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Protein

Homeobox protein SEBOX

Gene

SEBOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable transcription factor involved in the control of specification of mesoderm and endoderm.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi45 – 104HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SEBOX
Alternative name(s):
Homeobox OG-9
Skin-, embryo-, brain- and oocyte-specific homeobox
Gene namesi
Name:SEBOX
Synonyms:OG9X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000274529.4
HGNCiHGNC:32942 SEBOX
MIMi610975 gene
neXtProtiNX_Q9HB31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSEBOX
DMDMi322510071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113361 – 216Homeobox protein SEBOXAdd BLAST216

Proteomic databases

PaxDbiQ9HB31
PRIDEiQ9HB31
ProteomicsDBi81477

Expressioni

Gene expression databases

BgeeiENSG00000274529 Expressed in 14 organ(s), highest expression level in right lobe of liver
GenevisibleiQ9HB31 HS

Organism-specific databases

HPAiHPA045689

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000416240

Structurei

3D structure databases

ProteinModelPortaliQ9HB31
SMRiQ9HB31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231518
HOVERGENiHBG098434
InParanoidiQ9HB31
OrthoDBiEOG091G183Z
TreeFamiTF315976

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9HB31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGSGVGTAW HGPLARPSGT LPFASSMPSP VDASSADGGS GLGSHRRKRT
60 70 80 90 100
TFSKGQLLEL ERAFAAWPYP NISTHEHLAW VTCLPEAKVQ VWFQKRWAKI
110 120 130 140 150
IKNRKSGILS PGSECPQSSC SLPDTLQQPW DPQMPGQPPP SSGTPQRTSV
160 170 180 190 200
CRHSSCPAPG LSPRQGWEGA KAVAPWGSAG ASEVHPSLER ATPQTSLGSL
210
SDLIYALAIV VNVDHS
Length:216
Mass (Da):22,879
Last modified:February 8, 2011 - v2
Checksum:i97FD1BC8BF8F716C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6T8T6F6T8T6_HUMAN
Homeobox protein SEBOX
SEBOX
190Annotation score:

Sequence cautioni

The sequence AAG14458 differs from that shown. Reason: Frameshift at position 9.Curated
The sequence EAW51081 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037228207L → S2 PublicationsCorresponds to variant dbSNP:rs9910163Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284337 Genomic DNA Translation: AAG14458.1 Frameshift.
AC002094 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51081.1 Sequence problems.

Genome annotation databases

EnsembliENST00000438614; ENSP00000395142; ENSG00000274529
UCSCiuc010wai.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEBOX_HUMAN
AccessioniPrimary (citable) accession number: Q9HB31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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