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UniProtKB - Q9HBA9 (FOH1B_HUMAN)
Protein
Putative N-acetylated-alpha-linked acidic dipeptidase
Gene
FOLH1B
Organism
Homo sapiens (Human)
Status
Functioni
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.
By similarityExhibits a dipeptidyl-peptidase IV type activity.
By similarityCofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. Required for NAALADase activity.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 69 | Zinc 1By similarity | 1 | |
Metal bindingi | 69 | Zinc 1; via tele nitrogen; catalyticBy similarity | 1 | |
Metal bindingi | 79 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 79 | Zinc 2By similarity | 1 | |
Active sitei | 116 | For NAALADase activityBy similarity | 1 | |
Binding sitei | 116 | SubstrateBy similarity | 1 | |
Metal bindingi | 117 | Zinc 2By similarity | 1 | |
Metal bindingi | 125 | CalciumBy similarity | 1 | |
Metal bindingi | 128 | CalciumBy similarity | 1 | |
Metal bindingi | 145 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 211 | SubstrateBy similarity | 1 | |
Binding sitei | 244 | SubstrateBy similarity | 1 | |
Metal bindingi | 245 | Zinc 2; via tele nitrogenBy similarity | 1 | |
Active sitei | 320 | Charge relay systemBy similarity | 1 | |
Active sitei | 358 | Charge relay systemBy similarity | 1 | |
Active sitei | 381 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- carboxypeptidase activity Source: GO_Central
- dipeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallocarboxypeptidase activity Source: BHF-UCL
GO - Biological processi
- C-terminal protein deglutamylation Source: BHF-UCL
Keywordsi
Molecular function | Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9HBA9 |
Reactomei | R-HSA-8963693, Aspartate and asparagine metabolism |
SignaLinki | Q9HBA9 |
Protein family/group databases
MEROPSi | M28.010 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative N-acetylated-alpha-linked acidic dipeptidase (EC:3.4.-.-)Short name: NAALADase Alternative name(s): Cell growth-inhibiting gene 26 protein Prostate-specific membrane antigen-like protein Putative folate hydrolase 1B |
Gene namesi | Name:FOLH1B Synonyms:PSMAL ORF Names:GIG26 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13636, FOLH1B |
MIMi | 609020, gene |
neXtProti | NX_Q9HBA9 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 219595 |
PharmGKBi | PA165543408 |
Miscellaneous databases
Pharosi | Q9HBA9, Tbio |
Genetic variation databases
BioMutai | HGNC:13636 |
DMDMi | 74718738 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000256137 | 1 – 442 | Putative N-acetylated-alpha-linked acidic dipeptidaseAdd BLAST | 442 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Glycosylationi | 168 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Glycosylationi | 305 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9HBA9 |
MaxQBi | Q9HBA9 |
PeptideAtlasi | Q9HBA9 |
PRIDEi | Q9HBA9 |
ProteomicsDBi | 81517 |
PTM databases
GlyGeni | Q9HBA9, 5 sites |
iPTMneti | Q9HBA9 |
PhosphoSitePlusi | Q9HBA9 |
Expressioni
Tissue specificityi
Kidney and liver. Not expressed in the prostate.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 128556, 11 interactors |
Miscellaneous databases
RNActi | Q9HBA9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 209 – 210 | Substrate bindingBy similarity | 2 | |
Regioni | 226 – 228 | Substrate bindingBy similarity | 3 | |
Regioni | 244 – 245 | Substrate bindingBy similarity | 2 | |
Regioni | 391 – 392 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Phylogenomic databases
InParanoidi | Q9HBA9 |
OrthoDBi | 804230at2759 |
PhylomeDBi | Q9HBA9 |
Family and domain databases
Gene3Di | 1.20.930.40, 1 hit |
InterProi | View protein in InterPro IPR007484, Peptidase_M28 IPR039373, Peptidase_M28B IPR007365, TFR-like_dimer_dom IPR036757, TFR-like_dimer_dom_sf |
PANTHERi | PTHR10404, PTHR10404, 1 hit |
Pfami | View protein in Pfam PF04389, Peptidase_M28, 1 hit PF04253, TFR_dimer, 1 hit |
SUPFAMi | SSF47672, SSF47672, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HBA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGSAPPDSS WRGSLKVSYN VGPGFTGNFS TQKVKMHIHS TNEVTRIYNV
60 70 80 90 100
IGTLRGAVEP DRYVILGGHR DSWVFGGIDP QSGAAVVHET VRSFGTLKKE
110 120 130 140 150
GWRPRRTILF ASWDAEEFGL LGSTEWAEDN SRLLQERGVA YINADSSIEG
160 170 180 190 200
NYTLRVDCTP LMYSLVYNLT KELKSPDEGF EGKSLYESWT KKSPSPEFSG
210 220 230 240 250
MPRISKLGSG NDFEVFFQRL GIASGRARYT KNWETNKFSG YPLYHSVYET
260 270 280 290 300
YELVEKFYDP MFKYHLTVAQ VRGGMVFELA NSIVLPFDCR DYAVVLRKYA
310 320 330 340 350
DKIYNISMKH PQEMKTYSLS FDSLFSAVKN FTEIASKFSE RLQDFDKSNP
360 370 380 390 400
ILLRMMNDQL MFLERAFIDP LGLPDRPFYR HVIYAPSSHN KYAGESFPGI
410 420 430 440
YDALFDIESK VDPSKAWGDV KRQISVAAFT VQAAAETLSE VA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059782 | 151 | N → K. Corresponds to variant dbSNP:rs10830339Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF261715 mRNA Translation: AAG29102.1 AY544126 mRNA Translation: AAT11157.1 |
RefSeqi | NP_710163.1, NM_153696.2 |
Genome annotation databases
GeneIDi | 219595 |
KEGGi | hsa:219595 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF261715 mRNA Translation: AAG29102.1 AY544126 mRNA Translation: AAT11157.1 |
RefSeqi | NP_710163.1, NM_153696.2 |
3D structure databases
AlphaFoldDBi | Q9HBA9 |
SMRi | Q9HBA9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128556, 11 interactors |
Protein family/group databases
MEROPSi | M28.010 |
PTM databases
GlyGeni | Q9HBA9, 5 sites |
iPTMneti | Q9HBA9 |
PhosphoSitePlusi | Q9HBA9 |
Genetic variation databases
BioMutai | HGNC:13636 |
DMDMi | 74718738 |
Proteomic databases
MassIVEi | Q9HBA9 |
MaxQBi | Q9HBA9 |
PeptideAtlasi | Q9HBA9 |
PRIDEi | Q9HBA9 |
ProteomicsDBi | 81517 |
Protocols and materials databases
DNASUi | 219595 |
Genome annotation databases
GeneIDi | 219595 |
KEGGi | hsa:219595 |
Organism-specific databases
CTDi | 219595 |
DisGeNETi | 219595 |
GeneCardsi | FOLH1B |
HGNCi | HGNC:13636, FOLH1B |
MIMi | 609020, gene |
neXtProti | NX_Q9HBA9 |
PharmGKBi | PA165543408 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q9HBA9 |
OrthoDBi | 804230at2759 |
PhylomeDBi | Q9HBA9 |
Enzyme and pathway databases
PathwayCommonsi | Q9HBA9 |
Reactomei | R-HSA-8963693, Aspartate and asparagine metabolism |
SignaLinki | Q9HBA9 |
Miscellaneous databases
BioGRID-ORCSi | 219595, 4 hits in 118 CRISPR screens |
ChiTaRSi | FOLH1B, human |
GenomeRNAii | 219595 |
Pharosi | Q9HBA9, Tbio |
PROi | PR:Q9HBA9 |
RNActi | Q9HBA9, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.20.930.40, 1 hit |
InterProi | View protein in InterPro IPR007484, Peptidase_M28 IPR039373, Peptidase_M28B IPR007365, TFR-like_dimer_dom IPR036757, TFR-like_dimer_dom_sf |
PANTHERi | PTHR10404, PTHR10404, 1 hit |
Pfami | View protein in Pfam PF04389, Peptidase_M28, 1 hit PF04253, TFR_dimer, 1 hit |
SUPFAMi | SSF47672, SSF47672, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOH1B_HUMAN | |
Accessioni | Q9HBA9Primary (citable) accession number: Q9HBA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families