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Entry version 166 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Cytochrome P450 3A43

Gene

CYP3A43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits low testosterone 6-beta-hydroxylase activity.

Miscellaneous

Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi442Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 3A43 (EC:1.14.14.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP3A43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17450 CYP3A43

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606534 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HB55

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64816

Open Targets

More...
OpenTargetsi
ENSG00000021461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA427

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HB55

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5792

Drug and drug target database

More...
DrugBanki
DB11703 Acalabrutinib
DB13141 Ambroxol acefyllinate
DB11586 Asunaprevir
DB12267 Brigatinib
DB09065 Cobicistat
DB12483 Copanlisib
DB08865 Crizotinib
DB09102 Daclatasvir
DB01234 Dexamethasone
DB11994 Diacerein
DB08930 Dolutegravir
DB11979 Elagolix
DB11574 Elbasvir
DB00593 Ethosuximide
DB12307 Foretinib
DB13879 Glecaprevir
DB09054 Idelalisib
DB12070 Letermovir
DB01601 Lopinavir
DB12130 Lorlatinib
DB06595 Midostaurin
DB11792 Mirodenafil
DB11431 Moxidectin
DB09205 Moxisylyte
DB11605 Myrrh
DB11691 Naldemedine
DB01149 Nefazodone
DB09048 Netupitant
DB09568 Omega-3-carboxylic acids
DB00842 Oxazepam
DB06412 Oxymetholone
DB00780 Phenelzine
DB13878 Pibrentasvir
DB01058 Praziquantel
DB13174 Rhein
DB01045 Rifampicin
DB01201 Rifapentine
DB00503 Ritonavir
DB12332 Rucaparib
DB00624 Testosterone
DB13943 Testosterone cypionate
DB13944 Testosterone enanthate
DB13946 Testosterone undecanoate
DB13179 Troleandomycin

DrugCentral

More...
DrugCentrali
Q9HB55

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP3A43

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20137481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000518141 – 503Cytochrome P450 3A43Add BLAST503

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HB55

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HB55

PeptideAtlas

More...
PeptideAtlasi
Q9HB55

PRoteomics IDEntifications database

More...
PRIDEi
Q9HB55

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61978
81485 [Q9HB55-1]
81486 [Q9HB55-2]
81487 [Q9HB55-3]
81488 [Q9HB55-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HB55

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HB55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By rifampicin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000021461 Expressed in 86 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HB55 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HB55 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066463
HPA072245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9HB55, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222382

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9HB55

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HB55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0158 Eukaryota
COG2124 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182958

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039127

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HB55

KEGG Orthology (KO)

More...
KOi
K17692

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQAMIFI

Database of Orthologous Groups

More...
OrthoDBi
467733at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HB55

TreeFam database of animal gene trees

More...
TreeFami
TF105087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HB55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLIPNFAME TWVLVATSLV LLYIYGTHSH KLFKKLGIPG PTPLPFLGTI
60 70 80 90 100
LFYLRGLWNF DRECNEKYGE MWGLYEGQQP MLVIMDPDMI KTVLVKECYS
110 120 130 140 150
VFTNQMPLGP MGFLKSALSF AEDEEWKRIR TLLSPAFTSV KFKEMVPIIS
160 170 180 190 200
QCGDMLVRSL RQEAENSKSI NLKDFFGAYT MDVITGTLFG VNLDSLNNPQ
210 220 230 240 250
DPFLKNMKKL LKLDFLDPFL LLISLFPFLT PVFEALNIGL FPKDVTHFLK
260 270 280 290 300
NSIERMKESR LKDKQKHRVD FFQQMIDSQN SKETKSHKAL SDLELVAQSI
310 320 330 340 350
IIIFAAYDTT STTLPFIMYE LATHPDVQQK LQEEIDAVLP NKAPVTYDAL
360 370 380 390 400
VQMEYLDMVV NETLRLFPVV SRVTRVCKKD IEINGVFIPK GLAVMVPIYA
410 420 430 440 450
LHHDPKYWTE PEKFCPERFS KKNKDSIDLY RYIPFGAGPR NCIGMRFALT
460 470 480 490 500
NIKLAVIRAL QNFSFKPCKE TQIPLKLDNL PILQPEKPIV LKVHLRDGIT

SGP
Length:503
Mass (Da):57,670
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C585B9DC573F634
GO
Isoform 2 (identifier: Q9HB55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-417: E → ES

Show »
Length:504
Mass (Da):57,757
Checksum:iCB87C6873DAB7B0D
GO
Isoform 3 (identifier: Q9HB55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-420: FS → SH
     421-503: Missing.

Show »
Length:420
Mass (Da):48,304
Checksum:i60873437189BA207
GO
Isoform 4 (identifier: Q9HB55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-250: SLFPFLTPVFEALNIGLFPKDVTHFLK → YRVSLCCLGRSAWCDLGSLKPPPPGFE
     251-503: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:250
Mass (Da):28,490
Checksum:i858527154F617A06
GO
Isoform 7 (identifier: Q9HB55-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-224: GLWNFDRECN...FLDPFLLLIS → RSLNKIPSWA...VMKNTEKCGA

Show »
Length:393
Mass (Da):44,808
Checksum:iA0D1F6642FC1D9E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDL8E9PDL8_HUMAN
Cytochrome P450 3A43
CYP3A43
292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9HB50Q9HB50_HUMAN
Cytochrome P450 3A43
CYP3A43
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMH4E7EMH4_HUMAN
Cytochrome P450 3A43
CYP3A43
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6L8F8W6L8_HUMAN
Cytochrome P450 3A43
CYP3A43
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA26C9JA26_HUMAN
Cytochrome P450 3A43
CYP3A43
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PG90E9PG90_HUMAN
Cytochrome P450 3A43
CYP3A43
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01805025 – 88YGTHS…IMDPD → LGPIHINFLRSWEFLGQPLC LFWELFCSTLGVFGILTENV MKNTEKCGGCMRGNSPCWSS WIPT in allele CYP3A43*2. Add BLAST64
Natural variantiVAR_04844927T → A. Corresponds to variant dbSNP:rs45558032Ensembl.1
Natural variantiVAR_01805189 – 503Missing in allele CYP3A43*2. Add BLAST415
Natural variantiVAR_048450145M → I. Corresponds to variant dbSNP:rs45450092Ensembl.1
Natural variantiVAR_048451275M → I. Corresponds to variant dbSNP:rs45621431Ensembl.1
Natural variantiVAR_018052340P → A in allele CYP3A43*3. 1 PublicationCorresponds to variant dbSNP:rs680055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05673656 – 224GLWNF…LLLIS → RSLNKIPSWAWWLTPVIPAL WEAEAGGSPKVRSSRPALPT WVFGILTENVMKNTEKCGA in isoform 7. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_000612224 – 250SLFPF…THFLK → YRVSLCCLGRSAWCDLGSLK PPPPGFE in isoform 4. CuratedAdd BLAST27
Alternative sequenceiVSP_000613251 – 503Missing in isoform 4. CuratedAdd BLAST253
Alternative sequenceiVSP_000609417E → ES in isoform 2. Curated1
Alternative sequenceiVSP_000610419 – 420FS → SH in isoform 3. Curated2
Alternative sequenceiVSP_000611421 – 503Missing in isoform 3. CuratedAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF319634 mRNA Translation: AAK00325.1
AF337813 mRNA Translation: AAK38841.1
AF280107 Genomic DNA Translation: AAG32291.1
AF280108 mRNA Translation: AAG33009.1
AF280109 mRNA Translation: AAG33010.1
AF280110 mRNA Translation: AAG33011.1
AF280111 mRNA Translation: AAG33012.1
AY390423 mRNA Translation: AAQ92351.1
AY390424 mRNA Translation: AAQ92352.1
AY390425 mRNA Translation: AAQ92353.1
AY390426 mRNA Translation: AAQ92354.1
AC011904 Genomic DNA Translation: AAS07394.1
AC011904 Genomic DNA Translation: AAS07395.1
CH471091 Genomic DNA Translation: EAW76632.1
CH471091 Genomic DNA Translation: EAW76634.1
BC100981 mRNA Translation: AAI00982.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5675.1 [Q9HB55-2]
CCDS5676.1 [Q9HB55-1]
CCDS5677.1 [Q9HB55-3]
CCDS64723.1 [Q9HB55-6]

Protein sequence database of the Protein Information Resource

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PIRi
JC7627

NCBI Reference Sequences

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RefSeqi
NP_001265850.1, NM_001278921.1 [Q9HB55-6]
NP_073731.1, NM_022820.4 [Q9HB55-2]
NP_476436.1, NM_057095.2 [Q9HB55-1]
NP_476437.1, NM_057096.3 [Q9HB55-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000222382; ENSP00000222382; ENSG00000021461 [Q9HB55-2]
ENST00000312017; ENSP00000312110; ENSG00000021461 [Q9HB55-3]
ENST00000354829; ENSP00000346887; ENSG00000021461 [Q9HB55-1]
ENST00000417625; ENSP00000416581; ENSG00000021461 [Q9HB55-6]
ENST00000434806; ENSP00000411653; ENSG00000021461 [Q9HB55-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64816

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64816

UCSC genome browser

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UCSCi
uc003urx.3 human [Q9HB55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP3A43 alleles

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319634 mRNA Translation: AAK00325.1
AF337813 mRNA Translation: AAK38841.1
AF280107 Genomic DNA Translation: AAG32291.1
AF280108 mRNA Translation: AAG33009.1
AF280109 mRNA Translation: AAG33010.1
AF280110 mRNA Translation: AAG33011.1
AF280111 mRNA Translation: AAG33012.1
AY390423 mRNA Translation: AAQ92351.1
AY390424 mRNA Translation: AAQ92352.1
AY390425 mRNA Translation: AAQ92353.1
AY390426 mRNA Translation: AAQ92354.1
AC011904 Genomic DNA Translation: AAS07394.1
AC011904 Genomic DNA Translation: AAS07395.1
CH471091 Genomic DNA Translation: EAW76632.1
CH471091 Genomic DNA Translation: EAW76634.1
BC100981 mRNA Translation: AAI00982.1
CCDSiCCDS5675.1 [Q9HB55-2]
CCDS5676.1 [Q9HB55-1]
CCDS5677.1 [Q9HB55-3]
CCDS64723.1 [Q9HB55-6]
PIRiJC7627
RefSeqiNP_001265850.1, NM_001278921.1 [Q9HB55-6]
NP_073731.1, NM_022820.4 [Q9HB55-2]
NP_476436.1, NM_057095.2 [Q9HB55-1]
NP_476437.1, NM_057096.3 [Q9HB55-3]

3D structure databases

SMRiQ9HB55
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9HB55, 1 interactor
STRINGi9606.ENSP00000222382

Chemistry databases

BindingDBiQ9HB55
ChEMBLiCHEMBL5792
DrugBankiDB11703 Acalabrutinib
DB13141 Ambroxol acefyllinate
DB11586 Asunaprevir
DB12267 Brigatinib
DB09065 Cobicistat
DB12483 Copanlisib
DB08865 Crizotinib
DB09102 Daclatasvir
DB01234 Dexamethasone
DB11994 Diacerein
DB08930 Dolutegravir
DB11979 Elagolix
DB11574 Elbasvir
DB00593 Ethosuximide
DB12307 Foretinib
DB13879 Glecaprevir
DB09054 Idelalisib
DB12070 Letermovir
DB01601 Lopinavir
DB12130 Lorlatinib
DB06595 Midostaurin
DB11792 Mirodenafil
DB11431 Moxidectin
DB09205 Moxisylyte
DB11605 Myrrh
DB11691 Naldemedine
DB01149 Nefazodone
DB09048 Netupitant
DB09568 Omega-3-carboxylic acids
DB00842 Oxazepam
DB06412 Oxymetholone
DB00780 Phenelzine
DB13878 Pibrentasvir
DB01058 Praziquantel
DB13174 Rhein
DB01045 Rifampicin
DB01201 Rifapentine
DB00503 Ritonavir
DB12332 Rucaparib
DB00624 Testosterone
DB13943 Testosterone cypionate
DB13944 Testosterone enanthate
DB13946 Testosterone undecanoate
DB13179 Troleandomycin
DrugCentraliQ9HB55

PTM databases

iPTMnetiQ9HB55
PhosphoSitePlusiQ9HB55

Polymorphism and mutation databases

BioMutaiCYP3A43
DMDMi20137481

Proteomic databases

MassIVEiQ9HB55
PaxDbiQ9HB55
PeptideAtlasiQ9HB55
PRIDEiQ9HB55
ProteomicsDBi61978
81485 [Q9HB55-1]
81486 [Q9HB55-2]
81487 [Q9HB55-3]
81488 [Q9HB55-4]

Genome annotation databases

EnsembliENST00000222382; ENSP00000222382; ENSG00000021461 [Q9HB55-2]
ENST00000312017; ENSP00000312110; ENSG00000021461 [Q9HB55-3]
ENST00000354829; ENSP00000346887; ENSG00000021461 [Q9HB55-1]
ENST00000417625; ENSP00000416581; ENSG00000021461 [Q9HB55-6]
ENST00000434806; ENSP00000411653; ENSG00000021461 [Q9HB55-4]
GeneIDi64816
KEGGihsa:64816
UCSCiuc003urx.3 human [Q9HB55-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64816
DisGeNETi64816

GeneCards: human genes, protein and diseases

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GeneCardsi
CYP3A43
HGNCiHGNC:17450 CYP3A43
HPAiHPA066463
HPA072245
MIMi606534 gene
neXtProtiNX_Q9HB55
OpenTargetsiENSG00000021461
PharmGKBiPA427

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00950000182958
HOGENOMiHOG000039127
InParanoidiQ9HB55
KOiK17692
OMAiAQAMIFI
OrthoDBi467733at2759
PhylomeDBiQ9HB55
TreeFamiTF105087

Enzyme and pathway databases

ReactomeiR-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CYP3A43

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64816
PharosiQ9HB55

Protein Ontology

More...
PROi
PR:Q9HB55

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000021461 Expressed in 86 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ9HB55 baseline and differential
GenevisibleiQ9HB55 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP343_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HB55
Secondary accession number(s): Q495Y1
, Q75MK2, Q75MK3, Q9HB52, Q9HB53, Q9HB54, Q9HB57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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