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Protein

Ras-related GTP-binding protein C

Gene

RRAGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTPBy similarity8
Nucleotide bindingi116 – 120GTPBy similarity5
Nucleotide bindingi178 – 181GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTPase binding Source: CAFA
  • GTP binding Source: HGNC
  • magnesium ion binding Source: UniProtKB
  • protein heterodimerization activity Source: CAFA

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ9HB90

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related GTP-binding protein C
Short name:
Rag C
Short name:
RagC
Alternative name(s):
GTPase-interacting protein 2
TIB929
Gene namesi
Name:RRAGCImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116954.7
HGNCiHGNC:19902 RRAGC
MIMi608267 gene
neXtProtiNX_Q9HB90

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi75S → L: Increased RPTOR-binding. 1 Publication1
Mutagenesisi120Q → L: Decreased RPTOR-binding. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi64121
OpenTargetsiENSG00000116954
PharmGKBiPA134862062

Polymorphism and mutation databases

DMDMi74752776

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002399512 – 399Ras-related GTP-binding protein CAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei96PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HB90
MaxQBiQ9HB90
PaxDbiQ9HB90
PeptideAtlasiQ9HB90
PRIDEiQ9HB90
ProteomicsDBi81509

PTM databases

iPTMnetiQ9HB90
PhosphoSitePlusiQ9HB90

Expressioni

Gene expression databases

BgeeiENSG00000116954 Expressed in 125 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_RRAGC
GenevisibleiQ9HB90 HS

Organism-specific databases

HPAiHPA018247
HPA055489

Interactioni

Subunit structurei

Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:11073942, PubMed:14660641, PubMed:18497260, PubMed:22575674). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with SESN1, SESN2 AND SESN3 (PubMed:25259925).7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122074, 28 interactors
DIPiDIP-37515N
IntActiQ9HB90, 19 interactors
STRINGi9606.ENSP00000362092

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HB90
SMRiQ9HB90
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HB90

Family & Domainsi

Sequence similaritiesi

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG3887 Eukaryota
ENOG410XQS9 LUCA
GeneTreeiENSGT00550000074708
HOGENOMiHOG000203695
HOVERGENiHBG059482
InParanoidiQ9HB90
KOiK16186
OMAiEMNFEVF
OrthoDBiEOG091G0AN4
PhylomeDBiQ9HB90
TreeFamiTF300659

Family and domain databases

CDDicd11385 RagC_like, 1 hit
InterProiView protein in InterPro
IPR006762 Gtr1_RagA
IPR027417 P-loop_NTPase
IPR039400 RagC/D
PANTHERiPTHR11259 PTHR11259, 1 hit
PfamiView protein in Pfam
PF04670 Gtr1_RagA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HB90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQYGAEET PLAGSYGAAD SFPKDFGYGV EEEEEEAAAA GGGVGAGAGG
60 70 80 90 100
GCGPGGADSS KPRILLMGLR RSGKSSIQKV VFHKMSPNET LFLESTNKIY
110 120 130 140 150
KDDISNSSFV NFQIWDFPGQ MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY
160 170 180 190 200
MEALTRLHIT VSKAYKVNPD MNFEVFIHKV DGLSDDHKIE TQRDIHQRAN
210 220 230 240 250
DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL PTLENLLNIF
260 270 280 290 300
ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG
310 320 330 340 350
LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG
360 370 380 390
LIDYNFHCFR KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNAI
Length:399
Mass (Da):44,224
Last modified:March 1, 2001 - v1
Checksum:i35B3171253CC69CF
GO

Sequence cautioni

The sequence BAB14548 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206A → S in AAG45221 (PubMed:11145883).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07651175S → Y Found in a patient with idiopathic dilated cardiomyopathy; renders cells partially insensitive to amino acid deprivation and result in activated mTORC1 signaling. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323609 mRNA Translation: AAG45221.1
AF272035 mRNA Translation: AAG32662.1
AL139260 Genomic DNA No translation available.
BC016668 mRNA Translation: AAH16668.1
AK023373 mRNA Translation: BAB14548.1 Different initiation.
CCDSiCCDS430.1
RefSeqiNP_001258780.1, NM_001271851.1
NP_071440.1, NM_022157.3
UniGeneiHs.532461

Genome annotation databases

EnsembliENST00000373001; ENSP00000362092; ENSG00000116954
GeneIDi64121
KEGGihsa:64121
UCSCiuc001ccq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323609 mRNA Translation: AAG45221.1
AF272035 mRNA Translation: AAG32662.1
AL139260 Genomic DNA No translation available.
BC016668 mRNA Translation: AAH16668.1
AK023373 mRNA Translation: BAB14548.1 Different initiation.
CCDSiCCDS430.1
RefSeqiNP_001258780.1, NM_001271851.1
NP_071440.1, NM_022157.3
UniGeneiHs.532461

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LLUX-ray1.40A60-237[»]
6CESelectron microscopy4.00C1-399[»]
6EHRX-ray2.90G239-399[»]
ProteinModelPortaliQ9HB90
SMRiQ9HB90
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122074, 28 interactors
DIPiDIP-37515N
IntActiQ9HB90, 19 interactors
STRINGi9606.ENSP00000362092

PTM databases

iPTMnetiQ9HB90
PhosphoSitePlusiQ9HB90

Polymorphism and mutation databases

DMDMi74752776

Proteomic databases

EPDiQ9HB90
MaxQBiQ9HB90
PaxDbiQ9HB90
PeptideAtlasiQ9HB90
PRIDEiQ9HB90
ProteomicsDBi81509

Protocols and materials databases

DNASUi64121
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373001; ENSP00000362092; ENSG00000116954
GeneIDi64121
KEGGihsa:64121
UCSCiuc001ccq.4 human

Organism-specific databases

CTDi64121
DisGeNETi64121
EuPathDBiHostDB:ENSG00000116954.7
GeneCardsiRRAGC
HGNCiHGNC:19902 RRAGC
HPAiHPA018247
HPA055489
MIMi608267 gene
neXtProtiNX_Q9HB90
OpenTargetsiENSG00000116954
PharmGKBiPA134862062
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3887 Eukaryota
ENOG410XQS9 LUCA
GeneTreeiENSGT00550000074708
HOGENOMiHOG000203695
HOVERGENiHBG059482
InParanoidiQ9HB90
KOiK16186
OMAiEMNFEVF
OrthoDBiEOG091G0AN4
PhylomeDBiQ9HB90
TreeFamiTF300659

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ9HB90

Miscellaneous databases

ChiTaRSiRRAGC human
EvolutionaryTraceiQ9HB90
GeneWikiiRRAGC
GenomeRNAii64121
PROiPR:Q9HB90
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116954 Expressed in 125 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_RRAGC
GenevisibleiQ9HB90 HS

Family and domain databases

CDDicd11385 RagC_like, 1 hit
InterProiView protein in InterPro
IPR006762 Gtr1_RagA
IPR027417 P-loop_NTPase
IPR039400 RagC/D
PANTHERiPTHR11259 PTHR11259, 1 hit
PfamiView protein in Pfam
PF04670 Gtr1_RagA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRAGC_HUMAN
AccessioniPrimary (citable) accession number: Q9HB90
Secondary accession number(s): Q9H202, Q9H8Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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