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Entry version 149 (08 May 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Tumor necrosis factor receptor superfamily member 27

Gene

EDA2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5669034 TNFs bind their physiological receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9HAV5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9HAV5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 27
Alternative name(s):
X-linked ectodysplasin-A2 receptor
Short name:
EDA-A2 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDA2R
Synonyms:TNFRSF27, XEDAR
ORF Names:UNQ2448/PRO5727/PRO34080
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17756 EDA2R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300276 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 138ExtracellularSequence analysisAdd BLAST138
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei139 – 159Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini160 – 297CytoplasmicSequence analysisAdd BLAST138

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi256E → R: Abolishes TRAF6 association. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
60401

MalaCards human disease database

More...
MalaCardsi
EDA2R

Open Targets

More...
OpenTargetsi
ENSG00000131080

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
181 X-linked hypohidrotic ectodermal dysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974675

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EDA2R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104030

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000589381 – 297Tumor necrosis factor receptor superfamily member 27Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3 ↔ 15PROSITE-ProRule annotation
Disulfide bondi18 ↔ 31PROSITE-ProRule annotation
Disulfide bondi21 ↔ 41PROSITE-ProRule annotation
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi61 ↔ 75PROSITE-ProRule annotation
Disulfide bondi64 ↔ 83PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 104PROSITE-ProRule annotation
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q9HAV5

PRoteomics IDEntifications database

More...
PRIDEi
Q9HAV5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81446
81447 [Q9HAV5-2]
81448 [Q9HAV5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131080 Expressed in 88 organ(s), highest expression level in endocervix

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAV5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054522

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with TRAF1, TRAF3 and TRAF6.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121904, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HAV5, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379365

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HAV5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 41TNFR-Cys 1Add BLAST40
Repeati43 – 83TNFR-Cys 2Add BLAST41
Repeati85 – 118TNFR-Cys 3Add BLAST34

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000132464

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HAV5

KEGG Orthology (KO)

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KOi
K05163

Identification of Orthologs from Complete Genome Data

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OMAi
ILDDDCS

Database of Orthologous Groups

More...
OrthoDBi
672843at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAV5

TreeFam database of animal gene trees

More...
TreeFami
TF331385

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15838 TNFRSF27, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022319 TNFR_27
IPR034060 TNFRSF27_N

The PANTHER Classification System

More...
PANTHERi
PTHR12120:SF8 PTHR12120:SF8, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01973 TNFACTORR27

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HAV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDCQENEYWD QWGRCVTCQR CGPGQELSKD CGYGEGGDAY CTACPPRRYK
60 70 80 90 100
SSWGHHRCQS CITCAVINRV QKVNCTATSN AVCGDCLPRF YRKTRIGGLQ
110 120 130 140 150
DQECIPCTKQ TPTSEVQCAF QLSLVEADTP TVPPQEATLV ALVSSLLVVF
160 170 180 190 200
TLAFLGLFFL YCKQFFNRHC QRGGLLQFEA DKTAKEESLF PVPPSKETSA
210 220 230 240 250
ESQVSENIFQ TQPLNPILED DCSSTSGFPT QESFTMASCT SESHSHWVHS
260 270 280 290
PIECTELDLQ KFSSSASYTG AETLGGNTVE STGDRLELNV PFEVPSP
Length:297
Mass (Da):32,759
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05DBB377DC59350C
GO
Isoform 2 (identifier: Q9HAV5-2) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     172-172: R → REKLIIFSDPVPASLNLIPEFA

Show »
Length:318
Mass (Da):35,054
Checksum:iE18193A333561437
GO
Isoform 3 (identifier: Q9HAV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-172: R → RVT

Show »
Length:299
Mass (Da):32,959
Checksum:i09E894E7649780C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236M → V in AAN73210 (PubMed:12270937).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04451157R → K. Corresponds to variant dbSNP:rs1385699Ensembl.1
Natural variantiVAR_044512129T → A4 PublicationsCorresponds to variant dbSNP:rs1385698Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011568172R → REKLIIFSDPVPASLNLIPE FA in isoform 2. 1 Publication1
Alternative sequenceiVSP_011569172R → RVT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF298812 mRNA Translation: AAG28761.1
AY152724 mRNA Translation: AAN73210.1
AY358735 mRNA Translation: AAQ89952.1
AY358736 mRNA Translation: AAQ89953.1
AL353136 Genomic DNA No translation available.
BC034919 mRNA Translation: AAH34919.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14386.1 [Q9HAV5-1]
CCDS56603.1 [Q9HAV5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001186616.1, NM_001199687.2
NP_001229239.1, NM_001242310.1
NP_001311130.1, NM_001324201.1
NP_001311133.1, NM_001324204.1
NP_001311134.1, NM_001324205.1
NP_001311135.1, NM_001324206.1
NP_068555.1, NM_021783.4 [Q9HAV5-1]
XP_011529302.1, XM_011531000.1 [Q9HAV5-2]
XP_011529303.1, XM_011531001.1 [Q9HAV5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253392; ENSP00000253392; ENSG00000131080 [Q9HAV5-2]
ENST00000374719; ENSP00000363851; ENSG00000131080 [Q9HAV5-1]
ENST00000396050; ENSP00000379365; ENSG00000131080 [Q9HAV5-2]
ENST00000451436; ENSP00000415242; ENSG00000131080 [Q9HAV5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
60401

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60401

UCSC genome browser

More...
UCSCi
uc004dwq.4 human [Q9HAV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298812 mRNA Translation: AAG28761.1
AY152724 mRNA Translation: AAN73210.1
AY358735 mRNA Translation: AAQ89952.1
AY358736 mRNA Translation: AAQ89953.1
AL353136 Genomic DNA No translation available.
BC034919 mRNA Translation: AAH34919.1
CCDSiCCDS14386.1 [Q9HAV5-1]
CCDS56603.1 [Q9HAV5-2]
RefSeqiNP_001186616.1, NM_001199687.2
NP_001229239.1, NM_001242310.1
NP_001311130.1, NM_001324201.1
NP_001311133.1, NM_001324204.1
NP_001311134.1, NM_001324205.1
NP_001311135.1, NM_001324206.1
NP_068555.1, NM_021783.4 [Q9HAV5-1]
XP_011529302.1, XM_011531000.1 [Q9HAV5-2]
XP_011529303.1, XM_011531001.1 [Q9HAV5-2]

3D structure databases

SMRiQ9HAV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121904, 12 interactors
IntActiQ9HAV5, 17 interactors
STRINGi9606.ENSP00000379365

PTM databases

iPTMnetiQ9HAV5
PhosphoSitePlusiQ9HAV5

Polymorphism and mutation databases

BioMutaiEDA2R
DMDMi313104030

Proteomic databases

PeptideAtlasiQ9HAV5
PRIDEiQ9HAV5
ProteomicsDBi81446
81447 [Q9HAV5-2]
81448 [Q9HAV5-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
60401
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253392; ENSP00000253392; ENSG00000131080 [Q9HAV5-2]
ENST00000374719; ENSP00000363851; ENSG00000131080 [Q9HAV5-1]
ENST00000396050; ENSP00000379365; ENSG00000131080 [Q9HAV5-2]
ENST00000451436; ENSP00000415242; ENSG00000131080 [Q9HAV5-1]
GeneIDi60401
KEGGihsa:60401
UCSCiuc004dwq.4 human [Q9HAV5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60401
DisGeNETi60401

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EDA2R
HGNCiHGNC:17756 EDA2R
HPAiHPA054522
MalaCardsiEDA2R
MIMi300276 gene
neXtProtiNX_Q9HAV5
OpenTargetsiENSG00000131080
Orphaneti181 X-linked hypohidrotic ectodermal dysplasia
PharmGKBiPA134974675

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153259
HOGENOMiHOG000132464
InParanoidiQ9HAV5
KOiK05163
OMAiILDDDCS
OrthoDBi672843at2759
PhylomeDBiQ9HAV5
TreeFamiTF331385

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
SignaLinkiQ9HAV5
SIGNORiQ9HAV5

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Ectodysplasin_A2_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
60401

Protein Ontology

More...
PROi
PR:Q9HAV5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131080 Expressed in 88 organ(s), highest expression level in endocervix
GenevisibleiQ9HAV5 HS

Family and domain databases

CDDicd15838 TNFRSF27, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022319 TNFR_27
IPR034060 TNFRSF27_N
PANTHERiPTHR12120:SF8 PTHR12120:SF8, 2 hits
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01973 TNFACTORR27
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAV5
Secondary accession number(s): Q5VYX9
, Q5VYY0, Q6UWM2, Q8IZA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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