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UniProtKB - Q9HAW8 (UD110_HUMAN)

Entry version 173 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

UDP-glucuronosyltransferase 1A10

Gene

UGT1A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515).8 Publications
Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.2 Publications

Miscellaneous

UGT1A10 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values.4 Publications
  1. KM=13 µM for estrone (when assaying glucuronidation at position 3)1 Publication
  2. KM=4.07 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3)1 Publication
  3. KM=2.63 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
  4. KM=21.8 µM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3)1 Publication
  5. KM=68.4 µM for 16alpha,17beta-estriol/estriol (when assaying glucuronidation at position 3)1 Publication
  6. KM=59.8 µM for 16beta,17beta-estriol (when assaying glucuronidation at position 3)1 Publication
  7. KM=337 µM for 16alpha,17alpha-estriol (when assaying glucuronidation at position 3)1 Publication
  8. KM=12.34 µM for genistein1 Publication
  9. KM=31.5 µM for SN-38 (when assaying glucuronidation at position 10)1 Publication
  1. Vmax=1300 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate)1 Publication
  2. Vmax=6340 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  3. Vmax=83.6 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  4. Vmax=2100 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate)1 Publication
  5. Vmax=3040 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  6. Vmax=107 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  7. Vmax=321 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate)1 Publication
  8. Vmax=8.5 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  9. Vmax=1200 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 3-O-(beta-D-glucuronate)1 Publication
  10. Vmax=837 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 3-O-(beta-D-glucuronate)1 Publication
  11. Vmax=7700 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 3-O-(beta-D-glucuronate)1 Publication
  12. Vmax=3486 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 3-O-(beta-D-glucuronate)1 Publication
  13. Vmax=958 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate)1 Publication
  14. Vmax=407 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate)1 Publication
  15. Vmax=3 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  16. Vmax=3 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate)1 Publication
  17. Vmax=11 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  18. Vmax=1.04 nmol/min/mg enzyme for the formation of genistein glucuronide1 Publication
  19. Vmax=0.25 nmol/min/mg enzyme for the formation of prunetin-4'-O-(beta-D-glucuronoside)1 Publication
  20. Vmax=7.6 pmol/min/mg enzyme for the formation of SN-38 glucuronide1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.1.17, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HAW8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156588, Glucuronidation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9HAW8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9HAW8

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT1, Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001694

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1A101 Publication (EC:2.4.1.177 Publications)
Short name:
UGT1A10
Alternative name(s):
UDP-glucuronosyltransferase 1-10
Short name:
UDPGT 1-10
Short name:
UGT1*10
Short name:
UGT1-10
Short name:
UGT1.10
UDP-glucuronosyltransferase 1-J
Short name:
UGT-1J
Short name:
UGT1J
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT1A10Imported
Synonyms:GNT1, UGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000242515.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:12531, UGT1A10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		191740, gene
606435, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HAW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei488 – 504HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90F → G, A, V, L, I or Y: Loss of estrone and 16alpha-hydroxyestrone glucuronosyltransferase activity. 1 Publication1
Mutagenesisi93F → G: Increased estriol, 17-epiestriol and 16alpha-hydroxyestrone glucuronosyltransferase activity. Decreased of estrone and 16-epiestriol glucuronosyltransferase activity. 2 Publications1
Mutagenesisi93F → V, L or I: Loss of estrone and 16alpha-hydroxyestrone glucuronosyltransferase activity. 1 Publication1
Mutagenesisi93F → Y: Decreased estrone and 16alpha-hydroxyestrone glucuronosyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54575

Open Targets

More...OpenTargetsi		ENSG00000242515

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37174

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HAW8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1743320

Drug and drug target database

More...DrugBanki		DB06401, Bazedoxifene
DB14635, Curcumin sulfate
DB00783, Estradiol
DB00749, Etodolac
DB00555, Lamotrigine
DB00678, Losartan
DB00688, Mycophenolate mofetil
DB00788, Naproxen
DB09079, Nintedanib
DB00794, Primidone
DB09288, Propacetamol
DB00481, Raloxifene
DB00503, Ritonavir
DB00675, Tamoxifen
DB00197, Troglitazone
DB00313, Valproic acid

DrugCentral

More...DrugCentrali		Q9HAW8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UGT1A10

Domain mapping of disease mutations (DMDM)

More...DMDMi		29839636

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003600926 – 530UDP-glucuronosyltransferase 1A10Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HAW8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HAW8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HAW8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HAW8

PeptideAtlas

More...PeptideAtlasi		Q9HAW8

PRoteomics IDEntifications database

More...PRIDEi		Q9HAW8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69409
81455 [Q9HAW8-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1874, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HAW8, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HAW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HAW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver and colon (PubMed:9271343). Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000242515, Expressed in intestine and 50 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HAW8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HAW8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000242515, Group enriched (esophagus, gallbladder, intestine, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:17179145). Homooligomer (Probable).

Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9 to form heterodimers (PubMed:17179145).

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9 (PubMed:20610558).

1 Publication2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120053, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9HAW8, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343838

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9HAW8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HAW8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1192, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012949_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HAW8

KEGG Orthology (KO)

More...KOi		K00699

Identification of Orthologs from Complete Genome Data

More...OMAi		ATTRSIC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HAW8

TreeFam database of animal gene trees

More...TreeFami		TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00201, UDPGT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00375, UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HAW8-1) [UniParc]FASTAAdd to basket
Also known as: i11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARAGWTSPV PLCVCLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL 
        60         70         80         90        100
RGHEVVVVMP EVSWQLERSL NCTVKTYSTS YTLEDQNREF MVFAHAQWKA 
       110        120        130        140        150
QAQSIFSLLM SSSSGFLDLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF 
       160        170        180        190        200
DTCGLIVAKY FSLPSVVFTR GIFCHHLEEG AQCPAPLSYV PNDLLGFSDA 
       210        220        230        240        250
MTFKERVWNH IVHLEDHLFC QYLFRNALEI ASEILQTPVT AYDLYSHTSI 
       260        270        280        290        300
WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV 
       310        320        330        340        350
VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK 
       360        370        380        390        400
WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR 
       410        420        430        440        450
METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE 
       460        470        480        490        500
PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA 
       510        520        530
FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
Length:530
Mass (Da):59,810
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73774EEEC7FE37BA
GO
Isoform 2 (identifier: Q9HAW8-2) [UniParc]FASTAAdd to basket
Also known as: i21 Publication, UGT1A10s

The sequence of this isoform differs from the canonical sequence as follows:
     432-530: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:441
Mass (Da):49,586
Checksum:i06D89D99B1C0300E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 23MARAG…TCGFA → MAPRRVDQPRSFMCVSTADL WLC (PubMed:9271343).CuratedAdd BLAST23
Sequence conflicti40T → A in AAB81537 (PubMed:9271343).Curated1
Sequence conflicti175H → R in AAB81537 (PubMed:9271343).Curated1
Sequence conflicti224F → L in AAB81537 (PubMed:9271343).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01835459M → I1 PublicationCorresponds to variant dbSNP:rs56935833Ensembl.1
Natural variantiVAR_052464139E → K. Corresponds to variant dbSNP:rs10187694Ensembl.1
Natural variantiVAR_018355202T → I1 PublicationCorresponds to variant dbSNP:rs58704432Ensembl.1
Natural variantiVAR_052465244L → I. Corresponds to variant dbSNP:rs28969685Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053966432 – 530SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U89508 mRNA Translation: AAB81537.1
AF297093 Genomic DNA Translation: AAG30417.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC020971 mRNA Translation: AAH20971.1
BC053576 mRNA Translation: AAH53576.1
BC069210 mRNA Translation: AAH69210.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33403.1 [Q9HAW8-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5656

NCBI Reference Sequences

More...RefSeqi		NP_061948.1, NM_019075.2 [Q9HAW8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344644; ENSP00000343838; ENSG00000242515 [Q9HAW8-1]
ENST00000373445; ENSP00000362544; ENSG00000242515 [Q9HAW8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54575

UCSC genome browser

More...UCSCi		uc002vuq.4, human [Q9HAW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89508 mRNA Translation: AAB81537.1
AF297093 Genomic DNA Translation: AAG30417.1
AC006985 Genomic DNA No translation available.
AC019072 Genomic DNA No translation available.
BC020971 mRNA Translation: AAH20971.1
BC053576 mRNA Translation: AAH53576.1
BC069210 mRNA Translation: AAH69210.2
CCDSiCCDS33403.1 [Q9HAW8-1]
PIRiJC5656
RefSeqiNP_061948.1, NM_019075.2 [Q9HAW8-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120053, 21 interactors
IntActiQ9HAW8, 20 interactors
STRINGi9606.ENSP00000343838

Chemistry databases

BindingDBiQ9HAW8
ChEMBLiCHEMBL1743320
DrugBankiDB06401, Bazedoxifene
DB14635, Curcumin sulfate
DB00783, Estradiol
DB00749, Etodolac
DB00555, Lamotrigine
DB00678, Losartan
DB00688, Mycophenolate mofetil
DB00788, Naproxen
DB09079, Nintedanib
DB00794, Primidone
DB09288, Propacetamol
DB00481, Raloxifene
DB00503, Ritonavir
DB00675, Tamoxifen
DB00197, Troglitazone
DB00313, Valproic acid
DrugCentraliQ9HAW8
SwissLipidsiSLP:000001694

Protein family/group databases

CAZyiGT1, Glycosyltransferase Family 1

PTM databases

GlyConnecti1874, 2 N-Linked glycans (1 site)
GlyGeniQ9HAW8, 3 sites
iPTMnetiQ9HAW8
PhosphoSitePlusiQ9HAW8

Polymorphism and mutation databases

BioMutaiUGT1A10
DMDMi29839636

Proteomic databases

jPOSTiQ9HAW8
MassIVEiQ9HAW8
MaxQBiQ9HAW8
PaxDbiQ9HAW8
PeptideAtlasiQ9HAW8
PRIDEiQ9HAW8
ProteomicsDBi69409
81455 [Q9HAW8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35063, 29 antibodies

The DNASU plasmid repository

More...DNASUi		54575

Genome annotation databases

EnsembliENST00000344644; ENSP00000343838; ENSG00000242515 [Q9HAW8-1]
ENST00000373445; ENSP00000362544; ENSG00000242515 [Q9HAW8-2]
GeneIDi54575
KEGGihsa:54575
UCSCiuc002vuq.4, human [Q9HAW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54575
DisGeNETi54575
EuPathDBiHostDB:ENSG00000242515.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		UGT1A10
HGNCiHGNC:12531, UGT1A10
HPAiENSG00000242515, Group enriched (esophagus, gallbladder, intestine, stomach)
MIMi191740, gene
606435, gene
neXtProtiNX_Q9HAW8
OpenTargetsiENSG00000242515
PharmGKBiPA37174

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1192, Eukaryota
GeneTreeiENSGT00940000163976
HOGENOMiCLU_012949_3_1_1
InParanoidiQ9HAW8
KOiK00699
OMAiATTRSIC
PhylomeDBiQ9HAW8
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17, 2681
PathwayCommonsiQ9HAW8
ReactomeiR-HSA-156588, Glucuronidation
SABIO-RKiQ9HAW8
SIGNORiQ9HAW8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54575, 0 hits in 793 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UGT1A10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54575
PharosiQ9HAW8, Tbio

Protein Ontology

More...PROi		PR:Q9HAW8
RNActiQ9HAW8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000242515, Expressed in intestine and 50 other tissues
ExpressionAtlasiQ9HAW8, baseline and differential
GenevisibleiQ9HAW8, HS

Family and domain databases

InterProiView protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201, UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375, UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD110_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAW8
Secondary accession number(s): O00474, Q6NT91, Q7Z6H8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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