294 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451451M → MVPAKEQVPGRCDSTQRCFP GPSNWTGAGGRAGSQPFVGD GTLGTPNFCWDHKEKRAAES QLQAWEAM in isoform 4. 1 Publication1
Alternative sequenceiVSP_04514649 – 70VLMEW…RSLEE → HTWPSPVTGTGDTICGLARK TW in isoform 4 and isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_04514771 – 331Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_012953187S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_012954188 – 331Missing in isoform 3. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_004540272 – 273LH → IS in isoform 2. 1 Publication2
Alternative sequenceiVSP_004541274 – 331Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF237772 mRNA Translation: AAG27174.1
AL590887 mRNA Translation: CAC37414.1
AL355092 mRNA Translation: CAB90188.1
CR456480 mRNA Translation: CAG30366.1
AK293360 mRNA Translation: BAG56876.1
AK307294 mRNA No translation available.
AL031595 Genomic DNA No translation available.
BC034406 mRNA Translation: AAH34406.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14057.1 [Q9HBI0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001131077.1, NM_001137605.2 [Q9HBI0-1]
NP_071424.1, NM_022141.6 [Q9HBI0-1]
XP_005261759.1, XM_005261702.3 [Q9HBI0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356909; ENSP00000349378; ENSG00000138964 [Q9HBI0-3]
ENST00000415224; ENSP00000416761; ENSG00000138964 [Q9HBI0-3]
ENST00000422871; ENSP00000391453; ENSG00000138964 [Q9HBI0-1]
ENST00000444313; ENSP00000391583; ENSG00000138964 [Q9HBI0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64098

UCSC genome browser

More...
UCSCi
uc003bep.4, human [Q9HBI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237772 mRNA Translation: AAG27174.1
AL590887 mRNA Translation: CAC37414.1
AL355092 mRNA Translation: CAB90188.1
CR456480 mRNA Translation: CAG30366.1
AK293360 mRNA Translation: BAG56876.1
AK307294 mRNA No translation available.
AL031595 Genomic DNA No translation available.
BC034406 mRNA Translation: AAH34406.1
CCDSiCCDS14057.1 [Q9HBI0-1]
RefSeqiNP_001131077.1, NM_001137605.2 [Q9HBI0-1]
NP_071424.1, NM_022141.6 [Q9HBI0-1]
XP_005261759.1, XM_005261702.3 [Q9HBI0-1]

3D structure databases

SMRiQ9HBI0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122059, 41 interactors
IntActiQ9HBI0, 41 interactors
MINTiQ9HBI0
STRINGi9606.ENSP00000391583

Chemistry databases

ChEMBLiCHEMBL5793

PTM databases

iPTMnetiQ9HBI0
PhosphoSitePlusiQ9HBI0

Polymorphism and mutation databases

BioMutaiPARVG
DMDMi20143882

Proteomic databases

EPDiQ9HBI0
jPOSTiQ9HBI0
MassIVEiQ9HBI0
MaxQBiQ9HBI0
PaxDbiQ9HBI0
PeptideAtlasiQ9HBI0
PRIDEiQ9HBI0
ProteomicsDBi18673
3899
81556 [Q9HBI0-1]
81557 [Q9HBI0-2]
81558 [Q9HBI0-3]
TopDownProteomicsiQ9HBI0-2 [Q9HBI0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27676, 93 antibodies

The DNASU plasmid repository

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DNASUi
64098

Genome annotation databases

EnsembliENST00000356909; ENSP00000349378; ENSG00000138964 [Q9HBI0-3]
ENST00000415224; ENSP00000416761; ENSG00000138964 [Q9HBI0-3]
ENST00000422871; ENSP00000391453; ENSG00000138964 [Q9HBI0-1]
ENST00000444313; ENSP00000391583; ENSG00000138964 [Q9HBI0-1]
GeneIDi64098
KEGGihsa:64098
UCSCiuc003bep.4, human [Q9HBI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64098
DisGeNETi64098
EuPathDBiHostDB:ENSG00000138964.16

GeneCards: human genes, protein and diseases

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GeneCardsi
PARVG
HGNCiHGNC:14654, PARVG
HPAiENSG00000138964, Tissue enhanced (blood, bone marrow, lymphoid tissue)
MIMi608122, gene
neXtProtiNX_Q9HBI0
OpenTargetsiENSG00000138964
PharmGKBiPA32952

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3631, Eukaryota
GeneTreeiENSGT00950000183194
HOGENOMiCLU_047624_0_0_1
InParanoidiQ9HBI0
KOiK06275
OMAiHKVNTVK
OrthoDBi871306at2759
PhylomeDBiQ9HBI0
TreeFamiTF314025

Enzyme and pathway databases

PathwayCommonsiQ9HBI0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64098, 3 hits in 871 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PARVG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64098
PharosiQ9HBI0, Tbio

Protein Ontology

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PROi
PR:Q9HBI0
RNActiQ9HBI0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138964, Expressed in granulocyte and 165 other tissues
ExpressionAtlasiQ9HBI0, baseline and differential
GenevisibleiQ9HBI0, HS

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR028433, Parvin
PANTHERiPTHR12114, PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307, CH, 2 hits
PIRSFiPIRSF039131, Parvin, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARVG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBI0
Secondary accession number(s): B4DDW5
, E7EVM6, Q9BQX5, Q9NSG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: October 7, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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