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Entry version 137 (02 Dec 2020)
Sequence version 2 (01 Oct 2001)
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Protein

Ropporin-1A

Gene

ROPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.By similarity

Miscellaneous

'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9HAT0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5666185, RHO GTPases Activate Rhotekin and Rhophilins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ropporin-1A
Alternative name(s):
Cancer/testis antigen 91
Short name:
CT91
Rhophilin-associated protein 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROPN1
Synonyms:ROPN1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000065371.17

Human Gene Nomenclature Database

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HGNCi
HGNC:17692, ROPN1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAT0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54763

Open Targets

More...
OpenTargetsi
ENSG00000065371

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HAT0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ROPN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74718687

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073921 – 212Ropporin-1AAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HAT0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HAT0

PeptideAtlas

More...
PeptideAtlasi
Q9HAT0

PRoteomics IDEntifications database

More...
PRIDEi
Q9HAT0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81425 [Q9HAT0-1]
81426 [Q9HAT0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAT0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAT0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific in adult. Overexpressed in hematologic tumor cells.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000065371, Expressed in testis and 89 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HAT0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9HAT0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000065371, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17 (PubMed:17551920).

Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9HAT0
With#Exp.IntAct
AKAIN1 [P0CW23]3EBI-1378139,EBI-18397742
AKAP14 [Q86UN6]3EBI-1378139,EBI-2119626
AKAP5 [P24588]3EBI-1378139,EBI-703640
AKAP7 - isoform Alpha [O43687-2]9EBI-1378139,EBI-10185182
AP1M1 [Q9BXS5]3EBI-1378139,EBI-541426
BTBD16 - isoform 2 [Q32M84-2]3EBI-1378139,EBI-11961432
CDC37 [Q16543]3EBI-1378139,EBI-295634
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-1378139,EBI-10181988
CKS1B [P61024]6EBI-1378139,EBI-456371
CNST [Q6PJW8]5EBI-1378139,EBI-750390
DBF4B - isoform 2 [Q8NFT6-2]6EBI-1378139,EBI-12205861
ERCC3 [P19447]3EBI-1378139,EBI-1183307
FAM110A [Q9BQ89]3EBI-1378139,EBI-1752811
FAM153A [Q9UHL3]3EBI-1378139,EBI-2834075
FAM153B - isoform 2 [P0C7A2-2]5EBI-1378139,EBI-12940382
FAM161A [Q3B820]3EBI-1378139,EBI-719941
FAM90A1 [Q86YD7]3EBI-1378139,EBI-6658203
GNL3L [Q9NVN8]7EBI-1378139,EBI-746682
GPKOW [Q92917]6EBI-1378139,EBI-746309
HNRPUL1 [Q9BTB7]3EBI-1378139,EBI-10298318
KIAA0753 [Q2KHM9]3EBI-1378139,EBI-2805604
KIF9 [Q6PJI1]3EBI-1378139,EBI-10254090
LENG1 [Q96BZ8]8EBI-1378139,EBI-726510
LMO4 [P61968]3EBI-1378139,EBI-2798728
LNX1 [Q8TBB1]5EBI-1378139,EBI-739832
NTAQ1 [Q96HA8]5EBI-1378139,EBI-741158
PICK1 [Q9NRD5]3EBI-1378139,EBI-79165
PKP2 - isoform 1 [Q99959-2]3EBI-1378139,EBI-10987518
POLR3C [Q9BUI4]3EBI-1378139,EBI-5452779
PRDM6 [Q9NQX0]3EBI-1378139,EBI-11320284
PRKAA1 [Q13131]4EBI-1378139,EBI-1181405
PSMA1 [P25786]6EBI-1378139,EBI-359352
itself6EBI-1378139,EBI-1378139
RTP5 [Q14D33]6EBI-1378139,EBI-10217913
SDCBP [O00560]6EBI-1378139,EBI-727004
SERTAD1 [Q53GC0]3EBI-1378139,EBI-2826300
SORBS3 [O60504]3EBI-1378139,EBI-741237
SPA17 [Q15506]9EBI-1378139,EBI-1377865
SPG21 [Q9NZD8]3EBI-1378139,EBI-742688
SYTL4 [Q96C24]3EBI-1378139,EBI-747142
TRIM3 [O75382]3EBI-1378139,EBI-2129889
TSGA10IP [Q3SY00]3EBI-1378139,EBI-10241197
TSHZ3 [Q63HK5]3EBI-1378139,EBI-9053916
TULP3 [O75386]3EBI-1378139,EBI-5357290
UBE2W [Q96B02]3EBI-1378139,EBI-716589
UBE2W [Q96FI0]3EBI-1378139,EBI-10285774
VPS33A [Q96AX1]3EBI-1378139,EBI-2527283
XKR3 [B7ZMN2]3EBI-1378139,EBI-10176176

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120138, 54 interactors

Protein interaction database and analysis system

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IntActi
Q9HAT0, 56 interactors

Molecular INTeraction database

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MINTi
Q9HAT0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000184183

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HAT0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HAT0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 49RIIaAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni209 – 212Interaction with RHPN1By similarity4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RIIa domain mediates interaction with AKAP3.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ropporin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R2JI, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012731

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_069829_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HAT0

Identification of Orthologs from Complete Genome Data

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OMAi
QWASDYF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAT0

TreeFam database of animal gene trees

More...
TreeFami
TF105421

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQTDKPTCI PPELPKMLKE FAKAAIRVQP QDLIQWAADY FEALSRGETP
60 70 80 90 100
PVRERSERVA LCNRAELTPE LLKILHSQVA GRLIIRAEEL AQMWKVVNLP
110 120 130 140 150
TDLFNSVMNV GRFTEEIEWL KFLALACSAL GVTITKTLKI VCEVLSCDHN
160 170 180 190 200
GGSPRIPFST FQFLYTYIAK VDGEISASHV SRMLNYMEQE VIGPDGIITV
210
NDFTQNPRVQ LE
Length:212
Mass (Da):23,893
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB50D2859B464F6CC
GO
Isoform 2 (identifier: Q9HAT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-58: DYFEALSRGETPPVRERSER → EYVLLSRLHPLEDGRRQRVL
     59-212: Missing.

Show »
Length:58
Mass (Da):6,711
Checksum:iEC21C285B271B063
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J012C9J012_HUMAN
Ropporin-1A
ROPN1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6H4C9J6H4_HUMAN
Ropporin-1A
ROPN1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP07C9JP07_HUMAN
Ropporin-1A
ROPN1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02874339 – 58DYFEA…ERSER → EYVLLSRLHPLEDGRRQRVL in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_02874459 – 212Missing in isoform 2. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF303889 mRNA Translation: AAG27712.2
AL133624 mRNA Translation: CAB63750.2
CH471052 Genomic DNA Translation: EAW79425.1
CH471052 Genomic DNA Translation: EAW79426.1
CH471052 Genomic DNA Translation: EAW79427.1
BC132744 mRNA Translation: AAI32745.1
BC132746 mRNA Translation: AAI32747.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3026.1 [Q9HAT0-1]

NCBI Reference Sequences

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RefSeqi
NP_001304703.1, NM_001317774.1 [Q9HAT0-1]
NP_060048.2, NM_017578.3 [Q9HAT0-1]
XP_011511235.1, XM_011512933.2 [Q9HAT0-1]
XP_011511236.1, XM_011512934.2 [Q9HAT0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000184183; ENSP00000184183; ENSG00000065371 [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371 [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371 [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371 [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371 [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371 [Q9HAT0-2]
ENST00000620893; ENSP00000483603; ENSG00000065371 [Q9HAT0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54763

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54763

UCSC genome browser

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UCSCi
uc003eha.4, human [Q9HAT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303889 mRNA Translation: AAG27712.2
AL133624 mRNA Translation: CAB63750.2
CH471052 Genomic DNA Translation: EAW79425.1
CH471052 Genomic DNA Translation: EAW79426.1
CH471052 Genomic DNA Translation: EAW79427.1
BC132744 mRNA Translation: AAI32745.1
BC132746 mRNA Translation: AAI32747.1
CCDSiCCDS3026.1 [Q9HAT0-1]
RefSeqiNP_001304703.1, NM_001317774.1 [Q9HAT0-1]
NP_060048.2, NM_017578.3 [Q9HAT0-1]
XP_011511235.1, XM_011512933.2 [Q9HAT0-1]
XP_011511236.1, XM_011512934.2 [Q9HAT0-1]

3D structure databases

SMRiQ9HAT0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120138, 54 interactors
IntActiQ9HAT0, 56 interactors
MINTiQ9HAT0
STRINGi9606.ENSP00000184183

PTM databases

iPTMnetiQ9HAT0
PhosphoSitePlusiQ9HAT0

Polymorphism and mutation databases

BioMutaiROPN1
DMDMi74718687

Proteomic databases

MassIVEiQ9HAT0
PaxDbiQ9HAT0
PeptideAtlasiQ9HAT0
PRIDEiQ9HAT0
ProteomicsDBi81425 [Q9HAT0-1]
81426 [Q9HAT0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32969, 54 antibodies

The DNASU plasmid repository

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DNASUi
54763

Genome annotation databases

EnsembliENST00000184183; ENSP00000184183; ENSG00000065371 [Q9HAT0-1]
ENST00000405845; ENSP00000385919; ENSG00000065371 [Q9HAT0-1]
ENST00000459660; ENSP00000420590; ENSG00000065371 [Q9HAT0-2]
ENST00000479867; ENSP00000420567; ENSG00000065371 [Q9HAT0-2]
ENST00000484329; ENSP00000419205; ENSG00000065371 [Q9HAT0-2]
ENST00000495093; ENSP00000417379; ENSG00000065371 [Q9HAT0-2]
ENST00000620893; ENSP00000483603; ENSG00000065371 [Q9HAT0-1]
GeneIDi54763
KEGGihsa:54763
UCSCiuc003eha.4, human [Q9HAT0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54763
DisGeNETi54763
EuPathDBiHostDB:ENSG00000065371.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ROPN1
HGNCiHGNC:17692, ROPN1
HPAiENSG00000065371, Tissue enriched (testis)
neXtProtiNX_Q9HAT0
OpenTargetsiENSG00000065371
PharmGKBiPA134952827

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502R2JI, Eukaryota
GeneTreeiENSGT00390000012731
HOGENOMiCLU_069829_1_0_1
InParanoidiQ9HAT0
OMAiQWASDYF
PhylomeDBiQ9HAT0
TreeFamiTF105421

Enzyme and pathway databases

PathwayCommonsiQ9HAT0
ReactomeiR-HSA-5666185, RHO GTPases Activate Rhotekin and Rhophilins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54763, 12 hits in 831 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54763
PharosiQ9HAT0, Tbio

Protein Ontology

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PROi
PR:Q9HAT0
RNActiQ9HAT0, protein

Gene expression databases

BgeeiENSG00000065371, Expressed in testis and 89 other tissues
ExpressionAtlasiQ9HAT0, baseline and differential
GenevisibleiQ9HAT0, HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROP1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAT0
Secondary accession number(s): D3DN99, Q9UF38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2001
Last modified: December 2, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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