UniProtKB - Q9HBF4 (ZFYV1_HUMAN)
Zinc finger FYVE domain-containing protein 1
ZFYVE1
Functioni
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241).
Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241).
Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241).
Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).
4 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 604 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 607 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 620 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 623 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 628 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 631 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 651 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 654 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 721 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 724 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 737 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 740 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 745 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 748 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 767 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 770 | Zinc 4PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 598 – 659 | FYVE-type 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Zinc fingeri | 715 – 775 | FYVE-type 2PROSITE-ProRule annotationAdd BLAST | 61 |
GO - Molecular functioni
- 1-phosphatidylinositol binding Source: UniProtKB
- phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
- phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
- phosphatidylinositol-3-phosphate binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular response to starvation Source: ParkinsonsUK-UCL
- lipid droplet formation Source: UniProtKB
- macroautophagy Source: ParkinsonsUK-UCL
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9HBF4 |
SignaLinki | Q9HBF4 |
SIGNORi | Q9HBF4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger FYVE domain-containing protein 1Alternative name(s): Double FYVE-containing protein 1 SR3 Tandem FYVE fingers-1 |
Gene namesi | Name:ZFYVE1 Synonyms:DFCP1, KIAA1589, TAFF1, ZNFN2A1 ORF Names:PP10436 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13180, ZFYVE1 |
MIMi | 605471, gene |
neXtProti | NX_Q9HBF4 |
VEuPathDBi | HostDB:ENSG00000165861 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Golgi apparatus
- Golgi stack 1 Publication
- Golgi apparatus 3 Publications
Endoplasmic reticulum
- Endoplasmic reticulum 4 Publications
Other locations
- Lipid droplet 2 Publications
- Preautophagosomal structure 3 Publications
Note: Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386). During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663). Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241).4 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi stack Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- autophagosome Source: MGI
- extrinsic component of omegasome membrane Source: UniProtKB
- lipid droplet Source: UniProtKB
- mitochondria-associated endoplasmic reticulum membrane Source: MGI
- omegasome Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- phagophore assembly site Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Lipid droplet, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 543 | W → A: Disrupts its localization to lipid droplets. 1 Publication | 1 | |
Mutagenesisi | 616 | T → R: Partially restore PtdIns3P binding; when associated with R-733. 1 Publication | 1 | |
Mutagenesisi | 617 | K → A: Drastically reduce PtdIns3P binding; when associated with A-619 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication | 1 | |
Mutagenesisi | 619 | H → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication | 1 | |
Mutagenesisi | 621 | R → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-619. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication | 1 | |
Mutagenesisi | 654 | C → S: Abolishes PtdIns3P binding but has no effect on its localization to lipid droplets or its interaction with RAB18; when associated with S-770. 3 Publications | 1 | |
Mutagenesisi | 733 | S → R: Partially restored PtdIns3P binding; when associated with R-616. 1 Publication | 1 | |
Mutagenesisi | 734 | K → A: Drastically reduce PtdIns3P binding; when associated with A-736 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication | 1 | |
Mutagenesisi | 736 | H → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication | 1 | |
Mutagenesisi | 738 | R → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-736. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication | 1 | |
Mutagenesisi | 770 | C → S: Abolishes PtdIns3P binding but has no effect on its localization to lipid droplets or its interaction with RAB18; when associated with S-654. 4 Publications | 1 |
Organism-specific databases
DisGeNETi | 53349 |
OpenTargetsi | ENSG00000165861 |
PharmGKBi | PA37752 |
Miscellaneous databases
Pharosi | Q9HBF4, Tbio |
Genetic variation databases
BioMutai | ZFYVE1 |
DMDMi | 34098716 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000098713 | 1 – 777 | Zinc finger FYVE domain-containing protein 1Add BLAST | 777 |
Proteomic databases
EPDi | Q9HBF4 |
jPOSTi | Q9HBF4 |
MassIVEi | Q9HBF4 |
MaxQBi | Q9HBF4 |
PaxDbi | Q9HBF4 |
PeptideAtlasi | Q9HBF4 |
PRIDEi | Q9HBF4 |
ProteomicsDBi | 81536 [Q9HBF4-1] 81537 [Q9HBF4-2] |
PTM databases
iPTMneti | Q9HBF4 |
PhosphoSitePlusi | Q9HBF4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000165861, Expressed in pancreas and 222 other tissues |
ExpressionAtlasi | Q9HBF4, baseline and differential |
Genevisiblei | Q9HBF4, HS |
Organism-specific databases
HPAi | ENSG00000165861, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 119749, 16 interactors |
IntActi | Q9HBF4, 15 interactors |
MINTi | Q9HBF4 |
STRINGi | 9606.ENSP00000450742 |
Miscellaneous databases
RNActi | Q9HBF4, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 416 – 777 | Required for localization in the lipid droplets2 PublicationsAdd BLAST | 362 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 598 – 659 | FYVE-type 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Zinc fingeri | 715 – 775 | FYVE-type 2PROSITE-ProRule annotationAdd BLAST | 61 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1818, Eukaryota |
GeneTreei | ENSGT00390000016097 |
HOGENOMi | CLU_020922_0_0_1 |
InParanoidi | Q9HBF4 |
OrthoDBi | 198211at2759 |
PhylomeDBi | Q9HBF4 |
TreeFami | TF323237 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR042427, ZFYV1 IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR46624, PTHR46624, 1 hit |
Pfami | View protein in Pfam PF01363, FYVE, 2 hits |
SMARTi | View protein in SMART SM00064, FYVE, 2 hits |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF57903, SSF57903, 2 hits |
PROSITEi | View protein in PROSITE PS50178, ZF_FYVE, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH
60 70 80 90 100
RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINLC
110 120 130 140 150
LECQKRTHSG GNKRRHPVTV YNVSNLQESL EAEEMDEETK RKKMTEKVVS
160 170 180 190 200
FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT
210 220 230 240 250
FFYGREVFKT SPTQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT
260 270 280 290 300
RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA
310 320 330 340 350
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEVPEKLI QDRFRKLGRF
360 370 380 390 400
PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL
410 420 430 440 450
KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGVGC KKSMNHGKEG
460 470 480 490 500
VPHEAKSRCR YSHQYDNRVY TCKACYERGE EVSVVPKTSA STDSPWMGLA
510 520 530 540 550
KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDGFL
560 570 580 590 600
KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ
610 620 630 640 650
ILSCNKCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV
660 670 680 690 700
CDNCYEARNV QLAVTEAQVD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL
710 720 730 740 750
GLVKDAARPA YWVPDHEILH CHNCRKEFSI KLSKHHCRAC GQGFCDECSH
760 770
DRRAVPSRGW DHPVRVCFNC NKKPGDL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V5N8 | G3V5N8_HUMAN | Zinc finger FYVE domain-containing ... | ZFYVE1 | 789 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 | V → M in BC014902 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008007 | 1 – 415 | Missing in isoform 2. 1 PublicationAdd BLAST | 415 | |
Alternative sequenceiVSP_056770 | 507 – 520 | Missing in isoform 3. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF251025 mRNA Translation: AAG23748.1 AJ310569 mRNA Translation: CAC83950.1 AF311602 mRNA Translation: AAK27339.1 AB046809 mRNA Translation: BAB13415.1 Different initiation. AK027399 mRNA Translation: BAB55085.1 Different termination. AL442663 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81084.1 BC053520 mRNA Translation: AAH53520.1 BC014902 mRNA No translation available. AF318319 mRNA Translation: AAL55826.1 Frameshift. |
CCDSi | CCDS41969.1 [Q9HBF4-2] CCDS61498.1 [Q9HBF4-3] CCDS9811.1 [Q9HBF4-1] |
RefSeqi | NP_001268663.1, NM_001281734.1 [Q9HBF4-3] NP_001268664.1, NM_001281735.1 [Q9HBF4-2] NP_067083.1, NM_021260.3 [Q9HBF4-1] NP_848535.1, NM_178441.2 [Q9HBF4-2] XP_016876862.1, XM_017021373.1 [Q9HBF4-2] |
Genome annotation databases
Ensembli | ENST00000318876; ENSP00000326921; ENSG00000165861 [Q9HBF4-3] ENST00000394207; ENSP00000377757; ENSG00000165861 [Q9HBF4-2] ENST00000555072; ENSP00000452232; ENSG00000165861 [Q9HBF4-2] ENST00000556143; ENSP00000450742; ENSG00000165861 |
GeneIDi | 53349 |
KEGGi | hsa:53349 |
MANE-Selecti | ENST00000556143.6; ENSP00000450742.1; NM_021260.4; NP_067083.1 |
UCSCi | uc001xnl.5, human [Q9HBF4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF251025 mRNA Translation: AAG23748.1 AJ310569 mRNA Translation: CAC83950.1 AF311602 mRNA Translation: AAK27339.1 AB046809 mRNA Translation: BAB13415.1 Different initiation. AK027399 mRNA Translation: BAB55085.1 Different termination. AL442663 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81084.1 BC053520 mRNA Translation: AAH53520.1 BC014902 mRNA No translation available. AF318319 mRNA Translation: AAL55826.1 Frameshift. |
CCDSi | CCDS41969.1 [Q9HBF4-2] CCDS61498.1 [Q9HBF4-3] CCDS9811.1 [Q9HBF4-1] |
RefSeqi | NP_001268663.1, NM_001281734.1 [Q9HBF4-3] NP_001268664.1, NM_001281735.1 [Q9HBF4-2] NP_067083.1, NM_021260.3 [Q9HBF4-1] NP_848535.1, NM_178441.2 [Q9HBF4-2] XP_016876862.1, XM_017021373.1 [Q9HBF4-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119749, 16 interactors |
IntActi | Q9HBF4, 15 interactors |
MINTi | Q9HBF4 |
STRINGi | 9606.ENSP00000450742 |
PTM databases
iPTMneti | Q9HBF4 |
PhosphoSitePlusi | Q9HBF4 |
Genetic variation databases
BioMutai | ZFYVE1 |
DMDMi | 34098716 |
Proteomic databases
EPDi | Q9HBF4 |
jPOSTi | Q9HBF4 |
MassIVEi | Q9HBF4 |
MaxQBi | Q9HBF4 |
PaxDbi | Q9HBF4 |
PeptideAtlasi | Q9HBF4 |
PRIDEi | Q9HBF4 |
ProteomicsDBi | 81536 [Q9HBF4-1] 81537 [Q9HBF4-2] |
Protocols and materials databases
Antibodypediai | 143, 179 antibodies from 22 providers |
DNASUi | 53349 |
Genome annotation databases
Ensembli | ENST00000318876; ENSP00000326921; ENSG00000165861 [Q9HBF4-3] ENST00000394207; ENSP00000377757; ENSG00000165861 [Q9HBF4-2] ENST00000555072; ENSP00000452232; ENSG00000165861 [Q9HBF4-2] ENST00000556143; ENSP00000450742; ENSG00000165861 |
GeneIDi | 53349 |
KEGGi | hsa:53349 |
MANE-Selecti | ENST00000556143.6; ENSP00000450742.1; NM_021260.4; NP_067083.1 |
UCSCi | uc001xnl.5, human [Q9HBF4-1] |
Organism-specific databases
CTDi | 53349 |
DisGeNETi | 53349 |
GeneCardsi | ZFYVE1 |
HGNCi | HGNC:13180, ZFYVE1 |
HPAi | ENSG00000165861, Low tissue specificity |
MIMi | 605471, gene |
neXtProti | NX_Q9HBF4 |
OpenTargetsi | ENSG00000165861 |
PharmGKBi | PA37752 |
VEuPathDBi | HostDB:ENSG00000165861 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1818, Eukaryota |
GeneTreei | ENSGT00390000016097 |
HOGENOMi | CLU_020922_0_0_1 |
InParanoidi | Q9HBF4 |
OrthoDBi | 198211at2759 |
PhylomeDBi | Q9HBF4 |
TreeFami | TF323237 |
Enzyme and pathway databases
PathwayCommonsi | Q9HBF4 |
SignaLinki | Q9HBF4 |
SIGNORi | Q9HBF4 |
Miscellaneous databases
BioGRID-ORCSi | 53349, 6 hits in 1053 CRISPR screens |
ChiTaRSi | ZFYVE1, human |
GeneWikii | ZFYVE1 |
GenomeRNAii | 53349 |
Pharosi | Q9HBF4, Tbio |
PROi | PR:Q9HBF4 |
RNActi | Q9HBF4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165861, Expressed in pancreas and 222 other tissues |
ExpressionAtlasi | Q9HBF4, baseline and differential |
Genevisiblei | Q9HBF4, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR042427, ZFYV1 IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR46624, PTHR46624, 1 hit |
Pfami | View protein in Pfam PF01363, FYVE, 2 hits |
SMARTi | View protein in SMART SM00064, FYVE, 2 hits |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF57903, SSF57903, 2 hits |
PROSITEi | View protein in PROSITE PS50178, ZF_FYVE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFYV1_HUMAN | |
Accessioni | Q9HBF4Primary (citable) accession number: Q9HBF4 Secondary accession number(s): J3KNL9 Q9HCI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot