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UniProtKB - Q9HAV4 (XPO5_HUMAN)

Entry version 171 (23 Feb 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Exportin-5

Gene

XPO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.

Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14681208, PubMed:14631048, PubMed:15613540).

Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479).

Binding is dependent on Ran-GTP (PubMed:19965479).

4 Publications

(Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei441Pre-miRNA binding1 Publication1
Sitei448Pre-miRNA binding1 Publication1
Sitei718Pre-miRNA binding1 Publication1
Sitei1045Pre-miRNA binding1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, tRNA-binding
Biological processHost-virus interaction, Protein transport, RNA-mediated gene silencing, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HAV4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-203927, MicroRNA (miRNA) biogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HAV4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9HAV4

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-5
Short name:
Exp5
Alternative name(s):
Ran-binding protein 21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XPO5
Synonyms:KIAA1291, RANBP21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17675, XPO5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607845, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HAV4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124571

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57510

Open Targets

More...OpenTargetsi		ENSG00000124571

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134979214

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HAV4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		XPO5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74734245

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002352992 – 1204Exportin-5Add BLAST1203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei396N6-acetyllysineCombined sources1
Modified residuei826PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-140
CPTAC-141

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HAV4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HAV4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HAV4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HAV4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HAV4

PeptideAtlas

More...PeptideAtlasi		Q9HAV4

PRoteomics IDEntifications database

More...PRIDEi		Q9HAV4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81445

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9HAV4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HAV4

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9HAV4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HAV4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9HAV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124571, Expressed in testis and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HAV4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HAV4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124571, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a nuclear export receptor complex composed of XPO5, RAN, dsRNA-binding proteins and dsRNA.

Found in a nuclear export complex with XPO5, RAN, EEF1A1, and aminoacylated tRNA.

Found in a nuclear export complex with XPO5, RAN, ILF3 and dsRNA.

Found in a nuclear export complex with XPO5, RAN and pre-miRNA (PubMed:19965479).

Found in a nuclear export complex with XPO5, RAN, ILF3 and minihelix VA1 dsRNA.

Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and dsRNA.

Interacts with EEF1A1, ILF3, NUP153, NUP214 and ZNF346.

Interacts with RAN and cargo proteins in a GTP-dependent manner.

Interacts with isoform 5 of ADAR/ADAR1 (via DRBM domains).

Interacts with SMAD4; mediates nuclear export of SMAD4 (PubMed:26878725).

Interacts with RAN (GTP-bound form) (PubMed:19965479).

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

  • small GTPase binding Source: BHF-UCL
Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121574, 157 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9HAV4

Database of interacting proteins

More...DIPi		DIP-34547N

Protein interaction database and analysis system

More...IntActi		Q9HAV4, 46 interactors

Molecular INTeraction database

More...MINTi		Q9HAV4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265351

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HAV4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HAV4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HAV4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 108Necessary for interaction with RanAdd BLAST107
Regioni533 – 640Necessary for interaction with ILF3Add BLAST108
Regioni641 – 642Pre-miRNA binding1 Publication2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2020, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002828_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HAV4

Identification of Orthologs from Complete Genome Data

More...OMAi		WPDDPDR

Database of Orthologous Groups

More...OrthoDBi		203278at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HAV4

TreeFam database of animal gene trees

More...TreeFami		TF323382

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045478, Exportin-5_C
IPR001494, Importin-beta_N
IPR045065, XPO1/5
IPR040018, XPO5

The PANTHER Classification System

More...PANTHERi		PTHR11223, PTHR11223, 1 hit
PTHR11223:SF3, PTHR11223:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19273, Exportin-5, 1 hit
PF08389, Xpo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9HAV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMDQVNALC EQLVKAVTVM MDPNSTQRYR LEALKFCEEF KEKCPICVPC 
        60         70         80         90        100
GLRLAEKTQV AIVRHFGLQI LEHVVKFRWN GMSRLEKVYL KNSVMELIAN 
       110        120        130        140        150
GTLNILEEEN HIKDALSRIV VEMIKREWPQ HWPDMLIELD TLSKQGETQT 
       160        170        180        190        200
ELVMFILLRL AEDVVTFQTL PPQRRRDIQQ TLTQNMERIF SFLLNTLQEN 
       210        220        230        240        250
VNKYQQVKTD TSQESKAQAN CRVGVAALNT LAGYIDWVSM SHITAENCKL 
       260        270        280        290        300
LEILCLLLNE QELQLGAAEC LLIAVSRKGK LEDRKPLMVL FGDVAMHYIL 
       310        320        330        340        350
SAAQTADGGG LVEKHYVFLK RLCQVLCALG NQLCALLGAD SDVETPSNFG 
       360        370        380        390        400
KYLESFLAFT THPSQFLRSS TQMTWGALFR HEILSRDPLL LAIIPKYLRA 
       410        420        430        440        450
SMTNLVKMGF PSKTDSPSCE YSRFDFDSDE DFNAFFNSSR AQQGEVMRLA 
       460        470        480        490        500
CRLDPKTSFQ MAGEWLKYQL STFLDAGSVN SCSAVGTGEG SLCSVFSPSF 
       510        520        530        540        550
VQWEAMTLFL ESVITQMFRT LNREEIPVND GIELLQMVLN FDTKDPLILS 
       560        570        580        590        600
CVLTNVSALF PFVTYRPEFL PQVFSKLFSS VTFETVEESK APRTRAVRNV 
       610        620        630        640        650
RRHACSSIIK MCRDYPQLVL PNFDMLYNHV KQLLSNELLL TQMEKCALME 
       660        670        680        690        700
ALVLISNQFK NYERQKVFLE ELMAPVASIW LSQDMHRVLS DVDAFIAYVG 
       710        720        730        740        750
TDQKSCDPGL EDPCGLNRAR MSFCVYSILG VVKRTCWPTD LEEAKAGGFV 
       760        770        780        790        800
VGYTSSGNPI FRNPCTEQIL KLLDNLLALI RTHNTLYAPE MLAKMAEPFT 
       810        820        830        840        850
KALDMLDAEK SAILGLPQPL LELNDSPVFK TVLERMQRFF STLYENCFHI 
       860        870        880        890        900
LGKAGPSMQQ DFYTVEDLAT QLLSSAFVNL NNIPDYRLRP MLRVFVKPLV 
       910        920        930        940        950
LFCPPEHYEA LVSPILGPLF TYLHMRLSQK WQVINQRSLL CGEDEAADEN 
       960        970        980        990       1000
PESQEMLEEQ LVRMLTREVM DLITVCCVSK KGADHSSAPP ADGDDEEMMA 
      1010       1020       1030       1040       1050
TEVTPSAMAE LTDLGKCLMK HEDVCTALLI TAFNSLAWKD TLSCQRTTSQ 
      1060       1070       1080       1090       1100
LCWPLLKQVL SGTLLADAVT WLFTSVLKGL QMHGQHDGCM ASLVHLAFQI 
      1110       1120       1130       1140       1150
YEALRPRYLE IRAVMEQIPE IQKDSLDQFD CKLLNPSLQK VADKRRKDQF 
      1160       1170       1180       1190       1200
KRLIAGCIGK PLGEQFRKEV HIKNLPSLFK KTKPMLETEV LDNDGGGLAT 

IFEP
Length:1,204
Mass (Da):136,311
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3295A17DF7C37602
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3W3H0Y3W3_HUMAN
Exportin-5
XPO5
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2QRM3E2QRM3_HUMAN
Exportin-5
XPO5
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9I3H0Y9I3_HUMAN
Exportin-5
XPO5
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3Q8H0Y3Q8_HUMAN
Exportin-5
XPO5
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA57H0YA57_HUMAN
Exportin-5
XPO5
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00129 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86605 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91547 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81G → S in AAG53603 (PubMed:12426392).Curated1
Sequence conflicti697A → V in BAA86605 (PubMed:10574462).Curated1
Sequence conflicti988A → T in BAB14200 (PubMed:14574404).Curated1
Sequence conflicti1151K → E in BAA91547 (PubMed:14574404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048960241S → N. Corresponds to variant dbSNP:rs34324334Ensembl.1
Natural variantiVAR_076472552V → I Found in a patient with nephrotic syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs11544379EnsemblClinVar.1
Natural variantiVAR_028032610K → N. Corresponds to variant dbSNP:rs12173786Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF271159 mRNA Translation: AAG53603.1
AF298880 mRNA Translation: AAG17907.1
AB033117 mRNA Translation: BAA86605.2 Different initiation.
AL355802 Genomic DNA No translation available.
BC000129 mRNA Translation: AAH00129.1 Different initiation.
BC008347 mRNA Translation: AAH08347.1
BC009969 mRNA Translation: AAH09969.2
BC062635 mRNA Translation: AAH62635.1
AL137467 mRNA Translation: CAB70753.1
AK001195 mRNA Translation: BAA91547.1 Frameshift.
AK022718 mRNA Translation: BAB14200.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47430.1

Protein sequence database of the Protein Information Resource

More...PIRi		T46411

NCBI Reference Sequences

More...RefSeqi		NP_065801.1, NM_020750.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265351; ENSP00000265351; ENSG00000124571

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57510

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57510

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000265351.12; ENSP00000265351.7; NM_020750.3; NP_065801.1

UCSC genome browser

More...UCSCi		uc003ovp.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271159 mRNA Translation: AAG53603.1
AF298880 mRNA Translation: AAG17907.1
AB033117 mRNA Translation: BAA86605.2 Different initiation.
AL355802 Genomic DNA No translation available.
BC000129 mRNA Translation: AAH00129.1 Different initiation.
BC008347 mRNA Translation: AAH08347.1
BC009969 mRNA Translation: AAH09969.2
BC062635 mRNA Translation: AAH62635.1
AL137467 mRNA Translation: CAB70753.1
AK001195 mRNA Translation: BAA91547.1 Frameshift.
AK022718 mRNA Translation: BAB14200.1
CCDSiCCDS47430.1
PIRiT46411
RefSeqiNP_065801.1, NM_020750.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A6PX-ray2.92A/F1-1204[»]
5YU6X-ray3.00A/C1-1204[»]
5YU7X-ray3.30A1-1204[»]
SMRiQ9HAV4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121574, 157 interactors
CORUMiQ9HAV4
DIPiDIP-34547N
IntActiQ9HAV4, 46 interactors
MINTiQ9HAV4
STRINGi9606.ENSP00000265351

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

GlyGeniQ9HAV4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9HAV4
MetOSiteiQ9HAV4
PhosphoSitePlusiQ9HAV4
SwissPalmiQ9HAV4

Genetic variation databases

BioMutaiXPO5
DMDMi74734245

Proteomic databases

CPTACiCPTAC-140
CPTAC-141
EPDiQ9HAV4
jPOSTiQ9HAV4
MassIVEiQ9HAV4
MaxQBiQ9HAV4
PaxDbiQ9HAV4
PeptideAtlasiQ9HAV4
PRIDEiQ9HAV4
ProteomicsDBi81445

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3239, 223 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		57510

Genome annotation databases

EnsembliENST00000265351; ENSP00000265351; ENSG00000124571
GeneIDi57510
KEGGihsa:57510
MANE-SelectiENST00000265351.12; ENSP00000265351.7; NM_020750.3; NP_065801.1
UCSCiuc003ovp.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57510
DisGeNETi57510

GeneCards: human genes, protein and diseases

More...GeneCardsi		XPO5
HGNCiHGNC:17675, XPO5
HPAiENSG00000124571, Low tissue specificity
MIMi607845, gene
neXtProtiNX_Q9HAV4
OpenTargetsiENSG00000124571
PharmGKBiPA134979214
VEuPathDBiHostDB:ENSG00000124571

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2020, Eukaryota
GeneTreeiENSGT00940000153408
HOGENOMiCLU_002828_0_0_1
InParanoidiQ9HAV4
OMAiWPDDPDR
OrthoDBi203278at2759
PhylomeDBiQ9HAV4
TreeFamiTF323382

Enzyme and pathway databases

PathwayCommonsiQ9HAV4
ReactomeiR-HSA-203927, MicroRNA (miRNA) biogenesis
SignaLinkiQ9HAV4
SIGNORiQ9HAV4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57510, 471 hits in 1064 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		XPO5, human
EvolutionaryTraceiQ9HAV4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		XPO5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57510
PharosiQ9HAV4, Tbio

Protein Ontology

More...PROi		PR:Q9HAV4
RNActiQ9HAV4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124571, Expressed in testis and 206 other tissues
ExpressionAtlasiQ9HAV4, baseline and differential
GenevisibleiQ9HAV4, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045478, Exportin-5_C
IPR001494, Importin-beta_N
IPR045065, XPO1/5
IPR040018, XPO5
PANTHERiPTHR11223, PTHR11223, 1 hit
PTHR11223:SF3, PTHR11223:SF3, 1 hit
PfamiView protein in Pfam
PF19273, Exportin-5, 1 hit
PF08389, Xpo1, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAV4
Secondary accession number(s): Q5JTE6
, Q96G48, Q96HN3, Q9BWM6, Q9BZV5, Q9H9M4, Q9NT89, Q9NW39, Q9ULC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2001
Last modified: February 23, 2022
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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