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Entry version 157 (08 May 2019)
Sequence version 3 (15 Mar 2017)
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Protein

Aminopeptidase RNPEPL1

Gene

RNPEPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by calcium but not affected by chloride ions. Inhibited by amastatin and to a lower extent by bestatin. Weakly inhibited by puromycin.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.37 mM for Met-AMC1 Publication
  2. KM=0.17 mM for Citrulline-AMC1 Publication
  3. KM=1.72 mM for Ala-AMC1 Publication
  4. KM=0.91 mM for Arg-AMC1 Publication
  5. KM=0.89 mM for Asn-AMC1 Publication
  6. KM=0.41 mM for Gln-AMC1 Publication
  7. KM=0.18 mM for His-AMC1 Publication
  8. KM=1.05 mM for Ile-AMC1 Publication
  9. KM=0.34 mM for Leu-AMC1 Publication
  10. KM=1.72 mM for Lys-AMC1 Publication
  11. KM=0.65 mM for Phe-AMC1 Publication
  12. KM=1.76 mM for Ser-AMC1 Publication
  13. KM=0.12 mM for Trp-AMC1 Publication
  14. KM=0.12 mM for Tyr-AMC1 Publication

    pH dependencei

    Optimum pH is 6.6-8.0.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi353Zinc; catalyticBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei354Proton acceptorPROSITE-ProRule annotationBy similarity1
    Metal bindingi357Zinc; catalyticBy similarity1
    Metal bindingi376Zinc; catalyticBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei442Transition state stabilizerBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M01.022

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aminopeptidase RNPEPL11 Publication (EC:3.4.11.-1 Publication)
    Alternative name(s):
    Arginyl aminopeptidase-like 1Imported
    Methionyl aminopeptidase1 Publication (EC:3.4.11.181 Publication)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:RNPEPL11 PublicationImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10079 RNPEPL1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605287 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9HAU8

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    57140

    Open Targets

    More...
    OpenTargetsi
    ENSG00000142327

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA34452

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3831223

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    RNPEPL1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000950941 – 725Aminopeptidase RNPEPL1Add BLAST725

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9HAU8

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9HAU8

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9HAU8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9HAU8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9HAU8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9HAU8

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    81443

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9HAU8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9HAU8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitously expressed. Expressed at relatively higher levels in heart and skeletal muscle.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000142327 Expressed in 205 organ(s), highest expression level in apex of heart

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9HAU8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9HAU8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA036772

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    121399, 3 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9HAU8, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000270357

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9HAU8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni326 – 330Substrate bindingBy similarity5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1047 Eukaryota
    COG0308 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160400

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000293296

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9HAU8

    KEGG Orthology (KO)

    More...
    KOi
    K09605

    Database of Orthologous Groups

    More...
    OrthoDBi
    775595at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9HAU8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300758

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd09599 M1_LTA4H, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.390.10, 1 hit
    1.25.40.320, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016024 ARM-type_fold
    IPR038502 M1_LTA-4_hydro/amino_C_sf
    IPR034015 M1_LTA4H
    IPR001930 Peptidase_M1
    IPR015211 Peptidase_M1_C
    IPR014782 Peptidase_M1_dom
    IPR027268 Peptidase_M4/M1_CTD_sf
    IPR033525 RNPEPL1

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45726:SF2 PTHR45726:SF2, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF09127 Leuk-A4-hydro_C, 1 hit
    PF01433 Peptidase_M1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00756 ALADIPTASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01263 Leuk-A4-hydro_C, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48371 SSF48371, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9HAU8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAQCCCRQA PGAEAAPVRP PPEPPPALDV ASASSAQLFR LRHLQLGLEL
    60 70 80 90 100
    RPEARELAGC LVLELCALRP APRALVLDAH PALRLHSAAF RRAPAAAAET
    110 120 130 140 150
    PCAFAFSAPG PGPAPPPPLP AFPEAPGSEP ACCPLAFRVD PFTDYGSSLT
    160 170 180 190 200
    VTLPPELQAH QPFQVILRYT STDAPAIWWL DPELTYGCAK PFVFTQGHSV
    210 220 230 240 250
    CNRSFFPCFD TPAVKCTYSA VVKAPSGVQV LMSATRSAYM EEEGVFHFHM
    260 270 280 290 300
    EHPVPAYLVA LVAGDLKPAD IGPRSRVWAE PCLLPTATSK LSGAVEQWLS
    310 320 330 340 350
    AAERLYGPYM WGRYDIVFLP PSFPIVAMEN PCLTFIISSI LESDEFLVID
    360 370 380 390 400
    VIHEVAHSWF GNAVTNATWE EMWLSEGLAT YAQRRITTET YGAAFTCLET
    410 420 430 440 450
    AFRLDALHRQ MKLLGEDSPV SKLQVKLEPG VNPSHLMNLF TYEKGYCFVY
    460 470 480 490 500
    YLSQLCGDPQ RFDDFLRAYV EKYKFTSVVA QDLLDSFLSF FPELKEQSVD
    510 520 530 540 550
    CRAGLEFERW LNATGPPLAE PDLSQGSSLT RPVEALFQLW TAEPLDQAAA
    560 570 580 590 600
    SASAIDISKW RTFQTALFLD RLLDGSPLPQ EVVMSLSKCY SSLLDSMNAE
    610 620 630 640 650
    IRIRWLQIVV RNDYYPDLHR VRRFLESQMS RMYTIPLYED LCTGALKSFA
    660 670 680 690 700
    LEVFYQTQGR LHPNLRRAIQ QILSQGLGSS TEPASEPSTE LGKAEADTDS
    710 720
    DAQALLLGDE APSSAISLRD VNVSA
    Length:725
    Mass (Da):80,000
    Last modified:March 15, 2017 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D8153BD0320A0C4
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7C200H7C200_HUMAN
    Aminopeptidase RNPEPL1
    RNPEPL1
    247Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JSI2C9JSI2_HUMAN
    Aminopeptidase RNPEPL1
    RNPEPL1
    114Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAG22080 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAH67258 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAX88943 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence BAA91823 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti609V → E in AAG22080 (PubMed:11017071).Curated1
    Sequence conflicti609V → E in BAA91823 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036046478V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1454498603Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC124862 Genomic DNA Translation: AAX88943.1 Sequence problems.
    BC017301 mRNA Translation: AAH17301.2
    BC067258 mRNA Translation: AAH67258.2 Different initiation.
    BC082975 mRNA Translation: AAH82975.1
    AF300795 mRNA Translation: AAG22080.1 Different initiation.
    AK001668 mRNA Translation: BAA91823.1 Different initiation.
    AL512754 mRNA Translation: CAC21674.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_060696.4, NM_018226.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000270357; ENSP00000270357; ENSG00000142327

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    57140

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:57140

    UCSC genome browser

    More...
    UCSCi
    uc061uih.1 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC124862 Genomic DNA Translation: AAX88943.1 Sequence problems.
    BC017301 mRNA Translation: AAH17301.2
    BC067258 mRNA Translation: AAH67258.2 Different initiation.
    BC082975 mRNA Translation: AAH82975.1
    AF300795 mRNA Translation: AAG22080.1 Different initiation.
    AK001668 mRNA Translation: BAA91823.1 Different initiation.
    AL512754 mRNA Translation: CAC21674.1
    RefSeqiNP_060696.4, NM_018226.4

    3D structure databases

    SMRiQ9HAU8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi121399, 3 interactors
    IntActiQ9HAU8, 2 interactors
    STRINGi9606.ENSP00000270357

    Chemistry databases

    ChEMBLiCHEMBL3831223

    Protein family/group databases

    MEROPSiM01.022

    PTM databases

    iPTMnetiQ9HAU8
    PhosphoSitePlusiQ9HAU8

    Polymorphism and mutation databases

    BioMutaiRNPEPL1

    Proteomic databases

    EPDiQ9HAU8
    jPOSTiQ9HAU8
    MaxQBiQ9HAU8
    PaxDbiQ9HAU8
    PeptideAtlasiQ9HAU8
    PRIDEiQ9HAU8
    ProteomicsDBi81443

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000270357; ENSP00000270357; ENSG00000142327
    GeneIDi57140
    KEGGihsa:57140
    UCSCiuc061uih.1 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    57140
    DisGeNETi57140

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    RNPEPL1

    H-Invitational Database, human transcriptome db

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    H-InvDBi
    HIX0200261
    HGNCiHGNC:10079 RNPEPL1
    HPAiHPA036772
    MIMi605287 gene
    neXtProtiNX_Q9HAU8
    OpenTargetsiENSG00000142327
    PharmGKBiPA34452

    GenAtlas: human gene database

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    GenAtlasi
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    Phylogenomic databases

    eggNOGiKOG1047 Eukaryota
    COG0308 LUCA
    GeneTreeiENSGT00940000160400
    HOGENOMiHOG000293296
    InParanoidiQ9HAU8
    KOiK09605
    OrthoDBi775595at2759
    PhylomeDBiQ9HAU8
    TreeFamiTF300758

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    RNPEPL1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    57140

    Protein Ontology

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    PROi
    PR:Q9HAU8

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
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    Gene expression databases

    BgeeiENSG00000142327 Expressed in 205 organ(s), highest expression level in apex of heart
    ExpressionAtlasiQ9HAU8 baseline and differential
    GenevisibleiQ9HAU8 HS

    Family and domain databases

    CDDicd09599 M1_LTA4H, 1 hit
    Gene3Di1.10.390.10, 1 hit
    1.25.40.320, 1 hit
    InterProiView protein in InterPro
    IPR016024 ARM-type_fold
    IPR038502 M1_LTA-4_hydro/amino_C_sf
    IPR034015 M1_LTA4H
    IPR001930 Peptidase_M1
    IPR015211 Peptidase_M1_C
    IPR014782 Peptidase_M1_dom
    IPR027268 Peptidase_M4/M1_CTD_sf
    IPR033525 RNPEPL1
    PANTHERiPTHR45726:SF2 PTHR45726:SF2, 1 hit
    PfamiView protein in Pfam
    PF09127 Leuk-A4-hydro_C, 1 hit
    PF01433 Peptidase_M1, 1 hit
    PRINTSiPR00756 ALADIPTASE
    SMARTiView protein in SMART
    SM01263 Leuk-A4-hydro_C, 1 hit
    SUPFAMiSSF48371 SSF48371, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNPL1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAU8
    Secondary accession number(s): Q5XKC3
    , Q6NX56, Q96AC9, Q9H033, Q9NVD0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: March 15, 2017
    Last modified: May 8, 2019
    This is version 157 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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