Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 166 (12 Aug 2020)
Sequence version 2 (05 Oct 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

V-type proton ATPase 116 kDa subunit a isoform 4

Gene

ATP6V0A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000105929-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HBG4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-77387, Insulin receptor recycling
R-HSA-917977, Transferrin endocytosis and recycling
R-HSA-983712, Ion channel transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase 116 kDa subunit a isoform 4
Short name:
V-ATPase 116 kDa isoform a4
Alternative name(s):
Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4
Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP6V0A4
Synonyms:ATP6N1B, ATP6N2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105929.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:866, ATP6V0A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605239, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HBG4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 390CytoplasmicSequence analysisAdd BLAST390
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei391 – 409HelicalSequence analysisAdd BLAST19
Topological domaini410 – 411VacuolarSequence analysis2
Transmembranei412 – 428HelicalSequence analysisAdd BLAST17
Topological domaini429 – 443CytoplasmicSequence analysisAdd BLAST15
Transmembranei444 – 473HelicalSequence analysisAdd BLAST30
Topological domaini474 – 538VacuolarSequence analysisAdd BLAST65
Transmembranei539 – 558HelicalSequence analysisAdd BLAST20
Topological domaini559 – 576CytoplasmicSequence analysisAdd BLAST18
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 642VacuolarSequence analysisAdd BLAST45
Transmembranei643 – 662HelicalSequence analysisAdd BLAST20
Topological domaini663 – 727CytoplasmicSequence analysisAdd BLAST65
Transmembranei728 – 752HelicalSequence analysisAdd BLAST25
Topological domaini753 – 773VacuolarSequence analysisAdd BLAST21
Transmembranei774 – 812HelicalSequence analysisAdd BLAST39
Topological domaini813 – 840CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal tubular acidosis, distal, autosomal recessive (RTADR)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020993175G → D in RTADR. 1 Publication1
Natural variantiVAR_020994237Missing in RTADR. 1 Publication1
Natural variantiVAR_020995449R → H in RTADR. 1 PublicationCorresponds to variant dbSNP:rs1443883930EnsemblClinVar.1
Natural variantiVAR_017255524P → L in RTADR. 1 PublicationCorresponds to variant dbSNP:rs121908368EnsemblClinVar.1
Natural variantiVAR_017256580M → T in RTADR. 1 PublicationCorresponds to variant dbSNP:rs3807153EnsemblClinVar.1
Natural variantiVAR_020996807R → Q in RTADR. 1 PublicationCorresponds to variant dbSNP:rs28939081EnsemblClinVar.1
Natural variantiVAR_017257820G → R in RTADR. 1 PublicationCorresponds to variant dbSNP:rs267606671EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
50617

MalaCards human disease database

More...
MalaCardsi
ATP6V0A4
MIMi602722, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105929

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
402041, Autosomal recessive distal renal tubular acidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25147

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HBG4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP6V0A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153516

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001192191 – 840V-type proton ATPase 116 kDa subunit a isoform 4Add BLAST840

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HBG4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HBG4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HBG4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HBG4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HBG4

PeptideAtlas

More...
PeptideAtlasi
Q9HBG4

PRoteomics IDEntifications database

More...
PRIDEi
Q9HBG4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81539

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HBG4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HBG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult and fetal kidney. Found in the inner ear.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105929, Expressed in adult mammalian kidney and 108 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HBG4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HBG4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105929, Group enriched (kidney, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119097, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308122

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HBG4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HBG4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2189, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005230_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HBG4

KEGG Orthology (KO)

More...
KOi
K02154

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHSWVIK

Database of Orthologous Groups

More...
OrthoDBi
181796at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HBG4

TreeFam database of animal gene trees

More...
TreeFami
TF300346

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002490, V-ATPase_116kDa_su
IPR026028, V-type_ATPase_116kDa_su_euka

The PANTHER Classification System

More...
PANTHERi
PTHR11629, PTHR11629, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01496, V_ATPase_I, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001293, ATP6V0A1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9HBG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK
60 70 80 90 100
FVNEVRRCES LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL
110 120 130 140 150
EKLEGELQEA NQNQQALKQS FLELTELKYL LKKTQDFFET ETNLADDFFT
160 170 180 190 200
EDTSGLLELK AVPAYMTGKL GFIAGVINRE RMASFERLLW RICRGNVYLK
210 220 230 240 250
FSEMDAPLED PVTKEEIQKN IFIIFYQGEQ LRQKIKKICD GFRATVYPCP
260 270 280 290 300
EPAVERREML ESVNVRLEDL ITVITQTESH RQRLLQEAAA NWHSWLIKVQ
310 320 330 340 350
KMKAVYHILN MCNIDVTQQC VIAEIWFPVA DATRIKRALE QGMELSGSSM
360 370 380 390 400
APIMTTVQSK TAPPTFNRTN KFTAGFQNIV DAYGVGSYRE INPAPYTIIT
410 420 430 440 450
FPFLFAVMFG DCGHGTVMLL AALWMILNER RLLSQKTDNE IWNTFFHGRY
460 470 480 490 500
LILLMGIFSI YTGLIYNDCF SKSLNIFGSS WSVQPMFRNG TWNTHVMEES
510 520 530 540 550
LYLQLDPAIP GVYFGNPYPF GIDPIWNLAS NKLTFLNSYK MKMSVILGIV
560 570 580 590 600
QMVFGVILSL FNHIYFRRTL NIILQFIPEM IFILCLFGYL VFMIIFKWCC
610 620 630 640 650
FDVHVSQHAP SILIHFINMF LFNYSDSSNA PLYKHQQEVQ SFFVVMALIS
660 670 680 690 700
VPWMLLIKPF ILRASHRKSQ LQASRIQEDA TENIEGDSSS PSSRSGQRTS
710 720 730 740 750
ADTHGALDDH GEEFNFGDVF VHQAIHTIEY CLGCISNTAS YLRLWALSLA
760 770 780 790 800
HAQLSEVLWT MVMNSGLQTR GWGGIVGVFI IFAVFAVLTV AILLIMEGLS
810 820 830 840
AFLHALRLHW VEFQNKFYVG DGYKFSPFSF KHILDGTAEE
Length:840
Mass (Da):96,386
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i449964EBC01D4649
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6X9A0A2R8Y6X9_HUMAN
V-type proton ATPase subunit a
ATP6V0A4
582Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YE46A0A2R8YE46_HUMAN
V-type proton ATPase subunit a
ATP6V0A4
456Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7G6A0A2R8Y7G6_HUMAN
V-type proton ATPase subunit a
ATP6V0A4
353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGN5A0A2R8YGN5_HUMAN
V-type proton ATPase subunit a
ATP6V0A4
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252P → R in AAI09305 (PubMed:15489334).Curated1
Sequence conflicti252P → R in AAI09306 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0209922V → A2 PublicationsCorresponds to variant dbSNP:rs10258719EnsemblClinVar.1
Natural variantiVAR_020993175G → D in RTADR. 1 Publication1
Natural variantiVAR_020994237Missing in RTADR. 1 Publication1
Natural variantiVAR_020995449R → H in RTADR. 1 PublicationCorresponds to variant dbSNP:rs1443883930EnsemblClinVar.1
Natural variantiVAR_017255524P → L in RTADR. 1 PublicationCorresponds to variant dbSNP:rs121908368EnsemblClinVar.1
Natural variantiVAR_066612554F → L. Corresponds to variant dbSNP:rs1026435Ensembl.1
Natural variantiVAR_017256580M → T in RTADR. 1 PublicationCorresponds to variant dbSNP:rs3807153EnsemblClinVar.1
Natural variantiVAR_066613604H → Q. Corresponds to variant dbSNP:rs3807154Ensembl.1
Natural variantiVAR_020996807R → Q in RTADR. 1 PublicationCorresponds to variant dbSNP:rs28939081EnsemblClinVar.1
Natural variantiVAR_017257820G → R in RTADR. 1 PublicationCorresponds to variant dbSNP:rs267606671EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF245517 mRNA Translation: AAG11415.1
AK292945 mRNA Translation: BAF85634.1
AC018663 Genomic DNA No translation available.
AC020983 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24043.1
CH471070 Genomic DNA Translation: EAW83892.1
BC109304 mRNA Translation: AAI09305.1
BC109305 mRNA Translation: AAI09306.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5849.1

NCBI Reference Sequences

More...
RefSeqi
NP_065683.2, NM_020632.2
NP_570855.2, NM_130840.2
NP_570856.2, NM_130841.2
XP_005250450.1, XM_005250393.1
XP_005250451.1, XM_005250394.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310018; ENSP00000308122; ENSG00000105929
ENST00000353492; ENSP00000253856; ENSG00000105929
ENST00000393054; ENSP00000376774; ENSG00000105929
ENST00000645515; ENSP00000496421; ENSG00000105929

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50617

UCSC genome browser

More...
UCSCi
uc003vuf.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245517 mRNA Translation: AAG11415.1
AK292945 mRNA Translation: BAF85634.1
AC018663 Genomic DNA No translation available.
AC020983 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24043.1
CH471070 Genomic DNA Translation: EAW83892.1
BC109304 mRNA Translation: AAI09305.1
BC109305 mRNA Translation: AAI09306.1
CCDSiCCDS5849.1
RefSeqiNP_065683.2, NM_020632.2
NP_570855.2, NM_130840.2
NP_570856.2, NM_130841.2
XP_005250450.1, XM_005250393.1
XP_005250451.1, XM_005250394.3

3D structure databases

SMRiQ9HBG4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119097, 5 interactors
STRINGi9606.ENSP00000308122

Protein family/group databases

TCDBi3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiQ9HBG4
PhosphoSitePlusiQ9HBG4

Polymorphism and mutation databases

BioMutaiATP6V0A4
DMDMi308153516

Proteomic databases

EPDiQ9HBG4
jPOSTiQ9HBG4
MassIVEiQ9HBG4
MaxQBiQ9HBG4
PaxDbiQ9HBG4
PeptideAtlasiQ9HBG4
PRIDEiQ9HBG4
ProteomicsDBi81539

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3120, 119 antibodies

Genome annotation databases

EnsembliENST00000310018; ENSP00000308122; ENSG00000105929
ENST00000353492; ENSP00000253856; ENSG00000105929
ENST00000393054; ENSP00000376774; ENSG00000105929
ENST00000645515; ENSP00000496421; ENSG00000105929
GeneIDi50617
KEGGihsa:50617
UCSCiuc003vuf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50617
DisGeNETi50617
EuPathDBiHostDB:ENSG00000105929.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP6V0A4
HGNCiHGNC:866, ATP6V0A4
HPAiENSG00000105929, Group enriched (kidney, salivary gland)
MalaCardsiATP6V0A4
MIMi602722, phenotype
605239, gene
neXtProtiNX_Q9HBG4
OpenTargetsiENSG00000105929
Orphaneti402041, Autosomal recessive distal renal tubular acidosis
PharmGKBiPA25147

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2189, Eukaryota
GeneTreeiENSGT00950000182881
HOGENOMiCLU_005230_0_2_1
InParanoidiQ9HBG4
KOiK02154
OMAiWHSWVIK
OrthoDBi181796at2759
PhylomeDBiQ9HBG4
TreeFamiTF300346

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000105929-MONOMER
PathwayCommonsiQ9HBG4
ReactomeiR-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-77387, Insulin receptor recycling
R-HSA-917977, Transferrin endocytosis and recycling
R-HSA-983712, Ion channel transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
50617, 6 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP6V0A4, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATP6V0A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50617
PharosiQ9HBG4, Tbio

Protein Ontology

More...
PROi
PR:Q9HBG4
RNActiQ9HBG4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105929, Expressed in adult mammalian kidney and 108 other tissues
ExpressionAtlasiQ9HBG4, baseline and differential
GenevisibleiQ9HBG4, HS

Family and domain databases

InterProiView protein in InterPro
IPR002490, V-ATPase_116kDa_su
IPR026028, V-type_ATPase_116kDa_su_euka
PANTHERiPTHR11629, PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496, V_ATPase_I, 1 hit
PIRSFiPIRSF001293, ATP6V0A1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBG4
Secondary accession number(s): A4D1R4, A8KA80, Q32M47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 5, 2010
Last modified: August 12, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again