UniProtKB - Q9HB07 (MYG1_HUMAN)
Protein
MYG1 exonuclease
Gene
MYG1
Organism
Homo sapiens (Human)
Status
Functioni
3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).1 Publication1 Publication
GO - Molecular functioni
- nuclease activity Source: UniProtKB-KW
GO - Biological processi
- locomotory exploration behavior Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Nuclease |
Enzyme and pathway databases
PathwayCommonsi | Q9HB07 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139637.13 |
HGNCi | HGNC:17590, MYG1 |
MIMi | 611366, gene |
neXtProti | NX_Q9HB07 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 2 Publications
Nucleus
- nucleoplasm 2 Publications
- nucleolus By similarity
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Nucleus
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Several works have found that mRNA expression is elevated in the skin of vitiligo patients.3 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 106 – 108 | DHH → AAL: Catalytically inactive. 1 Publication | 3 | |
Mutagenesisi | 344 | H → Q: Loss of RNase activity and gained single stranded DNase activity. 1 Publication | 1 |
Organism-specific databases
PharmGKBi | PA25501 |
Miscellaneous databases
Pharosi | Q9HB07, Tbio |
Polymorphism and mutation databases
BioMutai | C12orf10 |
DMDMi | 296439232 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 47 | MitochondrionSequence analysisAdd BLAST | 47 | |
ChainiPRO_0000213483 | 48 – 376 | MYG1 exonucleaseAdd BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 267 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 273 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9HB07 |
jPOSTi | Q9HB07 |
MassIVEi | Q9HB07 |
MaxQBi | Q9HB07 |
PaxDbi | Q9HB07 |
PeptideAtlasi | Q9HB07 |
PRIDEi | Q9HB07 |
ProteomicsDBi | 81466 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00029444 |
PTM databases
iPTMneti | Q9HB07 |
MetOSitei | Q9HB07 |
PhosphoSitePlusi | Q9HB07 |
SwissPalmi | Q9HB07 |
Expressioni
Tissue specificityi
Ubiquitously expressed, with highest levels in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000139637, Expressed in right testis and 225 other tissues |
ExpressionAtlasi | Q9HB07, baseline and differential |
Genevisiblei | Q9HB07, HS |
Organism-specific databases
HPAi | HPA038626 HPA038627 |
Interactioni
Binary interactionsi
Hide detailsQ9HB07
Protein-protein interaction databases
IntActi | Q9HB07, 43 interactors |
MINTi | Q9HB07 |
STRINGi | 9606.ENSP00000267103 |
Miscellaneous databases
RNActi | Q9HB07, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MYG1 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2948, Eukaryota |
InParanoidi | Q9HB07 |
OMAi | FHCDEVV |
OrthoDBi | 1174497at2759 |
PhylomeDBi | Q9HB07 |
TreeFami | TF313313 |
Family and domain databases
InterProi | View protein in InterPro IPR003226, Met-dep_prot_hydro |
PANTHERi | PTHR11215, PTHR11215, 1 hit |
Pfami | View protein in Pfam PF03690, UPF0160, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9HB07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHRFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH
60 70 80 90 100
NGTFHCDEAL ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP
110 120 130 140 150
RRHRYDHHQR SFTETMSSLS PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT
160 170 180 190 200
SEEDSMVGTL YDKMYENFVE EVDAVDNGIS QWAEGEPRYA LTTTLSARVA
210 220 230 240 250
RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL PARALVEEAL
260 270 280 290 300
AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ
310 320 330 340 350
WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFTG
360 370
GHHTREGALS MARATLAQRS YLPQIS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VR84 | F8VR84_HUMAN | MYG1 exonuclease | MYG1 | 213 | Annotation score: | ||
F8VQQ3 | F8VQQ3_HUMAN | MYG1 exonuclease | MYG1 | 301 | Annotation score: | ||
H3BPH3 | H3BPH3_HUMAN | MYG1 exonuclease | MYG1 | 130 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | T → P in AAG17847 (Ref. 1) Curated | 1 | |
Sequence conflicti | 349 – 353 | TGGHH → IGGHR in AAH51871 (PubMed:15489334).Curated | 5 | |
Sequence conflicti | 353 | H → P in AAG17847 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083553 | 4 | R → Q Loss of mitochondrial location. 1 Publication | 1 | |
Natural variantiVAR_059854 | 349 | T → I1 PublicationCorresponds to variant dbSNP:rs1534282Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289485 mRNA Translation: AAG17847.1 AC073611 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96688.1 BC051871 mRNA Translation: AAH51871.1 |
CCDSi | CCDS31810.1 |
RefSeqi | NP_067653.3, NM_021640.3 |
Genome annotation databases
Ensembli | ENST00000267103; ENSP00000267103; ENSG00000139637 |
GeneIDi | 60314 |
KEGGi | hsa:60314 |
UCSCi | uc001scp.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289485 mRNA Translation: AAG17847.1 AC073611 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96688.1 BC051871 mRNA Translation: AAH51871.1 |
CCDSi | CCDS31810.1 |
RefSeqi | NP_067653.3, NM_021640.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9HB07, 43 interactors |
MINTi | Q9HB07 |
STRINGi | 9606.ENSP00000267103 |
PTM databases
iPTMneti | Q9HB07 |
MetOSitei | Q9HB07 |
PhosphoSitePlusi | Q9HB07 |
SwissPalmi | Q9HB07 |
Polymorphism and mutation databases
BioMutai | C12orf10 |
DMDMi | 296439232 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00029444 |
Proteomic databases
EPDi | Q9HB07 |
jPOSTi | Q9HB07 |
MassIVEi | Q9HB07 |
MaxQBi | Q9HB07 |
PaxDbi | Q9HB07 |
PeptideAtlasi | Q9HB07 |
PRIDEi | Q9HB07 |
ProteomicsDBi | 81466 |
Protocols and materials databases
Antibodypediai | 48361, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000267103; ENSP00000267103; ENSG00000139637 |
GeneIDi | 60314 |
KEGGi | hsa:60314 |
UCSCi | uc001scp.5, human |
Organism-specific databases
CTDi | 60314 |
EuPathDBi | HostDB:ENSG00000139637.13 |
GeneCardsi | MYG1 |
HGNCi | HGNC:17590, MYG1 |
HPAi | HPA038626 HPA038627 |
MIMi | 611366, gene |
neXtProti | NX_Q9HB07 |
PharmGKBi | PA25501 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2948, Eukaryota |
InParanoidi | Q9HB07 |
OMAi | FHCDEVV |
OrthoDBi | 1174497at2759 |
PhylomeDBi | Q9HB07 |
TreeFami | TF313313 |
Enzyme and pathway databases
PathwayCommonsi | Q9HB07 |
Miscellaneous databases
BioGRID-ORCSi | 60314, 26 hits in 847 CRISPR screens |
ChiTaRSi | C12orf10, human |
GenomeRNAii | 60314 |
Pharosi | Q9HB07, Tbio |
PROi | PR:Q9HB07 |
RNActi | Q9HB07, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139637, Expressed in right testis and 225 other tissues |
ExpressionAtlasi | Q9HB07, baseline and differential |
Genevisiblei | Q9HB07, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003226, Met-dep_prot_hydro |
PANTHERi | PTHR11215, PTHR11215, 1 hit |
Pfami | View protein in Pfam PF03690, UPF0160, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYG1_HUMAN | |
Accessioni | Q9HB07Primary (citable) accession number: Q9HB07 Secondary accession number(s): Q86UA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | June 17, 2020 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations