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Entry version 138 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Sialate O-acetylesterase

Gene

SIAE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialate O-acetylesterase (EC:3.1.1.53)
Alternative name(s):
H-Lse
Sialic acid-specific 9-O-acetylesterase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIAE
Synonyms:YSG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000110013.12

Human Gene Nomenclature Database

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HGNCi
HGNC:18187 SIAE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610079 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoimmune disease 6 (AIS6)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionIndividuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064444196C → F in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs143070599EnsemblClinVar.1
Natural variantiVAR_064445212G → R in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs149466359EnsemblClinVar.1
Natural variantiVAR_064446230R → W in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs200862001Ensembl.1
Natural variantiVAR_064447266C → G in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs746914032Ensembl.1
Natural variantiVAR_064448309Q → P in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs757586703Ensembl.1
Natural variantiVAR_064451349Y → C in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs749579541Ensembl.1
Natural variantiVAR_064452393R → H in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs552372846Ensembl.1
Natural variantiVAR_064454404F → S in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs201877149EnsemblClinVar.1
Natural variantiVAR_064458479R → C in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs376857712Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
54414

MalaCards human disease database

More...
MalaCardsi
SIAE
MIMi613551 phenotype

Open Targets

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OpenTargetsi
ENSG00000110013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670922

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9HAT2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIAE

Domain mapping of disease mutations (DMDM)

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DMDMi
74734243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004224124 – 523Sialate O-acetylesteraseAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi422N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HAT2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HAT2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9HAT2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HAT2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9HAT2

PeptideAtlas

More...
PeptideAtlasi
Q9HAT2

PRoteomics IDEntifications database

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PRIDEi
Q9HAT2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
81429 [Q9HAT2-1]
81430 [Q9HAT2-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1742

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9HAT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9HAT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high expression in the testis, prostate, and colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110013 Expressed in 198 organ(s), highest expression level in colonic mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HAT2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038052
HPA038053

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119945, 59 interactors

Protein interaction database and analysis system

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IntActi
Q9HAT2, 32 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263593

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9HAT2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGS1 Eukaryota
ENOG410XQ2Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000010608

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000065687

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HAT2

KEGG Orthology (KO)

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KOi
K05970

Identification of Orthologs from Complete Genome Data

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OMAi
GGPYEVM

Database of Orthologous Groups

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OrthoDBi
745508at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9HAT2

TreeFam database of animal gene trees

More...
TreeFami
TF328611

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1110, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005181 SASA
IPR036514 SGNH_hydro_sf
IPR039329 SIAE

The PANTHER Classification System

More...
PANTHERi
PTHR22901 PTHR22901, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03629 SASA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HAT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF
60 70 80 90 100
GTPGATVTVT LRQGQETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ
110 120 130 140 150
QTLEKINFTL RVHDVLFGDV WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ
160 170 180 190 200
SVRILSVSPI QAEQELEDLV AVDLQWSKPT SENLGHGYFK YMSAVCWLFG
210 220 230 240 250
RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ GSIPYDSVTG
260 270 280 290 300
PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW
310 320 330 340 350
RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV
360 370 380 390 400
PNPKMPNTFM AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK
410 420 430 440 450
NLTFEGPLPE KIELLAHKGL LNLTYYQQIQ VQKKDNKIFE ISCCSDHRCK
460 470 480 490 500
WLPASMNTVS TQSLTLAIDS CHGTVVALRY AWTTWPCEYK QCPLYHPSSA
510 520
LPAPPFIAFI TDQGPGHQSN VAK
Length:523
Mass (Da):58,315
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB72CF69636DBFED8
GO
Isoform 2 (identifier: Q9HAT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:488
Mass (Da):54,572
Checksum:iDBB030C82DA44916
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0644383A → G Rare variant found in a patient with Crohn disease; probably not involved in disease susceptibility; the mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs144571829Ensembl.1
Natural variantiVAR_06443933N → S Rare variant found in a patient with rheumatoid arthritis; probably not involved in disease susceptibility; the mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs762824510Ensembl.1
Natural variantiVAR_06444062R → H The mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs377634657Ensembl.1
Natural variantiVAR_06444164G → S The mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs76655561Ensembl.1
Natural variantiVAR_05135671K → R1 PublicationCorresponds to variant dbSNP:rs12282107Ensembl.1
Natural variantiVAR_06444289M → V Polymorphism that at homozygosity may predispose to autoimmunity; normal enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs78778622EnsemblClinVar.1
Natural variantiVAR_064443161Q → K The mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs200739060Ensembl.1
Natural variantiVAR_064444196C → F in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs143070599EnsemblClinVar.1
Natural variantiVAR_064445212G → R in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs149466359EnsemblClinVar.1
Natural variantiVAR_064446230R → W in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs200862001Ensembl.1
Natural variantiVAR_064447266C → G in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs746914032Ensembl.1
Natural variantiVAR_064448309Q → P in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs757586703Ensembl.1
Natural variantiVAR_064449312T → M May predispose to autoimmunity; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs144510878EnsemblClinVar.1
Natural variantiVAR_064450314R → H Defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs147649509Ensembl.1
Natural variantiVAR_064451349Y → C in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs749579541Ensembl.1
Natural variantiVAR_064452393R → H in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs552372846Ensembl.1
Natural variantiVAR_064453400K → N Rare variant found in a patient with Crohn disease; probably not involved in disease susceptibility; the mutant protein has normal activity. 1 PublicationCorresponds to variant dbSNP:rs766047951Ensembl.1
Natural variantiVAR_064454404F → S in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs201877149EnsemblClinVar.1
Natural variantiVAR_064455447H → R The mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs147161431Ensembl.1
Natural variantiVAR_064456456M → I The mutant enzyme has normal activity and is normally secreted. 1 Publication1
Natural variantiVAR_064457462Q → R The mutant enzyme has normal activity and is normally secreted. 1 PublicationCorresponds to variant dbSNP:rs143668140Ensembl.1
Natural variantiVAR_051357467A → V. Corresponds to variant dbSNP:rs7941523Ensembl.1
Natural variantiVAR_064458479R → C in AIS6; defective enzyme secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs376857712Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189931 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF300796 mRNA Translation: AAG15386.1
AF303378 mRNA Translation: AAG14897.1
AK056093 mRNA Translation: BAG51622.1
CH471065 Genomic DNA Translation: EAW67591.1
BC068450 mRNA Translation: AAH68450.1
AL137496 mRNA Translation: CAB70771.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55795.1 [Q9HAT2-2]
CCDS8449.1 [Q9HAT2-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46250

NCBI Reference Sequences

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RefSeqi
NP_001186851.1, NM_001199922.1 [Q9HAT2-2]
NP_733746.1, NM_170601.4 [Q9HAT2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263593; ENSP00000263593; ENSG00000110013 [Q9HAT2-1]
ENST00000545756; ENSP00000437877; ENSG00000110013 [Q9HAT2-2]
ENST00000618733; ENSP00000478211; ENSG00000110013 [Q9HAT2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54414

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54414

UCSC genome browser

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UCSCi
uc001qan.4 human [Q9HAT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF300796 mRNA Translation: AAG15386.1
AF303378 mRNA Translation: AAG14897.1
AK056093 mRNA Translation: BAG51622.1
CH471065 Genomic DNA Translation: EAW67591.1
BC068450 mRNA Translation: AAH68450.1
AL137496 mRNA Translation: CAB70771.1
CCDSiCCDS55795.1 [Q9HAT2-2]
CCDS8449.1 [Q9HAT2-1]
PIRiT46250
RefSeqiNP_001186851.1, NM_001199922.1 [Q9HAT2-2]
NP_733746.1, NM_170601.4 [Q9HAT2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119945, 59 interactors
IntActiQ9HAT2, 32 interactors
STRINGi9606.ENSP00000263593

PTM databases

GlyConnecti1742
iPTMnetiQ9HAT2
PhosphoSitePlusiQ9HAT2

Polymorphism and mutation databases

BioMutaiSIAE
DMDMi74734243

Proteomic databases

EPDiQ9HAT2
jPOSTiQ9HAT2
MassIVEiQ9HAT2
MaxQBiQ9HAT2
PaxDbiQ9HAT2
PeptideAtlasiQ9HAT2
PRIDEiQ9HAT2
ProteomicsDBi81429 [Q9HAT2-1]
81430 [Q9HAT2-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54414

Genome annotation databases

EnsembliENST00000263593; ENSP00000263593; ENSG00000110013 [Q9HAT2-1]
ENST00000545756; ENSP00000437877; ENSG00000110013 [Q9HAT2-2]
ENST00000618733; ENSP00000478211; ENSG00000110013 [Q9HAT2-2]
GeneIDi54414
KEGGihsa:54414
UCSCiuc001qan.4 human [Q9HAT2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54414
DisGeNETi54414
EuPathDBiHostDB:ENSG00000110013.12

GeneCards: human genes, protein and diseases

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GeneCardsi
SIAE
HGNCiHGNC:18187 SIAE
HPAiHPA038052
HPA038053
MalaCardsiSIAE
MIMi610079 gene
613551 phenotype
neXtProtiNX_Q9HAT2
OpenTargetsiENSG00000110013
PharmGKBiPA142670922

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGS1 Eukaryota
ENOG410XQ2Q LUCA
GeneTreeiENSGT00390000010608
HOGENOMiHOG000065687
InParanoidiQ9HAT2
KOiK05970
OMAiGGPYEVM
OrthoDBi745508at2759
PhylomeDBiQ9HAT2
TreeFamiTF328611

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SIAE human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54414
PharosiQ9HAT2 Tbio

Protein Ontology

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PROi
PR:Q9HAT2
RNActiQ9HAT2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110013 Expressed in 198 organ(s), highest expression level in colonic mucosa
GenevisibleiQ9HAT2 HS

Family and domain databases

Gene3Di3.40.50.1110, 1 hit
InterProiView protein in InterPro
IPR005181 SASA
IPR036514 SGNH_hydro_sf
IPR039329 SIAE
PANTHERiPTHR22901 PTHR22901, 1 hit
PfamiView protein in Pfam
PF03629 SASA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIAE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAT2
Secondary accession number(s): B3KPB0
, Q8IUT9, Q9HAU7, Q9NT71
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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