UniProtKB - Q9HBE5 (IL21R_HUMAN)

BLAST

>sp|Q9HBE5|IL21R_HUMAN Interleukin-21 receptor OS=Homo sapiens OX=9606 GN=IL21R PE=1 SV=1
MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKD
EATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKP
APPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDS
RSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLL
LLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSS
LELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGG
SAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLD
AGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGS
PLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS

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History
Entry version 164 (07 Nov 2018)
Sequence version 1 (01 Mar 2001)
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Protein

Interleukin-21 receptor

Gene

IL21R

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

This is a receptor for interleukin-21.

GO - Molecular functionⁱ

cytokine receptor activity
Source: MGI
Inferred from direct assayⁱ
- 11016959
interleukin-21 receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 11081504
transmembrane signaling receptor activity
Source: MGI
Inferred from direct assayⁱ
- 11016959

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

interleukin-21-mediated signaling pathway Source: Reactome
natural killer cell activation
Source: UniProtKB
Non-traceable author statementⁱ
- 11081504

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9020958 Interleukin-21 signaling
SignaLinkⁱ	Q9HBE5
SIGNORⁱ	Q9HBE5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-21 receptor Short name: IL-21 receptor Short name: IL-21R Alternative name(s): Novel interleukin receptor CD_antigen: CD360
Gene namesⁱ	Name:IL21R Synonyms:NILR ORF Names:UNQ3121/PRO10273
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103522.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6006 IL21R
MIMⁱ	605383 gene
neXtProtⁱ	NX_Q9HBE5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 232	ExtracellularSequence analysisAdd BLAST	213
Transmembraneⁱ	233 – 253	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	254 – 538	CytoplasmicSequence analysisAdd BLAST	285

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency 56 (IMD56)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50615
MalaCards human disease database More...MalaCardsⁱ	IL21R
MIMⁱ	615207 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000103522
Orphanetⁱ	357329 Cryptosporidiosis-chronic cholangitis-liver disease syndrome
PharmGKBⁱ	PA29821

Polymorphism and mutation databases

BioMutaⁱ	IL21R
DMDMⁱ	20454997

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST		19
ChainⁱPRO_0000010881	20 – 538	Interleukin-21 receptorAdd BLAST		519

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	20 ↔ 109	1 Publication
Disulfide bondⁱ	25 ↔ 35	1 Publication
Disulfide bondⁱ	65 ↔ 81	1 Publication
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	97	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	104	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	135	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	214	C-linked (Man) tryptophan1 Publication	1

Post-translational modificationⁱ

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HBE5
PaxDbⁱ	Q9HBE5
PeptideAtlas More...PeptideAtlasⁱ	Q9HBE5
PRIDEⁱ	Q9HBE5
ProteomicsDBⁱ	81535

PTM databases

iPTMnetⁱ	Q9HBE5
PhosphoSitePlusⁱ	Q9HBE5

Expressionⁱ

Tissue specificityⁱ

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

Gene expression databases

Bgeeⁱ	ENSG00000103522 Expressed in 125 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_IL21R
Genevisibleⁱ	Q9HBE5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042296

HPAⁱ

HPA042296

Interactionⁱ

Subunit structureⁱ

Heterodimer with the common gamma subunit. Associates with JAK1.1 Publication

Protein-protein interaction databases

BioGridⁱ	119095, 2 interactors
IntActⁱ	Q9HBE5, 1 interactor
STRINGⁱ	9606.ENSP00000338010

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 27	Combined sources	6
Beta strandⁱ	29 – 31	Combined sources	3
Beta strandⁱ	33 – 38	Combined sources	6
Beta strandⁱ	40 – 43	Combined sources	4
Beta strandⁱ	46 – 51	Combined sources	6
Beta strandⁱ	68 – 72	Combined sources	5
Beta strandⁱ	77 – 80	Combined sources	4
Helixⁱ	85 – 87	Combined sources	3
Beta strandⁱ	93 – 99	Combined sources	7
Beta strandⁱ	106 – 113	Combined sources	8
Helixⁱ	114 – 116	Combined sources	3
Beta strandⁱ	124 – 139	Combined sources	16
Helixⁱ	141 – 143	Combined sources	3
Turnⁱ	149 – 153	Combined sources	5
Beta strandⁱ	154 – 162	Combined sources	9
Beta strandⁱ	172 – 176	Combined sources	5
Beta strandⁱ	181 – 185	Combined sources	5
Helixⁱ	187 – 189	Combined sources	3
Beta strandⁱ	195 – 204	Combined sources	10
Turnⁱ	206 – 209	Combined sources	4
Beta strandⁱ	221 – 224	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9HBE5
SMRⁱ	Q9HBE5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – 118	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST		98
Domainⁱ	119 – 228	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST		110

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	214 – 218	WSXWS motif		5
Motifⁱ	266 – 274	Box 1 motif		9

Domainⁱ

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.1 Publication

The box 1 motif is required for JAK interaction and/or activation.1 Publication

Sequence similaritiesⁱ

Belongs to the type I cytokine receptor family. Type 4 subfamily.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEDJ Eukaryota ENOG41128NP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048783
HOGENOMⁱ	HOG000013192
HOVERGENⁱ	HBG052105
InParanoidⁱ	Q9HBE5
KEGG Orthology (KO) More...KOⁱ	K05075
OMAⁱ	FKKWVGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0374
PhylomeDBⁱ	Q9HBE5
TreeFamⁱ	TF337874

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003531 Hempt_rcpt_S_F1_CS IPR013783 Ig-like_fold
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9HBE5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRGWAAPLL LLLLQGGWGC PDLVCYTDYL QTVICILEMW NLHPSTLTLT 
        60         70         80         90        100
WQDQYEELKD EATSCSLHRS AHNATHATYT CHMDVFHFMA DDIFSVNITD 
       110        120        130        140        150
QSGNYSQECG SFLLAESIKP APPFNVTVTF SGQYNISWRS DYEDPAFYML 
       160        170        180        190        200
KGKLQYELQY RNRGDPWAVS PRRKLISVDS RSVSLLPLEF RKDSSYELQV 
       210        220        230        240        250
RAGPMPGSSY QGTWSEWSDP VIFQTQSEEL KEGWNPHLLL LLLLVIVFIP 
       260        270        280        290        300
AFWSLKTHPL WRLWKKIWAV PSPERFFMPL YKGCSGDFKK WVGAPFTGSS 
       310        320        330        340        350
LELGPWSPEV PSTLEVYSCH PPRSPAKRLQ LTELQEPAEL VESDGVPKPS 
       360        370        380        390        400
FWPTAQNSGG SAYSEERDRP YGLVSIDTVT VLDAEGPCTW PCSCEDDGYP 
       410        420        430        440        450
ALDLDAGLEP SPGLEDPLLD AGTTVLSCGC VSAGSPGLGG PLGSLLDRLK 
       460        470        480        490        500
PPLADGEDWA GGLPWGGRSP GGVSESEAGS PLAGLDMDTF DSGFVGSDCS 
       510        520        530 
SPVECDFTSP GDEGPPRSYL RQWVVIPPPL SSPGPQAS

Length:538

Mass (Da):59,130

Last modified:March 1, 2001 - v1

Checksum:ⁱ414079CCB974850A

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	386	G → R in AAG23419 (PubMed:11016959).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069898	81 – 82	Missing in IMD56; loss of function mutation. 1 Publication	2
Natural variantⁱVAR_014360	191	R → C1 PublicationCorresponds to variant dbSNP:rs3093370Ensembl.	1
Natural variantⁱVAR_069899	201	R → L in IMD56; loss of function mutation; the mutation results in defective trafficking of the protein, with misfolding, impaired processing and abnormal subcellular distribution rather than proper expression at the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs397514685Ensembl.	1
Natural variantⁱVAR_014361	318	S → R1 PublicationCorresponds to variant dbSNP:rs3093385EnsemblClinVar.	1
Natural variantⁱVAR_014362	484	G → S1 PublicationCorresponds to variant dbSNP:rs3093386EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF254067 mRNA Translation: AAG29346.1 AF269133 mRNA Translation: AAG23419.1 AY358826 mRNA Translation: AAQ89185.1 AY064474 Genomic DNA Translation: AAL39168.1 AK292663 mRNA Translation: BAF85352.1 CH471145 Genomic DNA Translation: EAW55746.1 CH471145 Genomic DNA Translation: EAW55747.1 CH471145 Genomic DNA Translation: EAW55748.1 BC004348 mRNA Translation: AAH04348.1 BC007946 mRNA Translation: AAH07946.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10630.1
NCBI Reference Sequences More...RefSeqⁱ	NP_068570.1, NM_021798.3 NP_851564.1, NM_181078.2 NP_851565.4, NM_181079.4 XP_016878746.1, XM_017023257.1
UniGeneⁱ	Hs.210546

Genome annotation databases

Ensemblⁱ	ENST00000337929; ENSP00000338010; ENSG00000103522 ENST00000395754; ENSP00000379103; ENSG00000103522 ENST00000564089; ENSP00000456707; ENSG00000103522
GeneIDⁱ	50615
KEGGⁱ	hsa:50615
UCSC genome browser More...UCSCⁱ	uc002doq.2 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HBE5	IL21R isoform 1		PANTR		538	UniRef90_Q9HBE5
IL21R isoform 1		PONAB		538
Interleukin-21 receptor		MACFA		538
Uncharacterized protein		NOMLE		538
Interleukin 21 receptor		MACNE		538
+30

Protein	Similar proteins		Species	Score	Length	Source
Q9HBE5	Interleukin-21 receptor		MOUSE		529	UniRef50_Q9HBE5
Uncharacterized protein		CERAT		538
IL21R isoform 1		PONAB		538
Uncharacterized protein		COLAP		538
Interleukin-21 receptor		MACMU		538
+156

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF254067 mRNA Translation: AAG29346.1 AF269133 mRNA Translation: AAG23419.1 AY358826 mRNA Translation: AAQ89185.1 AY064474 Genomic DNA Translation: AAL39168.1 AK292663 mRNA Translation: BAF85352.1 CH471145 Genomic DNA Translation: EAW55746.1 CH471145 Genomic DNA Translation: EAW55747.1 CH471145 Genomic DNA Translation: EAW55748.1 BC004348 mRNA Translation: AAH04348.1 BC007946 mRNA Translation: AAH07946.2
CCDSⁱ	CCDS10630.1
RefSeqⁱ	NP_068570.1, NM_021798.3 NP_851564.1, NM_181078.2 NP_851565.4, NM_181079.4 XP_016878746.1, XM_017023257.1
UniGeneⁱ	Hs.210546

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3TGX	X-ray	2.80	A/C/E/G/I/K/M/O	20-232	[»]
	4NZD	X-ray	2.75	A/B/C	20-232	[»]
ProteinModelPortalⁱ	Q9HBE5
SMRⁱ	Q9HBE5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119095, 2 interactors
IntActⁱ	Q9HBE5, 1 interactor
STRINGⁱ	9606.ENSP00000338010

PTM databases

iPTMnetⁱ	Q9HBE5
PhosphoSitePlusⁱ	Q9HBE5

Polymorphism and mutation databases

BioMutaⁱ	IL21R
DMDMⁱ	20454997

Proteomic databases

MaxQBⁱ	Q9HBE5
PaxDbⁱ	Q9HBE5
PeptideAtlasⁱ	Q9HBE5
PRIDEⁱ	Q9HBE5
ProteomicsDBⁱ	81535

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50615
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337929; ENSP00000338010; ENSG00000103522 ENST00000395754; ENSP00000379103; ENSG00000103522 ENST00000564089; ENSP00000456707; ENSG00000103522
GeneIDⁱ	50615
KEGGⁱ	hsa:50615
UCSCⁱ	uc002doq.2 human

Organism-specific databases

CTDⁱ	50615
DisGeNETⁱ	50615
EuPathDBⁱ	HostDB:ENSG00000103522.15
GeneCardsⁱ	IL21R
H-InvDBⁱ	HIX0012914
HGNCⁱ	HGNC:6006 IL21R
HPAⁱ	HPA042296
MalaCardsⁱ	IL21R
MIMⁱ	605383 gene 615207 phenotype
neXtProtⁱ	NX_Q9HBE5
OpenTargetsⁱ	ENSG00000103522
Orphanetⁱ	357329 Cryptosporidiosis-chronic cholangitis-liver disease syndrome
PharmGKBⁱ	PA29821
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEDJ Eukaryota ENOG41128NP LUCA
GeneTreeⁱ	ENSGT00510000048783
HOGENOMⁱ	HOG000013192
HOVERGENⁱ	HBG052105
InParanoidⁱ	Q9HBE5
KOⁱ	K05075
OMAⁱ	FKKWVGA
OrthoDBⁱ	EOG091G0374
PhylomeDBⁱ	Q9HBE5
TreeFamⁱ	TF337874

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9020958 Interleukin-21 signaling
SignaLinkⁱ	Q9HBE5
SIGNORⁱ	Q9HBE5

Miscellaneous databases

ChiTaRSⁱ	IL21R human
GeneWikiⁱ	Interleukin-21_receptor
GenomeRNAiⁱ	50615
Protein Ontology More...PROⁱ	PR:Q9HBE5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103522 Expressed in 125 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_IL21R
Genevisibleⁱ	Q9HBE5 HS

Family and domain databases

CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003531 Hempt_rcpt_S_F1_CS IPR013783 Ig-like_fold
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit PS01355 HEMATOPO_REC_S_F1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL21R_HUMAN
Accessionⁱ	Q9HBE5Primary (citable) accession number: Q9HBE5 Secondary accession number(s): A8K9E8 , D3DWF7, Q96HZ1, Q9HB91
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - Q9HBE5 (IL21R_HUMAN)

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Interleukin-21 receptor

IL21R

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ