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Protein

Gamma-parvin

Gene

PARVG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-parvin
Gene namesi
Name:PARVG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000138964.16
HGNCiHGNC:14654 PARVG
MIMi608122 gene
neXtProtiNX_Q9HBI0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64098
OpenTargetsiENSG00000138964
PharmGKBiPA32952

Chemistry databases

ChEMBLiCHEMBL5793

Polymorphism and mutation databases

DMDMi20143882

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215851 – 331Gamma-parvinAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HBI0
MaxQBiQ9HBI0
PaxDbiQ9HBI0
PeptideAtlasiQ9HBI0
PRIDEiQ9HBI0
ProteomicsDBi81556
81557 [Q9HBI0-2]
81558 [Q9HBI0-3]
TopDownProteomicsiQ9HBI0-2 [Q9HBI0-2]

PTM databases

iPTMnetiQ9HBI0
PhosphoSitePlusiQ9HBI0

Expressioni

Tissue specificityi

Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000138964 Expressed in 146 organ(s), highest expression level in blood
CleanExiHS_PARVG
ExpressionAtlasiQ9HBI0 baseline and differential
GenevisibleiQ9HBI0 HS

Organism-specific databases

HPAiHPA031833
HPA031834

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase and actin.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122059, 17 interactors
IntActiQ9HBI0, 32 interactors
MINTiQ9HBI0
STRINGi9606.ENSP00000391453

Structurei

3D structure databases

ProteinModelPortaliQ9HBI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 151Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini210 – 317Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9HBI0
KOiK06275
OMAiLEEDMFD
OrthoDBiEOG091G0B79
PhylomeDBiQ9HBI0
TreeFamiTF314025

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HBI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEFLYDLL QLPKGVEPPA EEELSKGGKK KYLPPTSRKD PKFEELQKVL
60 70 80 90 100
MEWINATLLP EHIVVRSLEE DMFDGLILHH LFQRLAALKL EAEDIALTAT
110 120 130 140 150
SQKHKLTVVL EAVNRSLQLE EWQAKWSVES IFNKDLLSTL HLLVALAKRF
160 170 180 190 200
QPDLSLPTNV QVEVITIEST KSGLKSEKLV EQLTEYSTDK DEPPKDVFDE
210 220 230 240 250
LFKLAPEKVN AVKEAIVNFV NQKLDRLGLS VQNLDTQFAD GVILLLLIGQ
260 270 280 290 300
LEGFFLHLKE FYLTPNSPAE MLHNVTLALE LLKDEGLLSC PVSPEDIVNK
310 320 330
DAKSTLRVLY GLFCKHTQKA HRDRTPHGAP N
Length:331
Mass (Da):37,485
Last modified:March 1, 2001 - v1
Checksum:i392BFCDD0B7D86A4
GO
Isoform 2 (identifier: Q9HBI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-273: LH → IS
     274-331: Missing.

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):31,042
Checksum:iD9BCB325BE989A1A
GO
Isoform 3 (identifier: Q9HBI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: S → R
     188-331: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,439
Checksum:i8B738B944A464753
GO
Isoform 4 (identifier: Q9HBI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAKEQVPGRCDSTQRCFPGPSNWTGAGGRAGSQPFVGDGTLGTPNFCWDHKEKRAAESQLQAWEAM
     49-70: VLMEWINATLLPEHIVVRSLEE → HTWPSPVTGTGDTICGLARKTW
     71-331: Missing.

Show »
Length:137
Mass (Da):15,114
Checksum:iA8F3E321CE899506
GO
Isoform 5 (identifier: Q9HBI0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-70: VLMEWINATLLPEHIVVRSLEE → HTWPSPVTGTGDTICGLARKTW
     71-331: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:70
Mass (Da):7,926
Checksum:i7D7626A275E126C0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYM9B0QYM9_HUMAN
Gamma-parvin
PARVG
26Annotation score:
B0QYN0B0QYN0_HUMAN
Gamma-parvin
PARVG
30Annotation score:
U3KQ67U3KQ67_HUMAN
Gamma-parvin
PARVG
34Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 5 (identifier: Q9HBI0-5)
Sequence conflicti63C → R in AK307294 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451451M → MVPAKEQVPGRCDSTQRCFP GPSNWTGAGGRAGSQPFVGD GTLGTPNFCWDHKEKRAAES QLQAWEAM in isoform 4. 1 Publication1
Alternative sequenceiVSP_04514649 – 70VLMEW…RSLEE → HTWPSPVTGTGDTICGLARK TW in isoform 4 and isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_04514771 – 331Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_012953187S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_012954188 – 331Missing in isoform 3. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_004540272 – 273LH → IS in isoform 2. 1 Publication2
Alternative sequenceiVSP_004541274 – 331Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237772 mRNA Translation: AAG27174.1
AL590887 mRNA Translation: CAC37414.1
AL355092 mRNA Translation: CAB90188.1
CR456480 mRNA Translation: CAG30366.1
AK293360 mRNA Translation: BAG56876.1
AK307294 mRNA No translation available.
AL031595 Genomic DNA No translation available.
BC034406 mRNA Translation: AAH34406.1
CCDSiCCDS14057.1 [Q9HBI0-1]
RefSeqiNP_001131077.1, NM_001137605.2 [Q9HBI0-1]
NP_071424.1, NM_022141.6 [Q9HBI0-1]
XP_005261759.1, XM_005261702.3 [Q9HBI0-1]
UniGeneiHs.658995
Hs.666944

Genome annotation databases

EnsembliENST00000356909; ENSP00000349378; ENSG00000138964 [Q9HBI0-3]
ENST00000415224; ENSP00000416761; ENSG00000138964 [Q9HBI0-3]
ENST00000422871; ENSP00000391453; ENSG00000138964 [Q9HBI0-1]
ENST00000444313; ENSP00000391583; ENSG00000138964 [Q9HBI0-1]
GeneIDi64098
KEGGihsa:64098
UCSCiuc003bep.4 human [Q9HBI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237772 mRNA Translation: AAG27174.1
AL590887 mRNA Translation: CAC37414.1
AL355092 mRNA Translation: CAB90188.1
CR456480 mRNA Translation: CAG30366.1
AK293360 mRNA Translation: BAG56876.1
AK307294 mRNA No translation available.
AL031595 Genomic DNA No translation available.
BC034406 mRNA Translation: AAH34406.1
CCDSiCCDS14057.1 [Q9HBI0-1]
RefSeqiNP_001131077.1, NM_001137605.2 [Q9HBI0-1]
NP_071424.1, NM_022141.6 [Q9HBI0-1]
XP_005261759.1, XM_005261702.3 [Q9HBI0-1]
UniGeneiHs.658995
Hs.666944

3D structure databases

ProteinModelPortaliQ9HBI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122059, 17 interactors
IntActiQ9HBI0, 32 interactors
MINTiQ9HBI0
STRINGi9606.ENSP00000391453

Chemistry databases

ChEMBLiCHEMBL5793

PTM databases

iPTMnetiQ9HBI0
PhosphoSitePlusiQ9HBI0

Polymorphism and mutation databases

DMDMi20143882

Proteomic databases

EPDiQ9HBI0
MaxQBiQ9HBI0
PaxDbiQ9HBI0
PeptideAtlasiQ9HBI0
PRIDEiQ9HBI0
ProteomicsDBi81556
81557 [Q9HBI0-2]
81558 [Q9HBI0-3]
TopDownProteomicsiQ9HBI0-2 [Q9HBI0-2]

Protocols and materials databases

DNASUi64098
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356909; ENSP00000349378; ENSG00000138964 [Q9HBI0-3]
ENST00000415224; ENSP00000416761; ENSG00000138964 [Q9HBI0-3]
ENST00000422871; ENSP00000391453; ENSG00000138964 [Q9HBI0-1]
ENST00000444313; ENSP00000391583; ENSG00000138964 [Q9HBI0-1]
GeneIDi64098
KEGGihsa:64098
UCSCiuc003bep.4 human [Q9HBI0-1]

Organism-specific databases

CTDi64098
DisGeNETi64098
EuPathDBiHostDB:ENSG00000138964.16
GeneCardsiPARVG
H-InvDBiHIX0016566
HGNCiHGNC:14654 PARVG
HPAiHPA031833
HPA031834
MIMi608122 gene
neXtProtiNX_Q9HBI0
OpenTargetsiENSG00000138964
PharmGKBiPA32952
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9HBI0
KOiK06275
OMAiLEEDMFD
OrthoDBiEOG091G0B79
PhylomeDBiQ9HBI0
TreeFamiTF314025

Miscellaneous databases

GeneWikiiPARVG
GenomeRNAii64098
PROiPR:Q9HBI0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138964 Expressed in 146 organ(s), highest expression level in blood
CleanExiHS_PARVG
ExpressionAtlasiQ9HBI0 baseline and differential
GenevisibleiQ9HBI0 HS

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPARVG_HUMAN
AccessioniPrimary (citable) accession number: Q9HBI0
Secondary accession number(s): B4DDW5
, E7EVM6, Q9BQX5, Q9NSG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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