Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-related family member 5

Gene

CDHR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • cell adhesion molecule binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-related family member 5Curated
Alternative name(s):
Mu-protocadherinImported
Mucin and cadherin-like protein1 Publication
Mucin-like protocadherin1 Publication
Short name:
MLPCDH1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDHR5Imported
Synonyms:MUCDHL1 Publication, MUPCDHImported
ORF Names:UNQ2781/PRO7168Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099834.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7521 CDHR5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606839 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HBB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 669ExtracellularSequence analysisAdd BLAST644
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Topological domaini691 – 845CytoplasmicSequence analysisAdd BLAST155

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi109R → G: Loss of binding to CDHR2. 1 Publication1
Mutagenesisi845I → R: Loss of interaction with USH1C. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
53841

Open Targets

More...
OpenTargetsi
ENSG00000099834

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165543311

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDHR5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439399

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000401226 – 845Cadherin-related family member 5Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineCurated1
Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi140N-linked (GlcNAc...) asparagineCurated1
Glycosylationi198N-linked (GlcNAc...) asparagineCurated1
Glycosylationi297N-linked (GlcNAc...) asparagineCurated1
Glycosylationi308N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi405N-linked (GlcNAc...) asparagineCurated1
Glycosylationi526N-linked (GlcNAc...) asparagineCurated1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei770PhosphoserineBy similarity1
Modified residuei810PhosphothreonineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei819PhosphoserineCombined sources1
Modified residuei821PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HBB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HBB8

PeptideAtlas

More...
PeptideAtlasi
Q9HBB8

PRoteomics IDEntifications database

More...
PRIDEi
Q9HBB8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81519
81520 [Q9HBB8-2]
81521 [Q9HBB8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HBB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HBB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099834 Expressed in 106 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

More...
CleanExi
HS_MUPCDH

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HBB8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HBB8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025004
HPA009081
HPA009173

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:26812018). Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation (PubMed:24725409).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119810, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HBB8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351118

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HBB8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 124Cadherin 1PROSITE-ProRule annotationCuratedAdd BLAST54
Domaini125 – 237Cadherin 2PROSITE-ProRule annotationCuratedAdd BLAST113
Domaini249 – 354Cadherin 3PROSITE-ProRule annotationCuratedAdd BLAST106
Domaini355 – 459Cadherin 4PROSITE-ProRule annotationCuratedAdd BLAST105
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati540 – 5701CuratedAdd BLAST31
Repeati571 – 6012CuratedAdd BLAST31
Repeati602 – 6313CuratedAdd BLAST30
Repeati632 – 6454; truncatedAdd BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni540 – 6454 X 31 AA approximate tandem repeatsAdd BLAST106
Regioni691 – 845Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization1 PublicationAdd BLAST155

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162463

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052536

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HBB8

KEGG Orthology (KO)

More...
KOi
K16505

Identification of Orthologs from Complete Genome Data

More...
OMAi
TYRITNN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HDO

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HBB8

TreeFam database of animal gene trees

More...
TreeFami
TF350567

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030326 Mucdhl

The PANTHER Classification System

More...
PANTHERi
PTHR45160 PTHR45160, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 1 hit
PS50268 CADHERIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated1 Publication (identifier: Q9HBB8-1) [UniParc]FASTAAdd to basket
Also known as: MUCDHL-FL1 Publication, MLPCDH-L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSWALLWPP LLFTGLLVRP PGTMAQAQYC SVNKDIFEVE ENTNVTEPLV
60 70 80 90 100
DIHVPEGQEV TLGALSTPFA FRIQGNQLFL NVTPDYEEKS LLEAQLLCQS
110 120 130 140 150
GGTLVTQLRV FVSVLDVNDN APEFPFKTKE IRVEEDTKVN STVIPETQLQ
160 170 180 190 200
AEDRDKDDIL FYTLQEMTAG ASDYFSLVSV NRPALRLDRP LDFYERPNMT
210 220 230 240 250
FWLLVRDTPG ENVEPSHTAT ATLVLNVVPA DLRPPWFLPC TFSDGYVCIQ
260 270 280 290 300
AQYHGAVPTG HILPSPLVLR PGPIYAEDGD RGINQPIIYS IFRGNVNGTF
310 320 330 340 350
IIHPDSGNLT VARSVPSPMT FLLLVKGQQA DLARYSVTQV TVEAVAAAGS
360 370 380 390 400
PPRFPQRLYR GTVARGAGAG VVVKDAAAPS QPLRIQAQDP EFSDLNSAIT
410 420 430 440 450
YRITNHSHFR MEGEVVLTTT TLAQAGAFYA EVEAHNTVTS GTATTVIEIQ
460 470 480 490 500
VSEQEPPSTD VPPSPEAGGT TGPWTSTTSE VPRPPEPSQG PSTTSSGGGT
510 520 530 540 550
GPHPPSGTTL RPPTSSTPGG PPGAENSTSH QPATPGGDTA QTPKPGTSQP
560 570 580 590 600
MPPGVGTSTS HQPATPSGGT AQTPEPGTSQ PMPPSMGTST SHQPATPGGG
610 620 630 640 650
TAQTPEAGTS QPMPPGMGTS TSHQPTTPGG GTAQTPEPGT SQPMPLSKST
660 670 680 690 700
PSSGGGPSED KRFSVVDMAA LGGVLGALLL LALLGLAVLV HKHYGPRLKC
710 720 730 740 750
CCGKAPEPQP QGFDNQAFLP DHKANWAPVP SPTHDPKPAE APMPAEPAPP
760 770 780 790 800
GPASPGGAPE PPAAARAGGS PTAVRSILTK ERRPEGGYKA VWFGEDIGTE
810 820 830 840
ADVVVLNAPT LDVDGASDSG SGDEGEGAGR GGGPYDAPGG DDSYI
Length:845
Mass (Da):88,223
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD872A8D67AF6677
GO
Isoform 2Curated (identifier: Q9HBB8-2) [UniParc]FASTAAdd to basket
Also known as: MLPCDH-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     460-653: Missing.

Show »
Length:651
Mass (Da):69,626
Checksum:i51776E20917A7B04
GO
Isoform 3 (identifier: Q9HBB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     460-465: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):87,631
Checksum:i414CB816397F4386
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JP44A0A0G2JP44_HUMAN
Cadherin-related family member 5
CDHR5 MUCDHL, hCG_1778294
651Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMW3A0A0G2JMW3_HUMAN
Cadherin-related family member 5
CDHR5
845Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLX6E9PLX6_HUMAN
Cadherin-related family member 5
CDHR5
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMY2E9PMY2_HUMAN
Cadherin-related family member 5
CDHR5
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPW2E9PPW2_HUMAN
Cadherin-related family member 5
CDHR5
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKR2E9PKR2_HUMAN
Cadherin-related family member 5
CDHR5
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG16730 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG16732 differs from that shown. Aberrant splicing.Curated
The sequence BAA91021 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAA91021 differs from that shown. Reason: Frameshift at position 763.Curated
The sequence BAA91021 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15052 differs from that shown. Reason: Frameshift at position 458.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti313R → S in BAA91021 (PubMed:14702039).Curated1
Sequence conflicti373V → A in BAB15052 (PubMed:14702039).Curated1
Sequence conflicti476S → G in AAG33495 (Ref. 2) Curated1
Sequence conflicti476S → G in BAA91021 (PubMed:14702039).Curated1
Sequence conflicti498G → E in AAG33495 (Ref. 2) Curated1
Sequence conflicti498G → E in BAA91021 (PubMed:14702039).Curated1
Sequence conflicti571A → V in AAG16733 (PubMed:11031102).Curated1
Sequence conflicti571A → V in AAG33495 (Ref. 2) Curated1
Sequence conflicti571A → V in BAA91021 (PubMed:14702039).Curated1
Sequence conflicti807N → S in AAG30821 (Ref. 2) Curated1
Sequence conflicti807N → S in AAG33495 (Ref. 2) Curated1
Sequence conflicti807N → S in BAA91130 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060412165Q → P1 PublicationCorresponds to variant dbSNP:rs2740374Ensembl.1
Natural variantiVAR_017920357R → S4 PublicationsCorresponds to variant dbSNP:rs2246614Ensembl.1
Natural variantiVAR_017921389D → N. Corresponds to variant dbSNP:rs2306066Ensembl.1
Natural variantiVAR_060413521P → S3 PublicationsCorresponds to variant dbSNP:rs2740375Ensembl.1
Natural variantiVAR_059192702C → S4 PublicationsCorresponds to variant dbSNP:rs2740379Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050693460 – 653Missing in isoform 2. 2 PublicationsAdd BLAST194
Alternative sequenceiVSP_050692460 – 465Missing in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF258674 Genomic DNA Translation: AAG16730.1 Sequence problems.
AF258674 Genomic DNA Translation: AAG16731.1
AF258675 mRNA Translation: AAG16732.1 Sequence problems.
AF258676 mRNA Translation: AAG16733.1
AF276242 mRNA Translation: AAG30821.1
AF301909 mRNA Translation: AAG33495.1
AY358368 mRNA Translation: AAQ88734.1
AK000226 mRNA Translation: BAA91021.1 Sequence problems.
AK000384 mRNA Translation: BAA91130.1
AK025012 mRNA Translation: BAB15052.1 Frameshift.
AP006284 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7707.1 [Q9HBB8-1]
CCDS7708.1 [Q9HBB8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001165439.1, NM_001171968.1
NP_068743.2, NM_021924.4
NP_112554.2, NM_031264.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.165619

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349570; ENSP00000345726; ENSG00000099834 [Q9HBB8-2]
ENST00000358353; ENSP00000351118; ENSG00000099834 [Q9HBB8-1]
ENST00000397542; ENSP00000380676; ENSG00000099834 [Q9HBB8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:53841

UCSC genome browser

More...
UCSCi
uc001lqj.3 human [Q9HBB8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

A tighter mesh - Issue 178 of April 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258674 Genomic DNA Translation: AAG16730.1 Sequence problems.
AF258674 Genomic DNA Translation: AAG16731.1
AF258675 mRNA Translation: AAG16732.1 Sequence problems.
AF258676 mRNA Translation: AAG16733.1
AF276242 mRNA Translation: AAG30821.1
AF301909 mRNA Translation: AAG33495.1
AY358368 mRNA Translation: AAQ88734.1
AK000226 mRNA Translation: BAA91021.1 Sequence problems.
AK000384 mRNA Translation: BAA91130.1
AK025012 mRNA Translation: BAB15052.1 Frameshift.
AP006284 Genomic DNA No translation available.
CCDSiCCDS7707.1 [Q9HBB8-1]
CCDS7708.1 [Q9HBB8-2]
RefSeqiNP_001165439.1, NM_001171968.1
NP_068743.2, NM_021924.4
NP_112554.2, NM_031264.3
UniGeneiHs.165619

3D structure databases

ProteinModelPortaliQ9HBB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119810, 11 interactors
IntActiQ9HBB8, 3 interactors
STRINGi9606.ENSP00000351118

PTM databases

iPTMnetiQ9HBB8
PhosphoSitePlusiQ9HBB8

Polymorphism and mutation databases

BioMutaiCDHR5
DMDMi296439399

Proteomic databases

MaxQBiQ9HBB8
PaxDbiQ9HBB8
PeptideAtlasiQ9HBB8
PRIDEiQ9HBB8
ProteomicsDBi81519
81520 [Q9HBB8-2]
81521 [Q9HBB8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349570; ENSP00000345726; ENSG00000099834 [Q9HBB8-2]
ENST00000358353; ENSP00000351118; ENSG00000099834 [Q9HBB8-1]
ENST00000397542; ENSP00000380676; ENSG00000099834 [Q9HBB8-1]
GeneIDi53841
KEGGihsa:53841
UCSCiuc001lqj.3 human [Q9HBB8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53841
DisGeNETi53841
EuPathDBiHostDB:ENSG00000099834.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDHR5
HGNCiHGNC:7521 CDHR5
HPAiCAB025004
HPA009081
HPA009173
MIMi606839 gene
neXtProtiNX_Q9HBB8
OpenTargetsiENSG00000099834
PharmGKBiPA165543311

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000162463
HOVERGENiHBG052536
InParanoidiQ9HBB8
KOiK16505
OMAiTYRITNN
OrthoDBiEOG091G0HDO
PhylomeDBiQ9HBB8
TreeFamiTF350567

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDHR5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MUPCDH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53841

Protein Ontology

More...
PROi
PR:Q9HBB8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099834 Expressed in 106 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_MUPCDH
ExpressionAtlasiQ9HBB8 baseline and differential
GenevisibleiQ9HBB8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030326 Mucdhl
PANTHERiPTHR45160 PTHR45160, 1 hit
SMARTiView protein in SMART
SM00112 CA, 3 hits
SUPFAMiSSF49313 SSF49313, 3 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 1 hit
PS50268 CADHERIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDHR5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HBB8
Secondary accession number(s): C9J7X1
, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again