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Protein

UDP-glucuronosyltransferase 1-8

Gene

UGT1A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.1 Publication

Miscellaneous

The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • drug binding Source: BHF-UCL
  • enzyme binding Source: BHF-UCL
  • enzyme inhibitor activity Source: BHF-UCL
  • fatty acid binding Source: BHF-UCL
  • glucuronosyltransferase activity Source: BHF-UCL
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • retinoic acid binding Source: BHF-UCL
  • steroid binding Source: BHF-UCL
  • UDP-glycosyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10706-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.17 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156588 Glucuronidation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9HAW9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HAW9

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001710

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-8 (EC:2.4.1.17)
Short name:
UDPGT 1-8
Short name:
UGT1*8
Short name:
UGT1-08
Short name:
UGT1.8
Alternative name(s):
UDP-glucuronosyltransferase 1-H
Short name:
UGT-1H
Short name:
UGT1H
UDP-glucuronosyltransferase 1A8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT1A8
Synonyms:GNT1, UGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000242366.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12540 UGT1A8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
191740 gene
606433 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAW9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei488 – 504HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54576

Open Targets

More...
OpenTargetsi
ENSG00000242366

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37183

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743318

Drug and drug target database

More...
DrugBanki
DB00861 Diflunisal
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB00818 Propofol
DB00197 Troglitazone
DB00313 Valproic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UGT1A8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29839637

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003600726 – 530UDP-glucuronosyltransferase 1-8Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi344N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HAW9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HAW9

PeptideAtlas

More...
PeptideAtlasi
Q9HAW9

PRoteomics IDEntifications database

More...
PRIDEi
Q9HAW9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81456

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1880

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Colon specific. Isoform 1 and 2 are expressed in liver, kidney, colon and small intestine; isoform 2 but not isoform 1 is expressed in liver (PubMed:18004212).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000242366 Expressed in 22 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HAW9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAW9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9HAW9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362549

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9HAW9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9HAW9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1192 Eukaryota
COG1819 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220832

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004033

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HAW9

KEGG Orthology (KO)

More...
KOi
K00699

Identification of Orthologs from Complete Genome Data

More...
OMAi
AKFDICL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03YY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAW9

TreeFam database of animal gene trees

More...
TreeFami
TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00201 UDPGT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00375 UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HAW9-1) [UniParc]FASTAAdd to basket
Also known as: i1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARTGWTSPI PLCVSLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL
60 70 80 90 100
RGHEVVVVMP EVSWQLGKSL NCTVKTYSTS YTLEDLDREF MDFADAQWKA
110 120 130 140 150
QVRSLFSLFL SSSNGFFNLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF
160 170 180 190 200
DACGLIVAKY FSLPSVVFAR GIACHYLEEG AQCPAPLSYV PRILLGFSDA
210 220 230 240 250
MTFKERVRNH IMHLEEHLFC QYFSKNALEI ASEILQTPVT AYDLYSHTSI
260 270 280 290 300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV
310 320 330 340 350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK
360 370 380 390 400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR
410 420 430 440 450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE
460 470 480 490 500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA
510 520 530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,742
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD838436940F4190
GO
Isoform 2 (identifier: Q9HAW9-2) [UniParc]FASTAAdd to basket
Also known as: i2, UGT1A8s

The sequence of this isoform differs from the canonical sequence as follows:
     432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:441
Mass (Da):49,518
Checksum:iCE3BAC9FD06D0565
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05246353H → N. Corresponds to variant dbSNP:rs45504099Ensembl.1
Natural variantiVAR_015543132K → R2 Publications1
Natural variantiVAR_058585144A → V1 PublicationCorresponds to variant dbSNP:rs17862841Ensembl.1
Natural variantiVAR_015544154G → A2 Publications1
Natural variantiVAR_015545173A → G in allele UGT1A8*2. 5 PublicationsCorresponds to variant dbSNP:rs1042597Ensembl.1
Natural variantiVAR_061871173A → V. Corresponds to variant dbSNP:rs1042597Ensembl.1
Natural variantiVAR_015546202T → A2 Publications1
Natural variantiVAR_015547212M → L2 PublicationsCorresponds to variant dbSNP:rs1126803Ensembl.1
Natural variantiVAR_058586231A → T1 PublicationCorresponds to variant dbSNP:rs72551325Ensembl.1
Natural variantiVAR_015549277C → Y in allele UGT1A8*3; dramatic reduction in catalytic activity. 2 PublicationsCorresponds to variant dbSNP:rs17863762Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053964432 – 530SYKEN…KSKTH → RKKQQSGRQM in isoform 2. CuratedAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF030310 mRNA Translation: AAB84259.1
AF297093 Genomic DNA Translation: AAG30416.1
AF462267 mRNA Translation: AAL75963.1
AF462268 mRNA Translation: AAL75964.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
AK313488 mRNA Translation: BAG36270.1
AF465198 Genomic DNA Translation: AAL73506.1
AF465199 Genomic DNA Translation: AAL73507.1
AF465200 Genomic DNA Translation: AAL73508.1
DQ364251 mRNA Translation: ABC96775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33402.1 [Q9HAW9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_061949.3, NM_019076.4 [Q9HAW9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.554822

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373450; ENSP00000362549; ENSG00000242366 [Q9HAW9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54576

UCSC genome browser

More...
UCSCi
uc002vup.4 human [Q9HAW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030310 mRNA Translation: AAB84259.1
AF297093 Genomic DNA Translation: AAG30416.1
AF462267 mRNA Translation: AAL75963.1
AF462268 mRNA Translation: AAL75964.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
AK313488 mRNA Translation: BAG36270.1
AF465198 Genomic DNA Translation: AAL73506.1
AF465199 Genomic DNA Translation: AAL73507.1
AF465200 Genomic DNA Translation: AAL73508.1
DQ364251 mRNA Translation: ABC96775.1
CCDSiCCDS33402.1 [Q9HAW9-1]
RefSeqiNP_061949.3, NM_019076.4 [Q9HAW9-1]
UniGeneiHs.554822

3D structure databases

ProteinModelPortaliQ9HAW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HAW9, 7 interactors
STRINGi9606.ENSP00000362549

Chemistry databases

BindingDBiQ9HAW9
ChEMBLiCHEMBL1743318
DrugBankiDB00861 Diflunisal
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB00818 Propofol
DB00197 Troglitazone
DB00313 Valproic Acid
SwissLipidsiSLP:000001710

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

GlyConnecti1880
iPTMnetiQ9HAW9
PhosphoSitePlusiQ9HAW9

Polymorphism and mutation databases

BioMutaiUGT1A8
DMDMi29839637

Proteomic databases

MaxQBiQ9HAW9
PaxDbiQ9HAW9
PeptideAtlasiQ9HAW9
PRIDEiQ9HAW9
ProteomicsDBi81456

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373450; ENSP00000362549; ENSG00000242366 [Q9HAW9-1]
GeneIDi54576
KEGGihsa:54576
UCSCiuc002vup.4 human [Q9HAW9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54576
DisGeNETi54576
EuPathDBiHostDB:ENSG00000242366.3

GeneCards: human genes, protein and diseases

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GeneCardsi
UGT1A8
HGNCiHGNC:12540 UGT1A8
MIMi191740 gene
606433 gene
neXtProtiNX_Q9HAW9
OpenTargetsiENSG00000242366
PharmGKBiPA37183

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00940000163976
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiQ9HAW9
KOiK00699
OMAiAKFDICL
OrthoDBiEOG091G03YY
PhylomeDBiQ9HAW9
TreeFamiTF315472

Enzyme and pathway databases

BioCyciMetaCyc:HS10706-MONOMER
BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
SABIO-RKiQ9HAW9
SIGNORiQ9HAW9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UGT1A8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UGT1A8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54576

Protein Ontology

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PROi
PR:Q9HAW9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000242366 Expressed in 22 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ9HAW9 baseline and differential
GenevisibleiQ9HAW9 HS

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAW9
Secondary accession number(s): B2R8S3
, B8K290, O14928, Q8TEX4, Q8WTQ9, Q8WX85
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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