UniProtKB - Q9HAV4 (XPO5_HUMAN)
Exportin-5
XPO5
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 441 | Pre-miRNA binding1 Publication | 1 | |
Sitei | 448 | Pre-miRNA binding1 Publication | 1 | |
Sitei | 718 | Pre-miRNA binding1 Publication | 1 | |
Sitei | 1045 | Pre-miRNA binding1 Publication | 1 |
GO - Molecular functioni
- mRNA binding Source: BHF-UCL
- nuclear export signal receptor activity Source: BHF-UCL
- pre-miRNA binding Source: BHF-UCL
- Ran GTPase binding Source: BHF-UCL
- RISC complex binding Source: GO_Central
- RNA binding Source: UniProtKB
- tRNA binding Source: UniProtKB-KW
GO - Biological processi
- miRNA metabolic process Source: Reactome
- positive regulation of RNA interference Source: BHF-UCL
- pre-miRNA export from nucleus Source: BHF-UCL
- protein export from nucleus Source: UniProtKB
- regulation of protein export from nucleus Source: GO_Central
- RNA export from nucleus Source: GO_Central
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding, tRNA-binding |
Biological process | Host-virus interaction, Protein transport, RNA-mediated gene silencing, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9HAV4 |
Reactomei | R-HSA-203927, MicroRNA (miRNA) biogenesis |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exportin-5Short name: Exp5 Alternative name(s): Ran-binding protein 21 |
Gene namesi | Name:XPO5 Synonyms:KIAA1291, RANBP21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17675, XPO5 |
MIMi | 607845, gene |
neXtProti | NX_Q9HAV4 |
VEuPathDBi | HostDB:ENSG00000124571.17 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- cytoplasm Source: BHF-UCL
- RISC complex Source: UniProtKB
- RNA nuclear export complex Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57510 |
OpenTargetsi | ENSG00000124571 |
PharmGKBi | PA134979214 |
Miscellaneous databases
Pharosi | Q9HAV4, Tbio |
Genetic variation databases
BioMutai | XPO5 |
DMDMi | 74734245 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000235299 | 2 – 1204 | Exportin-5Add BLAST | 1203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 396 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 826 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-140 CPTAC-141 |
EPDi | Q9HAV4 |
jPOSTi | Q9HAV4 |
MassIVEi | Q9HAV4 |
MaxQBi | Q9HAV4 |
PaxDbi | Q9HAV4 |
PeptideAtlasi | Q9HAV4 |
PRIDEi | Q9HAV4 |
ProteomicsDBi | 81445 |
PTM databases
iPTMneti | Q9HAV4 |
MetOSitei | Q9HAV4 |
PhosphoSitePlusi | Q9HAV4 |
SwissPalmi | Q9HAV4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000124571, Expressed in testis and 205 other tissues |
ExpressionAtlasi | Q9HAV4, baseline and differential |
Genevisiblei | Q9HAV4, HS |
Organism-specific databases
HPAi | ENSG00000124571, Low tissue specificity |
Interactioni
Subunit structurei
Component of a nuclear export receptor complex composed of XPO5, RAN, dsRNA-binding proteins and dsRNA.
Found in a nuclear export complex with XPO5, RAN, EEF1A1, and aminoacylated tRNA.
Found in a nuclear export complex with XPO5, RAN, ILF3 and dsRNA.
Found in a nuclear export complex with XPO5, RAN and pre-miRNA (PubMed:19965479).
Found in a nuclear export complex with XPO5, RAN, ILF3 and minihelix VA1 dsRNA.
Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA.
Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346.
Interacts with RAN and cargo proteins in a GTP-dependent manner.
Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains).
Interacts with SMAD4; mediates nuclear export of SMAD4 (PubMed:26878725).
Interacts with RAN (GTP-bound form) (PubMed:19965479).
10 PublicationsBinary interactionsi
Q9HAV4
With | #Exp. | IntAct |
---|---|---|
KLK6 [Q92876] | 3 | EBI-517949,EBI-2432309 |
GO - Molecular functioni
- Ran GTPase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 121574, 108 interactors |
CORUMi | Q9HAV4 |
DIPi | DIP-34547N |
IntActi | Q9HAV4, 40 interactors |
MINTi | Q9HAV4 |
STRINGi | 9606.ENSP00000265351 |
Miscellaneous databases
RNActi | Q9HAV4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9HAV4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9HAV4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 108 | Necessary for interaction with RanAdd BLAST | 107 | |
Regioni | 533 – 640 | Necessary for interaction with ILF3Add BLAST | 108 | |
Regioni | 641 – 642 | Pre-miRNA binding1 Publication | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2020, Eukaryota |
GeneTreei | ENSGT00940000153408 |
HOGENOMi | CLU_002828_0_0_1 |
InParanoidi | Q9HAV4 |
OMAi | WPDDPDR |
OrthoDBi | 203278at2759 |
PhylomeDBi | Q9HAV4 |
TreeFami | TF323382 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR040018, XPO5 |
PANTHERi | PTHR11223:SF3, PTHR11223:SF3, 1 hit |
Pfami | View protein in Pfam PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAMDQVNALC EQLVKAVTVM MDPNSTQRYR LEALKFCEEF KEKCPICVPC
60 70 80 90 100
GLRLAEKTQV AIVRHFGLQI LEHVVKFRWN GMSRLEKVYL KNSVMELIAN
110 120 130 140 150
GTLNILEEEN HIKDALSRIV VEMIKREWPQ HWPDMLIELD TLSKQGETQT
160 170 180 190 200
ELVMFILLRL AEDVVTFQTL PPQRRRDIQQ TLTQNMERIF SFLLNTLQEN
210 220 230 240 250
VNKYQQVKTD TSQESKAQAN CRVGVAALNT LAGYIDWVSM SHITAENCKL
260 270 280 290 300
LEILCLLLNE QELQLGAAEC LLIAVSRKGK LEDRKPLMVL FGDVAMHYIL
310 320 330 340 350
SAAQTADGGG LVEKHYVFLK RLCQVLCALG NQLCALLGAD SDVETPSNFG
360 370 380 390 400
KYLESFLAFT THPSQFLRSS TQMTWGALFR HEILSRDPLL LAIIPKYLRA
410 420 430 440 450
SMTNLVKMGF PSKTDSPSCE YSRFDFDSDE DFNAFFNSSR AQQGEVMRLA
460 470 480 490 500
CRLDPKTSFQ MAGEWLKYQL STFLDAGSVN SCSAVGTGEG SLCSVFSPSF
510 520 530 540 550
VQWEAMTLFL ESVITQMFRT LNREEIPVND GIELLQMVLN FDTKDPLILS
560 570 580 590 600
CVLTNVSALF PFVTYRPEFL PQVFSKLFSS VTFETVEESK APRTRAVRNV
610 620 630 640 650
RRHACSSIIK MCRDYPQLVL PNFDMLYNHV KQLLSNELLL TQMEKCALME
660 670 680 690 700
ALVLISNQFK NYERQKVFLE ELMAPVASIW LSQDMHRVLS DVDAFIAYVG
710 720 730 740 750
TDQKSCDPGL EDPCGLNRAR MSFCVYSILG VVKRTCWPTD LEEAKAGGFV
760 770 780 790 800
VGYTSSGNPI FRNPCTEQIL KLLDNLLALI RTHNTLYAPE MLAKMAEPFT
810 820 830 840 850
KALDMLDAEK SAILGLPQPL LELNDSPVFK TVLERMQRFF STLYENCFHI
860 870 880 890 900
LGKAGPSMQQ DFYTVEDLAT QLLSSAFVNL NNIPDYRLRP MLRVFVKPLV
910 920 930 940 950
LFCPPEHYEA LVSPILGPLF TYLHMRLSQK WQVINQRSLL CGEDEAADEN
960 970 980 990 1000
PESQEMLEEQ LVRMLTREVM DLITVCCVSK KGADHSSAPP ADGDDEEMMA
1010 1020 1030 1040 1050
TEVTPSAMAE LTDLGKCLMK HEDVCTALLI TAFNSLAWKD TLSCQRTTSQ
1060 1070 1080 1090 1100
LCWPLLKQVL SGTLLADAVT WLFTSVLKGL QMHGQHDGCM ASLVHLAFQI
1110 1120 1130 1140 1150
YEALRPRYLE IRAVMEQIPE IQKDSLDQFD CKLLNPSLQK VADKRRKDQF
1160 1170 1180 1190 1200
KRLIAGCIGK PLGEQFRKEV HIKNLPSLFK KTKPMLETEV LDNDGGGLAT
IFEP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y3W3 | H0Y3W3_HUMAN | Exportin-5 | XPO5 | 253 | Annotation score: | ||
E2QRM3 | E2QRM3_HUMAN | Exportin-5 | XPO5 | 76 | Annotation score: | ||
H0Y9I3 | H0Y9I3_HUMAN | Exportin-5 | XPO5 | 107 | Annotation score: | ||
H0Y3Q8 | H0Y3Q8_HUMAN | Exportin-5 | XPO5 | 24 | Annotation score: | ||
H0YA57 | H0YA57_HUMAN | Exportin-5 | XPO5 | 60 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 81 | G → S in AAG53603 (PubMed:12426392).Curated | 1 | |
Sequence conflicti | 697 | A → V in BAA86605 (PubMed:10574462).Curated | 1 | |
Sequence conflicti | 988 | A → T in BAB14200 (PubMed:14574404).Curated | 1 | |
Sequence conflicti | 1151 | K → E in BAA91547 (PubMed:14574404).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048960 | 241 | S → N. Corresponds to variant dbSNP:rs34324334Ensembl. | 1 | |
Natural variantiVAR_076472 | 552 | V → I Found in a patient with nephrotic syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs11544379EnsemblClinVar. | 1 | |
Natural variantiVAR_028032 | 610 | K → N. Corresponds to variant dbSNP:rs12173786Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF271159 mRNA Translation: AAG53603.1 AF298880 mRNA Translation: AAG17907.1 AB033117 mRNA Translation: BAA86605.2 Different initiation. AL355802 Genomic DNA No translation available. BC000129 mRNA Translation: AAH00129.1 Different initiation. BC008347 mRNA Translation: AAH08347.1 BC009969 mRNA Translation: AAH09969.2 BC062635 mRNA Translation: AAH62635.1 AL137467 mRNA Translation: CAB70753.1 AK001195 mRNA Translation: BAA91547.1 Frameshift. AK022718 mRNA Translation: BAB14200.1 |
CCDSi | CCDS47430.1 |
PIRi | T46411 |
RefSeqi | NP_065801.1, NM_020750.2 |
Genome annotation databases
Ensembli | ENST00000265351; ENSP00000265351; ENSG00000124571 |
GeneIDi | 57510 |
KEGGi | hsa:57510 |
UCSCi | uc003ovp.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF271159 mRNA Translation: AAG53603.1 AF298880 mRNA Translation: AAG17907.1 AB033117 mRNA Translation: BAA86605.2 Different initiation. AL355802 Genomic DNA No translation available. BC000129 mRNA Translation: AAH00129.1 Different initiation. BC008347 mRNA Translation: AAH08347.1 BC009969 mRNA Translation: AAH09969.2 BC062635 mRNA Translation: AAH62635.1 AL137467 mRNA Translation: CAB70753.1 AK001195 mRNA Translation: BAA91547.1 Frameshift. AK022718 mRNA Translation: BAB14200.1 |
CCDSi | CCDS47430.1 |
PIRi | T46411 |
RefSeqi | NP_065801.1, NM_020750.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3A6P | X-ray | 2.92 | A/F | 1-1204 | [»] | |
5YU6 | X-ray | 3.00 | A/C | 1-1204 | [»] | |
5YU7 | X-ray | 3.30 | A | 1-1204 | [»] | |
SMRi | Q9HAV4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121574, 108 interactors |
CORUMi | Q9HAV4 |
DIPi | DIP-34547N |
IntActi | Q9HAV4, 40 interactors |
MINTi | Q9HAV4 |
STRINGi | 9606.ENSP00000265351 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | Q9HAV4 |
MetOSitei | Q9HAV4 |
PhosphoSitePlusi | Q9HAV4 |
SwissPalmi | Q9HAV4 |
Genetic variation databases
BioMutai | XPO5 |
DMDMi | 74734245 |
Proteomic databases
CPTACi | CPTAC-140 CPTAC-141 |
EPDi | Q9HAV4 |
jPOSTi | Q9HAV4 |
MassIVEi | Q9HAV4 |
MaxQBi | Q9HAV4 |
PaxDbi | Q9HAV4 |
PeptideAtlasi | Q9HAV4 |
PRIDEi | Q9HAV4 |
ProteomicsDBi | 81445 |
Protocols and materials databases
Antibodypediai | 3239, 214 antibodies |
Genome annotation databases
Ensembli | ENST00000265351; ENSP00000265351; ENSG00000124571 |
GeneIDi | 57510 |
KEGGi | hsa:57510 |
UCSCi | uc003ovp.3, human |
Organism-specific databases
CTDi | 57510 |
DisGeNETi | 57510 |
GeneCardsi | XPO5 |
HGNCi | HGNC:17675, XPO5 |
HPAi | ENSG00000124571, Low tissue specificity |
MIMi | 607845, gene |
neXtProti | NX_Q9HAV4 |
OpenTargetsi | ENSG00000124571 |
PharmGKBi | PA134979214 |
VEuPathDBi | HostDB:ENSG00000124571.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2020, Eukaryota |
GeneTreei | ENSGT00940000153408 |
HOGENOMi | CLU_002828_0_0_1 |
InParanoidi | Q9HAV4 |
OMAi | WPDDPDR |
OrthoDBi | 203278at2759 |
PhylomeDBi | Q9HAV4 |
TreeFami | TF323382 |
Enzyme and pathway databases
PathwayCommonsi | Q9HAV4 |
Reactomei | R-HSA-203927, MicroRNA (miRNA) biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 57510, 450 hits in 890 CRISPR screens |
ChiTaRSi | XPO5, human |
EvolutionaryTracei | Q9HAV4 |
GeneWikii | XPO5 |
GenomeRNAii | 57510 |
Pharosi | Q9HAV4, Tbio |
PROi | PR:Q9HAV4 |
RNActi | Q9HAV4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124571, Expressed in testis and 205 other tissues |
ExpressionAtlasi | Q9HAV4, baseline and differential |
Genevisiblei | Q9HAV4, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR040018, XPO5 |
PANTHERi | PTHR11223:SF3, PTHR11223:SF3, 1 hit |
Pfami | View protein in Pfam PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XPO5_HUMAN | |
Accessioni | Q9HAV4Primary (citable) accession number: Q9HAV4 Secondary accession number(s): Q5JTE6 Q9ULC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families