NMUR1

Functionⁱ

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-24 is the initiator.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity
Source: UniProtKB
Traceable author statementⁱ
- 10899166
neuromedin U binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10894543
- 11027493
neuromedin U receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
neuropeptide receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10811630

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of phospholipase C activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10899166
calcium ion transport
Source: UniProtKB
Inferred from direct assayⁱ
- 10899166
calcium-mediated signaling
Source: UniProtKB
Inferred from direct assayⁱ
chloride transport
Source: UniProtKB
Inferred from direct assayⁱ
- 10899166
G-protein coupled receptor signaling pathway Source: Reactome
inositol phosphate-mediated signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 10899166
neuropeptide signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 10899166
phospholipase C-activating G-protein coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10899166
smooth muscle contraction
Source: UniProtKB
Inferred from expression patternⁱ
- 10899166

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	Q9HB89

Protein family/group databases

TCDBⁱ

9.A.14.1.13 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuromedin-U receptor 1 Short name: NMU-R1 Alternative name(s): G-protein coupled receptor 66 G-protein coupled receptor FM-3
Gene namesⁱ	Name:NMUR1 Synonyms:GPR66
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171596.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4518 NMUR1
MIMⁱ	604153 gene
neXtProtⁱ	NX_Q9HB89

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 65	ExtracellularSequence analysisAdd BLAST	65
Transmembraneⁱ	66 – 86	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	87 – 97	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	98 – 118	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	119 – 138	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	139 – 161	Helical; Name=3Sequence analysisAdd BLAST	23
Topological domainⁱ	162 – 181	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	182 – 202	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	203 – 235	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	236 – 256	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	257 – 294	CytoplasmicSequence analysisAdd BLAST	38
Transmembraneⁱ	295 – 315	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	316 – 338	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	339 – 359	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	360 – 426	CytoplasmicSequence analysisAdd BLAST	67

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10316
Open Targets More...OpenTargetsⁱ	ENSG00000171596
PharmGKBⁱ	PA28910

Chemistry databases

ChEMBLⁱ	CHEMBL1075178
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	298

Polymorphism and mutation databases

BioMutaⁱ	NMUR1
DMDMⁱ	74761608

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069906	1 – 426	Neuromedin-U receptor 1Add BLAST		426

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	7	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	27	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	134 ↔ 219	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9HB89
PeptideAtlas More...PeptideAtlasⁱ	Q9HB89
PRIDEⁱ	Q9HB89
ProteomicsDBⁱ	81508

PTM databases

iPTMnetⁱ	Q9HB89
PhosphoSitePlusⁱ	Q9HB89

Expressionⁱ

Tissue specificityⁱ

Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000171596
CleanExⁱ	HS_NMUR1
Genevisibleⁱ	Q9HB89 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027895

HPAⁱ

HPA027895

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115600, 2 interactors
STRINGⁱ	9606.ENSP00000305877

Chemistry databases

BindingDBⁱ

Q9HB89

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9HB89
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104070
HOGENOMⁱ	HOG000113804
HOVERGENⁱ	HBG103506
InParanoidⁱ	Q9HB89
KEGG Orthology (KO) More...KOⁱ	K05052
OMAⁱ	HKAMRTP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZDG
PhylomeDBⁱ	Q9HB89
TreeFamⁱ	TF318522

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR005390 NeuromedU_rcpt IPR005391 NeuromedU_rcpt_1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01565 NEUROMEDINUR PR01566 NEUROMEDNU1R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9HB89-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK 
        60         70         80         90        100
YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF 
       110        120        130        140        150
SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL 
       160        170        180        190        200
NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH 
       210        220        230        240        250
GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL 
       260        270        280        290        300
YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF 
       310        320        330        340        350
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA 
       360        370        380        390        400
ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD 
       410        420 
VGSLGSWVHP LAGNDGPEAQ QETDPS

Length:426

Mass (Da):47,351

Last modified:March 1, 2001 - v1

Checksum:ⁱF8DD781C020F04AA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	203	R → Q in AAH36543 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF272362 mRNA Translation: AAG24793.1 AC017104 Genomic DNA Translation: AAY24249.1 BC036543 mRNA Translation: AAH36543.1 BC051914 mRNA Translation: AAH51914.1 AF044601, AF044600 Genomic DNA Translation: AAC02680.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2486.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006047.3, NM_006056.4 XP_011508789.1, XM_011510487.2
UniGeneⁱ	Hs.471619

Genome annotation databases

Ensemblⁱ	ENST00000305141; ENSP00000305877; ENSG00000171596
GeneIDⁱ	10316
KEGGⁱ	hsa:10316
UCSC genome browser More...UCSCⁱ	uc002vry.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9HB89	UPI0000050470		HUMAN		403
NMUR1 isoform 1		PANTR		426
Uncharacterized protein (Fragment)		MACMU		426
Neuromedin U receptor 1		COLAP		426
NMUR1 isoform 1		PONAB		426
+18

Protein	Similar proteins		Species	Score	Length
Q9HB89	UPI0000050470		HUMAN		403
Uncharacterized protein (Fragment)		MACFA		426
NMUR1 isoform 1		PONAB		426
Neuromedin U receptor 1		GORGO		426
Neuromedin U receptor 1		MANLE		426
+74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF272362 mRNA Translation: AAG24793.1 AC017104 Genomic DNA Translation: AAY24249.1 BC036543 mRNA Translation: AAH36543.1 BC051914 mRNA Translation: AAH51914.1 AF044601, AF044600 Genomic DNA Translation: AAC02680.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2486.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006047.3, NM_006056.4 XP_011508789.1, XM_011510487.2
UniGeneⁱ	Hs.471619

3D structure databases

ProteinModelPortalⁱ	Q9HB89
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115600, 2 interactors
STRINGⁱ	9606.ENSP00000305877

Chemistry databases

BindingDBⁱ	Q9HB89
ChEMBLⁱ	CHEMBL1075178
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	298

Protein family/group databases

TCDBⁱ	9.A.14.1.13 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q9HB89
PhosphoSitePlusⁱ	Q9HB89

Polymorphism and mutation databases

BioMutaⁱ	NMUR1
DMDMⁱ	74761608

Proteomic databases

PaxDbⁱ	Q9HB89
PeptideAtlas More...PeptideAtlasⁱ	Q9HB89
PRIDEⁱ	Q9HB89
ProteomicsDBⁱ	81508

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000305141; ENSP00000305877; ENSG00000171596
GeneIDⁱ	10316
KEGGⁱ	hsa:10316
UCSC genome browser More...UCSCⁱ	uc002vry.5 human

Organism-specific databases

CTDⁱ	10316
DisGeNET More...DisGeNETⁱ	10316
EuPathDBⁱ	HostDB:ENSG00000171596.6
GeneCardsⁱ	NMUR1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4518 NMUR1
Human Protein Atlas More...HPAⁱ	HPA027895
MIMⁱ	604153 gene
neXtProtⁱ	NX_Q9HB89
Open Targets More...OpenTargetsⁱ	ENSG00000171596
PharmGKBⁱ	PA28910
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104070
HOGENOMⁱ	HOG000113804
HOVERGENⁱ	HBG103506
InParanoidⁱ	Q9HB89
KEGG Orthology (KO) More...KOⁱ	K05052
OMAⁱ	HKAMRTP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZDG
PhylomeDBⁱ	Q9HB89
TreeFamⁱ	TF318522

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	Q9HB89

Miscellaneous databases

ChiTaRSⁱ	NMUR1 human
GeneWikiⁱ	Neuromedin_U_receptor_1
GenomeRNAiⁱ	10316
Protein Ontology More...PROⁱ	PR:Q9HB89
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171596
CleanExⁱ	HS_NMUR1
Genevisibleⁱ	Q9HB89 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR005390 NeuromedU_rcpt IPR005391 NeuromedU_rcpt_1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01565 NEUROMEDINUR PR01566 NEUROMEDNU1R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NMUR1_HUMAN
Accessionⁱ	Q9HB89Primary (citable) accession number: Q9HB89 Secondary accession number(s): O43664, Q7LDP6, Q8NE20
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	March 1, 2001
	Last modified:	June 20, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q9HB89 (NMUR1_HUMAN)

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Neuromedin-U receptor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ