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Protein

Protein BEX1

Gene

BEX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).By similarity

Caution

Was named BEX2 by some authors.Curated

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX1
Alternative name(s):
Brain-expressed X-linked protein 1
Gene namesi
Name:BEX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000133169.5
HGNCiHGNC:1036 BEX1
MIMi300690 gene
neXtProtiNX_Q9HBH7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55859
OpenTargetsiENSG00000133169
PharmGKBiPA25340

Polymorphism and mutation databases

BioMutaiBEX1
DMDMi91208332

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297721 – 125Protein BEX1Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).By similarity
Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9HBH7
PeptideAtlasiQ9HBH7
PRIDEiQ9HBH7
ProteomicsDBi81553

PTM databases

iPTMnetiQ9HBH7
PhosphoSitePlusiQ9HBH7

Expressioni

Tissue specificityi

Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.3 Publications

Gene expression databases

BgeeiENSG00000133169
CleanExiHS_BEX1
GenevisibleiQ9HBH7 HS

Organism-specific databases

HPAiHPA045384

Interactioni

Subunit structurei

Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120961, 16 interactors
IntActiQ9HBH7, 23 interactors
MINTiQ9HBH7
STRINGi9606.ENSP00000361813

Structurei

3D structure databases

ProteinModelPortaliQ9HBH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY Eukaryota
ENOG4111DNW LUCA
GeneTreeiENSGT00810000125540
HOGENOMiHOG000236300
HOVERGENiHBG080240
InParanoidiQ9HBH7
OMAiEAGEYCV
OrthoDBiEOG091G0ZN3
PhylomeDBiQ9HBH7
TreeFamiTF337909

Family and domain databases

InterProiView protein in InterPro
IPR007623 BEX
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit
PIRSFiPIRSF008633 BEX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKEKRAVN SLSMENANQE NEEKEQVANK GEPLALPLDA GEYCVPRGNR
60 70 80 90 100
RRFRVRQPIL QYRWDMMHRL GEPQARMREE NMERIGEEVR QLMEKLREKQ
110 120
LSHSLRAVST DPPHHDHHDE FCLMP
Length:125
Mass (Da):14,860
Last modified:April 4, 2006 - v2
Checksum:i2406DD71F7E663D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → L in AAG09752 (PubMed:11989783).Curated1
Sequence conflicti88E → G in AAG09752 (PubMed:11989783).Curated1
Sequence conflicti100Q → R in BAF83647 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0426679V → L. Corresponds to variant dbSNP:rs3174500Ensembl.1
Natural variantiVAR_04266811S → N. Corresponds to variant dbSNP:rs1045058Ensembl.1
Natural variantiVAR_04266913S → I. Corresponds to variant dbSNP:rs1045061Ensembl.1
Natural variantiVAR_04267014M → V. Corresponds to variant dbSNP:rs1045063Ensembl.1
Natural variantiVAR_04267117A → V. Corresponds to variant dbSNP:rs1045065Ensembl.1
Natural variantiVAR_02575640A → V. Corresponds to variant dbSNP:rs709036Ensembl.1
Natural variantiVAR_02575766M → I. Corresponds to variant dbSNP:rs1045082Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237783 mRNA Translation: AAG09752.1
AY833561 mRNA Translation: AAX40679.1
AF183416 mRNA Translation: AAG09685.1
AF220189 mRNA Translation: AAF67654.1
AK290958 mRNA Translation: BAF83647.1
AL008708 Genomic DNA No translation available.
BC126427 mRNA Translation: AAI26428.1
BC126429 mRNA Translation: AAI26430.1
CCDSiCCDS35354.1
RefSeqiNP_060946.3, NM_018476.3
UniGeneiHs.334370

Genome annotation databases

EnsembliENST00000372728; ENSP00000361813; ENSG00000133169
GeneIDi55859
KEGGihsa:55859
UCSCiuc004ejt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBEX1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBH7
Secondary accession number(s): A0AVN1, A8K4J3, Q9NZ33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 18, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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