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UniProtKB - Q9HBF4 (ZFYV1_HUMAN)

Entry version 169 (23 Feb 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Zinc finger FYVE domain-containing protein 1

Gene

ZFYVE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241).

Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241).

Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241).

Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955).

4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi604Zinc 1PROSITE-ProRule annotation1
Metal bindingi607Zinc 1PROSITE-ProRule annotation1
Metal bindingi620Zinc 2PROSITE-ProRule annotation1
Metal bindingi623Zinc 2PROSITE-ProRule annotation1
Metal bindingi628Zinc 1PROSITE-ProRule annotation1
Metal bindingi631Zinc 1PROSITE-ProRule annotation1
Metal bindingi651Zinc 2PROSITE-ProRule annotation1
Metal bindingi654Zinc 2PROSITE-ProRule annotation1
Metal bindingi721Zinc 3PROSITE-ProRule annotation1
Metal bindingi724Zinc 3PROSITE-ProRule annotation1
Metal bindingi737Zinc 4PROSITE-ProRule annotation1
Metal bindingi740Zinc 4PROSITE-ProRule annotation1
Metal bindingi745Zinc 3PROSITE-ProRule annotation1
Metal bindingi748Zinc 3PROSITE-ProRule annotation1
Metal bindingi767Zinc 4PROSITE-ProRule annotation1
Metal bindingi770Zinc 4PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri598 – 659FYVE-type 1PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri715 – 775FYVE-type 2PROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HBF4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HBF4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9HBF4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 1
Alternative name(s):
Double FYVE-containing protein 1
SR3
Tandem FYVE fingers-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFYVE1
Synonyms:DFCP1, KIAA1589, TAFF1, ZNFN2A1
ORF Names:PP10436
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13180, ZFYVE1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605471, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HBF4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165861

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi543W → A: Disrupts its localization to lipid droplets. 1 Publication1
Mutagenesisi616T → R: Partially restore PtdIns3P binding; when associated with R-733. 1 Publication1
Mutagenesisi617K → A: Drastically reduce PtdIns3P binding; when associated with A-619 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication1
Mutagenesisi619H → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-621. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication1
Mutagenesisi621R → A: Drastically reduce PtdIns3P binding; when associated with A-617 and A-619. Abolishes PtdIns3P binding; when associated with A-734; A-736 and A-738. 1 Publication1
Mutagenesisi654C → S: Abolishes PtdIns3P binding but has no effect on its localization to lipid droplets or its interaction with RAB18; when associated with S-770. 3 Publications1
Mutagenesisi733S → R: Partially restored PtdIns3P binding; when associated with R-616. 1 Publication1
Mutagenesisi734K → A: Drastically reduce PtdIns3P binding; when associated with A-736 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication1
Mutagenesisi736H → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-738. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication1
Mutagenesisi738R → A: Drastically reduce PtdIns3P binding; when associated with A-734 and A-736. Abolishes PtdIns3P binding; when associated with A-617; A-619 and A-621. 1 Publication1
Mutagenesisi770C → S: Abolishes PtdIns3P binding but has no effect on its localization to lipid droplets or its interaction with RAB18; when associated with S-654. 4 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		53349

Open Targets

More...OpenTargetsi		ENSG00000165861

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37752

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HBF4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZFYVE1

Domain mapping of disease mutations (DMDM)

More...DMDMi		34098716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000987131 – 777Zinc finger FYVE domain-containing protein 1Add BLAST777

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HBF4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HBF4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HBF4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HBF4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HBF4

PeptideAtlas

More...PeptideAtlasi		Q9HBF4

PRoteomics IDEntifications database

More...PRIDEi		Q9HBF4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81536 [Q9HBF4-1]
81537 [Q9HBF4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HBF4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HBF4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart. Also detected in the testis.2 Publications
Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165861, Expressed in pancreas and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HBF4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HBF4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165861, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB18 (in GTP-bound form) (PubMed:31293035, PubMed:30970241).

Interacts with BSCL2 in a RAB18-dependent manner (PubMed:30970241).

Interacts with ZW10 (PubMed:30970241).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119749, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q9HBF4, 15 interactors

Molecular INTeraction database

More...MINTi		Q9HBF4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000450742

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HBF4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni416 – 777Required for localization in the lipid droplets2 PublicationsAdd BLAST362

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri598 – 659FYVE-type 1PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri715 – 775FYVE-type 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1818, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020922_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HBF4

Database of Orthologous Groups

More...OrthoDBi		198211at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HBF4

TreeFam database of animal gene trees

More...TreeFami		TF323237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR042427, ZFYV1
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR46624, PTHR46624, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01363, FYVE, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00064, FYVE, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50178, ZF_FYVE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HBF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH 
        60         70         80         90        100
RQERLRNHER IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINLC 
       110        120        130        140        150
LECQKRTHSG GNKRRHPVTV YNVSNLQESL EAEEMDEETK RKKMTEKVVS 
       160        170        180        190        200
FLLVDENEEI QVTNEEDFIR KLDCKPDQHL KVVSIFGNTG DGKSHTLNHT 
       210        220        230        240        250
FFYGREVFKT SPTQESCTVG VWAAYDPVHK VAVIDTEGLL GATVNLSQRT 
       260        270        280        290        300
RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA 
       310        320        330        340        350
RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEVPEKLI QDRFRKLGRF 
       360        370        380        390        400
PEAFSSIHYK GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL 
       410        420        430        440        450
KALSDRFSGE IPDDQMAHSS FFPDEYFTCS SLCLSCGVGC KKSMNHGKEG 
       460        470        480        490        500
VPHEAKSRCR YSHQYDNRVY TCKACYERGE EVSVVPKTSA STDSPWMGLA 
       510        520        530        540        550
KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV HVWPGTDGFL 
       560        570        580        590        600
KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ 
       610        620        630        640        650
ILSCNKCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV 
       660        670        680        690        700
CDNCYEARNV QLAVTEAQVD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL 
       710        720        730        740        750
GLVKDAARPA YWVPDHEILH CHNCRKEFSI KLSKHHCRAC GQGFCDECSH 
       760        770 
DRRAVPSRGW DHPVRVCFNC NKKPGDL
Length:777
Mass (Da):87,176
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11B5E561066CBCD5
GO
Isoform 2 (identifier: Q9HBF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-415: Missing.

Show »
Length:362
Mass (Da):40,260
Checksum:i70B405CA16F3EE9D
GO
Isoform 3 (identifier: Q9HBF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     507-520: Missing.

Show »
Length:763
Mass (Da):85,592
Checksum:i17702137AF3EFED7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5N8G3V5N8_HUMAN
Zinc finger FYVE domain-containing ...
ZFYVE1
789Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL55826 differs from that shown. Reason: Frameshift.Curated
The sequence BAB13415 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB55085 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120V → M in BC014902 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0080071 – 415Missing in isoform 2. 1 PublicationAdd BLAST415
Alternative sequenceiVSP_056770507 – 520Missing in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF251025 mRNA Translation: AAG23748.1
AJ310569 mRNA Translation: CAC83950.1
AF311602 mRNA Translation: AAK27339.1
AB046809 mRNA Translation: BAB13415.1 Different initiation.
AK027399 mRNA Translation: BAB55085.1 Different termination.
AL442663 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81084.1
BC053520 mRNA Translation: AAH53520.1
BC014902 mRNA No translation available.
AF318319 mRNA Translation: AAL55826.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41969.1 [Q9HBF4-2]
CCDS61498.1 [Q9HBF4-3]
CCDS9811.1 [Q9HBF4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001268663.1, NM_001281734.1 [Q9HBF4-3]
NP_001268664.1, NM_001281735.1 [Q9HBF4-2]
NP_067083.1, NM_021260.3 [Q9HBF4-1]
NP_848535.1, NM_178441.2 [Q9HBF4-2]
XP_016876862.1, XM_017021373.1 [Q9HBF4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000318876; ENSP00000326921; ENSG00000165861 [Q9HBF4-3]
ENST00000394207; ENSP00000377757; ENSG00000165861 [Q9HBF4-2]
ENST00000555072; ENSP00000452232; ENSG00000165861 [Q9HBF4-2]
ENST00000556143; ENSP00000450742; ENSG00000165861

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53349

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53349

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000556143.6; ENSP00000450742.1; NM_021260.4; NP_067083.1

UCSC genome browser

More...UCSCi		uc001xnl.5, human [Q9HBF4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251025 mRNA Translation: AAG23748.1
AJ310569 mRNA Translation: CAC83950.1
AF311602 mRNA Translation: AAK27339.1
AB046809 mRNA Translation: BAB13415.1 Different initiation.
AK027399 mRNA Translation: BAB55085.1 Different termination.
AL442663 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81084.1
BC053520 mRNA Translation: AAH53520.1
BC014902 mRNA No translation available.
AF318319 mRNA Translation: AAL55826.1 Frameshift.
CCDSiCCDS41969.1 [Q9HBF4-2]
CCDS61498.1 [Q9HBF4-3]
CCDS9811.1 [Q9HBF4-1]
RefSeqiNP_001268663.1, NM_001281734.1 [Q9HBF4-3]
NP_001268664.1, NM_001281735.1 [Q9HBF4-2]
NP_067083.1, NM_021260.3 [Q9HBF4-1]
NP_848535.1, NM_178441.2 [Q9HBF4-2]
XP_016876862.1, XM_017021373.1 [Q9HBF4-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119749, 16 interactors
IntActiQ9HBF4, 15 interactors
MINTiQ9HBF4
STRINGi9606.ENSP00000450742

PTM databases

iPTMnetiQ9HBF4
PhosphoSitePlusiQ9HBF4

Genetic variation databases

BioMutaiZFYVE1
DMDMi34098716

Proteomic databases

EPDiQ9HBF4
jPOSTiQ9HBF4
MassIVEiQ9HBF4
MaxQBiQ9HBF4
PaxDbiQ9HBF4
PeptideAtlasiQ9HBF4
PRIDEiQ9HBF4
ProteomicsDBi81536 [Q9HBF4-1]
81537 [Q9HBF4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		143, 179 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		53349

Genome annotation databases

EnsembliENST00000318876; ENSP00000326921; ENSG00000165861 [Q9HBF4-3]
ENST00000394207; ENSP00000377757; ENSG00000165861 [Q9HBF4-2]
ENST00000555072; ENSP00000452232; ENSG00000165861 [Q9HBF4-2]
ENST00000556143; ENSP00000450742; ENSG00000165861
GeneIDi53349
KEGGihsa:53349
MANE-SelectiENST00000556143.6; ENSP00000450742.1; NM_021260.4; NP_067083.1
UCSCiuc001xnl.5, human [Q9HBF4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53349
DisGeNETi53349

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZFYVE1
HGNCiHGNC:13180, ZFYVE1
HPAiENSG00000165861, Low tissue specificity
MIMi605471, gene
neXtProtiNX_Q9HBF4
OpenTargetsiENSG00000165861
PharmGKBiPA37752
VEuPathDBiHostDB:ENSG00000165861

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1818, Eukaryota
GeneTreeiENSGT00390000016097
HOGENOMiCLU_020922_0_0_1
InParanoidiQ9HBF4
OrthoDBi198211at2759
PhylomeDBiQ9HBF4
TreeFamiTF323237

Enzyme and pathway databases

PathwayCommonsiQ9HBF4
SignaLinkiQ9HBF4
SIGNORiQ9HBF4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53349, 6 hits in 1053 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFYVE1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZFYVE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53349
PharosiQ9HBF4, Tbio

Protein Ontology

More...PROi		PR:Q9HBF4
RNActiQ9HBF4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165861, Expressed in pancreas and 222 other tissues
ExpressionAtlasiQ9HBF4, baseline and differential
GenevisibleiQ9HBF4, HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR042427, ZFYV1
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR46624, PTHR46624, 1 hit
PfamiView protein in Pfam
PF01363, FYVE, 2 hits
SMARTiView protein in SMART
SM00064, FYVE, 2 hits
SUPFAMiSSF52540, SSF52540, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50178, ZF_FYVE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFYV1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBF4
Secondary accession number(s): J3KNL9
, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: February 23, 2022
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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