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Protein

Bcl-2-like protein 12

Gene

BCL2L12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNORiQ9HB09

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 12
Short name:
Bcl2-L-12
Alternative name(s):
Bcl-2-related proline-rich protein
Gene namesi
Name:BCL2L12
Synonyms:BPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126453.9
HGNCiHGNC:13787 BCL2L12
MIMi610837 gene
neXtProtiNX_Q9HB09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi83596
OpenTargetsiENSG00000126453
PharmGKBiPA25306

Polymorphism and mutation databases

BioMutaiBCL2L12
DMDMi23396468

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430721 – 334Bcl-2-like protein 12Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineCombined sources1
Modified residuei117PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei144Omega-N-methylarginineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9HB09
MaxQBiQ9HB09
PaxDbiQ9HB09
PeptideAtlasiQ9HB09
PRIDEiQ9HB09
ProteomicsDBi81467
81468 [Q9HB09-2]
81469 [Q9HB09-3]

PTM databases

iPTMnetiQ9HB09
PhosphoSitePlusiQ9HB09
SwissPalmiQ9HB09

Expressioni

Tissue specificityi

Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.

Gene expression databases

BgeeiENSG00000126453 Expressed in 153 organ(s), highest expression level in muscle of leg
CleanExiHS_BCL2L12
ExpressionAtlasiQ9HB09 baseline and differential
GenevisibleiQ9HB09 HS

Organism-specific databases

HPAiHPA020856

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123692, 9 interactors
IntActiQ9HB09, 3 interactors
STRINGi9606.ENSP00000246785

Structurei

3D structure databases

ProteinModelPortaliQ9HB09
SMRiQ9HB09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi311 – 322BH2Add BLAST12

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiENOG410IVDH Eukaryota
ENOG410YTZU LUCA
GeneTreeiENSGT00390000001825
HOGENOMiHOG000294149
HOVERGENiHBG050647
InParanoidiQ9HB09
OMAiRACWERH
OrthoDBiEOG091G0HI1
PhylomeDBiQ9HB09
TreeFamiTF338350

Family and domain databases

InterProiView protein in InterPro
IPR036834 Blc2-like_sf
SUPFAMiSSF56854 SSF56854, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HB09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRPAGLFPP LCPFLGFRPE ACWERHMQIE RAPSVPPFLR WAGYRPGPVR
60 70 80 90 100
RRGKVELIKF VRVQWRRPQV EWRRRRWGPG PGASMAGSEE LGLREDTLRV
110 120 130 140 150
LAAFLRRGEA AGSPVPTPPR SPAQEEPTDF LSRLRRCLPC SLGRGAAPSE
160 170 180 190 200
SPRPCSLPIR PCYGLEPGPA TPDFYALVAQ RLEQLVQEQL KSPPSPELQG
210 220 230 240 250
PPSTEKEAIL RRLVALLEEE AEVINQKLAS DPALRSKLVR LSSDSFARLV
260 270 280 290 300
ELFCSRDDSS RPSRACPGPP PPSPEPLARL ALAMELSRRV AGLGGTLAGL
310 320 330
SVEHVHSFTP WIQAHGGWEG ILAVSPVDLN LPLD
Length:334
Mass (Da):36,821
Last modified:March 1, 2001 - v1
Checksum:i5398E54C83E7CAB7
GO
Isoform 2 (identifier: Q9HB09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-176: SPAQEEPTDF...PGPATPDFYA → PSYSRLLCFG...GPAGGGGRSH
     177-334: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:176
Mass (Da):19,133
Checksum:iDC503A642100CAE4
GO
Isoform 3 (identifier: Q9HB09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):36,665
Checksum:iAC8C106CC9D01518
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSV0A0A087WSV0_HUMAN
Bcl-2-like protein 12
BCL2L12
250Annotation score:
M0R1Z8M0R1Z8_HUMAN
Bcl-2-like protein 12
BCL2L12
92Annotation score:
I6LJZ9I6LJZ9_HUMAN
BCL2L12 protein isoform 8
BCL2L12
193Annotation score:
I6LJZ7I6LJZ7_HUMAN
BCL2L12 protein isoform 5
BCL2L12
269Annotation score:
M0R1K0M0R1K0_HUMAN
BCL-2-like protein 12 isoform 19
BCL2L12
92Annotation score:
I6LK00I6LK00_HUMAN
BCL2L12 protein isoform 9
BCL2L12
130Annotation score:
M0QZM6M0QZM6_HUMAN
BCL-2-like protein 12 isoform 10
BCL2L12
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270P → S in AAH07724 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04841947G → V. Corresponds to variant dbSNP:rs2060263Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043269120Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_000522121 – 176SPAQE…PDFYA → PSYSRLLCFGGPAAGTAGPR AAEISAQPRITGSPIDREGS HTAEAGGPAGGGGRSH in isoform 2. CuratedAdd BLAST56
Alternative sequenceiVSP_000523177 – 334Missing in isoform 2. CuratedAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289220 Genomic DNA Translation: AAG29495.1
AF289220 Genomic DNA Translation: AAG29496.1
AC011495 Genomic DNA No translation available.
BC007724 mRNA Translation: AAH07724.2
BC104004 mRNA Translation: AAI04005.1
BC104005 mRNA Translation: AAI04006.1
BC104006 mRNA Translation: AAI04007.1
CCDSiCCDS12776.1 [Q9HB09-1]
CCDS46144.1 [Q9HB09-3]
RefSeqiNP_001035758.1, NM_001040668.1 [Q9HB09-3]
NP_001269445.1, NM_001282516.1
NP_001269446.1, NM_001282517.1 [Q9HB09-2]
NP_001269448.1, NM_001282519.1
NP_001269449.1, NM_001282520.1
NP_001269450.1, NM_001282521.1
NP_619580.1, NM_138639.1 [Q9HB09-1]
XP_016882835.1, XM_017027346.1 [Q9HB09-2]
UniGeneiHs.289052

Genome annotation databases

EnsembliENST00000246785; ENSP00000246785; ENSG00000126453 [Q9HB09-1]
ENST00000441864; ENSP00000393803; ENSG00000126453 [Q9HB09-3]
ENST00000616144; ENSP00000482218; ENSG00000126453 [Q9HB09-1]
GeneIDi83596
KEGGihsa:83596
UCSCiuc002ppa.4 human [Q9HB09-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289220 Genomic DNA Translation: AAG29495.1
AF289220 Genomic DNA Translation: AAG29496.1
AC011495 Genomic DNA No translation available.
BC007724 mRNA Translation: AAH07724.2
BC104004 mRNA Translation: AAI04005.1
BC104005 mRNA Translation: AAI04006.1
BC104006 mRNA Translation: AAI04007.1
CCDSiCCDS12776.1 [Q9HB09-1]
CCDS46144.1 [Q9HB09-3]
RefSeqiNP_001035758.1, NM_001040668.1 [Q9HB09-3]
NP_001269445.1, NM_001282516.1
NP_001269446.1, NM_001282517.1 [Q9HB09-2]
NP_001269448.1, NM_001282519.1
NP_001269449.1, NM_001282520.1
NP_001269450.1, NM_001282521.1
NP_619580.1, NM_138639.1 [Q9HB09-1]
XP_016882835.1, XM_017027346.1 [Q9HB09-2]
UniGeneiHs.289052

3D structure databases

ProteinModelPortaliQ9HB09
SMRiQ9HB09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123692, 9 interactors
IntActiQ9HB09, 3 interactors
STRINGi9606.ENSP00000246785

PTM databases

iPTMnetiQ9HB09
PhosphoSitePlusiQ9HB09
SwissPalmiQ9HB09

Polymorphism and mutation databases

BioMutaiBCL2L12
DMDMi23396468

Proteomic databases

EPDiQ9HB09
MaxQBiQ9HB09
PaxDbiQ9HB09
PeptideAtlasiQ9HB09
PRIDEiQ9HB09
ProteomicsDBi81467
81468 [Q9HB09-2]
81469 [Q9HB09-3]

Protocols and materials databases

DNASUi83596
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246785; ENSP00000246785; ENSG00000126453 [Q9HB09-1]
ENST00000441864; ENSP00000393803; ENSG00000126453 [Q9HB09-3]
ENST00000616144; ENSP00000482218; ENSG00000126453 [Q9HB09-1]
GeneIDi83596
KEGGihsa:83596
UCSCiuc002ppa.4 human [Q9HB09-1]

Organism-specific databases

CTDi83596
DisGeNETi83596
EuPathDBiHostDB:ENSG00000126453.9
GeneCardsiBCL2L12
HGNCiHGNC:13787 BCL2L12
HPAiHPA020856
MIMi610837 gene
neXtProtiNX_Q9HB09
OpenTargetsiENSG00000126453
PharmGKBiPA25306
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVDH Eukaryota
ENOG410YTZU LUCA
GeneTreeiENSGT00390000001825
HOGENOMiHOG000294149
HOVERGENiHBG050647
InParanoidiQ9HB09
OMAiRACWERH
OrthoDBiEOG091G0HI1
PhylomeDBiQ9HB09
TreeFamiTF338350

Enzyme and pathway databases

SIGNORiQ9HB09

Miscellaneous databases

ChiTaRSiBCL2L12 human
GeneWikiiBCL2L12
GenomeRNAii83596
PROiPR:Q9HB09
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126453 Expressed in 153 organ(s), highest expression level in muscle of leg
CleanExiHS_BCL2L12
ExpressionAtlasiQ9HB09 baseline and differential
GenevisibleiQ9HB09 HS

Family and domain databases

InterProiView protein in InterPro
IPR036834 Blc2-like_sf
SUPFAMiSSF56854 SSF56854, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2L12_HUMAN
AccessioniPrimary (citable) accession number: Q9HB09
Secondary accession number(s): Q3SY11
, Q3SY13, Q96I96, Q9HB08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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