Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 155 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Solute carrier family 28 member 3

Gene

SLC28A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.

4 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21.6 µM for uridine2 Publications
  2. KM=15.4 µM for cytidine2 Publications
  3. KM=21.2 µM for thymidine2 Publications
  4. KM=15.1 µM for adenosine2 Publications
  5. KM=43 µM for guanosine2 Publications
  6. KM=52.5 µM for inosine2 Publications
  1. Vmax=25.8 pmol/min/mg enzyme for uridine uptake2 Publications
  2. Vmax=32.8 pmol/min/mg enzyme for cytidine uptake2 Publications
  3. Vmax=24.2 pmol/min/mg enzyme for thymidine uptake2 Publications
  4. Vmax=30.4 pmol/min/mg enzyme for adenosine uptake2 Publications
  5. Vmax=51.4 pmol/min/mg enzyme for guanosine uptake2 Publications
  6. Vmax=44.8 pmol/min/mg enzyme for inosine uptake2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HAS3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9HAS3

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.41.2.8, the concentrative nucleoside transporter (cnt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 28 member 3
Alternative name(s):
Concentrative Na(+)-nucleoside cotransporter 3
Short name:
CNT 3
Short name:
hCNT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC28A3
Synonyms:CNT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16484, SLC28A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608269, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAS3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000197506.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 102CytoplasmicSequence analysisAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 127ExtracellularSequence analysis4
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 170CytoplasmicSequence analysisAdd BLAST22
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 200ExtracellularSequence analysis9
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 223CytoplasmicSequence analysis2
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 287ExtracellularSequence analysisAdd BLAST43
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 314CytoplasmicSequence analysis6
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 361ExtracellularSequence analysisAdd BLAST26
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 388CytoplasmicSequence analysis6
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 443ExtracellularSequence analysisAdd BLAST34
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 479CytoplasmicSequence analysisAdd BLAST15
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 553ExtracellularSequence analysisAdd BLAST53
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 593CytoplasmicSequence analysisAdd BLAST19
Transmembranei594 – 614HelicalSequence analysisAdd BLAST21
Topological domaini615 – 691ExtracellularSequence analysisAdd BLAST77

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi568S → P: Decreased uridine transport. Normal localization to the cell membrane. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64078

Open Targets

More...
OpenTargetsi
ENSG00000197506

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA426

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HAS3, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5707

Drug and drug target database

More...
DrugBanki
DB00640, Adenosine
DB00993, Azathioprine
DB00242, Cladribine
DB01073, Fludarabine
DB00441, Gemcitabine
DB04335, Inosine
DB01033, Mercaptopurine
DB00811, Ribavirin
DB09327, Tegafur-uracil
DB04485, Thymidine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1116

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC28A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752767

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241461 – 691Solute carrier family 28 member 3Add BLAST691

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HAS3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HAS3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HAS3

PeptideAtlas

More...
PeptideAtlasi
Q9HAS3

PRoteomics IDEntifications database

More...
PRIDEi
Q9HAS3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
24712
81424 [Q9HAS3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAS3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by phorbol myristate acetate (PMA) in HL-60 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197506, Expressed in oviduct epithelium and 127 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAS3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197506, Tissue enhanced (ductus deferens, pancreas, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122045, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365413

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9HAS3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HAS3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HAS3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 78DisorderedSequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 43Polar residuesSequence analysisAdd BLAST27
Compositional biasi44 – 78Basic and acidic residuesSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3747, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016813_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HAS3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAFQNEE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAS3

TreeFam database of animal gene trees

More...
TreeFami
TF314131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008276, C_nuclsd_transpt
IPR018270, C_nuclsd_transpt_met_bac
IPR030211, CNT3
IPR011657, CNT_C_dom
IPR002668, CNT_N_dom
IPR011642, Gate_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10590, PTHR10590, 1 hit
PTHR10590:SF18, PTHR10590:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07670, Gate, 1 hit
PF07662, Nucleos_tra2_C, 1 hit
PF01773, Nucleos_tra2_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00804, nupC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9HAS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELRSTAAPR AEGYSNVGFQ NEENFLENEN TSGNNSIRSR AVQSREHTNT
60 70 80 90 100
KQDEEQVTVE QDSPRNREHM EDDDEEMQQK GCLERRYDTV CGFCRKHKTT
110 120 130 140 150
LRHIIWGILL AGYLVMVISA CVLNFHRALP LFVITVAAIF FVVWDHLMAK
160 170 180 190 200
YEHRIDEMLS PGRRLLNSHW FWLKWVIWSS LVLAVIFWLA FDTAKLGQQQ
210 220 230 240 250
LVSFGGLIMY IVLLFLFSKY PTRVYWRPVL WGIGLQFLLG LLILRTDPGF
260 270 280 290 300
IAFDWLGRQV QTFLEYTDAG ASFVFGEKYK DHFFAFKVLP IVVFFSTVMS
310 320 330 340 350
MLYYLGLMQW IIRKVGWIML VTTGSSPIES VVASGNIFVG QTESPLLVRP
360 370 380 390 400
YLPYITKSEL HAIMTAGFST IAGSVLGAYI SFGVPSSHLL TASVMSAPAS
410 420 430 440 450
LAAAKLFWPE TEKPKITLKN AMKMESGDSG NLLEAATQGA SSSISLVANI
460 470 480 490 500
AVNLIAFLAL LSFMNSALSW FGNMFDYPQL SFELICSYIF MPFSFMMGVE
510 520 530 540 550
WQDSFMVARL IGYKTFFNEF VAYEHLSKWI HLRKEGGPKF VNGVQQYISI
560 570 580 590 600
RSEIIATYAL CGFANIGSLG IVIGGLTSMA PSRKRDIASG AVRALIAGTV
610 620 630 640 650
ACFMTACIAG ILSSTPVDIN CHHVLENAFN STFPGNTTKV IACCQSLLSS
660 670 680 690
TVAKGPGEVI PGGNHSLYSL KGCCTLLNPS TFNCNGISNT F
Length:691
Mass (Da):76,930
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80FD14518A8BFA61
GO
Isoform 2 (identifier: Q9HAS3-2) [UniParc]FASTAAdd to basket
Also known as: hCNT3ins

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway.Curated
Show »
Length:622
Mass (Da):69,027
Checksum:i8C9CB6F47D0AC0C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251I → V in BAG36748 (PubMed:14702039).Curated1
Sequence conflicti293V → I in BAG36748 (PubMed:14702039).Curated1
Sequence conflicti505F → L in BAG65240 (PubMed:14702039).Curated1
Sequence conflicti628A → S in BAF85538 (PubMed:14702039).Curated1
Sequence conflicti639K → E in BAG36748 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0396654R → K1 PublicationCorresponds to variant dbSNP:rs11568401Ensembl.1
Natural variantiVAR_0396665S → N2 PublicationsCorresponds to variant dbSNP:rs11568403EnsemblClinVar.1
Natural variantiVAR_03966762D → H1 PublicationCorresponds to variant dbSNP:rs45621433Ensembl.1
Natural variantiVAR_03966867R → K1 PublicationCorresponds to variant dbSNP:rs11568411Ensembl.1
Natural variantiVAR_039669113Y → C2 PublicationsCorresponds to variant dbSNP:rs10868138Ensembl.1
Natural variantiVAR_039670131L → F1 Publication1
Natural variantiVAR_039671221P → Q. Corresponds to variant dbSNP:rs11140503Ensembl.1
Natural variantiVAR_039672328I → V1 PublicationCorresponds to variant dbSNP:rs11568418Ensembl.1
Natural variantiVAR_039673349R → Q1 PublicationCorresponds to variant dbSNP:rs45525131Ensembl.1
Natural variantiVAR_070606366A → T1 PublicationCorresponds to variant dbSNP:rs140138960Ensembl.1
Natural variantiVAR_039674367G → R Reduced transport of inosine and thymidine. 1 PublicationCorresponds to variant dbSNP:rs11568388Ensembl.1
Natural variantiVAR_039675418L → I1 PublicationCorresponds to variant dbSNP:rs11568405Ensembl.1
Natural variantiVAR_039676513Y → F2 PublicationsCorresponds to variant dbSNP:rs56350726Ensembl.1
Natural variantiVAR_039677585R → H1 PublicationCorresponds to variant dbSNP:rs11568398Ensembl.1
Natural variantiVAR_039678602C → R Lower concentrative capacity and altered sodium binding capacity. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0538481 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF305210 mRNA Translation: AAG22551.1
AK292849 mRNA Translation: BAF85538.1
AK304406 mRNA Translation: BAG65240.1
AK314039 mRNA Translation: BAG36748.1
AL353787 Genomic DNA No translation available.
AL356134 Genomic DNA No translation available.
BC093821 mRNA Translation: AAH93821.1
BC093823 mRNA Translation: AAH93823.1
CH471089 Genomic DNA Translation: EAW62686.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6670.1 [Q9HAS3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001186562.1, NM_001199633.1 [Q9HAS3-1]
NP_071410.1, NM_022127.2 [Q9HAS3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376238; ENSP00000365413; ENSG00000197506 [Q9HAS3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64078

UCSC genome browser

More...
UCSCi
uc010mpz.4, human [Q9HAS3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305210 mRNA Translation: AAG22551.1
AK292849 mRNA Translation: BAF85538.1
AK304406 mRNA Translation: BAG65240.1
AK314039 mRNA Translation: BAG36748.1
AL353787 Genomic DNA No translation available.
AL356134 Genomic DNA No translation available.
BC093821 mRNA Translation: AAH93821.1
BC093823 mRNA Translation: AAH93823.1
CH471089 Genomic DNA Translation: EAW62686.1
CCDSiCCDS6670.1 [Q9HAS3-1]
RefSeqiNP_001186562.1, NM_001199633.1 [Q9HAS3-1]
NP_071410.1, NM_022127.2 [Q9HAS3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6KSWelectron microscopy3.60A/B/C70-691[»]
SMRiQ9HAS3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122045, 1 interactor
STRINGi9606.ENSP00000365413

Chemistry databases

BindingDBiQ9HAS3
ChEMBLiCHEMBL5707
DrugBankiDB00640, Adenosine
DB00993, Azathioprine
DB00242, Cladribine
DB01073, Fludarabine
DB00441, Gemcitabine
DB04335, Inosine
DB01033, Mercaptopurine
DB00811, Ribavirin
DB09327, Tegafur-uracil
DB04485, Thymidine
GuidetoPHARMACOLOGYi1116

Protein family/group databases

TCDBi2.A.41.2.8, the concentrative nucleoside transporter (cnt) family

PTM databases

iPTMnetiQ9HAS3
PhosphoSitePlusiQ9HAS3

Genetic variation databases

BioMutaiSLC28A3
DMDMi74752767

Proteomic databases

EPDiQ9HAS3
MassIVEiQ9HAS3
PaxDbiQ9HAS3
PeptideAtlasiQ9HAS3
PRIDEiQ9HAS3
ProteomicsDBi24712
81424 [Q9HAS3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13126, 67 antibodies

The DNASU plasmid repository

More...
DNASUi
64078

Genome annotation databases

EnsembliENST00000376238; ENSP00000365413; ENSG00000197506 [Q9HAS3-1]
GeneIDi64078
KEGGihsa:64078
UCSCiuc010mpz.4, human [Q9HAS3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64078
DisGeNETi64078

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC28A3
HGNCiHGNC:16484, SLC28A3
HPAiENSG00000197506, Tissue enhanced (ductus deferens, pancreas, seminal vesicle)
MIMi608269, gene
neXtProtiNX_Q9HAS3
OpenTargetsiENSG00000197506
PharmGKBiPA426
VEuPathDBiHostDB:ENSG00000197506.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3747, Eukaryota
GeneTreeiENSGT00390000016025
HOGENOMiCLU_016813_3_0_1
InParanoidiQ9HAS3
OMAiTAFQNEE
PhylomeDBiQ9HAS3
TreeFamiTF314131

Enzyme and pathway databases

PathwayCommonsiQ9HAS3
ReactomeiR-HSA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
SABIO-RKiQ9HAS3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
64078, 2 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC28A3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64078
PharosiQ9HAS3, Tchem

Protein Ontology

More...
PROi
PR:Q9HAS3
RNActiQ9HAS3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197506, Expressed in oviduct epithelium and 127 other tissues
GenevisibleiQ9HAS3, HS

Family and domain databases

InterProiView protein in InterPro
IPR008276, C_nuclsd_transpt
IPR018270, C_nuclsd_transpt_met_bac
IPR030211, CNT3
IPR011657, CNT_C_dom
IPR002668, CNT_N_dom
IPR011642, Gate_dom
PANTHERiPTHR10590, PTHR10590, 1 hit
PTHR10590:SF18, PTHR10590:SF18, 1 hit
PfamiView protein in Pfam
PF07670, Gate, 1 hit
PF07662, Nucleos_tra2_C, 1 hit
PF01773, Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804, nupC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS28A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAS3
Secondary accession number(s): A8K9Y4
, B1AML0, B2RA51, B4E2S8, F5GYE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again