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Entry version 163 (02 Jun 2021)
Sequence version 2 (27 Sep 2005)
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Protein

Netrin-4

Gene

NTN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HB63

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-373752, Netrin-1 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HB63

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin-4
Alternative name(s):
Beta-netrin
Hepar-derived netrin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13658, NTN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610401, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HB63

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000074527.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
59277

Open Targets

More...
OpenTargetsi
ENSG00000074527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31815

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HB63, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NTN4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
76789662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004211619 – 628Netrin-4Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi262 ↔ 271By similarity
Disulfide bondi264 ↔ 293By similarity
Disulfide bondi295 ↔ 304By similarity
Disulfide bondi307 ↔ 329By similarity
Disulfide bondi332 ↔ 341By similarity
Disulfide bondi334 ↔ 359By similarity
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi374 ↔ 392By similarity
Disulfide bondi395 ↔ 413By similarity
Disulfide bondi397 ↔ 420By similarity
Disulfide bondi422 ↔ 431By similarity
Disulfide bondi434 ↔ 446By similarity
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi506 ↔ 576By similarity
Disulfide bondi520 ↔ 627By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HB63

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HB63

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HB63

PeptideAtlas

More...
PeptideAtlasi
Q9HB63

PRoteomics IDEntifications database

More...
PRIDEi
Q9HB63

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81495 [Q9HB63-1]
81496 [Q9HB63-2]
81497 [Q9HB63-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9HB63, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HB63

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HB63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074527, Expressed in layer of synovial tissue and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HB63, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HB63, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000074527, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121866, 20 interactors

Database of interacting proteins

More...
DIPi
DIP-46274N

Protein interaction database and analysis system

More...
IntActi
Q9HB63, 20 interactors

Molecular INTeraction database

More...
MINTi
Q9HB63

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HB63, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HB63

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 261Laminin N-terminalPROSITE-ProRule annotationAdd BLAST232
Domaini262 – 331Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST70
Domaini332 – 394Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini395 – 448Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST54
Domaini506 – 627NTRPROSITE-ProRule annotationAdd BLAST122

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156615

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016961_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HB63

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVCNNCQ

Database of Orthologous Groups

More...
OrthoDBi
236390at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HB63

TreeFam database of animal gene trees

More...
TreeFami
TF352481

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03578, NTR_netrin-4_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002049, Laminin_EGF
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR035811, Netrin-4_NTR
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS01248, EGF_LAM_1, 2 hits
PS50027, EGF_LAM_2, 3 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HB63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSCARLLLL WGCTVVAAGL SGVAGVSSRC EKACNPRMGN LALGRKLWAD
60 70 80 90 100
TTCGQNATEL YCFYSENTDL TCRQPKCDKC NAAYPHLAHL PSAMADSSFR
110 120 130 140 150
FPRTWWQSAE DVHREKIQLD LEAEFYFTHL IVMFKSPRPA AMVLDRSQDF
160 170 180 190 200
GKTWKPYKYF ATNCSATFGL EDDVVKKGAI CTSKYSSPFP CTGGEVIFKA
210 220 230 240 250
LSPPYDTENP YSAKVQEQLK ITNLRVQLLK RQSCPCQRND LNEEPQHFTH
260 270 280 290 300
YAIYDFIVKG SCFCNGHADQ CIPVHGFRPV KAPGTFHMVH GKCMCKHNTA
310 320 330 340 350
GSHCQHCAPL YNDRPWEAAD GKTGAPNECR TCKCNGHADT CHFDVNVWEA
360 370 380 390 400
SGNRSGGVCD DCQHNTEGQY CQRCKPGFYR DLRRPFSAPD ACKPCSCHPV
410 420 430 440 450
GSAVLPANSV TFCDPSNGDC PCKPGVAGRR CDRCMVGYWG FGDYGCRPCD
460 470 480 490 500
CAGSCDPITG DCISSHTDID WYHEVPDFRP VHNKSEPAWE WEDAQGFSAL
510 520 530 540 550
LHSGKCECKE QTLGNAKAFC GMKYSYVLKI KILSAHDKGT HVEVNVKIKK
560 570 580 590 600
VLKSTKLKIF RGKRTLYPES WTDRGCTCPI LNPGLEYLVA GHEDIRTGKL
610 620
IVNMKSFVQH WKPSLGRKVM DILKRECK
Length:628
Mass (Da):70,071
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i275613B63A39B267
GO
Isoform 2 (identifier: Q9HB63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-526: Missing.

Show »
Length:605
Mass (Da):67,529
Checksum:iD9FB51CC6553CF5C
GO
Isoform 3 (identifier: Q9HB63-3) [UniParc]FASTAAdd to basket
Also known as: Hetrin

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Show »
Length:591
Mass (Da):66,352
Checksum:i912F3BA3726722A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6I8PS14A0A6I8PS14_HUMAN
Netrin-4
NTN4
624Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0I7F8W0I7_HUMAN
Netrin-4
NTN4
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68T → K in AAG30822 (PubMed:11038171).Curated1
Sequence conflicti161A → G in AAF69670 (Ref. 3) Curated1
Sequence conflicti222T → I in AAP92113 (Ref. 4) Curated1
Sequence conflicti331T → A (PubMed:11038171).Curated1
Sequence conflicti331T → A (Ref. 4) Curated1
Sequence conflicti462C → R in AAP92113 (Ref. 4) Curated1
Sequence conflicti472Y → C in AAG30822 (PubMed:11038171).Curated1
Sequence conflicti472Y → H in AAP92113 (Ref. 4) Curated1
Sequence conflicti545N → S in AAP92113 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023548205Y → H. Corresponds to variant dbSNP:rs17288108Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157451 – 37Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_015746504 – 526Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF278532 mRNA Translation: AAG30822.1
AF297711 mRNA Translation: AAG53651.1
AF119916 mRNA Translation: AAF69670.2
AY330211 mRNA Translation: AAP92113.1
AL137540 mRNA Translation: CAB70800.3
CH471054 Genomic DNA Translation: EAW97544.1
BC013591 mRNA Translation: AAH13591.2
BC136798 mRNA Translation: AAI36799.1
BC136799 mRNA Translation: AAI36800.1
AL833767 mRNA Translation: CAH56243.1
AK024691 mRNA Translation: BAB14964.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS86324.1 [Q9HB63-3]
CCDS86325.1 [Q9HB63-2]
CCDS9054.1 [Q9HB63-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46383

NCBI Reference Sequences

More...
RefSeqi
NP_001316629.1, NM_001329700.1 [Q9HB63-2]
NP_001316630.1, NM_001329701.1 [Q9HB63-3]
NP_001316631.1, NM_001329702.1 [Q9HB63-3]
NP_067052.2, NM_021229.3 [Q9HB63-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343702; ENSP00000340998; ENSG00000074527 [Q9HB63-1]
ENST00000344911; ENSP00000339436; ENSG00000074527 [Q9HB63-3]
ENST00000538383; ENSP00000444432; ENSG00000074527 [Q9HB63-3]
ENST00000553059; ENSP00000447292; ENSG00000074527 [Q9HB63-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
59277

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:59277

UCSC genome browser

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UCSCi
uc001tei.3, human [Q9HB63-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278532 mRNA Translation: AAG30822.1
AF297711 mRNA Translation: AAG53651.1
AF119916 mRNA Translation: AAF69670.2
AY330211 mRNA Translation: AAP92113.1
AL137540 mRNA Translation: CAB70800.3
CH471054 Genomic DNA Translation: EAW97544.1
BC013591 mRNA Translation: AAH13591.2
BC136798 mRNA Translation: AAI36799.1
BC136799 mRNA Translation: AAI36800.1
AL833767 mRNA Translation: CAH56243.1
AK024691 mRNA Translation: BAB14964.1
CCDSiCCDS86324.1 [Q9HB63-3]
CCDS86325.1 [Q9HB63-2]
CCDS9054.1 [Q9HB63-1]
PIRiT46383
RefSeqiNP_001316629.1, NM_001329700.1 [Q9HB63-2]
NP_001316630.1, NM_001329701.1 [Q9HB63-3]
NP_001316631.1, NM_001329702.1 [Q9HB63-3]
NP_067052.2, NM_021229.3 [Q9HB63-1]

3D structure databases

SMRiQ9HB63
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121866, 20 interactors
DIPiDIP-46274N
IntActiQ9HB63, 20 interactors
MINTiQ9HB63
STRINGi9606.ENSP00000340998

PTM databases

GlyGeniQ9HB63, 4 sites
iPTMnetiQ9HB63
PhosphoSitePlusiQ9HB63

Genetic variation databases

BioMutaiNTN4
DMDMi76789662

Proteomic databases

MassIVEiQ9HB63
MaxQBiQ9HB63
PaxDbiQ9HB63
PeptideAtlasiQ9HB63
PRIDEiQ9HB63
ProteomicsDBi81495 [Q9HB63-1]
81496 [Q9HB63-2]
81497 [Q9HB63-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30131, 203 antibodies

The DNASU plasmid repository

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DNASUi
59277

Genome annotation databases

EnsembliENST00000343702; ENSP00000340998; ENSG00000074527 [Q9HB63-1]
ENST00000344911; ENSP00000339436; ENSG00000074527 [Q9HB63-3]
ENST00000538383; ENSP00000444432; ENSG00000074527 [Q9HB63-3]
ENST00000553059; ENSP00000447292; ENSG00000074527 [Q9HB63-2]
GeneIDi59277
KEGGihsa:59277
UCSCiuc001tei.3, human [Q9HB63-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
59277
DisGeNETi59277

GeneCards: human genes, protein and diseases

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GeneCardsi
NTN4
HGNCiHGNC:13658, NTN4
HPAiENSG00000074527, Tissue enhanced (lymphoid)
MIMi610401, gene
neXtProtiNX_Q9HB63
OpenTargetsiENSG00000074527
PharmGKBiPA31815
VEuPathDBiHostDB:ENSG00000074527.11

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0994, Eukaryota
GeneTreeiENSGT00940000156615
HOGENOMiCLU_016961_2_1_1
InParanoidiQ9HB63
OMAiGVCNNCQ
OrthoDBi236390at2759
PhylomeDBiQ9HB63
TreeFamiTF352481

Enzyme and pathway databases

PathwayCommonsiQ9HB63
ReactomeiR-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-373752, Netrin-1 signaling
SIGNORiQ9HB63

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
59277, 6 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NTN4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
59277
PharosiQ9HB63, Tbio

Protein Ontology

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PROi
PR:Q9HB63
RNActiQ9HB63, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074527, Expressed in layer of synovial tissue and 211 other tissues
ExpressionAtlasiQ9HB63, baseline and differential
GenevisibleiQ9HB63, HS

Family and domain databases

CDDicd03578, NTR_netrin-4_like, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR002049, Laminin_EGF
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR035811, Netrin-4_NTR
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit
SUPFAMiSSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS01248, EGF_LAM_1, 2 hits
PS50027, EGF_LAM_2, 3 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNET4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HB63
Secondary accession number(s): B2RNC2
, Q658K9, Q7L3F1, Q7L9D6, Q7Z5B6, Q9BZP1, Q9NT44, Q9P133
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: June 2, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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