UniProtKB - Q9HAZ1 (CLK4_HUMAN)

BLAST

>sp|Q9HAZ1|CLK4_HUMAN Dual specificity protein kinase CLK4 OS=Homo sapiens OX=9606 GN=CLK4 PE=1 SV=1
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K

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History
Entry version 147 (07 Nov 2018)
Sequence version 1 (01 Mar 2001)
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Protein

Dual specificity protein kinase CLK4

Gene

CLK4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	189	ATPPROSITE-ProRule annotation		1
Active siteⁱ	286	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	165 – 173	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
protein serine/threonine kinase activity Source: UniProtKB
protein tyrosine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein autophosphorylation Source: Ensembl
regulation of RNA splicing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19168442

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9HAZ1
SIGNORⁱ	Q9HAZ1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity protein kinase CLK4 (EC:2.7.12.1) Alternative name(s): CDC-like kinase 4
Gene namesⁱ	Name:CLK4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113240.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13659 CLK4
MIMⁱ	607969 gene
neXtProtⁱ	NX_Q9HAZ1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	189	K → R: Loss of function. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000113240
PharmGKBⁱ	PA26598

Chemistry databases

ChEMBLⁱ	CHEMBL4203
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1993

Polymorphism and mutation databases

BioMutaⁱ	CLK4
DMDMⁱ	34922132

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085873	1 – 481	Dual specificity protein kinase CLK4Add BLAST		481

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	136	PhosphoserineCombined sources		1
Modified residueⁱ	138	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Autophosphorylates on all three types of residues.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9HAZ1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HAZ1
PaxDbⁱ	Q9HAZ1
PeptideAtlas More...PeptideAtlasⁱ	Q9HAZ1
PRIDEⁱ	Q9HAZ1
ProteomicsDBⁱ	81459

PTM databases

iPTMnetⁱ	Q9HAZ1
PhosphoSitePlusⁱ	Q9HAZ1

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, kidney, heart, muscle, brain and endothelial cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000113240 Expressed in 233 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CLK4
ExpressionAtlasⁱ	Q9HAZ1 baseline and differential
Genevisibleⁱ	Q9HAZ1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043746

HPAⁱ

HPA043746

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KPNA1	P52294	3	EBI-633400,EBI-358383
KRTAP10-7	P60409	3	EBI-633400,EBI-10172290
KRTAP10-8	P60410	3	EBI-633400,EBI-10171774
KRTAP10-9	P60411	3	EBI-633400,EBI-10172052

Protein-protein interaction databases

BioGridⁱ	121501, 20 interactors
IntActⁱ	Q9HAZ1, 13 interactors
STRINGⁱ	9606.ENSP00000316948

Chemistry databases

BindingDBⁱ

Q9HAZ1

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	156 – 158	Combined sources	3
Beta strandⁱ	159 – 167	Combined sources	9
Beta strandⁱ	169 – 178	Combined sources	10
Helixⁱ	179 – 181	Combined sources	3
Beta strandⁱ	185 – 191	Combined sources	7
Helixⁱ	195 – 214	Combined sources	20
Beta strandⁱ	225 – 231	Combined sources	7
Beta strandⁱ	234 – 239	Combined sources	6
Helixⁱ	246 – 252	Combined sources	7
Turnⁱ	253 – 255	Combined sources	3
Helixⁱ	260 – 278	Combined sources	19
Turnⁱ	279 – 281	Combined sources	3
Helixⁱ	289 – 291	Combined sources	3
Beta strandⁱ	292 – 295	Combined sources	4
Beta strandⁱ	299 – 303	Combined sources	5
Beta strandⁱ	310 – 315	Combined sources	6
Beta strandⁱ	319 – 321	Combined sources	3
Helixⁱ	341 – 343	Combined sources	3
Helixⁱ	346 – 349	Combined sources	4
Helixⁱ	357 – 372	Combined sources	16
Helixⁱ	382 – 393	Combined sources	12
Helixⁱ	398 – 403	Combined sources	6
Helixⁱ	407 – 409	Combined sources	3
Beta strandⁱ	410 – 415	Combined sources	6
Helixⁱ	422 – 430	Combined sources	9
Helixⁱ	434 – 437	Combined sources	4
Helixⁱ	443 – 455	Combined sources	13
Turnⁱ	460 – 462	Combined sources	3
Helixⁱ	466 – 470	Combined sources	5
Helixⁱ	473 – 478	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9HAZ1
SMRⁱ	Q9HAZ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	159 – 475	Protein kinasePROSITE-ProRule annotationAdd BLAST		317

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0671 Eukaryota ENOG410XQF2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081366
HOGENOMⁱ	HOG000203417
HOVERGENⁱ	HBG107720
InParanoidⁱ	Q9HAZ1
KEGG Orthology (KO) More...KOⁱ	K08823
OMAⁱ	HGMDGIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G033A
PhylomeDBⁱ	Q9HAZ1
TreeFamⁱ	TF101041

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

Q9HAZ1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRHSKRTHCP DWDSRESWGH ESYRGSHKRK RRSHSSTQEN RHCKPHHQFK 
        60         70         80         90        100
ESDCHYLEAR SLNERDYRDR RYVDEYRNDY CEGYVPRHYH RDIESGYRIH 
       110        120        130        140        150
CSKSSVRSRR SSPKRKRNRH CSSHQSRSKS HRRKRSRSIE DDEEGHLICQ 
       160        170        180        190        200
SGDVLRARYE IVDTLGEGAF GKVVECIDHG MDGMHVAVKI VKNVGRYREA 
       210        220        230        240        250
ARSEIQVLEH LNSTDPNSVF RCVQMLEWFD HHGHVCIVFE LLGLSTYDFI 
       260        270        280        290        300
KENSFLPFQI DHIRQMAYQI CQSINFLHHN KLTHTDLKPE NILFVKSDYV 
       310        320        330        340        350
VKYNSKMKRD ERTLKNTDIK VVDFGSATYD DEHHSTLVST RHYRAPEVIL 
       360        370        380        390        400
ALGWSQPCDV WSIGCILIEY YLGFTVFQTH DSKEHLAMME RILGPIPQHM 
       410        420        430        440        450
IQKTRKRKYF HHNQLDWDEH SSAGRYVRRR CKPLKEFMLC HDEEHEKLFD 
       460        470        480 
LVRRMLEYDP TQRITLDEAL QHPFFDLLKK K

Length:481

Mass (Da):57,492

Last modified:March 1, 2001 - v1

Checksum:ⁱF402C36835CDA306

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7ZL31	B7ZL31_HUMAN	CLK4 protein CLK4 protein (Dual-specificity protein kinase CLK4)	CLK4	373	Annotation score:
A0A087WX74	A0A087WX74_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK4	CLK4	373	Annotation score:
Q68D95	Q68D95_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK4	CLK4 DKFZp686A20267	53	Annotation score:
E7EWJ6	E7EWJ6_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK4	CLK4	89	Annotation score:
E7ES88	E7ES88_HUMAN	Dual-specificity protein kinase CLK... Dual-specificity protein kinase CLK4	CLK4	143	Annotation score:
Q6P090	Q6P090_HUMAN	CLK4 protein CLK4 protein (Dual-specificity protein kinase CLK4)	CLK4	54	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_040414	352	L → F1 PublicationCorresponds to variant dbSNP:rs35272416Ensembl.		1
Natural variantⁱVAR_040415	363	I → V1 PublicationCorresponds to variant dbSNP:rs55746655Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF294429 mRNA Translation: AAG10074.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4437.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065717.1, NM_020666.2
UniGeneⁱ	Hs.406557

Genome annotation databases

Ensemblⁱ	ENST00000316308; ENSP00000316948; ENSG00000113240
GeneIDⁱ	57396
KEGGⁱ	hsa:57396
UCSC genome browser More...UCSCⁱ	uc003mjf.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HAZ1	CDC-like kinase 4		PANTR		481	UniRef100_Q9HAZ1
Uncharacterized protein		PANPA		481

Protein	Similar proteins		Species	Score	Length	Source
Q9HAZ1	CDC-like kinase 4		PANTR		481	UniRef90_Q9HAZ1
Uncharacterized protein		PANPA		481
Uncharacterized protein		RHIBE		485
Uncharacterized protein		LOXAF		482
Uncharacterized protein		PIG		482
+88

Protein	Similar proteins		Species	Score	Length	Source
Q9HAZ1	Dual specificity protein kinase CLK4		MOUSE		481	UniRef50_O35493
Uncharacterized protein		MONDO		507
Uncharacterized protein		SARHA		479
dual specificity protein kinase CLK4 isoform X2		BALAS		491
dual specificity protein kinase CLK4 isoform X1		URSMA		491
+286

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF294429 mRNA Translation: AAG10074.1
CCDSⁱ	CCDS4437.1
RefSeqⁱ	NP_065717.1, NM_020666.2
UniGeneⁱ	Hs.406557

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6FYV	X-ray	2.46	A	146-480	[»]
ProteinModelPortalⁱ	Q9HAZ1
SMRⁱ	Q9HAZ1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121501, 20 interactors
IntActⁱ	Q9HAZ1, 13 interactors
STRINGⁱ	9606.ENSP00000316948

Chemistry databases

BindingDBⁱ	Q9HAZ1
ChEMBLⁱ	CHEMBL4203
GuidetoPHARMACOLOGYⁱ	1993

PTM databases

iPTMnetⁱ	Q9HAZ1
PhosphoSitePlusⁱ	Q9HAZ1

Polymorphism and mutation databases

BioMutaⁱ	CLK4
DMDMⁱ	34922132

Proteomic databases

EPDⁱ	Q9HAZ1
MaxQBⁱ	Q9HAZ1
PaxDbⁱ	Q9HAZ1
PeptideAtlasⁱ	Q9HAZ1
PRIDEⁱ	Q9HAZ1
ProteomicsDBⁱ	81459

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000316308; ENSP00000316948; ENSG00000113240
GeneIDⁱ	57396
KEGGⁱ	hsa:57396
UCSCⁱ	uc003mjf.2 human

Organism-specific databases

CTDⁱ	57396
EuPathDBⁱ	HostDB:ENSG00000113240.12
GeneCardsⁱ	CLK4
HGNCⁱ	HGNC:13659 CLK4
HPAⁱ	HPA043746
MIMⁱ	607969 gene
neXtProtⁱ	NX_Q9HAZ1
OpenTargetsⁱ	ENSG00000113240
PharmGKBⁱ	PA26598
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0671 Eukaryota ENOG410XQF2 LUCA
GeneTreeⁱ	ENSGT00580000081366
HOGENOMⁱ	HOG000203417
HOVERGENⁱ	HBG107720
InParanoidⁱ	Q9HAZ1
KOⁱ	K08823
OMAⁱ	HGMDGIH
OrthoDBⁱ	EOG091G033A
PhylomeDBⁱ	Q9HAZ1
TreeFamⁱ	TF101041

Enzyme and pathway databases

SignaLinkⁱ	Q9HAZ1
SIGNORⁱ	Q9HAZ1

Miscellaneous databases

ChiTaRSⁱ	CLK4 human
GenomeRNAiⁱ	57396
Protein Ontology More...PROⁱ	PR:Q9HAZ1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113240 Expressed in 233 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CLK4
ExpressionAtlasⁱ	Q9HAZ1 baseline and differential
Genevisibleⁱ	Q9HAZ1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLK4_HUMAN
Accessionⁱ	Q9HAZ1Primary (citable) accession number: Q9HAZ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q9HAZ1 (CLK4_HUMAN)

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Dual specificity protein kinase CLK4

CLK4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ