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Protein

Calcyclin-binding protein

Gene

CACYBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).1 Publication

GO - Molecular functioni

GO - Biological processi

  • heart development Source: GO_Central

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyclin-binding protein
Short name:
CacyBP
Short name:
hCacyBP
Alternative name(s):
S100A6-binding protein
Siah-interacting protein
Gene namesi
Name:CACYBP
Synonyms:S100A6BP, SIP
ORF Names:PNAS-107
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116161.17
HGNCiHGNC:30423 CACYBP
MIMi606186 gene
neXtProtiNX_Q9HB71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23 – 26KRVR → AAVA: Abolishes interaction with SIAH1. 1 Publication4
Mutagenesisi64V → N: Abolishes interaction with SIAH1; when associated with N-66. 1 Publication1
Mutagenesisi66P → N: Abolishes interaction with SIAH1; when associated with N-64. 1 Publication1

Organism-specific databases

DisGeNETi27101
OpenTargetsiENSG00000116161
PharmGKBiPA134894213

Polymorphism and mutation databases

BioMutaiCACYBP
DMDMi46576651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001853892 – 228Calcyclin-binding proteinAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei3PhosphoserineCombined sources1
Modified residuei8N6-acetyllysineCombined sources1
Modified residuei19N6-acetyllysineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei85N6-acetyllysineCombined sources1
Modified residuei118N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HB71
MaxQBiQ9HB71
PaxDbiQ9HB71
PeptideAtlasiQ9HB71
PRIDEiQ9HB71
ProteomicsDBi81499
81500 [Q9HB71-2]
TopDownProteomicsiQ9HB71-1 [Q9HB71-1]

2D gel databases

UCD-2DPAGEiQ9HB71

PTM databases

iPTMnetiQ9HB71
PhosphoSitePlusiQ9HB71
SwissPalmiQ9HB71

Expressioni

Gene expression databases

BgeeiENSG00000116161 Expressed in 236 organ(s), highest expression level in frontal cortex
CleanExiHS_CACYBP
ExpressionAtlasiQ9HB71 baseline and differential
GenevisibleiQ9HB71 HS

Organism-specific databases

HPAiHPA025753
HPA057038

Interactioni

Subunit structurei

Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118001, 67 interactors
CORUMiQ9HB71
ELMiQ9HB71
IntActiQ9HB71, 95 interactors
MINTiQ9HB71
STRINGi9606.ENSP00000356652

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00907
ProteinModelPortaliQ9HB71
SMRiQ9HB71
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HB71

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 167CSPROSITE-ProRule annotationAdd BLAST95
Domaini168 – 228SGSPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 80Interaction with SIAH1Add BLAST79
Regioni73 – 228Interaction with SKP11 PublicationAdd BLAST156
Regioni154 – 228Interaction with S100A6By similarityAdd BLAST75

Phylogenomic databases

eggNOGiKOG3260 Eukaryota
ENOG410XSB6 LUCA
GeneTreeiENSGT00390000016470
HOGENOMiHOG000238284
HOVERGENiHBG003242
InParanoidiQ9HB71
KOiK04507
OMAiWDVLTSI
OrthoDBiEOG091G0LQC
PhylomeDBiQ9HB71
TreeFamiTF323891

Family and domain databases

CDDicd06468 p23_CacyBP, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR037201 CacyBP_N
IPR037893 CS_CacyBP
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR015120 Siah-Interact_N
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF09032 Siah-Interact_N, 1 hit
SUPFAMiSSF140106 SSF140106, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HB71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK
60 70 80 90 100
KAELLDNEKP AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP
110 120 130 140 150
TENVQVHFTE RSFDLLVKNL NGKSYSMIVN NLLKPISVEG SSKKVKTDTV
160 170 180 190 200
LILCRKKVEN TRWDYLTQVE KECKEKEKPS YDTETDPSEG LMNVLKKIYE
210 220
DGDDDMKRTI NKAWVESREK QAKGDTEF
Length:228
Mass (Da):26,210
Last modified:April 26, 2004 - v2
Checksum:i88C822FB14A7EF89
GO
Isoform 2 (identifier: Q9HB71-2) [UniParc]FASTAAdd to basket
Also known as: SIP-S, S

The sequence of this isoform differs from the canonical sequence as follows:
     73-80: VKISNYGW → DGISQISL
     81-228: Missing.

Show »
Length:80
Mass (Da):8,956
Checksum:i13A2FAC2429FA9FD
GO
Isoform 3 (identifier: Q9HB71-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):21,228
Checksum:i99286837B26B2395
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2ZWH1B2ZWH1_HUMAN
Calcyclin-binding protein
CACYBP
50Annotation score:

Sequence cautioni

The sequence AAG23817 differs from that shown. Reason: Frameshift at position 203.Curated
The sequence BAG52713 differs from that shown. Reason: Frameshift at position 3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44M → V in AAG23817 (Ref. 4) Curated1
Sequence conflicti177E → K in AAG23817 (Ref. 4) Curated1
Sequence conflicti183T → P in AAG23817 (Ref. 4) Curated1
Sequence conflicti226T → P in AAG23817 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468621 – 43Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_01017173 – 80VKISNYGW → DGISQISL in isoform 2. Curated8
Alternative sequenceiVSP_01017281 – 228Missing in isoform 2. CuratedAdd BLAST148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057356 mRNA Translation: AAC21458.1
AF314752 mRNA Translation: AAG34170.1
AL035305 mRNA Translation: CAA22910.1
AF275803 mRNA Translation: AAG23817.1 Frameshift.
AY423723 mRNA Translation: AAS00486.1
AK093425 mRNA Translation: BAG52713.1 Frameshift.
AK313278 mRNA Translation: BAG36086.1
Z99127 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90982.1
BC005975 mRNA Translation: AAH05975.1
BC022352 mRNA Translation: AAH22352.1
BC078151 mRNA Translation: AAH78151.1
CCDSiCCDS1315.1 [Q9HB71-1]
CCDS30942.1 [Q9HB71-3]
RefSeqiNP_001007215.1, NM_001007214.1 [Q9HB71-3]
NP_055227.1, NM_014412.2 [Q9HB71-1]
XP_016856535.1, XM_017001046.1 [Q9HB71-3]
UniGeneiHs.508524

Genome annotation databases

EnsembliENST00000367679; ENSP00000356652; ENSG00000116161 [Q9HB71-1]
ENST00000405362; ENSP00000385771; ENSG00000116161 [Q9HB71-3]
ENST00000406752; ENSP00000384139; ENSG00000116161 [Q9HB71-2]
ENST00000613570; ENSP00000479414; ENSG00000116161 [Q9HB71-3]
GeneIDi27101
KEGGihsa:27101
UCSCiuc001gki.2 human [Q9HB71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057356 mRNA Translation: AAC21458.1
AF314752 mRNA Translation: AAG34170.1
AL035305 mRNA Translation: CAA22910.1
AF275803 mRNA Translation: AAG23817.1 Frameshift.
AY423723 mRNA Translation: AAS00486.1
AK093425 mRNA Translation: BAG52713.1 Frameshift.
AK313278 mRNA Translation: BAG36086.1
Z99127 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90982.1
BC005975 mRNA Translation: AAH05975.1
BC022352 mRNA Translation: AAH22352.1
BC078151 mRNA Translation: AAH78151.1
CCDSiCCDS1315.1 [Q9HB71-1]
CCDS30942.1 [Q9HB71-3]
RefSeqiNP_001007215.1, NM_001007214.1 [Q9HB71-3]
NP_055227.1, NM_014412.2 [Q9HB71-1]
XP_016856535.1, XM_017001046.1 [Q9HB71-3]
UniGeneiHs.508524

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5MNMR-A63-176[»]
2A25X-ray2.20B58-70[»]
2A26X-ray1.20A/B/C1-47[»]
DisProtiDP00907
ProteinModelPortaliQ9HB71
SMRiQ9HB71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118001, 67 interactors
CORUMiQ9HB71
ELMiQ9HB71
IntActiQ9HB71, 95 interactors
MINTiQ9HB71
STRINGi9606.ENSP00000356652

PTM databases

iPTMnetiQ9HB71
PhosphoSitePlusiQ9HB71
SwissPalmiQ9HB71

Polymorphism and mutation databases

BioMutaiCACYBP
DMDMi46576651

2D gel databases

UCD-2DPAGEiQ9HB71

Proteomic databases

EPDiQ9HB71
MaxQBiQ9HB71
PaxDbiQ9HB71
PeptideAtlasiQ9HB71
PRIDEiQ9HB71
ProteomicsDBi81499
81500 [Q9HB71-2]
TopDownProteomicsiQ9HB71-1 [Q9HB71-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367679; ENSP00000356652; ENSG00000116161 [Q9HB71-1]
ENST00000405362; ENSP00000385771; ENSG00000116161 [Q9HB71-3]
ENST00000406752; ENSP00000384139; ENSG00000116161 [Q9HB71-2]
ENST00000613570; ENSP00000479414; ENSG00000116161 [Q9HB71-3]
GeneIDi27101
KEGGihsa:27101
UCSCiuc001gki.2 human [Q9HB71-1]

Organism-specific databases

CTDi27101
DisGeNETi27101
EuPathDBiHostDB:ENSG00000116161.17
GeneCardsiCACYBP
HGNCiHGNC:30423 CACYBP
HPAiHPA025753
HPA057038
MIMi606186 gene
neXtProtiNX_Q9HB71
OpenTargetsiENSG00000116161
PharmGKBiPA134894213
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3260 Eukaryota
ENOG410XSB6 LUCA
GeneTreeiENSGT00390000016470
HOGENOMiHOG000238284
HOVERGENiHBG003242
InParanoidiQ9HB71
KOiK04507
OMAiWDVLTSI
OrthoDBiEOG091G0LQC
PhylomeDBiQ9HB71
TreeFamiTF323891

Miscellaneous databases

ChiTaRSiCACYBP human
EvolutionaryTraceiQ9HB71
GeneWikiiCACYBP
GenomeRNAii27101
PROiPR:Q9HB71
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116161 Expressed in 236 organ(s), highest expression level in frontal cortex
CleanExiHS_CACYBP
ExpressionAtlasiQ9HB71 baseline and differential
GenevisibleiQ9HB71 HS

Family and domain databases

CDDicd06468 p23_CacyBP, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR037201 CacyBP_N
IPR037893 CS_CacyBP
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR015120 Siah-Interact_N
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
PF09032 Siah-Interact_N, 1 hit
SUPFAMiSSF140106 SSF140106, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYBP_HUMAN
AccessioniPrimary (citable) accession number: Q9HB71
Secondary accession number(s): B2ZWH2
, B3KSF1, O60666, Q5R370, Q5R371
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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