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UniProtKB - Q9HAU5 (RENT2_HUMAN)

Protein

Regulator of nonsense transcripts 2

Gene

UPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: UniProtKB-KW
  • telomeric DNA binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • animal organ regeneration Source: Ensembl
  • liver development Source: Ensembl
  • mRNA export from nucleus Source: HGNC
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q9HAU5 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of nonsense transcripts 2
Alternative name(s):
Nonsense mRNA reducing factor 2
Up-frameshift suppressor 2 homolog
Short name:
hUpf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UPF2
Synonyms:KIAA1408, RENT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000151461.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:17854 UPF2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605529 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HAU5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi796 – 797RK → EE: Strongly impairs RNA-binding. 1 Publication2
Mutagenesisi847D → K: Does not abolish interaction with UPF3B. 1 Publication1
Mutagenesisi851 – 852ED → KR: Does not abolish interaction with UPF3B. Does not abolish interaction with UPF3B; when associated with D-854. 1 Publication2
Mutagenesisi854R → D: Does not abolish interaction with UPF3B; when associated with K-851 and R-852. 1 Publication1
Mutagenesisi858E → R: Abolishes interaction with UPF3B and association with SMG1 and RBM8A; reduces phosphorylation of UPF1. 2 Publications1
Mutagenesisi894Y → A: Does not impair RNA-binding; when associated with A-932. 1 Publication1
Mutagenesisi932Y → A: Does not impair RNA-binding; when associated with A-894. 1 Publication1
Mutagenesisi1113F → E: Abolishes interaction with UPF1. 1
Mutagenesisi1120M → E: Decreases interaction with UPF1; does not reduce NMD efficiency. 1 Publication1
Mutagenesisi1121M → E: Decreases interaction with UPF1; does not reduce NMD efficiency. 1 Publication1
Mutagenesisi1123E → R: Decreases interaction with UPF1. 1 Publication1
Mutagenesisi1169M → E: Decreases interaction with UPF1. 1 Publication1
Mutagenesisi1171F → E: Abolishes interaction with UPF1; reduces NMD efficiency. 1 Publication1
Mutagenesisi1171F → E: Greatly reduces NMD efficiency; when associated with E-1173 and E-1174. 1 Publication1
Mutagenesisi1173M → E: Abolishes interaction with UPF1. 1 Publication1
Mutagenesisi1173M → E: Greatly reduces NMD efficiency; when associated with E-1171 and E-1174. 1 Publication1
Mutagenesisi1174L → E: Abolishes interaction with UPF1; reduces NMD efficiency. 1 Publication1
Mutagenesisi1174L → E: Greatly reduces NMD efficiency; when associated with E-1171 and E-1173. 1 Publication1
Mutagenesisi1176R → E: Decreases interaction with UPF1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		26019

Open Targets

More...OpenTargetsi		ENSG00000151461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134945630

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UPF2

Domain mapping of disease mutations (DMDM)

More...DMDMi		60390647

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972481 – 1272Regulator of nonsense transcripts 2Add BLAST1272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1088PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9HAU5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HAU5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HAU5

PeptideAtlas

More...PeptideAtlasi		Q9HAU5

PRoteomics IDEntifications database

More...PRIDEi		Q9HAU5

ProteomicsDB human proteome resource

More...ProteomicsDBi		81440
81441 [Q9HAU5-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9HAU5

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HAU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HAU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151461 Expressed in 231 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HAU5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA067008

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1.10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117490, 94 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9HAU5

Database of interacting proteins

More...DIPi		DIP-31148N

Protein interaction database and analysis system

More...IntActi		Q9HAU5, 41 interactors

Molecular INTeraction database

More...MINTi		Q9HAU5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348708

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

More...DisProti		DP00949

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9HAU5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HAU5

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HAU5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 431MIF4G 1Add BLAST264
Domaini569 – 758MIF4G 2Add BLAST190
Domaini773 – 986MIF4G 3Add BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 133Sufficient for interaction with UPF1Add BLAST40
Regioni711 – 928Sufficient for interaction with UPF3A and UPF3BAdd BLAST218
Regioni757 – 1272Sufficient for interaction with EIF4A1 and EIF11 PublicationAdd BLAST516
Regioni839 – 859Binds to UPF3BAdd BLAST21
Regioni1084 – 1272Sufficient for interaction with UPF1 C-terminusAdd BLAST189
Regioni1105 – 1198Necessary for interaction with UPF1Add BLAST94
Regioni1105 – 1129Interaction with UPF1Add BLAST25
Regioni1167 – 1207Interaction with UPF1Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili54 – 134Sequence analysisAdd BLAST81
Coiled coili487 – 559Sequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 136Glu/Lys-richAdd BLAST131
Compositional biasi1025 – 1094Glu-richAdd BLAST70

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2051 Eukaryota
ENOG410XQ1E LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064318

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG079124

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HAU5

KEGG Orthology (KO)

More...KOi		K14327

Identification of Orthologs from Complete Genome Data

More...OMAi		LVFFQHY

Database of Orthologous Groups

More...OrthoDBi		EOG091G01PX

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HAU5

TreeFam database of animal gene trees

More...TreeFami		TF300543

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR039762 Nmd2/UPF2
IPR007193 Upf2/Nmd2_C

The PANTHER Classification System

More...PANTHERi		PTHR12839 PTHR12839, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02854 MIF4G, 3 hits
PF04050 Upf2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00543 MIF4G, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HAU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAERKKPAS MEEKDSLPNN KEKDCSERRT VSSKERPKDD IKLTAKKEVS 
        60         70         80         90        100
KAPEDKKKRL EDDKRKKEDK ERKKKDEEKV KAEEESKKKE EEEKKKHQEE 
       110        120        130        140        150
ERKKQEEQAK RQQEEEAAAQ MKEKEESIQL HQEAWERHHL RKELRSKNQN 
       160        170        180        190        200
APDSRPEENF FSRLDSSLKK NTAFVKKLKT ITEQQRDSLS HDFNGLNLSK 
       210        220        230        240        250
YIAEAVASIV EAKLKISDVN CAVHLCSLFH QRYADFAPSL LQVWKKHFEA 
       260        270        280        290        300
RKEEKTPNIT KLRTDLRFIA ELTIVGIFTD KEGLSLIYEQ LKNIINADRE 
       310        320        330        340        350
SHTHVSVVIS FCRHCGDDIA GLVPRKVKSA AEKFNLSFPP SEIISPEKQQ 
       360        370        380        390        400
PFQNLLKEYF TSLTKHLKRD HRELQNTERQ NRRILHSKGE LSEDRHKQYE 
       410        420        430        440        450
EFAMSYQKLL ANSQSLADLL DENMPDLPQD KPTPEEHGPG IDIFTPGKPG 
       460        470        480        490        500
EYDLEGGIWE DEDARNFYEN LIDLKAFVPA ILFKDNEKSC QNKESNKDDT 
       510        520        530        540        550
KEAKESKENK EVSSPDDLEL ELENLEINDD TLELEGGDEA EDLTKKLLDE 
       560        570        580        590        600
QEQEDEEAST GSHLKLIVDA FLQQLPNCVN RDLIDKAAMD FCMNMNTKAN 
       610        620        630        640        650
RKKLVRALFI VPRQRLDLLP FYARLVATLH PCMSDVAEDL CSMLRGDFRF 
       660        670        680        690        700
HVRKKDQINI ETKNKTVRFI GELTKFKMFT KNDTLHCLKM LLSDFSHHHI 
       710        720        730        740        750
EMACTLLETC GRFLFRSPES HLRTSVLLEQ MMRKKQAMHL DARYVTMVEN 
       760        770        780        790        800
AYYYCNPPPA EKTVKKKRPP LQEYVRKLLY KDLSKVTTEK VLRQMRKLPW 
       810        820        830        840        850
QDQEVKDYVI CCMINIWNVK YNSIHCVANL LAGLVLYQED VGIHVVDGVL 
       860        870        880        890        900
EDIRLGMEVN QPKFNQRRIS SAKFLGELYN YRMVESAVIF RTLYSFTSFG 
       910        920        930        940        950
VNPDGSPSSL DPPEHLFRIR LVCTILDTCG QYFDRGSSKR KLDCFLVYFQ 
       960        970        980        990       1000
RYVWWKKSLE VWTKDHPFPI DIDYMISDTL ELLRPKIKLC NSLEESIRQV 
      1010       1020       1030       1040       1050
QDLEREFLIK LGLVNDKDSK DSMTEGENLE EDEEEEEGGA ETEEQSGNES 
      1060       1070       1080       1090       1100
EVNEPEEEEG SDNDDDEGEE EEEENTDYLT DSNKENETDE ENTEVMIKGG 
      1110       1120       1130       1140       1150
GLKHVPCVED EDFIQALDKM MLENLQQRSG ESVKVHQLDV AIPLHLKSQL 
      1160       1170       1180       1190       1200
RKGPPLGGGE GEAESADTMP FVMLTRKGNK QQFKILNVPM SSQLAANHWN 
      1210       1220       1230       1240       1250
QQQAEQEERM RMKKLTLDIN ERQEQEDYQE MLQSLAQRPA PANTNRERRP 
      1260       1270 
RYQHPKGAPN ADLIFKTGGR RR
Length:1,272
Mass (Da):147,810
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95F3C57D2854BB44
GO
Isoform 2 (identifier: Q9HAU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-83: Missing.
     588-609: AMDFCMNMNTKANRKKLVRALF → EKAFCNGNLARVNLLLRMAVKK
     610-1272: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):66,842
Checksum:iFA8367F0C864C24E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92646 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119A → T in BAC04721 (PubMed:14702039).Curated1
Sequence conflicti338F → L in BAC04721 (PubMed:14702039).Curated1
Sequence conflicti844H → Q in AAG48509 (PubMed:11163187).Curated1
Sequence conflicti844H → Q in BAA92646 (PubMed:10718198).Curated1
Sequence conflicti969P → S in BAA92646 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024345496N → S. Corresponds to variant dbSNP:rs7079388Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01295854 – 83Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_012959588 – 609AMDFC…VRALF → EKAFCNGNLARVNLLLRMAV KK in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_012960610 – 1272Missing in isoform 2. 1 PublicationAdd BLAST663

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF301013 mRNA Translation: AAG33225.1
AY013249 mRNA Translation: AAG48509.1
AF318574 mRNA Translation: AAG60689.1
AB037829 mRNA Translation: BAA92646.1 Different initiation.
AK000764 mRNA Translation: BAA91369.1
AK096191 mRNA Translation: BAC04721.1
AC073160 Genomic DNA No translation available.
AL138898 Genomic DNA No translation available.
AL645617 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86329.1
CH471072 Genomic DNA Translation: EAW86330.1
CH471072 Genomic DNA Translation: EAW86332.1
CH471072 Genomic DNA Translation: EAW86333.1
BC114964 mRNA Translation: AAI14965.1
BC115737 mRNA Translation: AAI15738.1
AL080198 mRNA Translation: CAB45771.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7086.1 [Q9HAU5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T12507

NCBI Reference Sequences

More...RefSeqi		NP_056357.1, NM_015542.3 [Q9HAU5-1]
NP_542166.1, NM_080599.2 [Q9HAU5-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.370689
Hs.610110
Hs.732383

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356352; ENSP00000348708; ENSG00000151461 [Q9HAU5-1]
ENST00000357604; ENSP00000350221; ENSG00000151461 [Q9HAU5-1]
ENST00000397053; ENSP00000380244; ENSG00000151461 [Q9HAU5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26019

UCSC genome browser

More...UCSCi		uc001ila.3 human [Q9HAU5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301013 mRNA Translation: AAG33225.1
AY013249 mRNA Translation: AAG48509.1
AF318574 mRNA Translation: AAG60689.1
AB037829 mRNA Translation: BAA92646.1 Different initiation.
AK000764 mRNA Translation: BAA91369.1
AK096191 mRNA Translation: BAC04721.1
AC073160 Genomic DNA No translation available.
AL138898 Genomic DNA No translation available.
AL645617 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86329.1
CH471072 Genomic DNA Translation: EAW86330.1
CH471072 Genomic DNA Translation: EAW86332.1
CH471072 Genomic DNA Translation: EAW86333.1
BC114964 mRNA Translation: AAI14965.1
BC115737 mRNA Translation: AAI15738.1
AL080198 mRNA Translation: CAB45771.1
CCDSiCCDS7086.1 [Q9HAU5-1]
PIRiT12507
RefSeqiNP_056357.1, NM_015542.3 [Q9HAU5-1]
NP_542166.1, NM_080599.2 [Q9HAU5-1]
UniGeneiHs.370689
Hs.610110
Hs.732383

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UW4X-ray1.95B/D768-1015[»]
2WJVX-ray2.85D/E1105-1198[»]
4CEKX-ray2.35A455-757[»]
4CEMX-ray2.60A/B121-486[»]
DisProtiDP00949
ProteinModelPortaliQ9HAU5
SMRiQ9HAU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117490, 94 interactors
CORUMiQ9HAU5
DIPiDIP-31148N
IntActiQ9HAU5, 41 interactors
MINTiQ9HAU5
STRINGi9606.ENSP00000348708

Protein family/group databases

MoonDBiQ9HAU5 Predicted

PTM databases

CarbonylDBiQ9HAU5
iPTMnetiQ9HAU5
PhosphoSitePlusiQ9HAU5

Polymorphism and mutation databases

BioMutaiUPF2
DMDMi60390647

Proteomic databases

EPDiQ9HAU5
MaxQBiQ9HAU5
PaxDbiQ9HAU5
PeptideAtlasiQ9HAU5
PRIDEiQ9HAU5
ProteomicsDBi81440
81441 [Q9HAU5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356352; ENSP00000348708; ENSG00000151461 [Q9HAU5-1]
ENST00000357604; ENSP00000350221; ENSG00000151461 [Q9HAU5-1]
ENST00000397053; ENSP00000380244; ENSG00000151461 [Q9HAU5-1]
GeneIDi26019
KEGGihsa:26019
UCSCiuc001ila.3 human [Q9HAU5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26019
DisGeNETi26019
EuPathDBiHostDB:ENSG00000151461.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		UPF2
HGNCiHGNC:17854 UPF2
HPAiHPA067008
MIMi605529 gene
neXtProtiNX_Q9HAU5
OpenTargetsiENSG00000151461
PharmGKBiPA134945630

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2051 Eukaryota
ENOG410XQ1E LUCA
GeneTreeiENSGT00530000064318
HOVERGENiHBG079124
InParanoidiQ9HAU5
KOiK14327
OMAiLVFFQHY
OrthoDBiEOG091G01PX
PhylomeDBiQ9HAU5
TreeFamiTF300543

Enzyme and pathway databases

ReactomeiR-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UPF2 human
EvolutionaryTraceiQ9HAU5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UPF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26019

Protein Ontology

More...PROi		PR:Q9HAU5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151461 Expressed in 231 organ(s), highest expression level in testis
GenevisibleiQ9HAU5 HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR039762 Nmd2/UPF2
IPR007193 Upf2/Nmd2_C
PANTHERiPTHR12839 PTHR12839, 1 hit
PfamiView protein in Pfam
PF02854 MIF4G, 3 hits
PF04050 Upf2, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRENT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAU5
Secondary accession number(s): A6NLJ5
, D3DRS0, Q14BM1, Q5W0J4, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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