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UniProtKB - Q9HB07 (MYG1_HUMAN)

Entry version 145 (02 Dec 2020)
Sequence version 3 (17 Jun 2020)
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Protein

MYG1 exonuclease

Gene

MYG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nuclease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HB07

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MYG1 exonucleaseCurated (EC:3.1.-.-1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYG1Imported
Synonyms:C12orf10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000139637.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:17590, MYG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611366, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HB07

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Several works have found that mRNA expression is elevated in the skin of vitiligo patients.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106 – 108DHH → AAL: Catalytically inactive. 1 Publication3
Mutagenesisi344H → Q: Loss of RNase activity and gained single stranded DNase activity. 1 Publication1

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25501

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HB07, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C12orf10

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439232

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 47MitochondrionSequence analysisAdd BLAST47
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000021348348 – 376MYG1 exonucleaseAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphoserineCombined sources1
Modified residuei267N6-acetyllysineCombined sources1
Modified residuei273N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HB07

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HB07

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HB07

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HB07

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HB07

PeptideAtlas

More...PeptideAtlasi		Q9HB07

PRoteomics IDEntifications database

More...PRIDEi		Q9HB07

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81466

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00029444

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HB07

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9HB07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HB07

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9HB07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000139637, Expressed in right testis and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HB07, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HB07, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA038626
HPA038627

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9HB07
With#Exp.IntAct
AGTRAP [Q6RW13]4EBI-709754,EBI-741181
AGTRAP - isoform 2 [Q6RW13-2]3EBI-709754,EBI-11522760
ALDH7A1 - isoform 2 [P49419-2]3EBI-709754,EBI-11107920
AP1B1 - isoform C [Q10567-3]3EBI-709754,EBI-11978055
APOA5 [Q6Q788]3EBI-709754,EBI-3936819
ARL6IP1 [Q15041]6EBI-709754,EBI-714543
BSND [Q8WZ55]3EBI-709754,EBI-7996695
CDS2 [O95674]3EBI-709754,EBI-3913685
CMTM5 [Q96DZ9]4EBI-709754,EBI-2548702
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-709754,EBI-11522780
CPLX2 [Q6PUV4]3EBI-709754,EBI-2689453
DCDC2 [Q9UHG0]3EBI-709754,EBI-10303987
DDIT4L [Q96D03]3EBI-709754,EBI-742054
DESI2 [Q9BSY9]3EBI-709754,EBI-12878374
DGAT2L6 [Q6ZPD8]3EBI-709754,EBI-12831978
ERGIC3 [Q9Y282]3EBI-709754,EBI-781551
FAM9B [Q8IZU0]4EBI-709754,EBI-10175124
GADD45GIP1 [Q8TAE8]3EBI-709754,EBI-372506
GRB2 [P62993]3EBI-709754,EBI-401755
HORMAD1 [Q86X24]3EBI-709754,EBI-12165207
MAL2 [Q969L2]3EBI-709754,EBI-944295
MAN1C1 [Q9NR34]3EBI-709754,EBI-7260764
METTL9 [Q9H1A3]3EBI-709754,EBI-2804879
PLIN3 [O60664]3EBI-709754,EBI-725795
PPGB [Q59EV6]3EBI-709754,EBI-14210385
REEP6 - isoform 2 [Q96HR9-2]3EBI-709754,EBI-14065960
RHBDD2 - isoform 3 [Q6NTF9-3]3EBI-709754,EBI-17589229
ROM1 [Q03395]3EBI-709754,EBI-9395257
RXRB [P28702]3EBI-709754,EBI-748576
SFT2D1 [Q8WV19]3EBI-709754,EBI-2854842
SLC17A9 [Q9BYT1]3EBI-709754,EBI-3940816
SPG21 [Q9NZD8]3EBI-709754,EBI-742688
SYNGR1 - isoform 1B [O43759-2]3EBI-709754,EBI-12187159
SYP [P08247]3EBI-709754,EBI-9071725
TIMM17B [O60830]3EBI-709754,EBI-2372529
TLCD4 [Q96MV1]3EBI-709754,EBI-12947623
TMEM229B [Q8NBD8]3EBI-709754,EBI-12195227
TMEM239 [Q8WW34]3EBI-709754,EBI-9675724
TNMD - isoform 2 [Q9H2S6-2]3EBI-709754,EBI-12003398
WWOX - isoform 5 [Q9NZC7-5]3EBI-709754,EBI-12040603
YIF1A [O95070]3EBI-709754,EBI-2799703

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9HB07, 43 interactors

Molecular INTeraction database

More...MINTi		Q9HB07

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000267103

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HB07, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYG1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2948, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HB07

Identification of Orthologs from Complete Genome Data

More...OMAi		FHCDEVV

Database of Orthologous Groups

More...OrthoDBi		1174497at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HB07

TreeFam database of animal gene trees

More...TreeFami		TF313313

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003226, Met-dep_prot_hydro

The PANTHER Classification System

More...PANTHERi		PTHR11215, PTHR11215, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03690, UPF0160, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9HB07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHRFLRGLL TLLLPPPPLY TRHRMLGPES VPPPKRSRSK LMAPPRIGTH 
        60         70         80         90        100
NGTFHCDEAL ACALLRLLPE YRDAEIVRTR DPEKLASCDI VVDVGGEYDP 
       110        120        130        140        150
RRHRYDHHQR SFTETMSSLS PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT 
       160        170        180        190        200
SEEDSMVGTL YDKMYENFVE EVDAVDNGIS QWAEGEPRYA LTTTLSARVA 
       210        220        230        240        250
RLNPTWNHPD QDTEAGFKRA MDLVQEEFLQ RLDFYQHSWL PARALVEEAL 
       260        270        280        290        300
AQRFQVDPSG EIVELAKGAC PWKEHLYHLE SGLSPPVAIF FVIYTDQAGQ 
       310        320        330        340        350
WRIQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFTG 
       360        370 
GHHTREGALS MARATLAQRS YLPQIS
Length:376
Mass (Da):42,477
Last modified:June 17, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CCB511AFF6A0C16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VR84F8VR84_HUMAN
MYG1 exonuclease
MYG1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQQ3F8VQQ3_HUMAN
MYG1 exonuclease
MYG1
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPH3H3BPH3_HUMAN
MYG1 exonuclease
MYG1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150T → P in AAG17847 (Ref. 1) Curated1
Sequence conflicti349 – 353TGGHH → IGGHR in AAH51871 (PubMed:15489334).Curated5
Sequence conflicti353H → P in AAG17847 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0835534R → Q Loss of mitochondrial location. 1 Publication1
Natural variantiVAR_059854349T → I1 PublicationCorresponds to variant dbSNP:rs1534282Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF289485 mRNA Translation: AAG17847.1
AC073611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96688.1
BC051871 mRNA Translation: AAH51871.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31810.1

NCBI Reference Sequences

More...RefSeqi		NP_067653.3, NM_021640.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000267103; ENSP00000267103; ENSG00000139637

Database of genes from NCBI RefSeq genomes

More...GeneIDi		60314

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:60314

UCSC genome browser

More...UCSCi		uc001scp.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289485 mRNA Translation: AAG17847.1
AC073611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96688.1
BC051871 mRNA Translation: AAH51871.1
CCDSiCCDS31810.1
RefSeqiNP_067653.3, NM_021640.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9HB07, 43 interactors
MINTiQ9HB07
STRINGi9606.ENSP00000267103

PTM databases

iPTMnetiQ9HB07
MetOSiteiQ9HB07
PhosphoSitePlusiQ9HB07
SwissPalmiQ9HB07

Polymorphism and mutation databases

BioMutaiC12orf10
DMDMi296439232

2D gel databases

REPRODUCTION-2DPAGEiIPI00029444

Proteomic databases

EPDiQ9HB07
jPOSTiQ9HB07
MassIVEiQ9HB07
MaxQBiQ9HB07
PaxDbiQ9HB07
PeptideAtlasiQ9HB07
PRIDEiQ9HB07
ProteomicsDBi81466

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48361, 31 antibodies

Genome annotation databases

EnsembliENST00000267103; ENSP00000267103; ENSG00000139637
GeneIDi60314
KEGGihsa:60314
UCSCiuc001scp.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		60314
EuPathDBiHostDB:ENSG00000139637.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYG1
HGNCiHGNC:17590, MYG1
HPAiHPA038626
HPA038627
MIMi611366, gene
neXtProtiNX_Q9HB07
PharmGKBiPA25501

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2948, Eukaryota
InParanoidiQ9HB07
OMAiFHCDEVV
OrthoDBi1174497at2759
PhylomeDBiQ9HB07
TreeFamiTF313313

Enzyme and pathway databases

PathwayCommonsiQ9HB07

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		60314, 26 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C12orf10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		60314
PharosiQ9HB07, Tbio

Protein Ontology

More...PROi		PR:Q9HB07
RNActiQ9HB07, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000139637, Expressed in right testis and 225 other tissues
ExpressionAtlasiQ9HB07, baseline and differential
GenevisibleiQ9HB07, HS

Family and domain databases

InterProiView protein in InterPro
IPR003226, Met-dep_prot_hydro
PANTHERiPTHR11215, PTHR11215, 1 hit
PfamiView protein in Pfam
PF03690, UPF0160, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HB07
Secondary accession number(s): Q86UA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 17, 2020
Last modified: December 2, 2020
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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