UniProtKB - Q9HB89 (NMUR1_HUMAN)
Protein
Neuromedin-U receptor 1
Gene
NMUR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication
Caution
It is uncertain whether Met-1 or Met-24 is the initiator.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB
- neuromedin U binding Source: UniProtKB
- neuromedin U receptor activity Source: UniProtKB
- neuropeptide receptor activity Source: ProtInc
GO - Biological processi
- activation of phospholipase C activity Source: UniProtKB
- calcium ion transport Source: UniProtKB
- calcium-mediated signaling Source: UniProtKB
- chloride transport Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- inositol phosphate-mediated signaling Source: UniProtKB
- neuropeptide signaling pathway Source: UniProtKB
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- smooth muscle contraction Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9HB89 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q9HB89 |
Protein family/group databases
TCDBi | 9.A.14.1.13, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuromedin-U receptor 1Short name: NMU-R1 Alternative name(s): G-protein coupled receptor 66 G-protein coupled receptor FM-3 |
Gene namesi | Name:NMUR1 Synonyms:GPR66 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4518, NMUR1 |
MIMi | 604153, gene |
neXtProti | NX_Q9HB89 |
VEuPathDBi | HostDB:ENSG00000171596.6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 65 | ExtracellularSequence analysisAdd BLAST | 65 | |
Transmembranei | 66 – 86 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 97 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 98 – 118 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 138 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 139 – 161 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 162 – 181 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 182 – 202 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 235 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 236 – 256 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 294 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 295 – 315 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 316 – 338 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 339 – 359 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 360 – 426 | CytoplasmicSequence analysisAdd BLAST | 67 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10316 |
OpenTargetsi | ENSG00000171596 |
PharmGKBi | PA28910 |
Miscellaneous databases
Pharosi | Q9HB89, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1075178 |
GuidetoPHARMACOLOGYi | 298 |
Genetic variation databases
BioMutai | NMUR1 |
DMDMi | 74761608 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069906 | 1 – 426 | Neuromedin-U receptor 1Add BLAST | 426 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 27 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 134 ↔ 219 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9HB89 |
PRIDEi | Q9HB89 |
ProteomicsDBi | 81508 |
PTM databases
GlyGeni | Q9HB89, 3 sites |
iPTMneti | Q9HB89 |
PhosphoSitePlusi | Q9HB89 |
Expressioni
Tissue specificityi
Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.2 Publications
Gene expression databases
Bgeei | ENSG00000171596, Expressed in granulocyte and 99 other tissues |
Genevisiblei | Q9HB89, HS |
Organism-specific databases
HPAi | ENSG00000171596, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115600, 2 interactors |
STRINGi | 9606.ENSP00000305877 |
Chemistry databases
BindingDBi | Q9HB89 |
Miscellaneous databases
RNActi | Q9HB89, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222265 |
HOGENOMi | CLU_009579_6_5_1 |
InParanoidi | Q9HB89 |
OMAi | QYVHIIS |
OrthoDBi | 890529at2759 |
PhylomeDBi | Q9HB89 |
TreeFami | TF318522 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR005390, NeuromedU_rcpt IPR005391, NeuromedU_rcpt_1 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01565, NEUROMEDINUR PR01566, NEUROMEDNU1R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HB89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPLCLNCSV LPGDLYPGGA RNPMACNGSA ARGHFDPEDL NLTDEALRLK
60 70 80 90 100
YLGPQQTELF MPICATYLLI FVVGAVGNGL TCLVILRHKA MRTPTNYYLF
110 120 130 140 150
SLAVSDLLVL LVGLPLELYE MWHNYPFLLG VGGCYFRTLL FEMVCLASVL
160 170 180 190 200
NVTALSVERY VAVVHPLQAR SMVTRAHVRR VLGAVWGLAM LCSLPNTSLH
210 220 230 240 250
GIRQLHVPCR GPVPDSAVCM LVRPRALYNM VVQTTALLFF CLPMAIMSVL
260 270 280 290 300
YLLIGLRLRR ERLLLMQEAK GRGSAAARSR YTCRLQQHDR GRRQVTKMLF
310 320 330 340 350
VLVVVFGICW APFHADRVMW SVVSQWTDGL HLAFQHVHVI SGIFFYLGSA
360 370 380 390 400
ANPVLYSLMS SRFRETFQEA LCLGACCHRL RPRHSSHSLS RMTTGSTLCD
410 420
VGSLGSWVHP LAGNDGPEAQ QETDPS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 203 | R → Q in AAH36543 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272362 mRNA Translation: AAG24793.1 AC017104 Genomic DNA Translation: AAY24249.1 BC036543 mRNA Translation: AAH36543.1 BC051914 mRNA Translation: AAH51914.1 AF044601, AF044600 Genomic DNA Translation: AAC02680.1 |
CCDSi | CCDS2486.1 |
RefSeqi | NP_006047.3, NM_006056.4 XP_011508789.1, XM_011510487.2 |
Genome annotation databases
Ensembli | ENST00000305141; ENSP00000305877; ENSG00000171596 |
GeneIDi | 10316 |
KEGGi | hsa:10316 |
UCSCi | uc002vry.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272362 mRNA Translation: AAG24793.1 AC017104 Genomic DNA Translation: AAY24249.1 BC036543 mRNA Translation: AAH36543.1 BC051914 mRNA Translation: AAH51914.1 AF044601, AF044600 Genomic DNA Translation: AAC02680.1 |
CCDSi | CCDS2486.1 |
RefSeqi | NP_006047.3, NM_006056.4 XP_011508789.1, XM_011510487.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115600, 2 interactors |
STRINGi | 9606.ENSP00000305877 |
Chemistry databases
BindingDBi | Q9HB89 |
ChEMBLi | CHEMBL1075178 |
GuidetoPHARMACOLOGYi | 298 |
Protein family/group databases
TCDBi | 9.A.14.1.13, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9HB89, 3 sites |
iPTMneti | Q9HB89 |
PhosphoSitePlusi | Q9HB89 |
Genetic variation databases
BioMutai | NMUR1 |
DMDMi | 74761608 |
Proteomic databases
PaxDbi | Q9HB89 |
PRIDEi | Q9HB89 |
ProteomicsDBi | 81508 |
Protocols and materials databases
Antibodypediai | 20210, 209 antibodies |
Genome annotation databases
Ensembli | ENST00000305141; ENSP00000305877; ENSG00000171596 |
GeneIDi | 10316 |
KEGGi | hsa:10316 |
UCSCi | uc002vry.5, human |
Organism-specific databases
CTDi | 10316 |
DisGeNETi | 10316 |
GeneCardsi | NMUR1 |
HGNCi | HGNC:4518, NMUR1 |
HPAi | ENSG00000171596, Low tissue specificity |
MIMi | 604153, gene |
neXtProti | NX_Q9HB89 |
OpenTargetsi | ENSG00000171596 |
PharmGKBi | PA28910 |
VEuPathDBi | HostDB:ENSG00000171596.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222265 |
HOGENOMi | CLU_009579_6_5_1 |
InParanoidi | Q9HB89 |
OMAi | QYVHIIS |
OrthoDBi | 890529at2759 |
PhylomeDBi | Q9HB89 |
TreeFami | TF318522 |
Enzyme and pathway databases
PathwayCommonsi | Q9HB89 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q9HB89 |
Miscellaneous databases
BioGRID-ORCSi | 10316, 4 hits in 870 CRISPR screens |
ChiTaRSi | NMUR1, human |
GeneWikii | Neuromedin_U_receptor_1 |
GenomeRNAii | 10316 |
Pharosi | Q9HB89, Tchem |
PROi | PR:Q9HB89 |
RNActi | Q9HB89, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171596, Expressed in granulocyte and 99 other tissues |
Genevisiblei | Q9HB89, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR005390, NeuromedU_rcpt IPR005391, NeuromedU_rcpt_1 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01565, NEUROMEDINUR PR01566, NEUROMEDNU1R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NMUR1_HUMAN | |
Accessioni | Q9HB89Primary (citable) accession number: Q9HB89 Secondary accession number(s): O43664, Q7LDP6, Q8NE20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families