UniProtKB - Q9HB09 (B2L12_HUMAN)
Protein
Bcl-2-like protein 12
Gene
BCL2L12
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- p53 binding Source: Ensembl
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of cellular senescence Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of extrinsic apoptotic signaling pathway Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q9HB09 |
SIGNORi | Q9HB09 |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 12Short name: Bcl2-L-12 Alternative name(s): Bcl-2-related proline-rich protein |
Gene namesi | Name:BCL2L12 Synonyms:BPR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13787, BCL2L12 |
MIMi | 610837, gene |
neXtProti | NX_Q9HB09 |
VEuPathDBi | HostDB:ENSG00000126453.9 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 83596 |
OpenTargetsi | ENSG00000126453 |
PharmGKBi | PA25306 |
Miscellaneous databases
Pharosi | Q9HB09, Tbio |
Genetic variation databases
BioMutai | BCL2L12 |
DMDMi | 23396468 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143072 | 1 – 334 | Bcl-2-like protein 12Add BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 117 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 144 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | PhosphoserineCombined sources | 1 | |
Modified residuei | 243 | PhosphoserineCombined sources | 1 | |
Modified residuei | 245 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9HB09 |
jPOSTi | Q9HB09 |
MassIVEi | Q9HB09 |
MaxQBi | Q9HB09 |
PaxDbi | Q9HB09 |
PeptideAtlasi | Q9HB09 |
PRIDEi | Q9HB09 |
ProteomicsDBi | 81467 [Q9HB09-1] 81468 [Q9HB09-2] 81469 [Q9HB09-3] |
PTM databases
iPTMneti | Q9HB09 |
PhosphoSitePlusi | Q9HB09 |
SwissPalmi | Q9HB09 |
Expressioni
Tissue specificityi
Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.
Gene expression databases
Bgeei | ENSG00000126453, Expressed in muscle tissue and 174 other tissues |
ExpressionAtlasi | Q9HB09, baseline and differential |
Genevisiblei | Q9HB09, HS |
Organism-specific databases
HPAi | ENSG00000126453, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 1 [Q9HB09-1]
With | #Exp. | IntAct |
---|---|---|
UBC [P0CG48] | 3 | EBI-6968951,EBI-3390054 |
Isoform 2 [Q9HB09-2]
With | #Exp. | IntAct |
---|---|---|
HSPA1B [P08107] | 2 | EBI-6969019,EBI-629985 |
GO - Molecular functioni
- p53 binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 123692, 13 interactors |
IntActi | Q9HB09, 6 interactors |
STRINGi | 9606.ENSP00000482218 |
Miscellaneous databases
RNActi | Q9HB09, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 311 – 322 | BH2Add BLAST | 12 |
Sequence similaritiesi
Belongs to the Bcl-2 family.Curated
Phylogenomic databases
eggNOGi | ENOG502RYM6, Eukaryota |
GeneTreei | ENSGT00940000154318 |
InParanoidi | Q9HB09 |
OMAi | HGGWAGI |
OrthoDBi | 1368289at2759 |
PhylomeDBi | Q9HB09 |
TreeFami | TF338350 |
Family and domain databases
InterProi | View protein in InterPro IPR036834, Blc2-like_sf |
SUPFAMi | SSF56854, SSF56854, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9HB09-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRPAGLFPP LCPFLGFRPE ACWERHMQIE RAPSVPPFLR WAGYRPGPVR
60 70 80 90 100
RRGKVELIKF VRVQWRRPQV EWRRRRWGPG PGASMAGSEE LGLREDTLRV
110 120 130 140 150
LAAFLRRGEA AGSPVPTPPR SPAQEEPTDF LSRLRRCLPC SLGRGAAPSE
160 170 180 190 200
SPRPCSLPIR PCYGLEPGPA TPDFYALVAQ RLEQLVQEQL KSPPSPELQG
210 220 230 240 250
PPSTEKEAIL RRLVALLEEE AEVINQKLAS DPALRSKLVR LSSDSFARLV
260 270 280 290 300
ELFCSRDDSS RPSRACPGPP PPSPEPLARL ALAMELSRRV AGLGGTLAGL
310 320 330
SVEHVHSFTP WIQAHGGWEG ILAVSPVDLN LPLD
Isoform 2 (identifier: Q9HB09-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
121-176: SPAQEEPTDF...PGPATPDFYA → PSYSRLLCFG...GPAGGGGRSH
177-334: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WSV0 | A0A087WSV0_HUMAN | Bcl-2-like protein 12 | BCL2L12 | 250 | Annotation score: | ||
M0R1Z8 | M0R1Z8_HUMAN | Bcl-2-like protein 12 | BCL2L12 | 92 | Annotation score: | ||
I6LJZ7 | I6LJZ7_HUMAN | BCL2L12 protein isoform 5 | BCL2L12 | 269 | Annotation score: | ||
M0QZM6 | M0QZM6_HUMAN | BCL-2-like protein 12 isoform 10 | BCL2L12 | 138 | Annotation score: | ||
M0R1K0 | M0R1K0_HUMAN | BCL-2-like protein 12 isoform 19 | BCL2L12 | 92 | Annotation score: | ||
I6LJZ9 | I6LJZ9_HUMAN | BCL2L12 protein isoform 8 | BCL2L12 | 193 | Annotation score: | ||
I6LK00 | I6LK00_HUMAN | BCL2L12 protein isoform 9 | BCL2L12 | 130 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 270 | P → S in AAH07724 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048419 | 47 | G → V. Corresponds to variant dbSNP:rs2060263Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043269 | 120 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_000522 | 121 – 176 | SPAQE…PDFYA → PSYSRLLCFGGPAAGTAGPR AAEISAQPRITGSPIDREGS HTAEAGGPAGGGGRSH in isoform 2. CuratedAdd BLAST | 56 | |
Alternative sequenceiVSP_000523 | 177 – 334 | Missing in isoform 2. CuratedAdd BLAST | 158 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289220 Genomic DNA Translation: AAG29495.1 AF289220 Genomic DNA Translation: AAG29496.1 AC011495 Genomic DNA No translation available. BC007724 mRNA Translation: AAH07724.2 BC104004 mRNA Translation: AAI04005.1 BC104005 mRNA Translation: AAI04006.1 BC104006 mRNA Translation: AAI04007.1 |
CCDSi | CCDS46144.1 [Q9HB09-3] |
RefSeqi | NP_001035758.1, NM_001040668.1 [Q9HB09-3] NP_001269445.1, NM_001282516.1 NP_001269446.1, NM_001282517.1 [Q9HB09-2] NP_001269448.1, NM_001282519.1 NP_001269449.1, NM_001282520.1 NP_001269450.1, NM_001282521.1 NP_619580.1, NM_138639.1 XP_016882835.1, XM_017027346.1 [Q9HB09-2] |
Genome annotation databases
Ensembli | ENST00000246785; ENSP00000246785; ENSG00000126453 [Q9HB09-1] ENST00000441864; ENSP00000393803; ENSG00000126453 [Q9HB09-3] ENST00000616144; ENSP00000482218; ENSG00000126453 [Q9HB09-1] |
GeneIDi | 83596 |
KEGGi | hsa:83596 |
UCSCi | uc002ppa.4, human [Q9HB09-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289220 Genomic DNA Translation: AAG29495.1 AF289220 Genomic DNA Translation: AAG29496.1 AC011495 Genomic DNA No translation available. BC007724 mRNA Translation: AAH07724.2 BC104004 mRNA Translation: AAI04005.1 BC104005 mRNA Translation: AAI04006.1 BC104006 mRNA Translation: AAI04007.1 |
CCDSi | CCDS46144.1 [Q9HB09-3] |
RefSeqi | NP_001035758.1, NM_001040668.1 [Q9HB09-3] NP_001269445.1, NM_001282516.1 NP_001269446.1, NM_001282517.1 [Q9HB09-2] NP_001269448.1, NM_001282519.1 NP_001269449.1, NM_001282520.1 NP_001269450.1, NM_001282521.1 NP_619580.1, NM_138639.1 XP_016882835.1, XM_017027346.1 [Q9HB09-2] |
3D structure databases
SMRi | Q9HB09 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123692, 13 interactors |
IntActi | Q9HB09, 6 interactors |
STRINGi | 9606.ENSP00000482218 |
PTM databases
iPTMneti | Q9HB09 |
PhosphoSitePlusi | Q9HB09 |
SwissPalmi | Q9HB09 |
Genetic variation databases
BioMutai | BCL2L12 |
DMDMi | 23396468 |
Proteomic databases
EPDi | Q9HB09 |
jPOSTi | Q9HB09 |
MassIVEi | Q9HB09 |
MaxQBi | Q9HB09 |
PaxDbi | Q9HB09 |
PeptideAtlasi | Q9HB09 |
PRIDEi | Q9HB09 |
ProteomicsDBi | 81467 [Q9HB09-1] 81468 [Q9HB09-2] 81469 [Q9HB09-3] |
Protocols and materials databases
Antibodypediai | 18662, 199 antibodies |
DNASUi | 83596 |
Genome annotation databases
Ensembli | ENST00000246785; ENSP00000246785; ENSG00000126453 [Q9HB09-1] ENST00000441864; ENSP00000393803; ENSG00000126453 [Q9HB09-3] ENST00000616144; ENSP00000482218; ENSG00000126453 [Q9HB09-1] |
GeneIDi | 83596 |
KEGGi | hsa:83596 |
UCSCi | uc002ppa.4, human [Q9HB09-1] |
Organism-specific databases
CTDi | 83596 |
DisGeNETi | 83596 |
GeneCardsi | BCL2L12 |
HGNCi | HGNC:13787, BCL2L12 |
HPAi | ENSG00000126453, Low tissue specificity |
MIMi | 610837, gene |
neXtProti | NX_Q9HB09 |
OpenTargetsi | ENSG00000126453 |
PharmGKBi | PA25306 |
VEuPathDBi | HostDB:ENSG00000126453.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYM6, Eukaryota |
GeneTreei | ENSGT00940000154318 |
InParanoidi | Q9HB09 |
OMAi | HGGWAGI |
OrthoDBi | 1368289at2759 |
PhylomeDBi | Q9HB09 |
TreeFami | TF338350 |
Enzyme and pathway databases
PathwayCommonsi | Q9HB09 |
SIGNORi | Q9HB09 |
Miscellaneous databases
BioGRID-ORCSi | 83596, 25 hits in 875 CRISPR screens |
ChiTaRSi | BCL2L12, human |
GeneWikii | BCL2L12 |
GenomeRNAii | 83596 |
Pharosi | Q9HB09, Tbio |
PROi | PR:Q9HB09 |
RNActi | Q9HB09, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126453, Expressed in muscle tissue and 174 other tissues |
ExpressionAtlasi | Q9HB09, baseline and differential |
Genevisiblei | Q9HB09, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036834, Blc2-like_sf |
SUPFAMi | SSF56854, SSF56854, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2L12_HUMAN | |
Accessioni | Q9HB09Primary (citable) accession number: Q9HB09 Secondary accession number(s): Q3SY11 Q9HB08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families