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Protein

Neuromedin-U receptor 1

Gene

NMUR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB
  • neuromedin U binding Source: UniProtKB
  • neuromedin U receptor activity Source: UniProtKB
  • neuropeptide receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ9HB89

Protein family/group databases

TCDBi9.A.14.1.13 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:NMUR1
Synonyms:GPR66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171596.6
HGNCiHGNC:4518 NMUR1
MIMi604153 gene
neXtProtiNX_Q9HB89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65ExtracellularSequence analysisAdd BLAST65
Transmembranei66 – 86Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini87 – 97CytoplasmicSequence analysisAdd BLAST11
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 138ExtracellularSequence analysisAdd BLAST20
Transmembranei139 – 161Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini162 – 181CytoplasmicSequence analysisAdd BLAST20
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 235ExtracellularSequence analysisAdd BLAST33
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 294CytoplasmicSequence analysisAdd BLAST38
Transmembranei295 – 315Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini316 – 338ExtracellularSequence analysisAdd BLAST23
Transmembranei339 – 359Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini360 – 426CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10316
OpenTargetsiENSG00000171596
PharmGKBiPA28910

Chemistry databases

ChEMBLiCHEMBL1075178
GuidetoPHARMACOLOGYi298

Polymorphism and mutation databases

BioMutaiNMUR1
DMDMi74761608

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699061 – 426Neuromedin-U receptor 1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HB89
PeptideAtlasiQ9HB89
PRIDEiQ9HB89
ProteomicsDBi81508

PTM databases

iPTMnetiQ9HB89
PhosphoSitePlusiQ9HB89

Expressioni

Tissue specificityi

Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.2 Publications

Gene expression databases

BgeeiENSG00000171596 Expressed in 83 organ(s), highest expression level in blood
CleanExiHS_NMUR1
GenevisibleiQ9HB89 HS

Organism-specific databases

HPAiHPA027895

Interactioni

Protein-protein interaction databases

BioGridi115600, 2 interactors
STRINGi9606.ENSP00000305877

Chemistry databases

BindingDBiQ9HB89

Structurei

3D structure databases

ProteinModelPortaliQ9HB89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ9HB89
KOiK05052
OMAiEMFKEVM
OrthoDBiEOG091G0ZDG
PhylomeDBiQ9HB89
TreeFamiTF318522

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005391 NeuromedU_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01566 NEUROMEDNU1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HB89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK
60 70 80 90 100
YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF
110 120 130 140 150
SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL
160 170 180 190 200
NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH
210 220 230 240 250
GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL
260 270 280 290 300
YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF
310 320 330 340 350
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA
360 370 380 390 400
ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD
410 420
VGSLGSWVHP LAGNDGPEAQ QETDPS
Length:426
Mass (Da):47,351
Last modified:March 1, 2001 - v1
Checksum:iF8DD781C020F04AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203R → Q in AAH36543 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272362 mRNA Translation: AAG24793.1
AC017104 Genomic DNA Translation: AAY24249.1
BC036543 mRNA Translation: AAH36543.1
BC051914 mRNA Translation: AAH51914.1
AF044601, AF044600 Genomic DNA Translation: AAC02680.1
CCDSiCCDS2486.1
RefSeqiNP_006047.3, NM_006056.4
XP_011508789.1, XM_011510487.2
UniGeneiHs.471619

Genome annotation databases

EnsembliENST00000305141; ENSP00000305877; ENSG00000171596
GeneIDi10316
KEGGihsa:10316
UCSCiuc002vry.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272362 mRNA Translation: AAG24793.1
AC017104 Genomic DNA Translation: AAY24249.1
BC036543 mRNA Translation: AAH36543.1
BC051914 mRNA Translation: AAH51914.1
AF044601, AF044600 Genomic DNA Translation: AAC02680.1
CCDSiCCDS2486.1
RefSeqiNP_006047.3, NM_006056.4
XP_011508789.1, XM_011510487.2
UniGeneiHs.471619

3D structure databases

ProteinModelPortaliQ9HB89
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115600, 2 interactors
STRINGi9606.ENSP00000305877

Chemistry databases

BindingDBiQ9HB89
ChEMBLiCHEMBL1075178
GuidetoPHARMACOLOGYi298

Protein family/group databases

TCDBi9.A.14.1.13 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ9HB89
PhosphoSitePlusiQ9HB89

Polymorphism and mutation databases

BioMutaiNMUR1
DMDMi74761608

Proteomic databases

PaxDbiQ9HB89
PeptideAtlasiQ9HB89
PRIDEiQ9HB89
ProteomicsDBi81508

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305141; ENSP00000305877; ENSG00000171596
GeneIDi10316
KEGGihsa:10316
UCSCiuc002vry.5 human

Organism-specific databases

CTDi10316
DisGeNETi10316
EuPathDBiHostDB:ENSG00000171596.6
GeneCardsiNMUR1
HGNCiHGNC:4518 NMUR1
HPAiHPA027895
MIMi604153 gene
neXtProtiNX_Q9HB89
OpenTargetsiENSG00000171596
PharmGKBiPA28910
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ9HB89
KOiK05052
OMAiEMFKEVM
OrthoDBiEOG091G0ZDG
PhylomeDBiQ9HB89
TreeFamiTF318522

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ9HB89

Miscellaneous databases

ChiTaRSiNMUR1 human
GeneWikiiNeuromedin_U_receptor_1
GenomeRNAii10316
PROiPR:Q9HB89
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171596 Expressed in 83 organ(s), highest expression level in blood
CleanExiHS_NMUR1
GenevisibleiQ9HB89 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005391 NeuromedU_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01566 NEUROMEDNU1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMUR1_HUMAN
AccessioniPrimary (citable) accession number: Q9HB89
Secondary accession number(s): O43664, Q7LDP6, Q8NE20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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