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Entry version 175 (08 May 2019)
Sequence version 5 (30 Nov 2010)
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Protein

Sp110 nuclear body protein

Gene

SP110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri534 – 580PHD-typePROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sp110 nuclear body protein
Alternative name(s):
Interferon-induced protein 41/75
Speckled 110 kDa
Transcriptional coactivator Sp110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SP110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5401 SP110

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604457 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HB58

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hepatic venoocclusive disease with immunodeficiency (VODI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
3431

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SP110

MalaCards human disease database

More...
MalaCardsi
SP110
MIMi235550 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135899

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79124 Hepatic veno-occlusive disease-immunodeficiency syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35104

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SP110

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000741011 – 689Sp110 nuclear body proteinAdd BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei175PhosphoserineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (isoform 2).

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HB58

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HB58

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HB58

PeptideAtlas

More...
PeptideAtlasi
Q9HB58

PRoteomics IDEntifications database

More...
PRIDEi
Q9HB58

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81489
81490 [Q9HB58-2]
81491 [Q9HB58-3]
81492 [Q9HB58-4]
81493 [Q9HB58-5]
81494 [Q9HB58-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HB58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HB58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma and all-trans retinoic acid (ATRA).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135899 Expressed in 193 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HB58 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HB58 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047036
HPA058554

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Isoform 3 interacts with HCV core protein.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109657, 23 interactors

Protein interaction database and analysis system

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IntActi
Q9HB58, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9HB58

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258381

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HB58

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 108HSRPROSITE-ProRule annotationAdd BLAST108
Domaini454 – 535SANDPROSITE-ProRule annotationAdd BLAST82
Domaini581 – 676BromoAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni525 – 529Nuclear hormone receptor interactionSequence analysis5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi281 – 294Nuclear localization signalSequence analysisAdd BLAST14
Motifi428 – 444Nuclear localization signalSequence analysisAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri534 – 580PHD-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Bromodomain, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177 Eukaryota
ENOG4111G04 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155124

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000089984

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HB58

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCRMKRS

Database of Orthologous Groups

More...
OrthoDBi
377499at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HB58

TreeFam database of animal gene trees

More...
TreeFami
TF335091

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR004865 HSR_dom
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03172 HSR, 1 hit
PF01342 SAND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00258 SAND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
SSF63763 SSF63763, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51414 HSR, 1 hit
PS50864 SAND, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HB58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME
60 70 80 90 100
SLEACRNLIP VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY
110 120 130 140 150
RSFKRVGASY EWQSRDTPIL LEAPTGLAEG SSLHTPLALP PPQPPQPSCS
160 170 180 190 200
PCAPRVSEPG TSSQQSDEIL SESPSPSDPV LPLPALIQEG RSTSVTNDKL
210 220 230 240 250
TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE MPHSPLGSMP
260 270 280 290 300
EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG
310 320 330 340 350
TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE
360 370 380 390 400
IIDGTSEMNE GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD
410 420 430 440 450
DSTWNSEVMM RVQKARTKCA RKSRLKEKKK EKDICSSSKR RFQKNIHRRG
460 470 480 490 500
KPKSDTVDFH CSKLPVTCGE AKGILYKKKM KHGSSVKCIR NEDGTWLTPN
510 520 530 540 550
EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC CQGGQLLCCG
560 570 580 590 600
TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ
610 620 630 640 650
PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF
660 670 680
YKASDFGQVG LDLEAEFEKD LKDVLGFHEA NDGGFWTLP
Length:689
Mass (Da):78,396
Last modified:November 30, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31552E1A4C498EF7
GO
Isoform 2 (identifier: Q9HB58-2) [UniParc]FASTAAdd to basket
Also known as: IFI75, 75

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     606-611: IRDYGE → NVSSSS
     612-689: Missing.

Show »
Length:408
Mass (Da):46,285
Checksum:iC9AFB49FD426F9F5
GO
Isoform 3 (identifier: Q9HB58-3) [UniParc]FASTAAdd to basket
Also known as: Sp110b

The sequence of this isoform differs from the canonical sequence as follows:
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Show »
Length:549
Mass (Da):61,898
Checksum:iA074ED9825817FC3
GO
Isoform 4 (identifier: Q9HB58-4) [UniParc]FASTAAdd to basket
Also known as: IFI41, 41

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
     252-275: IRDNSPEPNDPEEPQEVSSTPSDK → MASSGVKNTPRWRRKAPHGRERKE
     300-349: Missing.
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Show »
Length:248
Mass (Da):28,510
Checksum:i54B0C13AA73E51E1
GO
Isoform 5 (identifier: Q9HB58-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-303: GTAS → AL
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Show »
Length:547
Mass (Da):61,766
Checksum:iFA0D7C52A2025D87
GO
Isoform 6 (identifier: Q9HB58-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     605-605: L → LKCEFLLLKAYCHPQSSFFTGIPFN

Show »
Length:713
Mass (Da):81,169
Checksum:i146D7A3D0EEB99EA
GO
Isoform 7 (identifier: Q9HB58-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRGFRM
     531-549: RKNSDECEVCCQGGQLLCC → SGLLLCPPRINLKRELNSK
     550-689: Missing.

Note: No experimental confirmation available.
Show »
Length:555
Mass (Da):62,603
Checksum:i44866BA4C9BBA7D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9C0G5E9C0_HUMAN
SP110 nuclear body protein, isoform...
SP110 hCG_32956
547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZQ4C9JZQ4_HUMAN
Sp110 nuclear body protein
SP110
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EM70E7EM70_HUMAN
Sp110 nuclear body protein
SP110
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF99318 differs from that shown. Reason: Frameshift at several positions.Curated
Isoform 3 : The sequence AAF99318 differs from that shown. Reason: Frameshift at position 534.Curated
The sequence AAG09826 differs from that shown. Reason: Frameshift at positions 141 and 143.Curated
The sequence AK026488 differs from that shown. Reason: Frameshift at positions 296, 542 and 567.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167D → T in AAF99318 (PubMed:10913195).Curated1
Sequence conflicti167D → T in AAG09826 (PubMed:10913195).Curated1
Sequence conflicti464L → S in AAA18806 (PubMed:7693701).Curated1
Sequence conflicti570M → I in AK026488 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0360298M → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200067258Ensembl.1
Natural variantiVAR_027170112W → R2 PublicationsCorresponds to variant dbSNP:rs1129411Ensembl.1
Natural variantiVAR_027171128A → V1 PublicationCorresponds to variant dbSNP:rs11556887EnsemblClinVar.1
Natural variantiVAR_047051173S → L. Corresponds to variant dbSNP:rs41552315Ensembl.1
Natural variantiVAR_027172206A → V1 PublicationCorresponds to variant dbSNP:rs28930679EnsemblClinVar.1
Natural variantiVAR_027173207E → K3 PublicationsCorresponds to variant dbSNP:rs9061EnsemblClinVar.1
Natural variantiVAR_047052210S → A. Corresponds to variant dbSNP:rs1063154Ensembl.1
Natural variantiVAR_027174212E → G1 PublicationCorresponds to variant dbSNP:rs1047254Ensembl.1
Natural variantiVAR_027175249M → V1 PublicationCorresponds to variant dbSNP:rs3769838Ensembl.1
Natural variantiVAR_027176267E → G1 PublicationCorresponds to variant dbSNP:rs1129425Ensembl.1
Natural variantiVAR_027177299G → R6 PublicationsCorresponds to variant dbSNP:rs1365776EnsemblClinVar.1
Natural variantiVAR_027178367T → M1 PublicationCorresponds to variant dbSNP:rs59573011EnsemblClinVar.1
Natural variantiVAR_027179425L → S Polymorphism; may be associated with increased susceptibility to tuberculosis. 3 PublicationsCorresponds to variant dbSNP:rs3948464Ensembl.1
Natural variantiVAR_027180523M → T2 PublicationsCorresponds to variant dbSNP:rs1135791EnsemblClinVar.1
Natural variantiVAR_027181579M → I1 PublicationCorresponds to variant dbSNP:rs3948463EnsemblClinVar.1
Natural variantiVAR_036030683G → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0059911 – 251Missing in isoform 4. 1 PublicationAdd BLAST251
Alternative sequenceiVSP_0059921 – 203Missing in isoform 2. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_0460791M → MGRGFRM in isoform 7. 1 Publication1
Alternative sequenceiVSP_005994252 – 275IRDNS…TPSDK → MASSGVKNTPRWRRKAPHGR ERKE in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_005995300 – 349Missing in isoform 4. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_005996300 – 303GTAS → AL in isoform 5. 1 Publication4
Alternative sequenceiVSP_005997531 – 549RKNSD…QLLCC → SGLLLCPPRINLKRELNSK in isoform 3, isoform 4, isoform 5 and isoform 7. 4 PublicationsAdd BLAST19
Alternative sequenceiVSP_006000550 – 689Missing in isoform 3, isoform 4, isoform 5 and isoform 7. 4 PublicationsAdd BLAST140
Alternative sequenceiVSP_035593605L → LKCEFLLLKAYCHPQSSFFT GIPFN in isoform 6. 1 Publication1
Alternative sequenceiVSP_006001606 – 611IRDYGE → NVSSSS in isoform 2. 1 Publication6
Alternative sequenceiVSP_006002612 – 689Missing in isoform 2. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L22342 mRNA Translation: AAA18806.1
L22343 mRNA Translation: AAD13402.1
AF280094 mRNA Translation: AAF99318.1 Frameshift.
AF280095 mRNA Translation: AAG09826.1 Frameshift.
AK026488 mRNA No translation available.
AK301097 mRNA Translation: BAG62696.1
AC009950 Genomic DNA Translation: AAX93281.1
CH471063 Genomic DNA Translation: EAW70915.1
BC019059 mRNA Translation: AAH19059.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2474.1 [Q9HB58-1]
CCDS2475.1 [Q9HB58-6]
CCDS2476.1 [Q9HB58-3]
CCDS54435.1 [Q9HB58-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49515

NCBI Reference Sequences

More...
RefSeqi
NP_001171944.1, NM_001185015.1 [Q9HB58-7]
NP_004500.3, NM_004509.3
NP_536349.2, NM_080424.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258381; ENSP00000258381; ENSG00000135899 [Q9HB58-6]
ENST00000258382; ENSP00000258382; ENSG00000135899 [Q9HB58-3]
ENST00000358662; ENSP00000351488; ENSG00000135899 [Q9HB58-1]
ENST00000540870; ENSP00000439558; ENSG00000135899 [Q9HB58-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3431

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3431

UCSC genome browser

More...
UCSCi
uc002vqg.5 human [Q9HB58-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SP110base

SP110 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22342 mRNA Translation: AAA18806.1
L22343 mRNA Translation: AAD13402.1
AF280094 mRNA Translation: AAF99318.1 Frameshift.
AF280095 mRNA Translation: AAG09826.1 Frameshift.
AK026488 mRNA No translation available.
AK301097 mRNA Translation: BAG62696.1
AC009950 Genomic DNA Translation: AAX93281.1
CH471063 Genomic DNA Translation: EAW70915.1
BC019059 mRNA Translation: AAH19059.1
CCDSiCCDS2474.1 [Q9HB58-1]
CCDS2475.1 [Q9HB58-6]
CCDS2476.1 [Q9HB58-3]
CCDS54435.1 [Q9HB58-7]
PIRiA49515
RefSeqiNP_001171944.1, NM_001185015.1 [Q9HB58-7]
NP_004500.3, NM_004509.3
NP_536349.2, NM_080424.2

3D structure databases

SMRiQ9HB58
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109657, 23 interactors
IntActiQ9HB58, 19 interactors
MINTiQ9HB58
STRINGi9606.ENSP00000258381

PTM databases

iPTMnetiQ9HB58
PhosphoSitePlusiQ9HB58

Polymorphism and mutation databases

BioMutaiSP110
DMDMi313104323

Proteomic databases

jPOSTiQ9HB58
MaxQBiQ9HB58
PaxDbiQ9HB58
PeptideAtlasiQ9HB58
PRIDEiQ9HB58
ProteomicsDBi81489
81490 [Q9HB58-2]
81491 [Q9HB58-3]
81492 [Q9HB58-4]
81493 [Q9HB58-5]
81494 [Q9HB58-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3431
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258381; ENSP00000258381; ENSG00000135899 [Q9HB58-6]
ENST00000258382; ENSP00000258382; ENSG00000135899 [Q9HB58-3]
ENST00000358662; ENSP00000351488; ENSG00000135899 [Q9HB58-1]
ENST00000540870; ENSP00000439558; ENSG00000135899 [Q9HB58-7]
GeneIDi3431
KEGGihsa:3431
UCSCiuc002vqg.5 human [Q9HB58-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3431
DisGeNETi3431

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SP110
GeneReviewsiSP110
HGNCiHGNC:5401 SP110
HPAiHPA047036
HPA058554
MalaCardsiSP110
MIMi235550 phenotype
604457 gene
neXtProtiNX_Q9HB58
OpenTargetsiENSG00000135899
Orphaneti79124 Hepatic veno-occlusive disease-immunodeficiency syndrome
PharmGKBiPA35104

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00940000155124
HOGENOMiHOG000089984
InParanoidiQ9HB58
OMAiFCRMKRS
OrthoDBi377499at2759
PhylomeDBiQ9HB58
TreeFamiTF335091

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SP110 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SP110

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3431

Protein Ontology

More...
PROi
PR:Q9HB58

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135899 Expressed in 193 organ(s), highest expression level in blood
ExpressionAtlasiQ9HB58 baseline and differential
GenevisibleiQ9HB58 HS

Family and domain databases

Gene3Di1.20.920.10, 2 hits
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR004865 HSR_dom
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PfamiView protein in Pfam
PF03172 HSR, 1 hit
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00258 SAND, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
SSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS51414 HSR, 1 hit
PS50864 SAND, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSP110_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HB58
Secondary accession number(s): B4DVI4
, F5H1M1, Q14976, Q14977, Q53TG2, Q8WUZ6, Q9HCT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 175 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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