UniProtKB - Q9HAU5 (RENT2_HUMAN)

BLAST

>sp|Q9HAU5|RENT2_HUMAN Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1
MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRL
EDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQ
MKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKT
ITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSL
LQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRE
SHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYF
TSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLL
DENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPA
ILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEA
EDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKAN
RKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINI
ETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPES
HLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLY
KDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQED
VGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFG
VNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLE
VWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSK
DSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLT
DSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDV
AIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWN
QQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPN
ADLIFKTGGRRR

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Format
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History
Entry version 163 (07 Nov 2018)
Sequence version 1 (01 Mar 2001)
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Protein

Regulator of nonsense transcripts 2

Gene

UPF2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.3 Publications

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW
telomeric DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17916692

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ regeneration Source: Ensembl
liver development Source: Ensembl
mRNA export from nucleus
Source: HGNC
Traceable author statementⁱ
- 16488880
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18369367

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Nonsense-mediated mRNA decay

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonDBⁱ	Q9HAU5 Predicted

MoonDBⁱ

Q9HAU5 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of nonsense transcripts 2 Alternative name(s): Nonsense mRNA reducing factor 2 Up-frameshift suppressor 2 homolog Short name: hUpf2
Gene namesⁱ	Name:UPF2 Synonyms:KIAA1408, RENT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151461.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17854 UPF2
MIMⁱ	605529 gene
neXtProtⁱ	NX_Q9HAU5

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	796 – 797	RK → EE: Strongly impairs RNA-binding. 1 Publication	2
Mutagenesisⁱ	847	D → K: Does not abolish interaction with UPF3B. 1 Publication	1
Mutagenesisⁱ	851 – 852	ED → KR: Does not abolish interaction with UPF3B. Does not abolish interaction with UPF3B; when associated with D-854. 1 Publication	2
Mutagenesisⁱ	854	R → D: Does not abolish interaction with UPF3B; when associated with K-851 and R-852. 1 Publication	1
Mutagenesisⁱ	858	E → R: Abolishes interaction with UPF3B and association with SMG1 and RBM8A; reduces phosphorylation of UPF1. 2 Publications	1
Mutagenesisⁱ	894	Y → A: Does not impair RNA-binding; when associated with A-932. 1 Publication	1
Mutagenesisⁱ	932	Y → A: Does not impair RNA-binding; when associated with A-894. 1 Publication	1
Mutagenesisⁱ	1113	F → E: Abolishes interaction with UPF1.	1
Mutagenesisⁱ	1120	M → E: Decreases interaction with UPF1; does not reduce NMD efficiency. 1 Publication	1
Mutagenesisⁱ	1121	M → E: Decreases interaction with UPF1; does not reduce NMD efficiency. 1 Publication	1
Mutagenesisⁱ	1123	E → R: Decreases interaction with UPF1. 1 Publication	1
Mutagenesisⁱ	1169	M → E: Decreases interaction with UPF1. 1 Publication	1
Mutagenesisⁱ	1171	F → E: Abolishes interaction with UPF1; reduces NMD efficiency. 1 Publication	1
Mutagenesisⁱ	1171	F → E: Greatly reduces NMD efficiency; when associated with E-1173 and E-1174. 1 Publication	1
Mutagenesisⁱ	1173	M → E: Abolishes interaction with UPF1. 1 Publication	1
Mutagenesisⁱ	1173	M → E: Greatly reduces NMD efficiency; when associated with E-1171 and E-1174. 1 Publication	1
Mutagenesisⁱ	1174	L → E: Abolishes interaction with UPF1; reduces NMD efficiency. 1 Publication	1
Mutagenesisⁱ	1174	L → E: Greatly reduces NMD efficiency; when associated with E-1171 and E-1173. 1 Publication	1
Mutagenesisⁱ	1176	R → E: Decreases interaction with UPF1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26019
Open Targets More...OpenTargetsⁱ	ENSG00000151461
PharmGKBⁱ	PA134945630

Polymorphism and mutation databases

BioMutaⁱ	UPF2
DMDMⁱ	60390647

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097248	1 – 1272	Regulator of nonsense transcripts 2Add BLAST		1272

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1088	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9HAU5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HAU5
PaxDbⁱ	Q9HAU5
PeptideAtlas More...PeptideAtlasⁱ	Q9HAU5
PRIDEⁱ	Q9HAU5
ProteomicsDBⁱ	81440 81441 [Q9HAU5-2]

PTM databases

CarbonylDBⁱ	Q9HAU5
iPTMnetⁱ	Q9HAU5
PhosphoSitePlusⁱ	Q9HAU5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151461 Expressed in 231 organ(s), highest expression level in testis
Genevisibleⁱ	Q9HAU5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067008

HPAⁱ

HPA067008

Interactionⁱ

Subunit structureⁱ

Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1.10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PUF60	Q9UHX1	3	EBI-372073,EBI-1053259
SMG1	Q96Q15	7	EBI-372073,EBI-1049832
UPF1	Q92900	29	EBI-372073,EBI-373471
UPF1	Q92900-2	9	EBI-372073,EBI-373492
UPF3A	Q9H1J1	5	EBI-372073,EBI-521530
UPF3B	Q9BZI7	8	EBI-372073,EBI-372780
UPF3B	Q9BZI7-2	7	EBI-372073,EBI-15674130

Protein-protein interaction databases

BioGridⁱ	117490, 94 interactors
CORUMⁱ	Q9HAU5
Database of interacting proteins More...DIPⁱ	DIP-31148N
IntActⁱ	Q9HAU5, 41 interactors
Molecular INTeraction database More...MINTⁱ	Q9HAU5
STRINGⁱ	9606.ENSP00000348708

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	122 – 149	Combined sources	28
Helixⁱ	152 – 154	Combined sources	3
Helixⁱ	158 – 162	Combined sources	5
Helixⁱ	168 – 177	Combined sources	10
Helixⁱ	178 – 180	Combined sources	3
Helixⁱ	183 – 185	Combined sources	3
Helixⁱ	186 – 195	Combined sources	10
Helixⁱ	202 – 211	Combined sources	10
Helixⁱ	216 – 218	Combined sources	3
Helixⁱ	219 – 232	Combined sources	14
Helixⁱ	236 – 253	Combined sources	18
Helixⁱ	259 – 274	Combined sources	16
Helixⁱ	280 – 297	Combined sources	18
Beta strandⁱ	299 – 301	Combined sources	3
Helixⁱ	305 – 320	Combined sources	16
Helixⁱ	325 – 334	Combined sources	10
Helixⁱ	346 – 375	Combined sources	30
Turnⁱ	376 – 382	Combined sources	7
Helixⁱ	383 – 386	Combined sources	4
Turnⁱ	387 – 389	Combined sources	3
Turnⁱ	395 – 398	Combined sources	4
Helixⁱ	399 – 419	Combined sources	21
Beta strandⁱ	460 – 462	Combined sources	3
Helixⁱ	463 – 469	Combined sources	7
Helixⁱ	474 – 476	Combined sources	3
Helixⁱ	539 – 549	Combined sources	11
Helixⁱ	560 – 574	Combined sources	15
Helixⁱ	575 – 577	Combined sources	3
Helixⁱ	581 – 594	Combined sources	14
Helixⁱ	598 – 609	Combined sources	12
Helixⁱ	613 – 618	Combined sources	6
Helixⁱ	619 – 629	Combined sources	11
Turnⁱ	630 – 632	Combined sources	3
Helixⁱ	635 – 653	Combined sources	19
Helixⁱ	660 – 675	Combined sources	16
Helixⁱ	681 – 693	Combined sources	13
Helixⁱ	697 – 716	Combined sources	20
Helixⁱ	718 – 737	Combined sources	20
Helixⁱ	742 – 755	Combined sources	14
Helixⁱ	770 – 780	Combined sources	11
Helixⁱ	788 – 796	Combined sources	9
Helixⁱ	803 – 814	Combined sources	12
Helixⁱ	816 – 818	Combined sources	3
Helixⁱ	821 – 823	Combined sources	3
Helixⁱ	824 – 834	Combined sources	11
Turnⁱ	835 – 837	Combined sources	3
Helixⁱ	839 – 859	Combined sources	21
Helixⁱ	862 – 864	Combined sources	3
Helixⁱ	865 – 880	Combined sources	16
Helixⁱ	886 – 898	Combined sources	13
Beta strandⁱ	909 – 911	Combined sources	3
Helixⁱ	917 – 929	Combined sources	13
Helixⁱ	930 – 932	Combined sources	3
Helixⁱ	936 – 957	Combined sources	22
Beta strandⁱ	964 – 966	Combined sources	3
Helixⁱ	970 – 983	Combined sources	14
Helixⁱ	993 – 1011	Combined sources	19
Helixⁱ	1108 – 1126	Combined sources	19
Beta strandⁱ	1168 – 1174	Combined sources	7
Beta strandⁱ	1183 – 1192	Combined sources	10
Helixⁱ	1193 – 1197	Combined sources	5

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00949
ProteinModelPortalⁱ	Q9HAU5
SMRⁱ	Q9HAU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9HAU5

EvolutionaryTraceⁱ

Q9HAU5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	168 – 431	MIF4G 1Add BLAST	264
Domainⁱ	569 – 758	MIF4G 2Add BLAST	190
Domainⁱ	773 – 986	MIF4G 3Add BLAST	214

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	94 – 133	Sufficient for interaction with UPF1Add BLAST	40
Regionⁱ	711 – 928	Sufficient for interaction with UPF3A and UPF3BAdd BLAST	218
Regionⁱ	757 – 1272	Sufficient for interaction with EIF4A1 and EIF11 PublicationAdd BLAST	516
Regionⁱ	839 – 859	Binds to UPF3BAdd BLAST	21
Regionⁱ	1084 – 1272	Sufficient for interaction with UPF1 C-terminusAdd BLAST	189
Regionⁱ	1105 – 1198	Necessary for interaction with UPF1Add BLAST	94
Regionⁱ	1105 – 1129	Interaction with UPF1Add BLAST	25
Regionⁱ	1167 – 1207	Interaction with UPF1Add BLAST	41

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	54 – 134	Sequence analysisAdd BLAST		81
Coiled coilⁱ	487 – 559	Sequence analysisAdd BLAST		73

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	6 – 136	Glu/Lys-richAdd BLAST		131
Compositional biasⁱ	1025 – 1094	Glu-richAdd BLAST		70

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG2051 Eukaryota ENOG410XQ1E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064318
HOVERGENⁱ	HBG079124
InParanoidⁱ	Q9HAU5
KEGG Orthology (KO) More...KOⁱ	K14327
OMAⁱ	LVFFQHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01PX
PhylomeDBⁱ	Q9HAU5
TreeFamⁱ	TF300543

Family and domain databases

Gene3Dⁱ	1.25.40.180, 3 hits
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR016021 MIF4-like_sf IPR003890 MIF4G-like_typ-3 IPR039762 Nmd2/UPF2 IPR007193 Upf2/Nmd2_C
PANTHERⁱ	PTHR12839 PTHR12839, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02854 MIF4G, 3 hits PF04050 Upf2, 1 hit
SMARTⁱ	View protein in SMART SM00543 MIF4G, 3 hits
SUPFAMⁱ	SSF48371 SSF48371, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9HAU5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MPAERKKPAS MEEKDSLPNN KEKDCSERRT VSSKERPKDD IKLTAKKEVS 
        60         70         80         90        100
KAPEDKKKRL EDDKRKKEDK ERKKKDEEKV KAEEESKKKE EEEKKKHQEE 
       110        120        130        140        150
ERKKQEEQAK RQQEEEAAAQ MKEKEESIQL HQEAWERHHL RKELRSKNQN 
       160        170        180        190        200
APDSRPEENF FSRLDSSLKK NTAFVKKLKT ITEQQRDSLS HDFNGLNLSK 
       210        220        230        240        250
YIAEAVASIV EAKLKISDVN CAVHLCSLFH QRYADFAPSL LQVWKKHFEA 
       260        270        280        290        300
RKEEKTPNIT KLRTDLRFIA ELTIVGIFTD KEGLSLIYEQ LKNIINADRE 
       310        320        330        340        350
SHTHVSVVIS FCRHCGDDIA GLVPRKVKSA AEKFNLSFPP SEIISPEKQQ 
       360        370        380        390        400
PFQNLLKEYF TSLTKHLKRD HRELQNTERQ NRRILHSKGE LSEDRHKQYE 
       410        420        430        440        450
EFAMSYQKLL ANSQSLADLL DENMPDLPQD KPTPEEHGPG IDIFTPGKPG 
       460        470        480        490        500
EYDLEGGIWE DEDARNFYEN LIDLKAFVPA ILFKDNEKSC QNKESNKDDT 
       510        520        530        540        550
KEAKESKENK EVSSPDDLEL ELENLEINDD TLELEGGDEA EDLTKKLLDE 
       560        570        580        590        600
QEQEDEEAST GSHLKLIVDA FLQQLPNCVN RDLIDKAAMD FCMNMNTKAN 
       610        620        630        640        650
RKKLVRALFI VPRQRLDLLP FYARLVATLH PCMSDVAEDL CSMLRGDFRF 
       660        670        680        690        700
HVRKKDQINI ETKNKTVRFI GELTKFKMFT KNDTLHCLKM LLSDFSHHHI 
       710        720        730        740        750
EMACTLLETC GRFLFRSPES HLRTSVLLEQ MMRKKQAMHL DARYVTMVEN 
       760        770        780        790        800
AYYYCNPPPA EKTVKKKRPP LQEYVRKLLY KDLSKVTTEK VLRQMRKLPW 
       810        820        830        840        850
QDQEVKDYVI CCMINIWNVK YNSIHCVANL LAGLVLYQED VGIHVVDGVL 
       860        870        880        890        900
EDIRLGMEVN QPKFNQRRIS SAKFLGELYN YRMVESAVIF RTLYSFTSFG 
       910        920        930        940        950
VNPDGSPSSL DPPEHLFRIR LVCTILDTCG QYFDRGSSKR KLDCFLVYFQ 
       960        970        980        990       1000
RYVWWKKSLE VWTKDHPFPI DIDYMISDTL ELLRPKIKLC NSLEESIRQV 
      1010       1020       1030       1040       1050
QDLEREFLIK LGLVNDKDSK DSMTEGENLE EDEEEEEGGA ETEEQSGNES 
      1060       1070       1080       1090       1100
EVNEPEEEEG SDNDDDEGEE EEEENTDYLT DSNKENETDE ENTEVMIKGG 
      1110       1120       1130       1140       1150
GLKHVPCVED EDFIQALDKM MLENLQQRSG ESVKVHQLDV AIPLHLKSQL 
      1160       1170       1180       1190       1200
RKGPPLGGGE GEAESADTMP FVMLTRKGNK QQFKILNVPM SSQLAANHWN 
      1210       1220       1230       1240       1250
QQQAEQEERM RMKKLTLDIN ERQEQEDYQE MLQSLAQRPA PANTNRERRP 
      1260       1270 
RYQHPKGAPN ADLIFKTGGR RR

Length:1,272

Mass (Da):147,810

Last modified:March 1, 2001 - v1

Checksum:ⁱ95F3C57D2854BB44

Isoform 2 (identifier: Q9HAU5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-83: Missing.
     588-609: AMDFCMNMNTKANRKKLVRALF → EKAFCNGNLARVNLLLRMAVKK
     610-1272: Missing.

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        10         20         30         40         50
MPAERKKPAS MEEKDSLPNN KEKDCSERRT VSSKERPKDD IKLTAKKEVS 
        60         70         80         90        100
KAPEESKKKE EEEKKKHQEE ERKKQEEQAK RQQEEEAAAQ MKEKEESIQL 
       110        120        130        140        150
HQEAWERHHL RKELRSKNQN APDSRPEENF FSRLDSSLKK NTAFVKKLKT 
       160        170        180        190        200
ITEQQRDSLS HDFNGLNLSK YIAEAVASIV EAKLKISDVN CAVHLCSLFH 
       210        220        230        240        250
QRYADFAPSL LQVWKKHFEA RKEEKTPNIT KLRTDLRFIA ELTIVGIFTD 
       260        270        280        290        300
KEGLSLIYEQ LKNIINADRE SHTHVSVVIS FCRHCGDDIA GLVPRKVKSA 
       310        320        330        340        350
AEKFNLSFPP SEIISPEKQQ PFQNLLKEYF TSLTKHLKRD HRELQNTERQ 
       360        370        380        390        400
NRRILHSKGE LSEDRHKQYE EFAMSYQKLL ANSQSLADLL DENMPDLPQD 
       410        420        430        440        450
KPTPEEHGPG IDIFTPGKPG EYDLEGGIWE DEDARNFYEN LIDLKAFVPA 
       460        470        480        490        500
ILFKDNEKSC QNKESNKDDT KEAKESKENK EVSSPDDLEL ELENLEINDD 
       510        520        530        540        550
TLELEGGDEA EDLTKKLLDE QEQEDEEAST GSHLKLIVDA FLQQLPNCVN 
       560        570 
RDLIDKAEKA FCNGNLARVN LLLRMAVKK

Note: No experimental confirmation available.

Show »

Length:579

Mass (Da):66,842

Checksum:ⁱFA8367F0C864C24E

Sequence cautionⁱ

The sequence BAA92646 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	119	A → T in BAC04721 (PubMed:14702039).Curated	1
Sequence conflictⁱ	338	F → L in BAC04721 (PubMed:14702039).Curated	1
Sequence conflictⁱ	844	H → Q in AAG48509 (PubMed:11163187).Curated	1
Sequence conflictⁱ	844	H → Q in BAA92646 (PubMed:10718198).Curated	1
Sequence conflictⁱ	969	P → S in BAA92646 (PubMed:10718198).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024345	496	N → S. Corresponds to variant dbSNP:rs7079388Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_012958	54 – 83	Missing in isoform 2. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_012959	588 – 609	AMDFC…VRALF → EKAFCNGNLARVNLLLRMAV KK in isoform 2. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_012960	610 – 1272	Missing in isoform 2. 1 PublicationAdd BLAST	663

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF301013 mRNA Translation: AAG33225.1 AY013249 mRNA Translation: AAG48509.1 AF318574 mRNA Translation: AAG60689.1 AB037829 mRNA Translation: BAA92646.1 Different initiation. AK000764 mRNA Translation: BAA91369.1 AK096191 mRNA Translation: BAC04721.1 AC073160 Genomic DNA No translation available. AL138898 Genomic DNA No translation available. AL645617 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86329.1 CH471072 Genomic DNA Translation: EAW86330.1 CH471072 Genomic DNA Translation: EAW86332.1 CH471072 Genomic DNA Translation: EAW86333.1 BC114964 mRNA Translation: AAI14965.1 BC115737 mRNA Translation: AAI15738.1 AL080198 mRNA Translation: CAB45771.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7086.1 [Q9HAU5-1]
PIRⁱ	T12507
NCBI Reference Sequences More...RefSeqⁱ	NP_056357.1, NM_015542.3 [Q9HAU5-1] NP_542166.1, NM_080599.2 [Q9HAU5-1]
UniGeneⁱ	Hs.370689 Hs.610110 Hs.732383

Genome annotation databases

Ensemblⁱ	ENST00000356352; ENSP00000348708; ENSG00000151461 [Q9HAU5-1] ENST00000357604; ENSP00000350221; ENSG00000151461 [Q9HAU5-1] ENST00000397053; ENSP00000380244; ENSG00000151461 [Q9HAU5-1]
GeneIDⁱ	26019
KEGGⁱ	hsa:26019
UCSC genome browser More...UCSCⁱ	uc001ila.3 human [Q9HAU5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HAU5	regulator of nonsense transcripts 2 isoform X1		URSMA		1336	UniRef90_Q9HAU5
Uncharacterized protein		FICAL		1299
UPF2, regulator of nonsense mediated mRNA decay		SHEEP		1273
Uncharacterized protein		MYOLU		1273
UPF2, regulator of nonsense mediated mRNA decay		BOVIN		1273
+283

Protein	Similar proteins		Species	Score	Length	Source
Q9HAU5	regulator of nonsense transcripts 2 isoform X1		URSMA		1336	UniRef50_Q9HAU5
Uncharacterized protein		FICAL		1299
UPF2, regulator of nonsense mediated mRNA decay		SHEEP		1273
Uncharacterized protein		MYOLU		1273
UPF2, regulator of nonsense mediated mRNA decay		BOVIN		1273
+284
Q9HAU5-2	Uncharacterized protein		BAMTH		610	UniRef50_Q9HAU5-2
UPF2, regulator of nonsense mediated mRNA decay		TAKRU		576
Regulator of nonsense transcripts 2 (Fragment)		TINGU		108
Regulator of nonsense transcripts 2 (Fragment)		PHALP		109
Regulator of nonsense transcripts 2 (Fragment)		GAVST		109
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF301013 mRNA Translation: AAG33225.1 AY013249 mRNA Translation: AAG48509.1 AF318574 mRNA Translation: AAG60689.1 AB037829 mRNA Translation: BAA92646.1 Different initiation. AK000764 mRNA Translation: BAA91369.1 AK096191 mRNA Translation: BAC04721.1 AC073160 Genomic DNA No translation available. AL138898 Genomic DNA No translation available. AL645617 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86329.1 CH471072 Genomic DNA Translation: EAW86330.1 CH471072 Genomic DNA Translation: EAW86332.1 CH471072 Genomic DNA Translation: EAW86333.1 BC114964 mRNA Translation: AAI14965.1 BC115737 mRNA Translation: AAI15738.1 AL080198 mRNA Translation: CAB45771.1
CCDSⁱ	CCDS7086.1 [Q9HAU5-1]
PIRⁱ	T12507
RefSeqⁱ	NP_056357.1, NM_015542.3 [Q9HAU5-1] NP_542166.1, NM_080599.2 [Q9HAU5-1]
UniGeneⁱ	Hs.370689 Hs.610110 Hs.732383

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1UW4	X-ray	1.95	B/D	768-1015	[»]
	2WJV	X-ray	2.85	D/E	1105-1198	[»]
	4CEK	X-ray	2.35	A	455-757	[»]
	4CEM	X-ray	2.60	A/B	121-486	[»]
DisProtⁱ	DP00949
ProteinModelPortalⁱ	Q9HAU5
SMRⁱ	Q9HAU5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117490, 94 interactors
CORUMⁱ	Q9HAU5
DIPⁱ	DIP-31148N
IntActⁱ	Q9HAU5, 41 interactors
MINTⁱ	Q9HAU5
STRINGⁱ	9606.ENSP00000348708

Protein family/group databases

MoonDBⁱ	Q9HAU5 Predicted

MoonDBⁱ

Q9HAU5 Predicted

PTM databases

CarbonylDBⁱ	Q9HAU5
iPTMnetⁱ	Q9HAU5
PhosphoSitePlusⁱ	Q9HAU5

Polymorphism and mutation databases

BioMutaⁱ	UPF2
DMDMⁱ	60390647

Proteomic databases

EPDⁱ	Q9HAU5
MaxQBⁱ	Q9HAU5
PaxDbⁱ	Q9HAU5
PeptideAtlasⁱ	Q9HAU5
PRIDEⁱ	Q9HAU5
ProteomicsDBⁱ	81440 81441 [Q9HAU5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356352; ENSP00000348708; ENSG00000151461 [Q9HAU5-1] ENST00000357604; ENSP00000350221; ENSG00000151461 [Q9HAU5-1] ENST00000397053; ENSP00000380244; ENSG00000151461 [Q9HAU5-1]
GeneIDⁱ	26019
KEGGⁱ	hsa:26019
UCSCⁱ	uc001ila.3 human [Q9HAU5-1]

Organism-specific databases

CTDⁱ	26019
DisGeNETⁱ	26019
EuPathDBⁱ	HostDB:ENSG00000151461.19
GeneCardsⁱ	UPF2
HGNCⁱ	HGNC:17854 UPF2
HPAⁱ	HPA067008
MIMⁱ	605529 gene
neXtProtⁱ	NX_Q9HAU5
OpenTargetsⁱ	ENSG00000151461
PharmGKBⁱ	PA134945630
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2051 Eukaryota ENOG410XQ1E LUCA
GeneTreeⁱ	ENSGT00530000064318
HOVERGENⁱ	HBG079124
InParanoidⁱ	Q9HAU5
KOⁱ	K14327
OMAⁱ	LVFFQHY
OrthoDBⁱ	EOG091G01PX
PhylomeDBⁱ	Q9HAU5
TreeFamⁱ	TF300543

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	UPF2 human
EvolutionaryTraceⁱ	Q9HAU5
GeneWikiⁱ	UPF2
GenomeRNAiⁱ	26019
Protein Ontology More...PROⁱ	PR:Q9HAU5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151461 Expressed in 231 organ(s), highest expression level in testis
Genevisibleⁱ	Q9HAU5 HS

Family and domain databases

Gene3Dⁱ	1.25.40.180, 3 hits
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR016021 MIF4-like_sf IPR003890 MIF4G-like_typ-3 IPR039762 Nmd2/UPF2 IPR007193 Upf2/Nmd2_C
PANTHERⁱ	PTHR12839 PTHR12839, 1 hit
Pfamⁱ	View protein in Pfam PF02854 MIF4G, 3 hits PF04050 Upf2, 1 hit
SMARTⁱ	View protein in SMART SM00543 MIF4G, 3 hits
SUPFAMⁱ	SSF48371 SSF48371, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RENT2_HUMAN
Accessionⁱ	Q9HAU5Primary (citable) accession number: Q9HAU5 Secondary accession number(s): A6NLJ5 Q9Y4M9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q9HAU5 (RENT2_HUMAN)

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Regulator of nonsense transcripts 2

UPF2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ