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Protein
Submitted name:

SMARCA4 isoform 2

Gene

SMARCA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SMARCA4 isoform 2Imported
Submitted name:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_cImported
Submitted name:
Transcription activator BRG1Imported
Gene namesi
Name:SMARCA4Imported
ORF Names:hCG_29955Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127616.17
HGNCiHGNC:11100 SMARCA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127616
PharmGKBiPA35950

PTM / Processingi

Proteomic databases

EPDiQ9HBD4
PRIDEiQ9HBD4

Expressioni

Gene expression databases

BgeeiENSG00000127616 Expressed in 229 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ9HBD4 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9HBD4, 9 interactors
MINTiQ9HBD4

Structurei

3D structure databases

SMRiQ9HBD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 206QLQInterPro annotationAdd BLAST36
Domaini460 – 532HSAInterPro annotationAdd BLAST73
Domaini766 – 931Helicase ATP-bindingInterPro annotationAdd BLAST166
Domaini1084 – 1246Helicase C-terminalInterPro annotationAdd BLAST163
Domaini1509 – 1579BromoInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili508 – 533Sequence analysisAdd BLAST26
Coiled coili573 – 595Sequence analysisAdd BLAST23
Coiled coili1429 – 1449Sequence analysisAdd BLAST21

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0386 Eukaryota
COG0553 LUCA
COG5076 LUCA
GeneTreeiENSGT00550000074659
HOGENOMiHOG000172363
HOVERGENiHBG056636
TreeFamiTF300785

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.20.920.10, 1 hit
2.20.28.130, 1 hit
3.40.50.10810, 2 hits
InterProiView protein in InterPro
IPR030100 BRG1
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF76 PTHR10799:SF76, 1 hit
PfamiView protein in Pfam
PF07533 BRK, 1 hit
PF00439 Bromodomain, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF08880 QLQ, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00297 BROMO, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS51666 QLQ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 29 potential isoforms that are computationally mapped.Show allAlign All

Q9HBD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP
60 70 80 90 100
SAGHPIPTQG PGGYPQDNMH QMHKPMESMH EKGMSDDPRY NQMKGMGMRS
110 120 130 140 150
GGHAGMGPPP SPMDQHSQGY PSPLGGSEHA SSPVPASGPS SGPQMSSGPG
160 170 180 190 200
GAPLDGADPQ ALGQQNRGPT PFNQNQLHQL RAQIMAYKML ARGQPLPDHL
210 220 230 240 250
QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP GPGPAPPNYS
260 270 280 290 300
RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ
310 320 330 340 350
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PMVPLHQKQS
360 370 380 390 400
RITPIQKPRG LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA
410 420 430 440 450
TIELKALRLL NFQRQLRQEV VVCMRRDTAL ETALNAKAYK RSKRQSLREA
460 470 480 490 500
RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL QHAKDFKEYH RSVTGKIQKL
510 520 530 540 550
TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK LIDQKKDKRL
560 570 580 590 600
AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG
610 620 630 640 650
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE
660 670 680 690 700
VAPRSDSEES GSEEEEEEEE EEQPQAAQPP TLPVEEKKKI PDPDSDDVSE
710 720 730 740 750
VDARHIIENA KQDVDDEYGV SQALARGLQS YYAVAHAVTE RVDKQSALMV
760 770 780 790 800
NGVLKQYQIK GLEWLVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK
810 820 830 840 850
RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS
860 870 880 890 900
GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH
910 920 930 940 950
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT
960 970 980 990 1000
GEKVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM
1010 1020 1030 1040 1050
SALQRVLYRH MQAKGVLLTD GSEKDKKGKG GTKTLMNTIM QLRKICNHPY
1060 1070 1080 1090 1100
MFQHIEESFS EHLGFTGGIV QGLDLYRASG KFELLDRILP KLRATNHKVL
1110 1120 1130 1140 1150
LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK TFNEPGSEYF
1160 1170 1180 1190 1200
IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR
1210 1220 1230 1240 1250
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI
1260 1270 1280 1290 1300
LEHEEQDESR HCSTGSGSAS FAHTAPPPAG VNPDLEEPPL KEEDEVPDDE
1310 1320 1330 1340 1350
TVNQMIARHE EEFDLFMRMD LDRRREEARN PKRKPRLMEE DELPSWIIKD
1360 1370 1380 1390 1400
DAEVERLTCE EEEEKMFGRG SRHRKEVDYS DSLTEKQWLK KITGKDIHDT
1410 1420 1430 1440 1450
ASSVARGLQF QRGLQFCTRA SKAIEEGTLE EIEEEVRQKK SSRKRKRDSD
1460 1470 1480 1490 1500
AGSSTPTTST RSRDKDDESK KQKKRGRPPA EKLSPNPPNL TKKMKKIVDA
1510 1520 1530 1540 1550
VIKYKDSSSG RQLSEVFIQL PSRKELPEYY ELIRKPVDFK KIKERIRNHK
1560 1570 1580 1590 1600
YRSLNDLEKD VMLLCQNAQT FNLEGSLIYE DSIVLQSVFT SVRQKIEKED
1610 1620 1630 1640 1650
DSEGEESEEE EEGEEEGSES ESRSVKVKIK LGRKEKAQDR LKGGRRRPSR
1660 1670
GSRAKPVVSD DDSEEEQEED RSGSGSEED
Length:1,679
Mass (Da):188,149
Last modified:March 1, 2001 - v1
Checksum:iC11A4EEF8086A175
GO

Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P51532SMCA4_HUMAN
Transcription activator BRG1
SMARCA4 BAF190A, BRG1, SNF2B, SNF2L4
1,647Annotation score:
A0A0A0MT49A0A0A0MT49_HUMAN
Transcription activator BRG1
SMARCA4
1,681Annotation score:
A0A2R8Y7S2A0A2R8Y7S2_HUMAN
Transcription activator BRG1
SMARCA4
1,646Annotation score:
A0A2R8Y4P4A0A2R8Y4P4_HUMAN
Transcription activator BRG1
SMARCA4
1,649Annotation score:
A0A2R8Y6N0A0A2R8Y6N0_HUMAN
Transcription activator BRG1
SMARCA4
1,145Annotation score:
A0A2R8YGG3A0A2R8YGG3_HUMAN
Transcription activator BRG1
SMARCA4
1,455Annotation score:
A0A2R8Y440A0A2R8Y440_HUMAN
Transcription activator BRG1
SMARCA4
1,192Annotation score:
A0A2R8YF80A0A2R8YF80_HUMAN
Transcription activator BRG1
SMARCA4
1,094Annotation score:
A0A2R8YF58A0A2R8YF58_HUMAN
Transcription activator BRG1
SMARCA4
1,065Annotation score:
A0A2R8Y7Y7A0A2R8Y7Y7_HUMAN
Transcription activator BRG1
SMARCA4
1,081Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006127 Genomic DNA No translation available.
AC011442 Genomic DNA No translation available.
AC011485 Genomic DNA No translation available.
KC877700 Genomic DNA No translation available.
AF254822 Genomic DNA Translation: AAG24790.1
CH471106 Genomic DNA Translation: EAW84164.1
RefSeqiNP_001122321.1, NM_001128849.1
XP_006722908.1, XM_006722845.2
XP_006722909.1, XM_006722846.2
XP_011526500.1, XM_011528198.1
UniGeneiHs.327527

Genome annotation databases

EnsembliENST00000450717; ENSP00000397783; ENSG00000127616
ENST00000646693; ENSP00000495368; ENSG00000127616
GeneIDi6597
UCSCiuc060tnv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006127 Genomic DNA No translation available.
AC011442 Genomic DNA No translation available.
AC011485 Genomic DNA No translation available.
KC877700 Genomic DNA No translation available.
AF254822 Genomic DNA Translation: AAG24790.1
CH471106 Genomic DNA Translation: EAW84164.1
RefSeqiNP_001122321.1, NM_001128849.1
XP_006722908.1, XM_006722845.2
XP_006722909.1, XM_006722846.2
XP_011526500.1, XM_011528198.1
UniGeneiHs.327527

3D structure databases

SMRiQ9HBD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HBD4, 9 interactors
MINTiQ9HBD4

Proteomic databases

EPDiQ9HBD4
PRIDEiQ9HBD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450717; ENSP00000397783; ENSG00000127616
ENST00000646693; ENSP00000495368; ENSG00000127616
GeneIDi6597
UCSCiuc060tnv.1 human

Organism-specific databases

CTDi6597
EuPathDBiHostDB:ENSG00000127616.17
HGNCiHGNC:11100 SMARCA4
OpenTargetsiENSG00000127616
PharmGKBiPA35950
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0386 Eukaryota
COG0553 LUCA
COG5076 LUCA
GeneTreeiENSGT00550000074659
HOGENOMiHOG000172363
HOVERGENiHBG056636
TreeFamiTF300785

Miscellaneous databases

ChiTaRSiSMARCA4 human
GenomeRNAii6597

Gene expression databases

BgeeiENSG00000127616 Expressed in 229 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ9HBD4 baseline and differential

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.20.920.10, 1 hit
2.20.28.130, 1 hit
3.40.50.10810, 2 hits
InterProiView protein in InterPro
IPR030100 BRG1
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF76 PTHR10799:SF76, 1 hit
PfamiView protein in Pfam
PF07533 BRK, 1 hit
PF00439 Bromodomain, 1 hit
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF08880 QLQ, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00297 BROMO, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS51666 QLQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9HBD4_HUMAN
AccessioniPrimary (citable) accession number: Q9HBD4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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