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Entry version 140 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Bcl-2-like protein 12

Gene

BCL2L12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HB09

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-like protein 12
Short name:
Bcl2-L-12
Alternative name(s):
Bcl-2-related proline-rich protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL2L12
Synonyms:BPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13787 BCL2L12

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610837 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HB09

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83596

Open Targets

More...
OpenTargetsi
ENSG00000126453

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25306

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCL2L12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23396468

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001430721 – 334Bcl-2-like protein 12Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113PhosphoserineCombined sources1
Modified residuei117PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei144Omega-N-methylarginineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HB09

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HB09

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HB09

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HB09

PeptideAtlas

More...
PeptideAtlasi
Q9HB09

PRoteomics IDEntifications database

More...
PRIDEi
Q9HB09

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81467
81468 [Q9HB09-2]
81469 [Q9HB09-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HB09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HB09

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9HB09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126453 Expressed in 153 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HB09 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HB09 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020856

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123692, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HB09, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HB09

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi311 – 322BH2Add BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVDH Eukaryota
ENOG410YTZU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294149

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HB09

Identification of Orthologs from Complete Genome Data

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OMAi
RACWERH

Database of Orthologous Groups

More...
OrthoDBi
1368289at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HB09

TreeFam database of animal gene trees

More...
TreeFami
TF338350

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036834 Blc2-like_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56854 SSF56854, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HB09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRPAGLFPP LCPFLGFRPE ACWERHMQIE RAPSVPPFLR WAGYRPGPVR
60 70 80 90 100
RRGKVELIKF VRVQWRRPQV EWRRRRWGPG PGASMAGSEE LGLREDTLRV
110 120 130 140 150
LAAFLRRGEA AGSPVPTPPR SPAQEEPTDF LSRLRRCLPC SLGRGAAPSE
160 170 180 190 200
SPRPCSLPIR PCYGLEPGPA TPDFYALVAQ RLEQLVQEQL KSPPSPELQG
210 220 230 240 250
PPSTEKEAIL RRLVALLEEE AEVINQKLAS DPALRSKLVR LSSDSFARLV
260 270 280 290 300
ELFCSRDDSS RPSRACPGPP PPSPEPLARL ALAMELSRRV AGLGGTLAGL
310 320 330
SVEHVHSFTP WIQAHGGWEG ILAVSPVDLN LPLD
Length:334
Mass (Da):36,821
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5398E54C83E7CAB7
GO
Isoform 2 (identifier: Q9HB09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-176: SPAQEEPTDF...PGPATPDFYA → PSYSRLLCFG...GPAGGGGRSH
     177-334: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:176
Mass (Da):19,133
Checksum:iDC503A642100CAE4
GO
Isoform 3 (identifier: Q9HB09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):36,665
Checksum:iAC8C106CC9D01518
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSV0A0A087WSV0_HUMAN
Bcl-2-like protein 12
BCL2L12
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1Z8M0R1Z8_HUMAN
Bcl-2-like protein 12
BCL2L12
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6LJZ7I6LJZ7_HUMAN
BCL2L12 protein isoform 5
BCL2L12
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1K0M0R1K0_HUMAN
BCL-2-like protein 12 isoform 19
BCL2L12
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZM6M0QZM6_HUMAN
BCL-2-like protein 12 isoform 10
BCL2L12
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6LJZ9I6LJZ9_HUMAN
BCL2L12 protein isoform 8
BCL2L12
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6LK00I6LK00_HUMAN
BCL2L12 protein isoform 9
BCL2L12
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti270P → S in AAH07724 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04841947G → V. Corresponds to variant dbSNP:rs2060263Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043269120Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_000522121 – 176SPAQE…PDFYA → PSYSRLLCFGGPAAGTAGPR AAEISAQPRITGSPIDREGS HTAEAGGPAGGGGRSH in isoform 2. CuratedAdd BLAST56
Alternative sequenceiVSP_000523177 – 334Missing in isoform 2. CuratedAdd BLAST158

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF289220 Genomic DNA Translation: AAG29495.1
AF289220 Genomic DNA Translation: AAG29496.1
AC011495 Genomic DNA No translation available.
BC007724 mRNA Translation: AAH07724.2
BC104004 mRNA Translation: AAI04005.1
BC104005 mRNA Translation: AAI04006.1
BC104006 mRNA Translation: AAI04007.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12776.1 [Q9HB09-1]
CCDS46144.1 [Q9HB09-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001035758.1, NM_001040668.1 [Q9HB09-3]
NP_001269445.1, NM_001282516.1
NP_001269446.1, NM_001282517.1 [Q9HB09-2]
NP_001269448.1, NM_001282519.1
NP_001269449.1, NM_001282520.1
NP_001269450.1, NM_001282521.1
NP_619580.1, NM_138639.1 [Q9HB09-1]
XP_016882835.1, XM_017027346.1 [Q9HB09-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000246785; ENSP00000246785; ENSG00000126453 [Q9HB09-1]
ENST00000441864; ENSP00000393803; ENSG00000126453 [Q9HB09-3]
ENST00000616144; ENSP00000482218; ENSG00000126453 [Q9HB09-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83596

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83596

UCSC genome browser

More...
UCSCi
uc002ppa.4 human [Q9HB09-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289220 Genomic DNA Translation: AAG29495.1
AF289220 Genomic DNA Translation: AAG29496.1
AC011495 Genomic DNA No translation available.
BC007724 mRNA Translation: AAH07724.2
BC104004 mRNA Translation: AAI04005.1
BC104005 mRNA Translation: AAI04006.1
BC104006 mRNA Translation: AAI04007.1
CCDSiCCDS12776.1 [Q9HB09-1]
CCDS46144.1 [Q9HB09-3]
RefSeqiNP_001035758.1, NM_001040668.1 [Q9HB09-3]
NP_001269445.1, NM_001282516.1
NP_001269446.1, NM_001282517.1 [Q9HB09-2]
NP_001269448.1, NM_001282519.1
NP_001269449.1, NM_001282520.1
NP_001269450.1, NM_001282521.1
NP_619580.1, NM_138639.1 [Q9HB09-1]
XP_016882835.1, XM_017027346.1 [Q9HB09-2]

3D structure databases

SMRiQ9HB09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123692, 12 interactors
IntActiQ9HB09, 3 interactors
STRINGi9606.ENSP00000482218

PTM databases

iPTMnetiQ9HB09
PhosphoSitePlusiQ9HB09
SwissPalmiQ9HB09

Polymorphism and mutation databases

BioMutaiBCL2L12
DMDMi23396468

Proteomic databases

EPDiQ9HB09
jPOSTiQ9HB09
MaxQBiQ9HB09
PaxDbiQ9HB09
PeptideAtlasiQ9HB09
PRIDEiQ9HB09
ProteomicsDBi81467
81468 [Q9HB09-2]
81469 [Q9HB09-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
83596
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246785; ENSP00000246785; ENSG00000126453 [Q9HB09-1]
ENST00000441864; ENSP00000393803; ENSG00000126453 [Q9HB09-3]
ENST00000616144; ENSP00000482218; ENSG00000126453 [Q9HB09-1]
GeneIDi83596
KEGGihsa:83596
UCSCiuc002ppa.4 human [Q9HB09-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83596
DisGeNETi83596

GeneCards: human genes, protein and diseases

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GeneCardsi
BCL2L12
HGNCiHGNC:13787 BCL2L12
HPAiHPA020856
MIMi610837 gene
neXtProtiNX_Q9HB09
OpenTargetsiENSG00000126453
PharmGKBiPA25306

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IVDH Eukaryota
ENOG410YTZU LUCA
GeneTreeiENSGT00940000154318
HOGENOMiHOG000294149
InParanoidiQ9HB09
OMAiRACWERH
OrthoDBi1368289at2759
PhylomeDBiQ9HB09
TreeFamiTF338350

Enzyme and pathway databases

SIGNORiQ9HB09

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BCL2L12 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BCL2L12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83596

Protein Ontology

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PROi
PR:Q9HB09

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126453 Expressed in 153 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ9HB09 baseline and differential
GenevisibleiQ9HB09 HS

Family and domain databases

InterProiView protein in InterPro
IPR036834 Blc2-like_sf
SUPFAMiSSF56854 SSF56854, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2L12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HB09
Secondary accession number(s): Q3SY11
, Q3SY13, Q96I96, Q9HB08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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